Brimonidine_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brimonidine perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brimonidine_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.189742
KDM2A lysine (K)-specific demethylase 2A 0.103035
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0997297
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0980891
AKAP12 A kinase (PRKA) anchor protein 12 0.0826081
EFNA5 ephrin-A5 0.080264
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0786729
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0784579
FNDC3B fibronectin type III domain containing 3B 0.0773915
PCBP2 poly(rC) binding protein 2 0.0743393
ELL2 elongation factor, RNA polymerase II, 2 0.0741329
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0722306
NPC1 Niemann-Pick disease, type C1 0.0699194
SIK3 SIK family kinase 3 0.0685978
AKAP13 A kinase (PRKA) anchor protein 13 0.0681939
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0677849
SMAD3 SMAD family member 3 0.0655566
DOCK5 dedicator of cytokinesis 5 0.0608839
IGFBP3 insulin-like growth factor binding protein 3 0.0601763
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0593435
RICTOR RPTOR independent companion of MTOR, complex 2 0.0590587
ZEB2 zinc finger E-box binding homeobox 2 0.0553906
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0534773
TGM2 transglutaminase 2 0.0526028
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0521284
OSMR oncostatin M receptor 0.0516086
RAP1B RAP1B, member of RAS oncogene family 0.0505475
PELI1 pellino E3 ubiquitin protein ligase 1 0.0464404
HAS2 hyaluronan synthase 2 0.0454009
BASP1 brain abundant, membrane attached signal protein 1 0.0451386
USP34 ubiquitin specific peptidase 34 0.0450169
SOD2 superoxide dismutase 2, mitochondrial 0.0446832
CTNND1 catenin (cadherin-associated protein), delta 1 0.0410427
ARHGAP5 Rho GTPase activating protein 5 0.0406296
VEGFA vascular endothelial growth factor A 0.0391934
ATP13A3 ATPase type 13A3 0.0389155
GRB10 growth factor receptor-bound protein 10 0.0382251
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.037805
SREBF2 sterol regulatory element binding transcription factor 2 0.0374713
FTH1 ferritin, heavy polypeptide 1 0.0367891
RNF24 ring finger protein 24 0.0367556
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0364661
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0354369
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0353734
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0325667
SDK1 sidekick cell adhesion molecule 1 0.0322081
NRP1 neuropilin 1 0.0314125
RB1CC1 RB1-inducible coiled-coil 1 0.0312417
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0310636
JMJD1C jumonji domain containing 1C 0.0308127
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0303428
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0302161
UBE2H ubiquitin-conjugating enzyme E2H 0.0302042
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0299795
RAB27B RAB27B, member RAS oncogene family 0.0297491
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0296981
SPRED2 sprouty-related, EVH1 domain containing 2 0.0296417
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0295939
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0294716
MAP2K1 mitogen-activated protein kinase kinase 1 0.0294317
WWTR1 WW domain containing transcription regulator 1 0.0291852
PTBP3 polypyrimidine tract binding protein 3 0.029082
TMEM165 transmembrane protein 165 0.0290634
VMP1 vacuole membrane protein 1 0.028804
SNX9 sorting nexin 9 0.0284551
PCNX1 pecanex 1 0.0281131
UBA6 ubiquitin-like modifier activating enzyme 6 0.0279985
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0279151
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0272822
CHD1L chromodomain helicase DNA binding protein 1-like 0.027189
DUSP5 dual specificity phosphatase 5 0.0267797
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0267527
MSN moesin 0.0264602
NAV2 neuron navigator 2 0.0262346
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0260872
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0260243
STC1 stanniocalcin 1 0.025914
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0258443
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0255328
AMPD3 adenosine monophosphate deaminase 3 0.0253866
ADD3 adducin 3 (gamma) 0.0250972
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0250913
USP47 ubiquitin specific peptidase 47 0.0250484
AHR aryl hydrocarbon receptor 0.0248764
UGCG UDP-glucose ceramide glucosyltransferase 0.024861
MT2A metallothionein 2A 0.0247772
ADM adrenomedullin 0.0247051
ARID3B AT rich interactive domain 3B (BRIGHT-like) 0.0242709
RNF149 ring finger protein 149 0.0241323
ITGAV integrin, alpha V 0.0241009
ADAM28 ADAM metallopeptidase domain 28 0.0238868
GLCCI1 glucocorticoid induced 1 0.0238724
BIRC3 baculoviral IAP repeat containing 3 0.0236933
ARRDC3 arrestin domain containing 3 0.0234702
ARHGAP42 Rho GTPase activating protein 42 0.0233643
SYAP1 synapse associated protein 1 0.0233347
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0232584
ANXA5 annexin A5 0.0231499
DPYSL3 dihydropyrimidinase-like 3 0.022975
AGFG1 ArfGAP with FG repeats 1 0.0229295

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.198631
FN1 fibronectin 1 -0.193798
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.19165
VIM vimentin -0.103184
CDH13 cadherin 13 -0.0950003
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0945503
TMSB10 thymosin beta 10 -0.0848974
DST dystonin -0.0803388
ENO1 enolase 1, (alpha) -0.0786337
SYT1 synaptotagmin I -0.0764784
PSD3 pleckstrin and Sec7 domain containing 3 -0.0712324
HMGA2 high mobility group AT-hook 2 -0.0655185
CANX calnexin -0.0653134
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0615215
HDLBP high density lipoprotein binding protein -0.0574761
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0560946
DDIT3 DNA-damage-inducible transcript 3 -0.0548592
MAML3 mastermind-like 3 (Drosophila) -0.0547667
PTMA prothymosin, alpha -0.0518147
AHNAK AHNAK nucleoprotein -0.0514821
LOX lysyl oxidase -0.0514176
TAS2R14 taste receptor, type 2, member 14 -0.0489922
ZNF804A zinc finger protein 804A -0.0483426
SAMD9 sterile alpha motif domain containing 9 -0.0483286
FAM20C family with sequence similarity 20, member C -0.045499
FTL ferritin, light polypeptide -0.0452856
RPLP1 ribosomal protein, large, P1 -0.0445453
VCL vinculin -0.0443742
ASPH aspartate beta-hydroxylase -0.0434563
FBN1 fibrillin 1 -0.0431333
PGK1 phosphoglycerate kinase 1 -0.0430765
RPS8 ribosomal protein S8 -0.0425433
MECOM MDS1 and EVI1 complex locus -0.0395559
SUMF1 sulfatase modifying factor 1 -0.0377041
TPT1 tumor protein, translationally-controlled 1 -0.037567
SQSTM1 sequestosome 1 -0.0375353
RPL32 ribosomal protein L32 -0.0371404
LMAN1 lectin, mannose-binding, 1 -0.0366541
RPL35A ribosomal protein L35a -0.0360442
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0355903
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0351836
GOLGA4 golgin A4 -0.0350869
DPYD dihydropyrimidine dehydrogenase -0.0347073
INTS6 integrator complex subunit 6 -0.0346317
GPC6 glypican 6 -0.034419
SP100 SP100 nuclear antigen -0.0343727
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0338203
RPL34 ribosomal protein L34 -0.0336136
LRMDA leucine rich melanocyte differentiation associated -0.0335889
RAI14 retinoic acid induced 14 -0.0334296
EXOC4 exocyst complex component 4 -0.0333002
IER3 immediate early response 3 -0.0327926
EHBP1 EH domain binding protein 1 -0.0323579
TMSB4X thymosin beta 4, X-linked -0.0322162
PRELID2 PRELI domain containing 2 -0.0321929
TTC3 tetratricopeptide repeat domain 3 -0.0321788
DLG1 discs, large homolog 1 (Drosophila) -0.0319956
PTPRK protein tyrosine phosphatase, receptor type, K -0.0315288
RPS6 ribosomal protein S6 -0.0312524
LIMCH1 LIM and calponin homology domains 1 -0.0312454
RPLP0 ribosomal protein, large, P0 -0.0311634
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0306022
EXT1 exostosin glycosyltransferase 1 -0.0304955
PDIA4 protein disulfide isomerase family A, member 4 -0.0303066
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0299041
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.029838
RPL12 ribosomal protein L12 -0.0291595
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0284447
KCTD16 potassium channel tetramerization domain containing 16 -0.0281848
KDM3A lysine (K)-specific demethylase 3A -0.027995
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0277152
RPS29 ribosomal protein S29 -0.0276839
RACK1 receptor for activated C kinase 1 -0.0276211
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0274749
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0274507
TMTC1 transmembrane and tetratricopeptide repeat containing 1 -0.0273883
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0271772
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0270674
RPL19 ribosomal protein L19 -0.0270558
MEF2A myocyte enhancer factor 2A -0.0268455
IARS1 isoleucyl-tRNA synthetase 1 -0.0266935
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.026613
ARHGAP35 Rho GTPase activating protein 35 -0.0265825
AADAC arylacetamide deacetylase -0.0265487
GOLGB1 golgin B1 -0.0264612
RPS24 ribosomal protein S24 -0.0263405
CALR calreticulin -0.0262027
PKM pyruvate kinase, muscle -0.0261766
RPS19 ribosomal protein S19 -0.0261397
RAD51B RAD51 paralog B -0.0261209
NAP1L1 nucleosome assembly protein 1-like 1 -0.0255335
LDHA lactate dehydrogenase A -0.0254791
PHF3 PHD finger protein 3 -0.0254718
RPL5 ribosomal protein L5 -0.0254026
MAP1B microtubule-associated protein 1B -0.0253951
SLIT2 slit homolog 2 (Drosophila) -0.0252106
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.024811
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0246729
SEC31A SEC31 homolog A (S. cerevisiae) -0.0246581
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0244274