Brimonidine_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brimonidine perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brimonidine_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.141146
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.129888
PDE4D phosphodiesterase 4D, cAMP-specific 0.123071
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0792658
THSD4 thrombospondin, type I, domain containing 4 0.0708354
SVIL supervillin 0.0527747
DOCK5 dedicator of cytokinesis 5 0.0483992
CMIP c-Maf inducing protein 0.0452435
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0446736
SAMD4A sterile alpha motif domain containing 4A 0.0440177
PM20D1 peptidase M20 domain containing 1 0.0427904
TXNRD1 thioredoxin reductase 1 0.0424561
DOCK4 dedicator of cytokinesis 4 0.0424465
HDAC9 histone deacetylase 9 0.0387137
KYNU kynureninase 0.0364986
AKAP12 A kinase (PRKA) anchor protein 12 0.0356539
BICC1 BicC family RNA binding protein 1 0.0350413
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0338181
FAM107B family with sequence similarity 107, member B 0.0321855
IGFBP3 insulin-like growth factor binding protein 3 0.0321313
OSMR oncostatin M receptor 0.0319919
ASPH aspartate beta-hydroxylase 0.0307698
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0307123
MAML3 mastermind-like 3 (Drosophila) 0.0295494
EFNA5 ephrin-A5 0.0293163
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0283905
SMOC1 SPARC related modular calcium binding 1 0.0281914
CXCL8 chemokine (C-X-C motif) ligand 8 0.0276853
GLIS3 GLIS family zinc finger 3 0.0271347
RAD51B RAD51 paralog B 0.0264666
IGF2 insulin-like growth factor 2 0.0261037
TTC28 tetratricopeptide repeat domain 28 0.0260092
EGFR epidermal growth factor receptor 0.0257986
NTN4 netrin 4 0.0247189
PYGL phosphorylase, glycogen, liver 0.0245932
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0242993
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0239915
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0231085
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0227289
NAV3 neuron navigator 3 0.0225775
ERRFI1 ERBB receptor feedback inhibitor 1 0.0224812
ZBTB20 zinc finger and BTB domain containing 20 0.0222937
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0221983
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0220106
NRG1 neuregulin 1 0.0215927
BASP1 brain abundant, membrane attached signal protein 1 0.0209439
USP34 ubiquitin specific peptidase 34 0.0208104
EHBP1 EH domain binding protein 1 0.020705
SPIDR scaffolding protein involved in DNA repair 0.0201745
NEBL nebulette 0.0188805
DST dystonin 0.018846
ANKRD12 ankyrin repeat domain 12 0.0187048
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0186775
UTRN utrophin 0.0185374
CFLAR CASP8 and FADD-like apoptosis regulator 0.0183992
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0183666
VMP1 vacuole membrane protein 1 0.018274
BABAM2 BRISC and BRCA1 A complex member 2 0.0182391
TM4SF1 transmembrane 4 L six family member 1 0.0181705
PTPRM protein tyrosine phosphatase, receptor type, M 0.0181471
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0180129
ATXN1 ataxin 1 0.017029
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.016849
AGO2 argonaute RISC catalytic component 2 0.0166378
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.01653
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0164984
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0163777
TBC1D5 TBC1 domain family, member 5 0.0160651
WWOX WW domain containing oxidoreductase 0.015978
NEGR1 neuronal growth regulator 1 0.0159305
EXOC6B exocyst complex component 6B 0.0155023
BIRC6 baculoviral IAP repeat containing 6 0.0155019
ZNF638 zinc finger protein 638 0.0152542
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0151262
RPTOR regulatory associated protein of MTOR, complex 1 0.0150672
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.0148808
FOXP1 forkhead box P1 0.0146879
BMP5 bone morphogenetic protein 5 0.0145125
ARHGAP26 Rho GTPase activating protein 26 0.0143446
KLF6 Kruppel-like factor 6 0.0142642
RASAL2 RAS protein activator like 2 0.0141989
PCNX4 pecanex 4 0.0140549
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0140531
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0139689
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0139646
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.013961
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0139587
RB1CC1 RB1-inducible coiled-coil 1 0.0139498
ZEB1 zinc finger E-box binding homeobox 1 0.013933
WWTR1 WW domain containing transcription regulator 1 0.013921
VCL vinculin 0.0139116
PATJ PATJ crumbs cell polarity complex component 0.0137842
BICD1 bicaudal D homolog 1 (Drosophila) 0.0137554
TAS2R14 taste receptor, type 2, member 14 0.0137509
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0137492
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.0135251
EXOC4 exocyst complex component 4 0.0135244
BCAR3 breast cancer anti-estrogen resistance 3 0.0135054
NIPBL Nipped-B homolog (Drosophila) 0.0135019
SMAD2 SMAD family member 2 0.0132516

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.20483
MT2A metallothionein 2A -0.192893
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.1844
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.155932
TMSB10 thymosin beta 10 -0.148917
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.094724
VIM vimentin -0.0926112
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.089722
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0878209
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0814362
RPL19 ribosomal protein L19 -0.0740277
PTMA prothymosin, alpha -0.0541467
FTH1 ferritin, heavy polypeptide 1 -0.0540839
RPLP1 ribosomal protein, large, P1 -0.0520922
TPM3 tropomyosin 3 -0.0515096
RPL23 ribosomal protein L23 -0.0508726
PFN1 profilin 1 -0.0495961
YBX1 Y box binding protein 1 -0.0468514
RPS19 ribosomal protein S19 -0.0459678
RPS8 ribosomal protein S8 -0.0457221
RPS6 ribosomal protein S6 -0.0431746
RPS12 ribosomal protein S12 -0.042003
HMGA1 high mobility group AT-hook 1 -0.0415834
RPL36 ribosomal protein L36 -0.0401685
RPLP0 ribosomal protein, large, P0 -0.0397956
POTEF POTE ankyrin domain family, member F -0.0392332
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0383542
PDIA6 protein disulfide isomerase family A, member 6 -0.0377426
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0365908
EEF2 eukaryotic translation elongation factor 2 -0.0359793
PKM pyruvate kinase, muscle -0.0342011
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0331596
ZNF207 zinc finger protein 207 -0.0327998
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0324087
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0322569
S100A10 S100 calcium binding protein A10 -0.0317063
RPS29 ribosomal protein S29 -0.0311431
USP3 ubiquitin specific peptidase 3 -0.0309092
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0304642
RPS25 ribosomal protein S25 -0.0300108
RPL8 ribosomal protein L8 -0.0292948
RPL37A ribosomal protein L37a -0.0287049
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0286413
RPS23 ribosomal protein S23 -0.028019
RPS3 ribosomal protein S3 -0.0275516
ADAM9 ADAM metallopeptidase domain 9 -0.0274278
RPL7 ribosomal protein L7 -0.0272701
RBM25 RNA binding motif protein 25 -0.0269471
PDIA3 protein disulfide isomerase family A, member 3 -0.0262267
RPS5 ribosomal protein S5 -0.0258698
RTN4 reticulon 4 -0.0258599
EIF1 eukaryotic translation initiation factor 1 -0.0257934
TFG TRK-fused gene -0.025619
RBM39 RNA binding motif protein 39 -0.0253744
RPS27A ribosomal protein S27a -0.025159
RPS16 ribosomal protein S16 -0.0246843
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0244432
CCNL1 cyclin L1 -0.0240261
RNF145 ring finger protein 145 -0.0239806
HMGB1 high mobility group box 1 -0.023919
RPS21 ribosomal protein S21 -0.0235102
ATP5F1E ATP synthase F1 subunit epsilon -0.0234956
TRA2A transformer 2 alpha homolog (Drosophila) -0.0233754
ZNF292 zinc finger protein 292 -0.0233591
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0232985
PCBP2 poly(rC) binding protein 2 -0.0232204
NOP58 NOP58 ribonucleoprotein -0.0231428
RPS17 ribosomal protein S17 -0.0231247
PFDN2 prefoldin subunit 2 -0.0229392
ANXA2 annexin A2 -0.0227908
RPL28 ribosomal protein L28 -0.0227861
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0224517
RPS15 ribosomal protein S15 -0.0224176
VDAC1 voltage-dependent anion channel 1 -0.0222258
RPS20 ribosomal protein S20 -0.0221491
KIF5B kinesin family member 5B -0.0220598
RPLP2 ribosomal protein, large, P2 -0.021939
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0218684
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0217899
ENAH enabled homolog (Drosophila) -0.0213952
ACTG1 actin gamma 1 -0.0213564
CALR calreticulin -0.0212451
SERF2 small EDRK-rich factor 2 -0.0210228
PAWR PRKC, apoptosis, WT1, regulator -0.0210224
PA2G4 proliferation-associated 2G4, 38kDa -0.0203662
TAGLN2 transgelin 2 -0.0203299
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0202678
MATR3 matrin 3 -0.0200468
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0199968
SLC38A1 solute carrier family 38, member 1 -0.0199227
FNBP1L formin binding protein 1-like -0.019885
GNAS GNAS complex locus -0.0198629
TMEM123 transmembrane protein 123 -0.0196885
LGALS1 lectin, galactoside-binding, soluble, 1 -0.019117
RSRC2 arginine/serine-rich coiled-coil 2 -0.0191117
RCC1 regulator of chromosome condensation 1 -0.0190982
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0189935
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0188974
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0188838
RPL5 ribosomal protein L5 -0.0188642