Brimonidine_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brimonidine perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brimonidine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.200174
FTL ferritin, light polypeptide 0.142441
VIM vimentin 0.114443
EIF1 eukaryotic translation initiation factor 1 0.0859602
TMSB10 thymosin beta 10 0.0735194
KYNU kynureninase 0.0708246
PTMA prothymosin, alpha 0.0700057
ENO1 enolase 1, (alpha) 0.0679169
TRIO trio Rho guanine nucleotide exchange factor 0.0653109
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0581358
MT2A metallothionein 2A 0.0571642
TXNRD1 thioredoxin reductase 1 0.0556209
LOC102724023 ES1 protein homolog, mitochondrial 0.0512141
RPL31 ribosomal protein L31 0.0508321
STC1 stanniocalcin 1 0.0508075
ZMYND8 zinc finger, MYND-type containing 8 0.0500122
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0500018
RBM25 RNA binding motif protein 25 0.0491072
LOC112694756 uncharaterized LOC112694756 0.0481472
RPL23 ribosomal protein L23 0.0478489
POTEF POTE ankyrin domain family, member F 0.0477831
YBX1 Y box binding protein 1 0.0476428
TIMP3 TIMP metallopeptidase inhibitor 3 0.0474135
TXNIP thioredoxin interacting protein 0.0468987
RNF213 ring finger protein 213 0.0463695
GPHN gephyrin 0.0460905
RPL19 ribosomal protein L19 0.0451725
NAMPT nicotinamide phosphoribosyltransferase 0.0450969
NLGN1 neuroligin 1 0.0435507
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0430339
CELF1 CUGBP, Elav-like family member 1 0.0425725
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0424725
NCOA3 nuclear receptor coactivator 3 0.0424056
PGK1 phosphoglycerate kinase 1 0.0422407
RPS6 ribosomal protein S6 0.0411054
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0408266
UHMK1 U2AF homology motif (UHM) kinase 1 0.0403378
EPSTI1 epithelial stromal interaction 1 (breast) 0.0399868
RAB2A RAB2A, member RAS oncogene family 0.039371
BHLHE40 basic helix-loop-helix family, member e40 0.0390879
AKAP9 A kinase (PRKA) anchor protein 9 0.0388635
RPS19 ribosomal protein S19 0.0385588
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0385446
ITPKC inositol-trisphosphate 3-kinase C 0.0385139
RACK1 receptor for activated C kinase 1 0.0382352
PDE10A phosphodiesterase 10A 0.037307
RPS3 ribosomal protein S3 0.0370445
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0364414
MAP1B microtubule-associated protein 1B 0.0364317
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0362289
TBC1D5 TBC1 domain family, member 5 0.0350766
GSK3B glycogen synthase kinase 3 beta 0.0348884
NDRG1 N-myc downstream regulated 1 0.0348186
SCAF11 SR-related CTD-associated factor 11 0.0345728
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0343081
PRRC2C proline-rich coiled-coil 2C 0.034194
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0338936
B2M beta-2-microglobulin 0.032683
RFX7 regulatory factor X, 7 0.0325514
ZNF292 zinc finger protein 292 0.0324196
RUNX1 runt-related transcription factor 1 0.0316086
APLP2 amyloid beta (A4) precursor-like protein 2 0.0314474
DOCK5 dedicator of cytokinesis 5 0.0310645
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0306827
RPS27 ribosomal protein S27 0.0304817
RPL35A ribosomal protein L35a 0.0304437
TSC22D2 TSC22 domain family, member 2 0.0302599
ZFR zinc finger RNA binding protein 0.0302197
RPL11 ribosomal protein L11 0.0301545
MACC1 metastasis associated in colon cancer 1 0.0300438
PHF21A PHD finger protein 21A 0.0299976
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0295531
PIBF1 progesterone immunomodulatory binding factor 1 0.0295258
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.029424
CCNL1 cyclin L1 0.0293227
FOXP1 forkhead box P1 0.0292722
GOLGA4 golgin A4 0.0289373
BRWD3 bromodomain and WD repeat domain containing 3 0.0288094
RAD51B RAD51 paralog B 0.0286604
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0286081
SPAG9 sperm associated antigen 9 0.0285641
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0284672
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0283631
FAM13A family with sequence similarity 13, member A 0.0283592
RPS12 ribosomal protein S12 0.0283317
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0280854
KRT17 keratin 17, type I 0.0279227
RPL15 ribosomal protein L15 0.0278147
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0275892
RPL12 ribosomal protein L12 0.0272156
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.027213
TPD52 tumor protein D52 0.0271884
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0270566
KMT2A lysine (K)-specific methyltransferase 2A 0.0268203
ZMYM2 zinc finger, MYM-type 2 0.02682
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0268081
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.026786
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0267272
CCNI cyclin I 0.0267104
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0266664

decreased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 -0.170093
SAMD4A sterile alpha motif domain containing 4A -0.165317
CEMIP cell migration inducing protein, hyaluronan binding -0.14075
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.139419
MYO1E myosin IE -0.131555
LIMCH1 LIM and calponin homology domains 1 -0.117676
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.107202
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0936637
LMO7 LIM domain 7 -0.0906378
PDE4D phosphodiesterase 4D, cAMP-specific -0.0844653
LAMB3 laminin, beta 3 -0.0817899
PLAUR plasminogen activator, urokinase receptor -0.0801602
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0762377
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0698695
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0694789
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0678251
ADGRB3 adhesion G protein-coupled receptor B3 -0.0661276
ATOSA atos homolog A -0.0640548
BACE2 beta-site APP-cleaving enzyme 2 -0.0627077
ERRFI1 ERBB receptor feedback inhibitor 1 -0.062041
F3 coagulation factor III (thromboplastin, tissue factor) -0.0606265
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0597043
CMIP c-Maf inducing protein -0.059196
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0575093
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0569095
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0554787
AHNAK AHNAK nucleoprotein -0.0548612
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0540601
PTPRM protein tyrosine phosphatase, receptor type, M -0.0529174
LAMC2 laminin, gamma 2 -0.0526246
PARD3 par-3 family cell polarity regulator -0.0525258
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0522256
MAML2 mastermind-like 2 (Drosophila) -0.0517222
COL6A3 collagen, type VI, alpha 3 -0.0515141
NABP1 nucleic acid binding protein 1 -0.0509929
MXD1 MAX dimerization protein 1 -0.0497638
MUC16 mucin 16, cell surface associated -0.0486798
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0484076
MMP1 matrix metallopeptidase 1 -0.0470108
RBM47 RNA binding motif protein 47 -0.0460066
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0453536
SVIL supervillin -0.0450403
CATSPERB catsper channel auxiliary subunit beta -0.0447753
SHB Src homology 2 domain containing adaptor protein B -0.0443919
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0442467
CA12 carbonic anhydrase XII -0.0442367
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0440523
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.043505
ARHGAP32 Rho GTPase activating protein 32 -0.0431334
FOXO1 forkhead box O1 -0.0429911
TUFT1 tuftelin 1 -0.0403408
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0392379
ABI3BP ABI family, member 3 (NESH) binding protein -0.0391464
TC2N tandem C2 domains, nuclear -0.0390602
FER fer (fps/fes related) tyrosine kinase -0.0388677
MAML3 mastermind-like 3 (Drosophila) -0.0382503
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0378059
HOMER1 homer scaffolding protein 1 -0.0375259
TCP11L2 t-complex 11, testis-specific-like 2 -0.0369554
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0366168
SACK1A scaffolding CK1 anchoring protein A -0.0353623
SEPTIN10 septin 10 -0.0350905
ARHGAP21 Rho GTPase activating protein 21 -0.0350803
HPCAL1 hippocalcin-like 1 -0.0347466
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0344235
DSPP dentin sialophosphoprotein -0.0344004
ABHD17C abhydrolase domain containing 17C -0.0338805
SDCBP2 syndecan binding protein (syntenin) 2 -0.0338052
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0336924
EXT1 exostosin glycosyltransferase 1 -0.0336342
MYO6 myosin VI -0.0335403
WARS1 tryptophanyl-tRNA synthetase 1 -0.0334698
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0334645
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0334524
SDC4 syndecan 4 -0.0333981
PLEC plectin -0.0333177
HMGA2 high mobility group AT-hook 2 -0.0332879
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein -0.0332731
PAIP2 poly(A) binding protein interacting protein 2 -0.0327919
NPTN neuroplastin -0.0327185
OCLN occludin -0.032602
AK1 adenylate kinase 1 -0.0322555
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0321212
TRPS1 trichorhinophalangeal syndrome I -0.0320983
IGF1R insulin-like growth factor 1 receptor -0.0319067
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0318578
LEPROT leptin receptor overlapping transcript -0.0318577
TJP2 tight junction protein 2 -0.0318188
SPPL3 signal peptide peptidase like 3 -0.0317133
DENND4A DENN/MADD domain containing 4A -0.0316184
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.031397
C1D C1D nuclear receptor corepressor -0.031373
NSD3 nuclear receptor binding SET domain protein 3 -0.0311806
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0311382
ZNF185 zinc finger protein 185 (LIM domain) -0.0309212
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0309023
CTBP2 C-terminal binding protein 2 -0.0308375
FAAH2 fatty acid amide hydrolase 2 -0.030672
FBXO11 F-box protein 11 -0.0300306
FBXO34 F-box protein 34 -0.0298577