Brimonidine_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brimonidine perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brimonidine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.202372
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.103982
TXNRD1 thioredoxin reductase 1 0.0889224
GRAMD1B GRAM domain containing 1B 0.0883306
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0725956
ELL2 elongation factor, RNA polymerase II, 2 0.0661791
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0627895
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0625248
OSMR oncostatin M receptor 0.0615082
YBX3 Y box binding protein 3 0.0579658
MCL1 myeloid cell leukemia 1 0.0499946
VMP1 vacuole membrane protein 1 0.0493762
DOCK5 dedicator of cytokinesis 5 0.0477603
NABP1 nucleic acid binding protein 1 0.0469989
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0469264
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0436542
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0404876
MARCHF4 membrane associated ring-CH-type finger 4 0.0400774
ERRFI1 ERBB receptor feedback inhibitor 1 0.0396464
CDK17 cyclin-dependent kinase 17 0.0393234
JMJD1C jumonji domain containing 1C 0.0390892
ANO6 anoctamin 6 0.0383571
VCL vinculin 0.0376784
EGR1 early growth response 1 0.0369326
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0363815
SPRED2 sprouty-related, EVH1 domain containing 2 0.0346132
ZSWIM6 zinc finger, SWIM-type containing 6 0.0338179
POTEF POTE ankyrin domain family, member F 0.0326206
TFPI2 tissue factor pathway inhibitor 2 0.0313404
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0313061
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.031213
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0304749
ACTN1 actinin, alpha 1 0.0297389
THSD4 thrombospondin, type I, domain containing 4 0.0296083
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0293765
CCNL1 cyclin L1 0.0292142
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0292097
WWTR1 WW domain containing transcription regulator 1 0.0290512
RASAL2 RAS protein activator like 2 0.0287504
TRIO trio Rho guanine nucleotide exchange factor 0.0286607
YAP1 Yes-associated protein 1 0.0278515
SFPQ splicing factor proline/glutamine-rich 0.0274158
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0272607
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0269649
SNAP25 synaptosomal-associated protein, 25kDa 0.0266362
SLC38A2 solute carrier family 38, member 2 0.0265376
EXT1 exostosin glycosyltransferase 1 0.0261799
CSNK1A1 casein kinase 1, alpha 1 0.0260113
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0256525
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0255764
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0254707
MYPN myopalladin 0.0253548
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0248405
PDLIM5 PDZ and LIM domain 5 0.0240876
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0239547
SNX9 sorting nexin 9 0.0238434
RICTOR RPTOR independent companion of MTOR, complex 2 0.0237928
STC1 stanniocalcin 1 0.023721
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0234642
ATP13A3 ATPase type 13A3 0.0232467
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0230841
RIMS2 regulating synaptic membrane exocytosis 2 0.0230121
TMEM41B transmembrane protein 41B 0.022932
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0221616
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0221131
RTN4 reticulon 4 0.0219764
GSK3B glycogen synthase kinase 3 beta 0.0219411
CHIC2 cysteine-rich hydrophobic domain 2 0.0215197
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0214463
RAB7A RAB7A, member RAS oncogene family 0.0214119
PLSCR1 phospholipid scramblase 1 0.0213729
RNF145 ring finger protein 145 0.0211811
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0209361
EXOC6B exocyst complex component 6B 0.0207756
PDE10A phosphodiesterase 10A 0.0203569
NRG1 neuregulin 1 0.0203056
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0202996
RUNX1 runt-related transcription factor 1 0.0202021
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0198986
WDR26 WD repeat domain 26 0.0193945
ATP11A ATPase, class VI, type 11A 0.0193308
TM4SF1 transmembrane 4 L six family member 1 0.019319
BRD2 bromodomain containing 2 0.0190137
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0189372
CCDC91 coiled-coil domain containing 91 0.0189163
LUZP1 leucine zipper protein 1 0.0189067
CALD1 caldesmon 1 0.0188867
FMNL2 formin-like 2 0.0187773
SYNE2 spectrin repeat containing, nuclear envelope 2 0.018756
CTTNBP2NL CTTNBP2 N-terminal like 0.0183789
ETNK1 ethanolamine kinase 1 0.0183139
CDCP1 CUB domain containing protein 1 0.0180989
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0180715
LATS2 large tumor suppressor kinase 2 0.0178037
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0173142
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0172565
MAN1A2 mannosidase, alpha, class 1A, member 2 0.0171955
BMAL2 basic helix-loop-helix ARNT like 2 0.0170882
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0170689
IFI6 interferon, alpha-inducible protein 6 0.0170296

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.145456
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.137428
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.130281
PTMA prothymosin, alpha -0.104635
TMSB10 thymosin beta 10 -0.0801758
VIM vimentin -0.0796599
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0714545
CANX calnexin -0.0553424
RPL37 ribosomal protein L37 -0.04532
RPS8 ribosomal protein S8 -0.0446881
RPS3 ribosomal protein S3 -0.0444679
EEF2 eukaryotic translation elongation factor 2 -0.0398497
NAP1L1 nucleosome assembly protein 1-like 1 -0.0378508
TPT1 tumor protein, translationally-controlled 1 -0.0374541
CSDE1 cold shock domain containing E1, RNA-binding -0.0361274
RPL35A ribosomal protein L35a -0.0360826
PDIA4 protein disulfide isomerase family A, member 4 -0.0350913
GOLGA4 golgin A4 -0.0337752
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0329119
RPL12 ribosomal protein L12 -0.0328924
GNAS GNAS complex locus -0.0326621
RPS27A ribosomal protein S27a -0.0321656
KDM3A lysine (K)-specific demethylase 3A -0.0319791
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.031842
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0314601
ENO1 enolase 1, (alpha) -0.03139
RPS21 ribosomal protein S21 -0.0308546
RPL19 ribosomal protein L19 -0.0301965
RPL26 ribosomal protein L26 -0.0300503
RPL37A ribosomal protein L37a -0.0292193
RPLP1 ribosomal protein, large, P1 -0.0290112
CALR calreticulin -0.0287809
SRP72 signal recognition particle 72kDa -0.0287651
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0280576
RAB1A RAB1A, member RAS oncogene family -0.0273843
CALU calumenin -0.0273368
RPS19 ribosomal protein S19 -0.0272681
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0272011
RPL38 ribosomal protein L38 -0.026556
RACK1 receptor for activated C kinase 1 -0.0264658
RPS15 ribosomal protein S15 -0.0262468
RPL34 ribosomal protein L34 -0.0257455
RPL23 ribosomal protein L23 -0.0254954
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0254948
RPL32 ribosomal protein L32 -0.0252194
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0250802
RPL8 ribosomal protein L8 -0.0247043
RPL11 ribosomal protein L11 -0.0245706
RPS4X ribosomal protein S4, X-linked -0.0244516
SRP54 signal recognition particle 54kDa -0.0244406
VDAC1 voltage-dependent anion channel 1 -0.0238844
DEK DEK proto-oncogene -0.0238495
PDIA6 protein disulfide isomerase family A, member 6 -0.0236612
WDR45B WD repeat domain 45B -0.0236374
BBX bobby sox homolog (Drosophila) -0.0235444
TOP2A topoisomerase (DNA) II alpha 170kDa -0.023454
RPS12 ribosomal protein S12 -0.0230101
RPS24 ribosomal protein S24 -0.0229902
LMAN1 lectin, mannose-binding, 1 -0.0226124
RPL5 ribosomal protein L5 -0.0225321
RPS29 ribosomal protein S29 -0.0223359
KMT2A lysine (K)-specific methyltransferase 2A -0.0222971
FTL ferritin, light polypeptide -0.0220825
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0220178
RPL13A ribosomal protein L13a -0.0218865
PREPL prolyl endopeptidase-like -0.0216818
SRRM2 serine/arginine repetitive matrix 2 -0.0215669
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0212085
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0211343
RPL31 ribosomal protein L31 -0.0211307
RPLP2 ribosomal protein, large, P2 -0.020809
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0199651
ZNF292 zinc finger protein 292 -0.0198697
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0198341
ACBD3 acyl-CoA binding domain containing 3 -0.0198053
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0195984
HDLBP high density lipoprotein binding protein -0.0192428
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0192043
RPL36 ribosomal protein L36 -0.0190846
SPDYA speedy/RINGO cell cycle regulator family member A -0.0187089
PHF20 PHD finger protein 20 -0.0186969
RPS27 ribosomal protein S27 -0.018572
RAD21 RAD21 homolog (S. pombe) -0.0184579
CCDC47 coiled-coil domain containing 47 -0.0183258
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0182279
CAMTA1 calmodulin binding transcription activator 1 -0.0181464
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0181262
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0180847
NACA nascent polypeptide-associated complex alpha subunit -0.0180123
RPS10 ribosomal protein S10 -0.0178426
AHNAK AHNAK nucleoprotein -0.0177232
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0175791
GARS1 glycyl-tRNA synthetase 1 -0.0175529
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0175513
OGA O-GlcNAcase -0.0174609
NCOR1 nuclear receptor corepressor 1 -0.017275
RPS6 ribosomal protein S6 -0.0172199
COPA coatomer protein complex, subunit alpha -0.0170496
RPL9 ribosomal protein L9 -0.0169197
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0168156