Brimonidine_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brimonidine perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brimonidine_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.225465
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.205695
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.159776
ASPH aspartate beta-hydroxylase 0.108052
NPEPPS aminopeptidase puromycin sensitive 0.092927
ERRFI1 ERBB receptor feedback inhibitor 1 0.0791798
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0753456
NAMPT nicotinamide phosphoribosyltransferase 0.0709354
NDRG1 N-myc downstream regulated 1 0.0702438
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0688137
LMO7 LIM domain 7 0.0675573
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0662829
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0661642
FNDC3B fibronectin type III domain containing 3B 0.065812
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0595393
LAMC2 laminin, gamma 2 0.0583622
LAMB3 laminin, beta 3 0.0581741
ARRDC3 arrestin domain containing 3 0.0581652
TMEM165 transmembrane protein 165 0.0560001
FAM13A family with sequence similarity 13, member A 0.0551209
ITCH itchy E3 ubiquitin protein ligase 0.0549915
DSCAM Down syndrome cell adhesion molecule 0.0535929
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0531688
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0515209
RHOA ras homolog family member A 0.0512181
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0511762
CD2AP CD2-associated protein 0.0503568
MYO6 myosin VI 0.0502029
ELL2 elongation factor, RNA polymerase II, 2 0.0490864
TXNIP thioredoxin interacting protein 0.0490227
FTH1 ferritin, heavy polypeptide 1 0.0486358
LDHA lactate dehydrogenase A 0.0481457
KMT2E lysine (K)-specific methyltransferase 2E 0.0461523
FAM3C family with sequence similarity 3, member C 0.0457847
CTSB cathepsin B 0.0449295
CAPN2 calpain 2, (m/II) large subunit 0.0448609
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0441582
TMEM263 transmembrane protein 263 0.0426619
MARCHF6 membrane associated ring-CH-type finger 6 0.0424034
CDCP1 CUB domain containing protein 1 0.0421226
PGK1 phosphoglycerate kinase 1 0.0416551
VEZT vezatin, adherens junctions transmembrane protein 0.0407301
CCNL1 cyclin L1 0.0393469
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0387227
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0381802
TOP1 topoisomerase (DNA) I 0.0379403
RAB6A RAB6A, member RAS oncogene family 0.0377745
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0377579
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0375963
TPM4 tropomyosin 4 0.0371745
COPA coatomer protein complex, subunit alpha 0.0371275
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0363962
IGFBP3 insulin-like growth factor binding protein 3 0.0361151
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0357398
S100A6 S100 calcium binding protein A6 0.0355762
SLC38A1 solute carrier family 38, member 1 0.0352132
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0350309
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0348062
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.0347967
IL6ST interleukin 6 signal transducer 0.0347629
ACTG1 actin gamma 1 0.0347224
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.034658
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0339668
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0337016
KDM6A lysine (K)-specific demethylase 6A 0.0336721
ESYT2 extended synaptotagmin-like protein 2 0.0335892
UBC ubiquitin C 0.0335168
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0333988
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0333988
RAB1A RAB1A, member RAS oncogene family 0.0333673
YTHDC1 YTH domain containing 1 0.0330985
RTN4 reticulon 4 0.0330432
MBNL1 muscleblind-like splicing regulator 1 0.0328654
BZW1 basic leucine zipper and W2 domains 1 0.0326841
RBM39 RNA binding motif protein 39 0.0325923
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0325165
ANXA1 annexin A1 0.032146
RNF145 ring finger protein 145 0.0320488
HLA-A major histocompatibility complex, class I, A 0.0317738
ANXA2 annexin A2 0.0316731
PTBP3 polypyrimidine tract binding protein 3 0.0316332
TENT2 terminal nucleotidyltransferase 2 0.0315992
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0310551
CD46 CD46 molecule, complement regulatory protein 0.030993
IQGAP1 IQ motif containing GTPase activating protein 1 0.0308759
PARD3 par-3 family cell polarity regulator 0.0306431
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0306058
GOLGA4 golgin A4 0.0305443
TES testin LIM domain protein 0.0302793
NRIP1 nuclear receptor interacting protein 1 0.0302286
NEK7 NIMA-related kinase 7 0.0301855
CSDE1 cold shock domain containing E1, RNA-binding 0.0299767
SOX4 SRY (sex determining region Y)-box 4 0.0298181
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0297585
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0297188
CD47 CD47 molecule 0.0296115
PELI1 pellino E3 ubiquitin protein ligase 1 0.0293039
PDIA3 protein disulfide isomerase family A, member 3 0.0293021
STRN3 striatin, calmodulin binding protein 3 0.0292358
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0292058

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.213132
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.12257
TMSB10 thymosin beta 10 -0.102412
RPL35A ribosomal protein L35a -0.0733436
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0718801
HMGA1 high mobility group AT-hook 1 -0.0654096
SAMD4A sterile alpha motif domain containing 4A -0.0619825
RPS19 ribosomal protein S19 -0.0599019
RPS8 ribosomal protein S8 -0.0541097
LPP LIM domain containing preferred translocation partner in lipoma -0.0498254
RNF213 ring finger protein 213 -0.048227
RACK1 receptor for activated C kinase 1 -0.0475936
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0475209
RPL32 ribosomal protein L32 -0.0467393
RPL23 ribosomal protein L23 -0.0463916
RPS6 ribosomal protein S6 -0.0424714
PTMA prothymosin, alpha -0.0411599
RPL8 ribosomal protein L8 -0.0401915
PGBD5 piggyBac transposable element derived 5 -0.0387061
PDLIM5 PDZ and LIM domain 5 -0.0385705
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0382166
RPL19 ribosomal protein L19 -0.0381261
NAV2 neuron navigator 2 -0.0379088
MT2A metallothionein 2A -0.0377371
ISG15 ISG15 ubiquitin-like modifier -0.0376229
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0363295
ARHGAP20 Rho GTPase activating protein 20 -0.0360591
RPL28 ribosomal protein L28 -0.0348221
INTS6 integrator complex subunit 6 -0.0340053
RPS3 ribosomal protein S3 -0.0333894
RPL9 ribosomal protein L9 -0.0330863
RPS29 ribosomal protein S29 -0.032928
YBX1 Y box binding protein 1 -0.0328457
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0328005
RPS23 ribosomal protein S23 -0.0325056
RPL36 ribosomal protein L36 -0.0312079
IFITM3 interferon induced transmembrane protein 3 -0.0301098
GRB10 growth factor receptor-bound protein 10 -0.030024
RPL34 ribosomal protein L34 -0.0299341
S100A10 S100 calcium binding protein A10 -0.0296319
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0288374
ENO1 enolase 1, (alpha) -0.0280065
GPX4 glutathione peroxidase 4 -0.0279085
G0S2 G0/G1 switch 2 -0.0272654
RPL11 ribosomal protein L11 -0.0271671
RPS5 ribosomal protein S5 -0.0269145
RIGI RNA sensor RIG-I -0.0267237
RPS10 ribosomal protein S10 -0.0264893
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0264363
FHIT fragile histidine triad -0.0257779
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0257517
FNIP1 folliculin interacting protein 1 -0.025543
RPLP1 ribosomal protein, large, P1 -0.0252527
RPL35 ribosomal protein L35 -0.0247719
MX2 MX dynamin-like GTPase 2 -0.0246642
RPL27 ribosomal protein L27 -0.0240398
CTBP2 C-terminal binding protein 2 -0.0239973
EEF1G eukaryotic translation elongation factor 1 gamma -0.0239853
RPS27 ribosomal protein S27 -0.0238758
PHLDA2 pleckstrin homology-like domain, family A, member 2 -0.0232477
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0228979
RAD51B RAD51 paralog B -0.0228853
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0225088
RPS13 ribosomal protein S13 -0.0221334
EGR1 early growth response 1 -0.0218944
RPLP2 ribosomal protein, large, P2 -0.0218261
HDLBP high density lipoprotein binding protein -0.0217654
S100A9 S100 calcium binding protein A9 -0.0217266
RPS14 ribosomal protein S14 -0.0215911
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0214891
IFI27 interferon, alpha-inducible protein 27 -0.020669
RPL5 ribosomal protein L5 -0.0203597
LMNA lamin A/C -0.0203287
SP100 SP100 nuclear antigen -0.0199096
RPL31 ribosomal protein L31 -0.0198626
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0197528
AGO2 argonaute RISC catalytic component 2 -0.0197495
GOLGB1 golgin B1 -0.0194683
COL8A1 collagen, type VIII, alpha 1 -0.0192955
RPS21 ribosomal protein S21 -0.0192343
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0191335
MCL1 myeloid cell leukemia 1 -0.0191028
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0190707
TBCA tubulin folding cofactor A -0.0190167
FLNA filamin A, alpha -0.0189701
NABP1 nucleic acid binding protein 1 -0.0188445
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0187198
HMGB1 high mobility group box 1 -0.0187052
IFI44L interferon-induced protein 44-like -0.0185869
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.018502
ATP5F1E ATP synthase F1 subunit epsilon -0.0184959
ETV6 ets variant 6 -0.0184833
RPL18 ribosomal protein L18 -0.0184456
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0184455
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.018442
TPST1 tyrosylprotein sulfotransferase 1 -0.0181794
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0181391
NPC2 Niemann-Pick disease, type C2 -0.0180904
WARS1 tryptophanyl-tRNA synthetase 1 -0.0180852
RPL12 ribosomal protein L12 -0.0179694