Brimonidine_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brimonidine perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brimonidine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GDA guanine deaminase 0.100285
EFNA5 ephrin-A5 0.096722
NAMPT nicotinamide phosphoribosyltransferase 0.0898215
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0665792
TXNRD1 thioredoxin reductase 1 0.064883
TRIO trio Rho guanine nucleotide exchange factor 0.0621101
GRAMD1B GRAM domain containing 1B 0.0566761
NEK7 NIMA-related kinase 7 0.0558974
IGFBP3 insulin-like growth factor binding protein 3 0.0530811
RTN4 reticulon 4 0.0455335
CD109 CD109 molecule 0.0443523
SAMD4A sterile alpha motif domain containing 4A 0.0384208
ASPH aspartate beta-hydroxylase 0.0373333
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0371627
NPAS2 neuronal PAS domain protein 2 0.0347617
ELL2 elongation factor, RNA polymerase II, 2 0.0345843
LIMCH1 LIM and calponin homology domains 1 0.0338831
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0334933
CARD16 caspase recruitment domain family, member 16 0.0314917
CTSC cathepsin C 0.0312557
TNPO1 transportin 1 0.0307222
ENAH enabled homolog (Drosophila) 0.0305283
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0305262
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0301289
ATP13A3 ATPase type 13A3 0.028411
AVL9 AVL9 homolog (S. cerevisiase) 0.0277807
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0272762
COL4A5 collagen, type IV, alpha 5 0.026491
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0263192
AGFG1 ArfGAP with FG repeats 1 0.02527
ZEB2 zinc finger E-box binding homeobox 2 0.0246815
ANKRD28 ankyrin repeat domain 28 0.0239059
COL4A6 collagen, type IV, alpha 6 0.0239042
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.023838
ARHGAP29 Rho GTPase activating protein 29 0.0234944
FLNB filamin B, beta 0.023405
BCAR3 breast cancer anti-estrogen resistance 3 0.023305
WDR43 WD repeat domain 43 0.0223184
RBM39 RNA binding motif protein 39 0.0223013
PCBP2 poly(rC) binding protein 2 0.0221914
MFF mitochondrial fission factor 0.0221195
KYNU kynureninase 0.0219113
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0215419
PTEN phosphatase and tensin homolog 0.0213614
OGA O-GlcNAcase 0.0213434
BIRC6 baculoviral IAP repeat containing 6 0.0213344
ESYT2 extended synaptotagmin-like protein 2 0.0211265
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0208447
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0201745
MYOF myoferlin 0.020108
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0198643
FAM13A family with sequence similarity 13, member A 0.0194803
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0192464
DPYD dihydropyrimidine dehydrogenase 0.0191077
MSN moesin 0.018533
DPY19L1 dpy-19-like 1 (C. elegans) 0.0183714
USP9X ubiquitin specific peptidase 9, X-linked 0.0183061
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0180787
ANKRD17 ankyrin repeat domain 17 0.017683
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0175789
WDR26 WD repeat domain 26 0.0175186
TFPI2 tissue factor pathway inhibitor 2 0.0174597
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0173764
PRRC2C proline-rich coiled-coil 2C 0.017283
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0172521
IL1RAP interleukin 1 receptor accessory protein 0.017185
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0170933
EZR ezrin 0.0169531
PTK2 protein tyrosine kinase 2 0.0169135
SFPQ splicing factor proline/glutamine-rich 0.0166807
RNF145 ring finger protein 145 0.0164943
PHIP pleckstrin homology domain interacting protein 0.0164386
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0164242
STRN3 striatin, calmodulin binding protein 3 0.0163325
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0162331
RBM25 RNA binding motif protein 25 0.0161679
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0160529
MCL1 myeloid cell leukemia 1 0.0160151
ANXA5 annexin A5 0.0160126
TGFBI transforming growth factor, beta-induced, 68kDa 0.0159666
KDM6A lysine (K)-specific demethylase 6A 0.015725
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0157057
CD46 CD46 molecule, complement regulatory protein 0.0156972
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0155882
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0155629
VMP1 vacuole membrane protein 1 0.0155393
SRPK2 SRSF protein kinase 2 0.0155031
JMJD1C jumonji domain containing 1C 0.0154544
PUM2 pumilio RNA-binding family member 2 0.015441
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0153246
RAI1 retinoic acid induced 1 0.015306
DIAPH3 diaphanous-related formin 3 0.0152712
SPRED2 sprouty-related, EVH1 domain containing 2 0.0152643
USP3 ubiquitin specific peptidase 3 0.0152437
RUNX1 runt-related transcription factor 1 0.0152337
WDFY2 WD repeat and FYVE domain containing 2 0.0151904
UHMK1 U2AF homology motif (UHM) kinase 1 0.0151618
RICTOR RPTOR independent companion of MTOR, complex 2 0.0151119
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0149017
NUP58 nucleoporin 58 0.0148632

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.269807
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.247765
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.165971
FN1 fibronectin 1 -0.164178
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.162431
VIM vimentin -0.161474
TPT1 tumor protein, translationally-controlled 1 -0.126431
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.122173
CDH13 cadherin 13 -0.117248
PTMA prothymosin, alpha -0.103535
RPS6 ribosomal protein S6 -0.0938987
TMSB10 thymosin beta 10 -0.0908153
RPS8 ribosomal protein S8 -0.0904782
RPLP1 ribosomal protein, large, P1 -0.0880203
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0827401
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0784802
NALF1 NALCN channel auxiliary factor 1 -0.0694336
RPS24 ribosomal protein S24 -0.0646369
RPL26 ribosomal protein L26 -0.0627861
RPL37A ribosomal protein L37a -0.0620557
LSAMP limbic system-associated membrane protein -0.0597182
RPL31 ribosomal protein L31 -0.059717
ENO1 enolase 1, (alpha) -0.0594531
RPL12 ribosomal protein L12 -0.0582569
P3H2 prolyl 3-hydroxylase 2 -0.0569127
FTL ferritin, light polypeptide -0.0555893
RPS19 ribosomal protein S19 -0.0546683
PSD3 pleckstrin and Sec7 domain containing 3 -0.0537576
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0536742
RPL34 ribosomal protein L34 -0.0534086
RPL19 ribosomal protein L19 -0.0531692
RPL35A ribosomal protein L35a -0.0531593
RPS12 ribosomal protein S12 -0.052817
WARS1 tryptophanyl-tRNA synthetase 1 -0.052187
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0518485
PTPRM protein tyrosine phosphatase, receptor type, M -0.0515006
RPS27A ribosomal protein S27a -0.0493222
HLA-B major histocompatibility complex, class I, B -0.0488709
RPS23 ribosomal protein S23 -0.0470884
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0469881
RPL36A ribosomal protein L36a -0.0423335
CANX calnexin -0.0423061
RPS25 ribosomal protein S25 -0.0420131
RPS14 ribosomal protein S14 -0.0417646
RPL7A ribosomal protein L7a -0.0414708
PRKN parkin RBR E3 ubiquitin protein ligase -0.0409146
RPLP0 ribosomal protein, large, P0 -0.0408904
RPS27 ribosomal protein S27 -0.0405945
ACTG1 actin gamma 1 -0.0398915
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0398488
SQSTM1 sequestosome 1 -0.0392677
RACK1 receptor for activated C kinase 1 -0.0392503
S100A10 S100 calcium binding protein A10 -0.0390569
RPL38 ribosomal protein L38 -0.0386343
RPS3 ribosomal protein S3 -0.0382828
RPL37 ribosomal protein L37 -0.0382188
RPS17 ribosomal protein S17 -0.0377186
RPLP2 ribosomal protein, large, P2 -0.0372791
RPL9 ribosomal protein L9 -0.0357185
RPS16 ribosomal protein S16 -0.0354726
RPS29 ribosomal protein S29 -0.0354423
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0350719
PKM pyruvate kinase, muscle -0.0347965
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0330844
SOX4 SRY (sex determining region Y)-box 4 -0.0330109
MAP7 microtubule-associated protein 7 -0.0323705
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0318172
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0314234
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0307853
STC1 stanniocalcin 1 -0.0307241
RPS13 ribosomal protein S13 -0.0304165
GNAS GNAS complex locus -0.0302495
AUTS2 autism susceptibility candidate 2 -0.0302445
RPL11 ribosomal protein L11 -0.0301373
CUX1 cut-like homeobox 1 -0.030069
MAML3 mastermind-like 3 (Drosophila) -0.0299955
B2M beta-2-microglobulin -0.0292688
RPL23 ribosomal protein L23 -0.0292418
S100A6 S100 calcium binding protein A6 -0.0290556
OASL 2'-5'-oligoadenylate synthetase-like -0.0288898
IFIH1 interferon induced with helicase C domain 1 -0.0287584
PGK1 phosphoglycerate kinase 1 -0.0287337
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0280806
PRELID2 PRELI domain containing 2 -0.0279142
SH3KBP1 SH3-domain kinase binding protein 1 -0.0278772
RPL5 ribosomal protein L5 -0.027765
COL5A2 collagen, type V, alpha 2 -0.0275916
NCKAP5 NCK-associated protein 5 -0.0271992
UBC ubiquitin C -0.0271679
RPL27 ribosomal protein L27 -0.0270374
VCL vinculin -0.0270288
BZW1 basic leucine zipper and W2 domains 1 -0.0269827
RPS21 ribosomal protein S21 -0.026978
LMNA lamin A/C -0.0269487
XYLT1 xylosyltransferase I -0.0269134
HLA-A major histocompatibility complex, class I, A -0.0268871
RPS4X ribosomal protein S4, X-linked -0.0268535
RPL32 ribosomal protein L32 -0.0267849
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0265215
ASTN2 astrotactin 2 -0.0264139