Brimonidine_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brimonidine perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

175 genes differentially expressed following the Brimonidine_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.196574
PSD3 pleckstrin and Sec7 domain containing 3 0.0807173
SLIT2 slit homolog 2 (Drosophila) 0.0690489
TRIO trio Rho guanine nucleotide exchange factor 0.0654155
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0634598
HMGA2 high mobility group AT-hook 2 0.0596395
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0524046
NF1 neurofibromin 1 0.0509198
NPEPPS aminopeptidase puromycin sensitive 0.0508394
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0486775
ZBTB20 zinc finger and BTB domain containing 20 0.0461165
USP9X ubiquitin specific peptidase 9, X-linked 0.0459068
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0445984
ASPH aspartate beta-hydroxylase 0.0430941
PRKCA protein kinase C, alpha 0.0426515
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0405978
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0398872
FNDC3B fibronectin type III domain containing 3B 0.0388919
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0381657
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0360694
CHD9 chromodomain helicase DNA binding protein 9 0.0359882
KMT2C lysine (K)-specific methyltransferase 2C 0.034184
NALF1 NALCN channel auxiliary factor 1 0.0330033
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0325722
EZR ezrin 0.0324058
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.031081
FNIP1 folliculin interacting protein 1 0.0291161
DSCAM Down syndrome cell adhesion molecule 0.0279491
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0262478
MEF2A myocyte enhancer factor 2A 0.0255421
ZFAND3 zinc finger, AN1-type domain 3 0.0255357
CARD16 caspase recruitment domain family, member 16 0.0250719
NPC1 Niemann-Pick disease, type C1 0.024622
UBE2K ubiquitin-conjugating enzyme E2K 0.0233754
BIRC6 baculoviral IAP repeat containing 6 0.0227506
MAML2 mastermind-like 2 (Drosophila) 0.0226207
MYOF myoferlin 0.0212625
FAM13A family with sequence similarity 13, member A 0.0201885
SPAG9 sperm associated antigen 9 0.0195202
GRB10 growth factor receptor-bound protein 10 0.0180782
PTK2 protein tyrosine kinase 2 0.0170003
JMJD1C jumonji domain containing 1C 0.0154429
STAG2 stromal antigen 2 0.0142891
PARD3 par-3 family cell polarity regulator 0.014077
MBNL1 muscleblind-like splicing regulator 1 0.0140044
EGFR epidermal growth factor receptor 0.0127061
MYO5B myosin VB 0.0125251
SND1 staphylococcal nuclease and tudor domain containing 1 0.0120766
SNX9 sorting nexin 9 0.0115476
PDE4D phosphodiesterase 4D, cAMP-specific 0.0112427
SP100 SP100 nuclear antigen 0.0109658
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.0106687
MCL1 myeloid cell leukemia 1 0.0104001
PUM2 pumilio RNA-binding family member 2 0.00966477
AFF4 AF4/FMR2 family, member 4 0.00821976
EXT1 exostosin glycosyltransferase 1 0.00800267
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.00776442
KMT2E lysine (K)-specific methyltransferase 2E 0.00765716
PDLIM5 PDZ and LIM domain 5 0.00737555
NAV2 neuron navigator 2 0.00722857
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0071965
RPL37 ribosomal protein L37 0.00660954
PDE10A phosphodiesterase 10A 0.00567932
FMNL2 formin-like 2 0.00563212
ARHGAP32 Rho GTPase activating protein 32 0.00507793
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.00415559
TMSB10 thymosin beta 10 0.00396358
LMO7 LIM domain 7 0.00315848
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.00315368
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.00258871
WASF2 WAS protein family, member 2 0.00207822
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.00157143
MAML3 mastermind-like 3 (Drosophila) 0.00148684
OGA O-GlcNAcase 0.00137338
IGFBP5 insulin-like growth factor binding protein 5 0.00136543
ITGA6 integrin, alpha 6 8.85959E-4
PRELID2 PRELI domain containing 2 8.16277E-4
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 6.93104E-4

decreased expression

Symbol Name Standardized Value
GPC6 glypican 6 -0.0952681
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0824767
VMP1 vacuole membrane protein 1 -0.0820067
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0754985
ACTG1 actin gamma 1 -0.07375
VIM vimentin -0.0671802
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0655001
ZNF292 zinc finger protein 292 -0.0617083
RPS6 ribosomal protein S6 -0.0499571
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0497204
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0493295
PTMA prothymosin, alpha -0.0483217
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0465302
GOLGA4 golgin A4 -0.0462381
RPL19 ribosomal protein L19 -0.0453997
RPLP0 ribosomal protein, large, P0 -0.0443377
RPS8 ribosomal protein S8 -0.0435895
DST dystonin -0.0431465
FLNB filamin B, beta -0.0428059
EEF2 eukaryotic translation elongation factor 2 -0.0422103
RAP1B RAP1B, member of RAS oncogene family -0.0417934
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0413951
IGFBP3 insulin-like growth factor binding protein 3 -0.0411095
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0408095
PDIA3 protein disulfide isomerase family A, member 3 -0.0401848
LDHA lactate dehydrogenase A -0.0378834
RPL23 ribosomal protein L23 -0.0376104
TPT1 tumor protein, translationally-controlled 1 -0.0357326
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0352584
KRT8 keratin 8, type II -0.0337456
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0310322
RPL32 ribosomal protein L32 -0.0307103
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0301045
RPL26 ribosomal protein L26 -0.0284439
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0267133
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0264819
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0252889
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0242391
SYT1 synaptotagmin I -0.024227
ARHGAP26 Rho GTPase activating protein 26 -0.0239306
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0235778
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.022653
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0211817
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0211031
NDRG1 N-myc downstream regulated 1 -0.0203662
MT2A metallothionein 2A -0.020059
EIF1 eukaryotic translation initiation factor 1 -0.0200402
RTN4 reticulon 4 -0.0198423
CEMIP cell migration inducing protein, hyaluronan binding -0.0184629
SBF2 SET binding factor 2 -0.017422
ANKRD12 ankyrin repeat domain 12 -0.0172045
PCBP2 poly(rC) binding protein 2 -0.0170919
RAB7A RAB7A, member RAS oncogene family -0.0164496
PGK1 phosphoglycerate kinase 1 -0.0164332
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0161681
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0161533
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0161437
NAMPT nicotinamide phosphoribosyltransferase -0.0159898
EGR1 early growth response 1 -0.0158959
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0138298
SEC31A SEC31 homolog A (S. cerevisiae) -0.01292
RASA3 RAS p21 protein activator 3 -0.0126371
RPLP2 ribosomal protein, large, P2 -0.0125018
FTL ferritin, light polypeptide -0.0118826
KDM5B lysine (K)-specific demethylase 5B -0.0118351
MYO1E myosin IE -0.011829
DTNA dystrobrevin, alpha -0.0113549
MON2 MON2 homolog (S. cerevisiae) -0.0110443
KAT6B K(lysine) acetyltransferase 6B -0.0107769
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0100395
PRRC2C proline-rich coiled-coil 2C -0.00934864
SRPK2 SRSF protein kinase 2 -0.00917675
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.00895876
LAMB3 laminin, beta 3 -0.00843757
UBE2Z ubiquitin-conjugating enzyme E2Z -0.00833717
NKD1 naked cuticle homolog 1 (Drosophila) -0.00766049
SRRM2 serine/arginine repetitive matrix 2 -0.00744748
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.00726175
WDR45B WD repeat domain 45B -0.00671919
GMDS GDP-mannose 4,6-dehydratase -0.00669048
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.00630012
P4HB prolyl 4-hydroxylase, beta polypeptide -0.00562656
NPAS2 neuronal PAS domain protein 2 -0.00560483
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.00514737
RBM25 RNA binding motif protein 25 -0.00505354
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0048098
RPS16 ribosomal protein S16 -0.00327472
SPATA13 spermatogenesis associated 13 -0.00320758
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.00319183
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.00308654
MACF1 microtubule-actin crosslinking factor 1 -0.00292836
RBM39 RNA binding motif protein 39 -0.00264206
CDK6 cyclin-dependent kinase 6 -0.00235431
RAB6A RAB6A, member RAS oncogene family -0.00182458
RPLP1 ribosomal protein, large, P1 -0.0016082
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.00103015
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -5.89916E-4