Brimonidine_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brimonidine perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brimonidine_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 0.0693794
ZNF292 zinc finger protein 292 0.068639
USP3 ubiquitin specific peptidase 3 0.040204
ZFAND3 zinc finger, AN1-type domain 3 0.0356064
KMT2C lysine (K)-specific methyltransferase 2C 0.0341933
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0327193
MTF2 metal response element binding transcription factor 2 0.0306345
CCNL1 cyclin L1 0.0298956
RHEB Ras homolog enriched in brain 0.0287035
STRN3 striatin, calmodulin binding protein 3 0.027406
WDR43 WD repeat domain 43 0.0265594
ADAM9 ADAM metallopeptidase domain 9 0.0265036
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0254312
ATP5F1B ATP synthase F1 subunit beta 0.0238425
PUM1 pumilio RNA-binding family member 1 0.0222478
MEMO1 mediator of cell motility 1 0.0221999
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0218411
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0214726
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0209997
TRA2A transformer 2 alpha homolog (Drosophila) 0.0205425
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.0205212
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0198893
GARS1 glycyl-tRNA synthetase 1 0.0198627
HELZ helicase with zinc finger 0.0191389
ECT2 epithelial cell transforming 2 0.0190752
GRB2 growth factor receptor-bound protein 2 0.0184468
NOP58 NOP58 ribonucleoprotein 0.0177139
AHCTF1 AT hook containing transcription factor 1 0.0172562
FXR1 fragile X mental retardation, autosomal homolog 1 0.0171959
OLA1 Obg-like ATPase 1 0.0167758
FAM135A family with sequence similarity 135, member A 0.0167025
SRRM1 serine/arginine repetitive matrix 1 0.0166963
PICALM phosphatidylinositol binding clathrin assembly protein 0.0165325
ITGAV integrin, alpha V 0.0163622
FIGN fidgetin 0.0162753
U2SURP U2 snRNP-associated SURP domain containing 0.0161016
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.015957
HSF2 heat shock transcription factor 2 0.0159545
CRY1 cryptochrome circadian clock 1 0.0159335
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0158287
HP1BP3 heterochromatin protein 1, binding protein 3 0.0157361
CPNE8 copine VIII 0.0154453
CDK19 cyclin-dependent kinase 19 0.0151337
RIOK3 RIO kinase 3 0.0149965
TMEM87A transmembrane protein 87A 0.0149794
AGFG1 ArfGAP with FG repeats 1 0.0148161
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0147804
TWSG1 twisted gastrulation BMP signaling modulator 1 0.0147662
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0144921
PRKCI protein kinase C, iota 0.0144612
MATR3 matrin 3 0.0143596
SKIC3 SKI3 subunit of superkiller complex 0.0142452
FNBP1L formin binding protein 1-like 0.0142161
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.0141409
CABIN1 calcineurin binding protein 1 0.0140832
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0140372
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0140316
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0138259
PGAP1 post-GPI attachment to proteins 1 0.0137975
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.0137966
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.013617
SNX2 sorting nexin 2 0.0135463
WDR70 WD repeat domain 70 0.0135244
BAG4 BCL2-associated athanogene 4 0.0135082
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0134884
PDGFC platelet derived growth factor C 0.0133242
ZEB2 zinc finger E-box binding homeobox 2 0.0133178
GLS2 glutaminase 2 (liver, mitochondrial) 0.0133125
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0131476
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0131243
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0130512
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0129826
TMEM39A transmembrane protein 39A 0.0127747
QKI QKI, KH domain containing, RNA binding 0.0127132
MCMBP minichromosome maintenance complex binding protein 0.0127118
IMMT inner membrane protein, mitochondrial 0.0127005
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0126668
ATAD2B ATPase family, AAA domain containing 2B 0.0125583
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0124522
TXNL1 thioredoxin-like 1 0.0124301
MSL2 male-specific lethal 2 homolog (Drosophila) 0.0123328
FEM1C fem-1 homolog c (C. elegans) 0.0123168
TMEM165 transmembrane protein 165 0.0122619
ATL2 atlastin GTPase 2 0.0122045
NFIB nuclear factor I/B 0.0121523
EP300 E1A binding protein p300 0.0121266
TMEM64 transmembrane protein 64 0.0121185
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0120622
NUDCD3 NudC domain containing 3 0.0120536
NCKAP1 NCK-associated protein 1 0.0120019
CDC14A cell division cycle 14A 0.0119327
BCLAF1 BCL2-associated transcription factor 1 0.0118412
RLF rearranged L-myc fusion 0.0117771
SFMBT1 Scm-like with four mbt domains 1 0.0117554
MEF2A myocyte enhancer factor 2A 0.0116746
RMP64 ribonuclease MRP subunit p64 0.011629
KAT6A K(lysine) acetyltransferase 6A 0.0115966
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0115945
THOC2 THO complex 2 0.0114756
FBXO11 F-box protein 11 0.011428

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.221585
COL11A1 collagen, type XI, alpha 1 -0.199732
CADM2 cell adhesion molecule 2 -0.156827
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.140938
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.122993
TMSB10 thymosin beta 10 -0.121289
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.10741
PCLO piccolo presynaptic cytomatrix protein -0.0964981
GPC3 glypican 3 -0.0941186
PTMA prothymosin, alpha -0.0920429
COL3A1 collagen, type III, alpha 1 -0.0900785
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0888326
PCDH9 protocadherin 9 -0.0871151
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0859026
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0854401
ADGRL2 adhesion G protein-coupled receptor L2 -0.079129
ENO1 enolase 1, (alpha) -0.0694363
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.069185
RPS16 ribosomal protein S16 -0.0656345
ADGRV1 adhesion G protein-coupled receptor V1 -0.0633365
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0631169
ACTG1 actin gamma 1 -0.0630114
RPS8 ribosomal protein S8 -0.062656
TENM3 teneurin transmembrane protein 3 -0.0619575
GNAS GNAS complex locus -0.0561414
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0549893
TPT1 tumor protein, translationally-controlled 1 -0.053609
NPAS3 neuronal PAS domain protein 3 -0.0535377
RPS27A ribosomal protein S27a -0.0529258
RPS6 ribosomal protein S6 -0.052817
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0519577
PARD3B par-3 family cell polarity regulator beta -0.0518789
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0501885
RPLP1 ribosomal protein, large, P1 -0.0474604
RPL19 ribosomal protein L19 -0.0450019
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0446756
LDHA lactate dehydrogenase A -0.0443461
AHNAK AHNAK nucleoprotein -0.0439346
DST dystonin -0.0436655
PDE4D phosphodiesterase 4D, cAMP-specific -0.0423136
COL1A2 collagen, type I, alpha 2 -0.0406781
THBS1 thrombospondin 1 -0.0405211
APP amyloid beta (A4) precursor protein -0.0401605
HSPB1 heat shock 27kDa protein 1 -0.0401094
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0385183
COL5A2 collagen, type V, alpha 2 -0.0381093
RPL31 ribosomal protein L31 -0.0379445
PGK1 phosphoglycerate kinase 1 -0.0379052
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0369071
LRRC4C leucine rich repeat containing 4C -0.036805
RPL37A ribosomal protein L37a -0.0365638
UBC ubiquitin C -0.0364434
RPL5 ribosomal protein L5 -0.0364373
NCAM2 neural cell adhesion molecule 2 -0.0364174
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.036409
RPL35A ribosomal protein L35a -0.0363395
RPS12 ribosomal protein S12 -0.0361769
RPS19 ribosomal protein S19 -0.0360513
MDK midkine (neurite growth-promoting factor 2) -0.0357439
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0351193
RPS21 ribosomal protein S21 -0.0349427
SAMD4A sterile alpha motif domain containing 4A -0.0349053
RPL23 ribosomal protein L23 -0.0347618
FN1 fibronectin 1 -0.0341596
PCDH7 protocadherin 7 -0.0337559
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.033731
S100A10 S100 calcium binding protein A10 -0.0334491
RPL12 ribosomal protein L12 -0.033209
SORBS2 sorbin and SH3 domain containing 2 -0.0331829
CDH19 cadherin 19, type 2 -0.0331673
EMP1 epithelial membrane protein 1 -0.0330697
SLIT2 slit homolog 2 (Drosophila) -0.0329871
RPL37 ribosomal protein L37 -0.032964
RPS13 ribosomal protein S13 -0.0328601
B2M beta-2-microglobulin -0.0326752
RPL26 ribosomal protein L26 -0.0320678
RACK1 receptor for activated C kinase 1 -0.0315718
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0314713
HMGB1 high mobility group box 1 -0.0311381
RAD51B RAD51 paralog B -0.0309226
MACF1 microtubule-actin crosslinking factor 1 -0.0304221
DOCK5 dedicator of cytokinesis 5 -0.0301699
FTL ferritin, light polypeptide -0.0299561
CEP350 centrosomal protein 350kDa -0.0298965
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0298423
HMCN1 hemicentin 1 -0.0291329
ANXA2 annexin A2 -0.0287433
PALLD palladin, cytoskeletal associated protein -0.0284295
USP53 ubiquitin specific peptidase 53 -0.0283955
CALR calreticulin -0.0283199
PRELID2 PRELI domain containing 2 -0.0282761
NAP1L1 nucleosome assembly protein 1-like 1 -0.0281861
SRRM2 serine/arginine repetitive matrix 2 -0.0281285
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0276707
DMD dystrophin -0.0276066
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0274459
GSE1 Gse1 coiled-coil protein -0.0272765
CUX1 cut-like homeobox 1 -0.027248
RPS17 ribosomal protein S17 -0.0271749
UTRN utrophin -0.0270699