Brimonidine_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brimonidine perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brimonidine_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RBMS3 RNA binding motif, single stranded interacting protein 3 0.124887
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.113688
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.1131
PDE4B phosphodiesterase 4B, cAMP-specific 0.107375
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0955194
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0939638
EGFR epidermal growth factor receptor 0.0928203
PKM pyruvate kinase, muscle 0.0907669
PDE4D phosphodiesterase 4D, cAMP-specific 0.0881003
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0748101
FOXP1 forkhead box P1 0.0744929
HDAC9 histone deacetylase 9 0.0739546
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0663182
EFNA5 ephrin-A5 0.0651837
POTEF POTE ankyrin domain family, member F 0.0649411
DPYD dihydropyrimidine dehydrogenase 0.061158
ENO2 enolase 2 (gamma, neuronal) 0.0611194
DLG1 discs, large homolog 1 (Drosophila) 0.0603376
EZR ezrin 0.0599426
TJP1 tight junction protein 1 0.0587442
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0562244
NBEA neurobeachin 0.0551623
SOX6 SRY (sex determining region Y)-box 6 0.0539438
RHOA ras homolog family member A 0.0526408
TXNRD1 thioredoxin reductase 1 0.0524728
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0519803
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0504372
ADAM10 ADAM metallopeptidase domain 10 0.0498425
PCBP2 poly(rC) binding protein 2 0.0493473
NPAS2 neuronal PAS domain protein 2 0.0488461
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.046715
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0446498
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0435135
FLNB filamin B, beta 0.0420602
TTC28 tetratricopeptide repeat domain 28 0.0412615
GLI3 GLI family zinc finger 3 0.0407104
LDHA lactate dehydrogenase A 0.0407063
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0397824
EXOC6B exocyst complex component 6B 0.0386856
SMYD3 SET and MYND domain containing 3 0.0383014
SDK1 sidekick cell adhesion molecule 1 0.0361709
PRELID2 PRELI domain containing 2 0.0358734
ZBTB20 zinc finger and BTB domain containing 20 0.035406
N4BP2L2 NEDD4 binding protein 2-like 2 0.0347757
CSF1 colony stimulating factor 1 (macrophage) 0.034181
TBC1D5 TBC1 domain family, member 5 0.0341521
EVI5 ecotropic viral integration site 5 0.0331275
APLP2 amyloid beta (A4) precursor-like protein 2 0.0330325
PTPRG protein tyrosine phosphatase, receptor type, G 0.0326135
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0309011
CPED1 cadherin-like and PC-esterase domain containing 1 0.0308296
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0302861
CAMKMT calmodulin-lysine N-methyltransferase 0.0295794
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0295043
PDIA3 protein disulfide isomerase family A, member 3 0.0283282
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0277451
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0276118
TTC3 tetratricopeptide repeat domain 3 0.0267679
CCND1 cyclin D1 0.0267232
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0262947
GPHN gephyrin 0.0261796
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0261311
CD47 CD47 molecule 0.0261089
MYO5A myosin VA (heavy chain 12, myoxin) 0.0258726
MACROD2 MACRO domain containing 2 0.0256007
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0253707
PRDX2 peroxiredoxin 2 0.0253413
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0252942
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0251045
NFIA nuclear factor I/A 0.0248454
MBNL1 muscleblind-like splicing regulator 1 0.0244915
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0244055
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0242956
GLS2 glutaminase 2 (liver, mitochondrial) 0.024261
GLI2 GLI family zinc finger 2 0.0240967
RPL3 ribosomal protein L3 0.0239986
TSC22D1 TSC22 domain family, member 1 0.0235878
KTN1 kinectin 1 (kinesin receptor) 0.0234113
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0229435
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0228468
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.0227578
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0227011
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0224845
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0224203
ASPH aspartate beta-hydroxylase 0.0223168
SLC38A2 solute carrier family 38, member 2 0.0222394
AHCYL2 adenosylhomocysteinase-like 2 0.0222226
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0221657
NCEH1 neutral cholesterol ester hydrolase 1 0.0221541
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0220244
EEF2 eukaryotic translation elongation factor 2 0.0218693
TRERF1 transcriptional regulating factor 1 0.0218324
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0216493
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0215628
RABGAP1L RAB GTPase activating protein 1-like 0.0215617
NUP58 nucleoporin 58 0.0214639
TAC4 tachykinin 4 (hemokinin) 0.0214444
KIF5C kinesin family member 5C 0.0213671
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0211713
SBF2 SET binding factor 2 0.0210332

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.222434
PTMA prothymosin, alpha -0.17854
TPT1 tumor protein, translationally-controlled 1 -0.142645
TMSB4X thymosin beta 4, X-linked -0.0816647
AHNAK AHNAK nucleoprotein -0.0684097
RPLP1 ribosomal protein, large, P1 -0.0533986
RPL35A ribosomal protein L35a -0.0505841
ACTG1 actin gamma 1 -0.0482145
RPL34 ribosomal protein L34 -0.0476386
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0454389
KDM3A lysine (K)-specific demethylase 3A -0.0444201
RBM39 RNA binding motif protein 39 -0.0434837
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0430244
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0427576
RPL13A ribosomal protein L13a -0.0390834
RAD21 RAD21 homolog (S. pombe) -0.0382576
MKI67 marker of proliferation Ki-67 -0.0376877
RPS24 ribosomal protein S24 -0.0373528
HDLBP high density lipoprotein binding protein -0.0372912
RPL12 ribosomal protein L12 -0.0368487
RSL1D1 ribosomal L1 domain containing 1 -0.0366632
NAMPT nicotinamide phosphoribosyltransferase -0.0360129
RPL19 ribosomal protein L19 -0.0358513
RPLP2 ribosomal protein, large, P2 -0.0352832
NAP1L1 nucleosome assembly protein 1-like 1 -0.0351377
RPS27A ribosomal protein S27a -0.034796
RRBP1 ribosome binding protein 1 -0.0340157
RPL4 ribosomal protein L4 -0.0335769
TM4SF1 transmembrane 4 L six family member 1 -0.033216
NAV2 neuron navigator 2 -0.0319299
RPL31 ribosomal protein L31 -0.0312904
GARS1 glycyl-tRNA synthetase 1 -0.0309563
MYL12B myosin, light chain 12B, regulatory -0.0309331
ZFAND3 zinc finger, AN1-type domain 3 -0.0305387
HMGB1 high mobility group box 1 -0.0304063
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0300257
NCKAP1 NCK-associated protein 1 -0.0296259
ABI1 abl-interactor 1 -0.0296084
CAMTA1 calmodulin binding transcription activator 1 -0.0293974
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0293659
VIM vimentin -0.0292701
WSB1 WD repeat and SOCS box containing 1 -0.0286822
RPL26 ribosomal protein L26 -0.0286272
ANKRD10 ankyrin repeat domain 10 -0.0285875
S100A6 S100 calcium binding protein A6 -0.0285756
RPS8 ribosomal protein S8 -0.0283352
MARCHF6 membrane associated ring-CH-type finger 6 -0.0277657
HMGB2 high mobility group box 2 -0.0275679
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0274559
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0273591
RAB1A RAB1A, member RAS oncogene family -0.0272605
MIS18BP1 MIS18 binding protein 1 -0.0262349
TMSB10 thymosin beta 10 -0.0261761
RPS29 ribosomal protein S29 -0.0253657
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0252783
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0249506
RPS23 ribosomal protein S23 -0.0248521
FUS FUS RNA binding protein -0.024799
RPS19 ribosomal protein S19 -0.0247753
RPS16 ribosomal protein S16 -0.0247659
ANLN anillin, actin binding protein -0.0246149
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0245522
RPS25 ribosomal protein S25 -0.0241193
HJURP Holliday junction recognition protein -0.0240355
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.023986
OGA O-GlcNAcase -0.0239129
RPL32 ribosomal protein L32 -0.0236384
RPS6 ribosomal protein S6 -0.023438
RPL36A ribosomal protein L36a -0.023287
SEC24D SEC24 family member D -0.0231433
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0230841
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0227754
GOLGA4 golgin A4 -0.0227725
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0227563
RPL37A ribosomal protein L37a -0.022733
RPL7A ribosomal protein L7a -0.022637
TPX2 TPX2, microtubule-associated -0.0224223
RPS13 ribosomal protein S13 -0.0222965
RPS11 ribosomal protein S11 -0.0221917
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0221139
TRA2A transformer 2 alpha homolog (Drosophila) -0.021926
ZNF292 zinc finger protein 292 -0.0217356
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.0214129
UBQLN1 ubiquilin 1 -0.0212979
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0212892
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0212861
KLF6 Kruppel-like factor 6 -0.0212365
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0212086
RPL9 ribosomal protein L9 -0.021031
RPS3 ribosomal protein S3 -0.0209651
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0208643
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0206543
EWSR1 EWS RNA-binding protein 1 -0.0205093
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0204168
CENPF centromere protein F, 350/400kDa -0.0203015
JUN jun proto-oncogene -0.0202074
RTN4 reticulon 4 -0.0201902
RPL38 ribosomal protein L38 -0.0201093
STAU1 staufen double-stranded RNA binding protein 1 -0.0199587
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0199156