Brimonidine_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brimonidine perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brimonidine_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.140022
NAMPT nicotinamide phosphoribosyltransferase 0.121302
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.119946
FNDC3B fibronectin type III domain containing 3B 0.106581
FN1 fibronectin 1 0.0909831
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0909699
TRIO trio Rho guanine nucleotide exchange factor 0.0898524
IGFBP3 insulin-like growth factor binding protein 3 0.0886967
PDE10A phosphodiesterase 10A 0.0805168
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0748135
ZMYND8 zinc finger, MYND-type containing 8 0.0728397
NDRG1 N-myc downstream regulated 1 0.0728053
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0718218
HDAC9 histone deacetylase 9 0.0715921
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0685336
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0683891
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0665956
DST dystonin 0.0652211
AKAP12 A kinase (PRKA) anchor protein 12 0.0645976
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0645729
JMJD1C jumonji domain containing 1C 0.0560876
VCAN versican 0.054552
ASPH aspartate beta-hydroxylase 0.0538585
ATXN1 ataxin 1 0.0530173
ELL2 elongation factor, RNA polymerase II, 2 0.0529851
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0523411
VMP1 vacuole membrane protein 1 0.0469028
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0453228
TNS3 tensin 3 0.0451779
VEGFA vascular endothelial growth factor A 0.0449063
SDK1 sidekick cell adhesion molecule 1 0.0449022
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0445939
PRELID2 PRELI domain containing 2 0.0437872
FLNB filamin B, beta 0.0435416
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0432598
STC1 stanniocalcin 1 0.0420594
MMP12 matrix metallopeptidase 12 0.0415273
BACE2 beta-site APP-cleaving enzyme 2 0.0413389
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0407858
GLIS3 GLIS family zinc finger 3 0.0393156
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.039096
RBMS3 RNA binding motif, single stranded interacting protein 3 0.038926
MSN moesin 0.0377614
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0368881
LDHA lactate dehydrogenase A 0.0366236
EFNA5 ephrin-A5 0.0358421
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0354686
CDK19 cyclin-dependent kinase 19 0.0354135
FNIP1 folliculin interacting protein 1 0.0352596
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0345839
RNF213 ring finger protein 213 0.0339837
PPARD peroxisome proliferator-activated receptor delta 0.0337627
TXNIP thioredoxin interacting protein 0.0334651
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0331337
RB1CC1 RB1-inducible coiled-coil 1 0.0330146
ERRFI1 ERBB receptor feedback inhibitor 1 0.0328091
RND3 Rho family GTPase 3 0.032694
PHF21A PHD finger protein 21A 0.0326488
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0324985
HMGA2 high mobility group AT-hook 2 0.0324041
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0321044
CD44 CD44 molecule (Indian blood group) 0.0318059
EGFR epidermal growth factor receptor 0.0313833
MYOF myoferlin 0.0310606
RAI14 retinoic acid induced 14 0.0310111
ARFGEF3 ARFGEF family member 3 0.0308544
ZNF292 zinc finger protein 292 0.0304338
MCL1 myeloid cell leukemia 1 0.0303906
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0300909
YEATS2 YEATS domain containing 2 0.0299854
TENT5A terminal nucleotidyltransferase 5A 0.0298218
KDM2A lysine (K)-specific demethylase 2A 0.0297296
DLG1 discs, large homolog 1 (Drosophila) 0.0296479
C3 complement component 3 0.0291966
EXT1 exostosin glycosyltransferase 1 0.0289454
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0287299
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0286735
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0285836
IFI16 interferon, gamma-inducible protein 16 0.0285673
PSD3 pleckstrin and Sec7 domain containing 3 0.0285544
DIAPH2 diaphanous-related formin 2 0.0285176
KDM4C lysine (K)-specific demethylase 4C 0.0284736
ARRDC3 arrestin domain containing 3 0.028434
RAD51B RAD51 paralog B 0.0284086
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0280834
FMNL2 formin-like 2 0.0280484
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0279887
SMYD3 SET and MYND domain containing 3 0.0278573
IL6ST interleukin 6 signal transducer 0.0274031
RUNX1 runt-related transcription factor 1 0.0272666
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0271686
PHF3 PHD finger protein 3 0.026878
PLIN2 perilipin 2 0.026874
DOCK5 dedicator of cytokinesis 5 0.026841
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0266561
ZBTB20 zinc finger and BTB domain containing 20 0.0262817
ZBTB38 zinc finger and BTB domain containing 38 0.0262371
C6ORF62 chromosome 6 open reading frame 62 0.0261734
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0261207
MYO9A myosin IXA 0.0260647

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.127367
IER3 immediate early response 3 -0.077379
FTL ferritin, light polypeptide -0.0771118
TPT1 tumor protein, translationally-controlled 1 -0.072042
TMSB10 thymosin beta 10 -0.0716143
VIM vimentin -0.0708531
RPS6 ribosomal protein S6 -0.0620564
RPS8 ribosomal protein S8 -0.0580045
RPL23 ribosomal protein L23 -0.0475808
RPL19 ribosomal protein L19 -0.0444291
PTMA prothymosin, alpha -0.0438881
RPS3 ribosomal protein S3 -0.0434822
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0431088
ANXA2 annexin A2 -0.042797
RPL12 ribosomal protein L12 -0.0425831
RPS4X ribosomal protein S4, X-linked -0.0410314
RPL32 ribosomal protein L32 -0.037451
RPL35A ribosomal protein L35a -0.0373266
RPLP1 ribosomal protein, large, P1 -0.0364686
ACTG1 actin gamma 1 -0.0338805
RPS19 ribosomal protein S19 -0.033309
RPL26 ribosomal protein L26 -0.0329179
RPS24 ribosomal protein S24 -0.0319407
RPLP0 ribosomal protein, large, P0 -0.0299958
RPLP2 ribosomal protein, large, P2 -0.0299904
RPL5 ribosomal protein L5 -0.0293318
RACK1 receptor for activated C kinase 1 -0.0277316
RPL36 ribosomal protein L36 -0.027559
HLA-B major histocompatibility complex, class I, B -0.027485
RPS23 ribosomal protein S23 -0.0264353
DEK DEK proto-oncogene -0.0262864
RPS5 ribosomal protein S5 -0.0258729
RPL13A ribosomal protein L13a -0.0257161
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0255017
KDM3A lysine (K)-specific demethylase 3A -0.0254735
RPL31 ribosomal protein L31 -0.0250437
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0248203
RPS21 ribosomal protein S21 -0.0248063
RPL28 ribosomal protein L28 -0.0245316
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0244919
RPL36A ribosomal protein L36a -0.0244648
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0243428
MKI67 marker of proliferation Ki-67 -0.0242169
RPS27A ribosomal protein S27a -0.0239539
RPL35 ribosomal protein L35 -0.0238537
YBX1 Y box binding protein 1 -0.0237592
THBS1 thrombospondin 1 -0.0237303
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0234707
GNAS GNAS complex locus -0.0230714
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0228816
RPL38 ribosomal protein L38 -0.0228549
RPL9 ribosomal protein L9 -0.0228398
RPL11 ribosomal protein L11 -0.0226722
RPL8 ribosomal protein L8 -0.0221443
RPL7A ribosomal protein L7a -0.0219749
RPL37A ribosomal protein L37a -0.021148
RPL7 ribosomal protein L7 -0.0207883
RPS13 ribosomal protein S13 -0.0207553
QKI QKI, KH domain containing, RNA binding -0.0207102
RPS12 ribosomal protein S12 -0.0201193
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0201105
OGA O-GlcNAcase -0.0200442
TKT transketolase -0.01969
RPL34 ribosomal protein L34 -0.01937
EEF2 eukaryotic translation elongation factor 2 -0.0192209
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0190263
RPS27 ribosomal protein S27 -0.0189903
NT5C2 5'-nucleotidase, cytosolic II -0.0184814
RPS14 ribosomal protein S14 -0.0184128
FLNA filamin A, alpha -0.0183885
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0178478
EIF1 eukaryotic translation initiation factor 1 -0.0177779
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0176217
RPS29 ribosomal protein S29 -0.0174439
SRGN serglycin -0.0173489
RPS10 ribosomal protein S10 -0.0172927
ATP5F1E ATP synthase F1 subunit epsilon -0.0172766
S100A9 S100 calcium binding protein A9 -0.0171923
SDC4 syndecan 4 -0.017038
LCORL ligand dependent nuclear receptor corepressor-like -0.0169321
UBC ubiquitin C -0.0169264
RNF145 ring finger protein 145 -0.0167759
RPS17 ribosomal protein S17 -0.0167606
MT2A metallothionein 2A -0.0165203
WDR45B WD repeat domain 45B -0.0163736
THBS2 thrombospondin 2 -0.0163052
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0162061
LOC112694756 uncharaterized LOC112694756 -0.016161
CRY1 cryptochrome circadian clock 1 -0.0161507
WTAP Wilms tumor 1 associated protein -0.015876
SMC4 structural maintenance of chromosomes 4 -0.0156729
RPL4 ribosomal protein L4 -0.0154527
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0152469
ASTN2 astrotactin 2 -0.0150727
RPS15 ribosomal protein S15 -0.0150354
SFRP1 secreted frizzled-related protein 1 -0.0149407
POTEF POTE ankyrin domain family, member F -0.0149121
RPL27A ribosomal protein L27a -0.0146307
ZFAND3 zinc finger, AN1-type domain 3 -0.0142768
SPAG9 sperm associated antigen 9 -0.014184