| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Brimonidine perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Brimonidine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0628398 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0569183 |
| FAM13A | family with sequence similarity 13, member A | 0.0505029 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0502782 |
| NDRG1 | N-myc downstream regulated 1 | 0.0480937 |
| NRXN3 | neurexin 3 | 0.0476136 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0439986 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0417141 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0406433 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0405603 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0401037 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0387842 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.037927 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0369475 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0366107 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0353799 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0316846 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0305926 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.03011 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0296609 |
| RAB8B | RAB8B, member RAS oncogene family | 0.029084 |
| SGCE | sarcoglycan, epsilon | 0.0283402 |
| INSIG2 | insulin induced gene 2 | 0.027986 |
| COG6 | component of oligomeric golgi complex 6 | 0.027853 |
| VMP1 | vacuole membrane protein 1 | 0.0274759 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0273069 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0272059 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0270977 |
| PTN | pleiotrophin | 0.02706 |
| RNF145 | ring finger protein 145 | 0.0269054 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0266913 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.02658 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0265031 |
| C1D | C1D nuclear receptor corepressor | 0.0258557 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0257807 |
| TMEM165 | transmembrane protein 165 | 0.0257799 |
| RNF24 | ring finger protein 24 | 0.0253037 |
| ARRDC3 | arrestin domain containing 3 | 0.0252287 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0243912 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0243247 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0242365 |
| USP3 | ubiquitin specific peptidase 3 | 0.0241504 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.024149 |
| WDR26 | WD repeat domain 26 | 0.0241094 |
| WASHC4 | WASH complex subunit 4 | 0.0240906 |
| BET1 | Bet1 golgi vesicular membrane trafficking protein | 0.0238839 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0238613 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.023716 |
| COG5 | component of oligomeric golgi complex 5 | 0.0237043 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0236651 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0235706 |
| MT1X | metallothionein 1X | 0.0233582 |
| CD109 | CD109 molecule | 0.0232591 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0231082 |
| YTHDC1 | YTH domain containing 1 | 0.0230382 |
| TBC1D23 | TBC1 domain family, member 23 | 0.0228361 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0226759 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0226088 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0225102 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0224636 |
| OPTN | optineurin | 0.022355 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0222301 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0221685 |
| RNF169 | ring finger protein 169 | 0.0221577 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0221572 |
| UBN2 | ubinuclein 2 | 0.0217503 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0217297 |
| FMNL2 | formin-like 2 | 0.0216004 |
| GOLGA4 | golgin A4 | 0.0215939 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0214937 |
| FEM1C | fem-1 homolog c (C. elegans) | 0.0213465 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | 0.0212713 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0212538 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0211969 |
| DENND5A | DENN/MADD domain containing 5A | 0.0209983 |
| LEPROT | leptin receptor overlapping transcript | 0.0208544 |
| TMF1 | TATA element modulatory factor 1 | 0.0208324 |
| FAM13B | family with sequence similarity 13, member B | 0.0207135 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | 0.0207009 |
| ZNF148 | zinc finger protein 148 | 0.0204745 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0204629 |
| ZNF638 | zinc finger protein 638 | 0.020305 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0202966 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0201406 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0200101 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0199759 |
| SMYD3 | SET and MYND domain containing 3 | 0.0198828 |
| CLEC1B | C-type lectin domain family 1, member B | 0.0197817 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.0197724 |
| CPAP | centrosome assembly and centriole elongation protein | 0.0197653 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0196855 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0194335 |
| HELZ | helicase with zinc finger | 0.0191965 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0191904 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0191585 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0190888 |
| TGFB1 | transforming growth factor, beta 1 | 0.0189656 |
| STK17B | serine/threonine kinase 17b | 0.0189315 |
| MORF4L2 | mortality factor 4 like 2 | 0.018763 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0187098 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.17508 |
| COL6A3 | collagen, type VI, alpha 3 | -0.168533 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.148799 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.141148 |
| FN1 | fibronectin 1 | -0.138198 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.124408 |
| TMSB10 | thymosin beta 10 | -0.0954374 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0933781 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0855442 |
| ANXA2 | annexin A2 | -0.0763934 |
| B2M | beta-2-microglobulin | -0.0719972 |
| ACTG1 | actin gamma 1 | -0.0719434 |
| MAP1B | microtubule-associated protein 1B | -0.0697384 |
| FTL | ferritin, light polypeptide | -0.0686873 |
| PTMA | prothymosin, alpha | -0.0681396 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.067701 |
| VCL | vinculin | -0.0673622 |
| POTEF | POTE ankyrin domain family, member F | -0.0640771 |
| CDH13 | cadherin 13 | -0.0617821 |
| CALU | calumenin | -0.0602477 |
| PRSS23 | protease, serine, 23 | -0.0600147 |
| CALD1 | caldesmon 1 | -0.0593206 |
| ENO1 | enolase 1, (alpha) | -0.0589392 |
| TPM4 | tropomyosin 4 | -0.0582857 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0565628 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0535249 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0513465 |
| HLA-B | major histocompatibility complex, class I, B | -0.0512039 |
| COL1A1 | collagen, type I, alpha 1 | -0.0478277 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0459853 |
| STC1 | stanniocalcin 1 | -0.0456475 |
| RAI14 | retinoic acid induced 14 | -0.0449905 |
| LOX | lysyl oxidase | -0.0448275 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.044237 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0410265 |
| RPS8 | ribosomal protein S8 | -0.0409041 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0399794 |
| COL1A2 | collagen, type I, alpha 2 | -0.039319 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0393112 |
| COL5A1 | collagen, type V, alpha 1 | -0.0383257 |
| CD44 | CD44 molecule (Indian blood group) | -0.036603 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.036107 |
| RPL35A | ribosomal protein L35a | -0.0347057 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0344568 |
| TNNC1 | troponin C type 1 (slow) | -0.0342935 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0342301 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0337649 |
| MAP4 | microtubule-associated protein 4 | -0.0336862 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0335874 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.033326 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0328972 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0324846 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.032239 |
| RPL11 | ribosomal protein L11 | -0.031697 |
| COL7A1 | collagen, type VII, alpha 1 | -0.031613 |
| TMSB4X | thymosin beta 4, X-linked | -0.0314954 |
| CLTC | clathrin, heavy chain (Hc) | -0.0310606 |
| LOXL2 | lysyl oxidase-like 2 | -0.0306267 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0305887 |
| KYNU | kynureninase | -0.030281 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0302493 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0295348 |
| MYO10 | myosin X | -0.029249 |
| ROS1 | ROS proto-oncogene 1 , receptor tyrosine kinase | -0.0286567 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0285531 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0283612 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0283045 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0281022 |
| RPL15 | ribosomal protein L15 | -0.0277814 |
| RPLP1 | ribosomal protein, large, P1 | -0.0275388 |
| S100A10 | S100 calcium binding protein A10 | -0.0274344 |
| SRPK2 | SRSF protein kinase 2 | -0.0268023 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0267452 |
| CTSB | cathepsin B | -0.0263894 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0263584 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0263116 |
| USP34 | ubiquitin specific peptidase 34 | -0.0261965 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.026169 |
| CDK6 | cyclin-dependent kinase 6 | -0.0261097 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0260046 |
| CDK13 | cyclin-dependent kinase 13 | -0.0258277 |
| NAV1 | neuron navigator 1 | -0.025731 |
| RASAL2 | RAS protein activator like 2 | -0.025595 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0251956 |
| THBS1 | thrombospondin 1 | -0.0247775 |
| UBC | ubiquitin C | -0.0246465 |
| HLA-C | major histocompatibility complex, class I, C | -0.0246396 |
| RPL34 | ribosomal protein L34 | -0.0245141 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0242532 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0239591 |
| TNS3 | tensin 3 | -0.0239287 |
| MYOF | myoferlin | -0.0238298 |
| HMGB1 | high mobility group box 1 | -0.023581 |
| LAMB1 | laminin, beta 1 | -0.0235555 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0235401 |
| FAT1 | FAT atypical cadherin 1 | -0.0234882 |
| KAZN | kazrin, periplakin interacting protein | -0.0232382 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0231259 |
| TOMM7 | translocase of outer mitochondrial membrane 7 homolog (yeast) | -0.0229704 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0229285 |
