Brimonidine_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brimonidine perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brimonidine_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.235607
IGFBP3 insulin-like growth factor binding protein 3 0.206865
FNDC3B fibronectin type III domain containing 3B 0.182943
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0993519
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0820471
BASP1 brain abundant, membrane attached signal protein 1 0.0724417
DNER delta/notch-like EGF repeat containing 0.0711663
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0710919
VIM vimentin 0.0687623
LDHA lactate dehydrogenase A 0.0672144
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0629131
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0585092
FTH1 ferritin, heavy polypeptide 1 0.0560808
NAMPT nicotinamide phosphoribosyltransferase 0.0551965
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0550824
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0548517
OSMR oncostatin M receptor 0.053924
ZMYND8 zinc finger, MYND-type containing 8 0.053596
PDE8A phosphodiesterase 8A 0.0510211
NF1 neurofibromin 1 0.0509331
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0504034
BPTF bromodomain PHD finger transcription factor 0.0502524
FMN1 formin 1 0.048412
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0471507
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0469071
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0446635
MED13 mediator complex subunit 13 0.0442057
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0441905
PBX3 pre-B-cell leukemia homeobox 3 0.0440969
DGKD diacylglycerol kinase, delta 130kDa 0.0430323
DERA deoxyribose-phosphate aldolase (putative) 0.0426858
DSCAM Down syndrome cell adhesion molecule 0.0420982
MBNL1 muscleblind-like splicing regulator 1 0.0420272
SVIL supervillin 0.041753
FLNB filamin B, beta 0.041587
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0404589
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0403106
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0400499
VMP1 vacuole membrane protein 1 0.0397768
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0396082
CUL5 cullin 5 0.0390139
ANKRD11 ankyrin repeat domain 11 0.0383828
ZNF292 zinc finger protein 292 0.0381943
IL1RAP interleukin 1 receptor accessory protein 0.0375549
EPAS1 endothelial PAS domain protein 1 0.0373879
ZFAND3 zinc finger, AN1-type domain 3 0.0369788
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0368899
ERRFI1 ERBB receptor feedback inhibitor 1 0.0366844
ZBTB20 zinc finger and BTB domain containing 20 0.0365664
LOC112694756 uncharaterized LOC112694756 0.0358547
CCDC91 coiled-coil domain containing 91 0.0350568
PCNX4 pecanex 4 0.0347842
ATP13A3 ATPase type 13A3 0.0344798
UGCG UDP-glucose ceramide glucosyltransferase 0.0342524
EGFR epidermal growth factor receptor 0.0341575
JMJD1C jumonji domain containing 1C 0.0340926
CD44 CD44 molecule (Indian blood group) 0.0332444
WWTR1 WW domain containing transcription regulator 1 0.0332166
ANKHD1 ankyrin repeat and KH domain containing 1 0.0331732
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0325094
SAMD4A sterile alpha motif domain containing 4A 0.0324503
IGF2 insulin-like growth factor 2 0.0323507
FMNL2 formin-like 2 0.0322564
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0320263
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.031849
H3-3B H3.3 histone B 0.0318228
RIN2 Ras and Rab interactor 2 0.0315969
ASPH aspartate beta-hydroxylase 0.0315493
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0309459
EFNA5 ephrin-A5 0.0307029
ETV6 ets variant 6 0.0304472
DOCK4 dedicator of cytokinesis 4 0.0304329
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0304094
NCEH1 neutral cholesterol ester hydrolase 1 0.0303642
AKAP13 A kinase (PRKA) anchor protein 13 0.0301827
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0300243
THSD4 thrombospondin, type I, domain containing 4 0.0299627
NIBAN2 niban apoptosis regulator 2 0.0298652
NSD1 nuclear receptor binding SET domain protein 1 0.0291041
EIF1 eukaryotic translation initiation factor 1 0.0291029
TAOK3 TAO kinase 3 0.0290912
DPYD dihydropyrimidine dehydrogenase 0.0290424
TXNIP thioredoxin interacting protein 0.0288648
SH3KBP1 SH3-domain kinase binding protein 1 0.0286475
PHF14 PHD finger protein 14 0.0283002
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0280431
ANO6 anoctamin 6 0.0279993
ITCH itchy E3 ubiquitin protein ligase 0.0279095
SASH1 SAM and SH3 domain containing 1 0.0278763
ARL15 ADP-ribosylation factor-like 15 0.0278506
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0278101
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0276596
TRIO trio Rho guanine nucleotide exchange factor 0.0276285
ITSN2 intersectin 2 0.0271316
KDM6A lysine (K)-specific demethylase 6A 0.0270505
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0267692
RNF213 ring finger protein 213 0.0267588
MAP2K5 mitogen-activated protein kinase kinase 5 0.025839
NLRP1 NLR family, pyrin domain containing 1 0.0257868
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0257415

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0763217
TPX2 TPX2, microtubule-associated -0.071366
CENPF centromere protein F, 350/400kDa -0.0640685
GOLGA4 golgin A4 -0.0613388
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0574487
CKAP2 cytoskeleton associated protein 2 -0.0554447
NAV2 neuron navigator 2 -0.053768
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0516123
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.049532
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0484742
NAP1L1 nucleosome assembly protein 1-like 1 -0.0454164
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0419828
SPAG9 sperm associated antigen 9 -0.0406934
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0404695
OGA O-GlcNAcase -0.0382289
LMO7 LIM domain 7 -0.037686
PTMA prothymosin, alpha -0.0370682
MACF1 microtubule-actin crosslinking factor 1 -0.0362739
NUP58 nucleoporin 58 -0.0355701
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0354805
ANKRD37 ankyrin repeat domain 37 -0.0336301
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0333684
RPL19 ribosomal protein L19 -0.0330076
CLTC clathrin, heavy chain (Hc) -0.0327068
CEP57 centrosomal protein 57kDa -0.0327065
RAB1A RAB1A, member RAS oncogene family -0.0324538
RRBP1 ribosome binding protein 1 -0.0318265
HSPA8 heat shock 70kDa protein 8 -0.0311737
GOLT1B golgi transport 1B -0.0302651
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -0.0300681
ANLN anillin, actin binding protein -0.0298224
RPL36 ribosomal protein L36 -0.0278662
CANX calnexin -0.0278254
PRR11 proline rich 11 -0.0276043
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0268306
RBM39 RNA binding motif protein 39 -0.0267085
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.026606
KIF4A kinesin family member 4A -0.0264592
INTS6 integrator complex subunit 6 -0.0263878
SQSTM1 sequestosome 1 -0.026295
RBMX RNA binding motif protein, X-linked -0.0262002
VDAC1 voltage-dependent anion channel 1 -0.0259377
RPL9 ribosomal protein L9 -0.0255307
RPS2 ribosomal protein S2 -0.0252285
SPOPL speckle-type POZ protein-like -0.0251007
ASXL1 additional sex combs like transcriptional regulator 1 -0.0250798
EIF3B eukaryotic translation initiation factor 3, subunit B -0.024419
HJURP Holliday junction recognition protein -0.0242456
RPL32 ribosomal protein L32 -0.0241279
FUS FUS RNA binding protein -0.0240396
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0239493
AHNAK AHNAK nucleoprotein -0.0239003
DEK DEK proto-oncogene -0.0237685
CCNB1 cyclin B1 -0.0235898
TJP2 tight junction protein 2 -0.0235381
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0235244
AURKA aurora kinase A -0.0234929
RPL38 ribosomal protein L38 -0.0233888
NCKAP1 NCK-associated protein 1 -0.023354
TRIM44 tripartite motif containing 44 -0.0232548
ARHGAP5 Rho GTPase activating protein 5 -0.0232331
ZNF706 zinc finger protein 706 -0.0231848
WDR45B WD repeat domain 45B -0.0231276
DST dystonin -0.0230972
CENPE centromere protein E, 312kDa -0.0227968
RPL37A ribosomal protein L37a -0.0223711
TRA2A transformer 2 alpha homolog (Drosophila) -0.0222497
RPLP1 ribosomal protein, large, P1 -0.0222475
NRBP1 nuclear receptor binding protein 1 -0.0221721
TPD52 tumor protein D52 -0.0221454
IARS1 isoleucyl-tRNA synthetase 1 -0.0220873
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0217192
CDC5L cell division cycle 5-like -0.0217047
HMGA2 high mobility group AT-hook 2 -0.0216451
RPS29 ribosomal protein S29 -0.0215931
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0214166
RPS12 ribosomal protein S12 -0.0212947
KIF23 kinesin family member 23 -0.0212673
UBQLN1 ubiquilin 1 -0.021229
CALU calumenin -0.0211229
FLNA filamin A, alpha -0.0208522
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.020819
LMNA lamin A/C -0.0206479
DCAF7 DDB1 and CUL4 associated factor 7 -0.0206272
ZNF638 zinc finger protein 638 -0.0205219
RPS25 ribosomal protein S25 -0.0204398
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0202342
CKAP5 cytoskeleton associated protein 5 -0.020032
RPL31 ribosomal protein L31 -0.0198957
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.0197115
DBF4 DBF4 zinc finger -0.0196268
PMM2 phosphomannomutase 2 -0.0195942
PTPRK protein tyrosine phosphatase, receptor type, K -0.0194268
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0190109
NKTR natural killer cell triggering receptor -0.0189459
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0188128
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -0.0185377
ICAM1 intercellular adhesion molecule 1 -0.0185162
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0184594
DIAPH1 diaphanous-related formin 1 -0.0184234