| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Brimonidine perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Brimonidine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.148095 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.115706 |
| OSMR | oncostatin M receptor | 0.111872 |
| NRP1 | neuropilin 1 | 0.110358 |
| ITGA1 | integrin, alpha 1 | 0.103316 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0997681 |
| TMEM156 | transmembrane protein 156 | 0.0904382 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0765368 |
| SMOX | spermine oxidase | 0.0730139 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0643621 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0631155 |
| FOXP1 | forkhead box P1 | 0.0623678 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0603204 |
| EFNA5 | ephrin-A5 | 0.0600946 |
| CAB39 | calcium binding protein 39 | 0.0589448 |
| TXNIP | thioredoxin interacting protein | 0.0585702 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0582493 |
| IL6ST | interleukin 6 signal transducer | 0.0574615 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0565326 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0554021 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.054949 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0547162 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.054068 |
| TMEM165 | transmembrane protein 165 | 0.0519945 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0508071 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0485687 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0475645 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0475461 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0472158 |
| ETV1 | ets variant 1 | 0.0467491 |
| NTN4 | netrin 4 | 0.0452729 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0447624 |
| ADD3 | adducin 3 (gamma) | 0.0443808 |
| WDR26 | WD repeat domain 26 | 0.0439267 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0436284 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0434663 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0428621 |
| KLHL5 | kelch-like family member 5 | 0.0428392 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.042204 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0416898 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0409404 |
| FNBP1 | formin binding protein 1 | 0.0404738 |
| AHR | aryl hydrocarbon receptor | 0.0404293 |
| SSH1 | slingshot protein phosphatase 1 | 0.0396315 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0395203 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0390148 |
| ITGB5 | integrin, beta 5 | 0.0389689 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0383311 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0382801 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0376993 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.037679 |
| CDCP1 | CUB domain containing protein 1 | 0.0375724 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.03613 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0356488 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.0347386 |
| TOP1 | topoisomerase (DNA) I | 0.0347321 |
| FAF2 | Fas associated factor family member 2 | 0.0339686 |
| FRY | furry homolog (Drosophila) | 0.0338973 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0335246 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0333077 |
| TPR | translocated promoter region, nuclear basket protein | 0.0332723 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0331702 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.032908 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0328838 |
| BPTF | bromodomain PHD finger transcription factor | 0.032073 |
| PELO | pelota homolog (Drosophila) | 0.0317441 |
| CARD16 | caspase recruitment domain family, member 16 | 0.031372 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0313295 |
| GLIS3 | GLIS family zinc finger 3 | 0.0309751 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0309173 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0308166 |
| VMP1 | vacuole membrane protein 1 | 0.0307752 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0307422 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0305801 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0305271 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0303442 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0302463 |
| RAB31 | RAB31, member RAS oncogene family | 0.0300621 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0297224 |
| ETNK1 | ethanolamine kinase 1 | 0.0296802 |
| RUNX2 | runt-related transcription factor 2 | 0.0293594 |
| ASPH | aspartate beta-hydroxylase | 0.029183 |
| GOLGA4 | golgin A4 | 0.0290698 |
| PLIN2 | perilipin 2 | 0.0290124 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0289944 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0283244 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0282523 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0282418 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0277129 |
| SYNJ2 | synaptojanin 2 | 0.0276468 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.027635 |
| MKI67 | marker of proliferation Ki-67 | 0.0275713 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0272723 |
| AOPEP | aminopeptidase O (putative) | 0.0272607 |
| CD44 | CD44 molecule (Indian blood group) | 0.0272521 |
| JMJD1C | jumonji domain containing 1C | 0.0268158 |
| LRP5 | low density lipoprotein receptor-related protein 5 | 0.0265676 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0262654 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0262323 |
| BICC1 | BicC family RNA binding protein 1 | 0.0261508 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.185958 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.136429 |
| FN1 | fibronectin 1 | -0.116163 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.102238 |
| NRG1 | neuregulin 1 | -0.0721868 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0689963 |
| LMNA | lamin A/C | -0.0679718 |
| MT2A | metallothionein 2A | -0.0658148 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0548371 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0547296 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0542649 |
| TMSB4X | thymosin beta 4, X-linked | -0.051889 |
| S100A10 | S100 calcium binding protein A10 | -0.0485246 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0482037 |
| TMSB10 | thymosin beta 10 | -0.0481688 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0478973 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0477241 |
| CADM1 | cell adhesion molecule 1 | -0.0463713 |
| INTS6 | integrator complex subunit 6 | -0.0463064 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0436348 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0398041 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0392302 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0381034 |
| EMP1 | epithelial membrane protein 1 | -0.0380348 |
| MYOF | myoferlin | -0.0375021 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0372027 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0365792 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0362309 |
| RNF145 | ring finger protein 145 | -0.0353217 |
| HELZ | helicase with zinc finger | -0.0352398 |
| SEPTIN7 | septin 7 | -0.0352365 |
| RLF | rearranged L-myc fusion | -0.035126 |
| FLNA | filamin A, alpha | -0.0350337 |
| VIM | vimentin | -0.0348647 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0348146 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0345374 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0331886 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0324956 |
| TUFT1 | tuftelin 1 | -0.0316007 |
| GNAS | GNAS complex locus | -0.0314708 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0311003 |
| FMNL2 | formin-like 2 | -0.0306313 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0304904 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0304806 |
| FAM13A | family with sequence similarity 13, member A | -0.0303214 |
| PIM3 | Pim-3 proto-oncogene, serine/threonine kinase | -0.0302939 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0295996 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0294368 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.029164 |
| RPL32 | ribosomal protein L32 | -0.0291382 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.028741 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0285902 |
| H1-0 | H1.0 linker histone | -0.0279429 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0278593 |
| ANXA2 | annexin A2 | -0.0277145 |
| FAT1 | FAT atypical cadherin 1 | -0.0273759 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0273558 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0268054 |
| HBP1 | HMG-box transcription factor 1 | -0.0267715 |
| RPL28 | ribosomal protein L28 | -0.026715 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0265222 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0260177 |
| LRRC23 | leucine rich repeat containing 23 | -0.0257606 |
| FERMT2 | fermitin family member 2 | -0.0256855 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0256245 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0252239 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0251855 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0251163 |
| RYBP | RING1 and YY1 binding protein | -0.0248058 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0247139 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0246875 |
| JUN | jun proto-oncogene | -0.0244811 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0244722 |
| TFG | TRK-fused gene | -0.0238948 |
| TENM4 | teneurin transmembrane protein 4 | -0.0238555 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0236609 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0235868 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0235605 |
| USP3 | ubiquitin specific peptidase 3 | -0.0229186 |
| AEBP2 | AE binding protein 2 | -0.022884 |
| ATF3 | activating transcription factor 3 | -0.0227958 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0225914 |
| AHNAK | AHNAK nucleoprotein | -0.0225446 |
| SDCBP | syndecan binding protein (syntenin) | -0.0223669 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0223459 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0223408 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0222337 |
| RPS5 | ribosomal protein S5 | -0.0220908 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0217188 |
| WDR45B | WD repeat domain 45B | -0.0216826 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0215954 |
| ARF1 | ADP-ribosylation factor 1 | -0.021579 |
| RPL11 | ribosomal protein L11 | -0.0215571 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0214636 |
| CTBP2 | C-terminal binding protein 2 | -0.0213381 |
| SPAG9 | sperm associated antigen 9 | -0.0212419 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0211421 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0211076 |
| YBX1 | Y box binding protein 1 | -0.0209501 |
| HMGA2 | high mobility group AT-hook 2 | -0.0208746 |
