Brivudine_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brivudine perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brivudine_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.223943
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.14172
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.137472
CD44 CD44 molecule (Indian blood group) 0.129617
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.121086
MT2A metallothionein 2A 0.118806
CALR calreticulin 0.0935275
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0863824
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0852206
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0750113
B2M beta-2-microglobulin 0.0683074
UBC ubiquitin C 0.0681472
PTMA prothymosin, alpha 0.0674464
PLAT plasminogen activator, tissue 0.0585942
COL3A1 collagen, type III, alpha 1 0.0581576
RHOBTB3 Rho-related BTB domain containing 3 0.0568364
STC1 stanniocalcin 1 0.0561866
FBN1 fibrillin 1 0.0558853
FNDC3B fibronectin type III domain containing 3B 0.0550975
AKAP12 A kinase (PRKA) anchor protein 12 0.0529578
SQSTM1 sequestosome 1 0.0527536
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0509752
S100A10 S100 calcium binding protein A10 0.047041
RPS3 ribosomal protein S3 0.0452793
LDHA lactate dehydrogenase A 0.0448962
TMSB10 thymosin beta 10 0.0448293
APP amyloid beta (A4) precursor protein 0.044696
EEF2 eukaryotic translation elongation factor 2 0.0406376
MYH9 myosin, heavy chain 9, non-muscle 0.0402007
IQGAP1 IQ motif containing GTPase activating protein 1 0.0393205
ENO1 enolase 1, (alpha) 0.0388727
SFTPA2 surfactant protein A2 0.0388061
CANX calnexin 0.0382442
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0381544
NAP1L1 nucleosome assembly protein 1-like 1 0.0380719
EIF1 eukaryotic translation initiation factor 1 0.0379328
RPL26 ribosomal protein L26 0.0373577
TMSB4X thymosin beta 4, X-linked 0.0371071
GLIS3 GLIS family zinc finger 3 0.0354736
RPL23 ribosomal protein L23 0.0349053
CD99 CD99 molecule 0.0348992
TPM3 tropomyosin 3 0.0345983
PRRC2C proline-rich coiled-coil 2C 0.0344432
GLS2 glutaminase 2 (liver, mitochondrial) 0.0343252
WWTR1 WW domain containing transcription regulator 1 0.0338277
HDAC9 histone deacetylase 9 0.0332034
TPT1 tumor protein, translationally-controlled 1 0.0330272
ACTG1 actin gamma 1 0.0328318
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0327633
RPS6 ribosomal protein S6 0.0326347
FLNB filamin B, beta 0.0322916
RPS8 ribosomal protein S8 0.03207
GPC6 glypican 6 0.0320421
SEPTIN9 septin 9 0.0319177
OPTN optineurin 0.0318302
RACK1 receptor for activated C kinase 1 0.031323
STAT1 signal transducer and activator of transcription 1, 91kDa 0.031248
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0311811
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0310407
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0309843
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0307797
RPL12 ribosomal protein L12 0.0306891
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0305501
SBF2 SET binding factor 2 0.0300279
DPYSL2 dihydropyrimidinase-like 2 0.0298065
PKM pyruvate kinase, muscle 0.0297181
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0291447
FTH1 ferritin, heavy polypeptide 1 0.0282324
ANXA2 annexin A2 0.0280316
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0276864
RPL19 ribosomal protein L19 0.0275245
CTSB cathepsin B 0.0272714
ERBIN erbb2 interacting protein 0.0266715
RPLP2 ribosomal protein, large, P2 0.0266162
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0265031
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0264426
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0262085
ATP13A3 ATPase type 13A3 0.0261763
MB21D2 Mab-21 domain containing 2 0.0260707
RPL37A ribosomal protein L37a 0.0259723
RASA2 RAS p21 protein activator 2 0.0257622
RPS24 ribosomal protein S24 0.0256911
MAP4 microtubule-associated protein 4 0.0256449
TM4SF1 transmembrane 4 L six family member 1 0.0253146
RPLP1 ribosomal protein, large, P1 0.0252721
MPRIP myosin phosphatase Rho interacting protein 0.0252597
RPS27A ribosomal protein S27a 0.0251555
KLF6 Kruppel-like factor 6 0.0251228
OSBPL8 oxysterol binding protein-like 8 0.0249427
OGA O-GlcNAcase 0.0249069
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0248023
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0247952
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0244833
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0241403
SMYD3 SET and MYND domain containing 3 0.0240075
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0236519
ASPH aspartate beta-hydroxylase 0.0234951
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0234407
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0233911
AKAP13 A kinase (PRKA) anchor protein 13 0.0231629

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.250901
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.14889
FN1 fibronectin 1 -0.116538
COL5A1 collagen, type V, alpha 1 -0.108742
ABI3BP ABI family, member 3 (NESH) binding protein -0.103285
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0791246
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0747741
TRIO trio Rho guanine nucleotide exchange factor -0.074163
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0717489
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0623576
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0612549
SUCNR1 succinate receptor 1 -0.0568079
DCLK2 doublecortin-like kinase 2 -0.0536137
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0511013
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0462912
CDH13 cadherin 13 -0.0461141
MSI2 musashi RNA-binding protein 2 -0.0453661
RIGI RNA sensor RIG-I -0.0448407
PRSS23 protease, serine, 23 -0.0446961
SAMD9 sterile alpha motif domain containing 9 -0.0423466
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0405323
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.040294
SORBS2 sorbin and SH3 domain containing 2 -0.0358081
MX2 MX dynamin-like GTPase 2 -0.0344027
PODXL podocalyxin-like -0.0331128
EGFR epidermal growth factor receptor -0.0326856
MEIS2 Meis homeobox 2 -0.0319318
NAV1 neuron navigator 1 -0.0312131
FLT1 fms-related tyrosine kinase 1 -0.0300527
SLC38A1 solute carrier family 38, member 1 -0.0292511
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.028985
CUX1 cut-like homeobox 1 -0.028956
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.028084
MRPS6 mitochondrial ribosomal protein S6 -0.0277984
DGKG diacylglycerol kinase, gamma 90kDa -0.0276659
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0271996
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0264578
IL7R interleukin 7 receptor -0.0260134
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.025659
SLC39A11 solute carrier family 39, member 11 -0.0254856
TNS3 tensin 3 -0.0254107
NDRG1 N-myc downstream regulated 1 -0.0241512
FNDC3A fibronectin type III domain containing 3A -0.0240967
CD109 CD109 molecule -0.0239976
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.023957
THBS2 thrombospondin 2 -0.0239117
OASL 2'-5'-oligoadenylate synthetase-like -0.0236688
PCDH7 protocadherin 7 -0.0234448
KRT81 keratin 81, type II -0.0224176
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0218011
PLXNA2 plexin A2 -0.0217228
RPTOR regulatory associated protein of MTOR, complex 1 -0.0217055
FGF13 fibroblast growth factor 13 -0.0215187
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0214535
TENM3 teneurin transmembrane protein 3 -0.0214239
DLG1 discs, large homolog 1 (Drosophila) -0.0214149
COL8A1 collagen, type VIII, alpha 1 -0.021408
LRRC17 leucine rich repeat containing 17 -0.0213591
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0212668
LOXL2 lysyl oxidase-like 2 -0.021016
WARS1 tryptophanyl-tRNA synthetase 1 -0.0207898
MACF1 microtubule-actin crosslinking factor 1 -0.0204542
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0201474
COL1A1 collagen, type I, alpha 1 -0.0198824
MAP1B microtubule-associated protein 1B -0.0194566
ULK1 unc-51 like autophagy activating kinase 1 -0.0194127
HILPDA hypoxia inducible lipid droplet-associated -0.018851
ZMYND8 zinc finger, MYND-type containing 8 -0.0184609
TPM1 tropomyosin 1 (alpha) -0.0183699
PDE4D phosphodiesterase 4D, cAMP-specific -0.018258
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0174134
MED13L mediator complex subunit 13-like -0.0171314
IFITM1 interferon induced transmembrane protein 1 -0.0165774
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0165053
BHLHE40 basic helix-loop-helix family, member e40 -0.0164832
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0160958
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0158247
MTCL1 microtubule crosslinking factor 1 -0.0156155
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0152808
SH3RF3 SH3 domain containing ring finger 3 -0.0150209
TOX thymocyte selection-associated high mobility group box -0.0150176
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0149975
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.0148384
IGFBP6 insulin-like growth factor binding protein 6 -0.0148118
RNF213 ring finger protein 213 -0.0147238
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.014664
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0145972
AEBP2 AE binding protein 2 -0.0145925
FMN2 formin 2 -0.0140757
MBNL1 muscleblind-like splicing regulator 1 -0.0132056
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0131324
DENND1A DENN/MADD domain containing 1A -0.0128989
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0126775
JAZF1 JAZF zinc finger 1 -0.0126629
SYTL3 synaptotagmin-like 3 -0.0126438
CCND1 cyclin D1 -0.012633
IARS1 isoleucyl-tRNA synthetase 1 -0.0126231
ISG15 ISG15 ubiquitin-like modifier -0.0126212
IKBIP IKBKB interacting protein -0.0125051
HLA-C major histocompatibility complex, class I, C -0.0123578