Brivudine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brivudine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brivudine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.185432
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.151468
ACTG1 actin gamma 1 0.145166
VCL vinculin 0.14169
RPL23 ribosomal protein L23 0.140161
ZSWIM6 zinc finger, SWIM-type containing 6 0.126793
PTMA prothymosin, alpha 0.121543
VIM vimentin 0.117308
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.112639
RPS6 ribosomal protein S6 0.105373
RPS3 ribosomal protein S3 0.0989725
TPT1 tumor protein, translationally-controlled 1 0.0891583
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0888827
EXT1 exostosin glycosyltransferase 1 0.0884012
LPIN1 lipin 1 0.0842571
RPLP1 ribosomal protein, large, P1 0.0778945
RPL19 ribosomal protein L19 0.0755018
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0736639
PRKCA protein kinase C, alpha 0.0708406
RACK1 receptor for activated C kinase 1 0.0659702
NRG1 neuregulin 1 0.0658076
RPS12 ribosomal protein S12 0.0635433
RPL35A ribosomal protein L35a 0.0625591
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0619413
RPL34 ribosomal protein L34 0.0615139
RPL31 ribosomal protein L31 0.0604985
CALR calreticulin 0.0602004
RPS24 ribosomal protein S24 0.058532
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0576153
TIMP2 TIMP metallopeptidase inhibitor 2 0.0570973
NALF1 NALCN channel auxiliary factor 1 0.0554722
ENAH enabled homolog (Drosophila) 0.055195
RPL37 ribosomal protein L37 0.0535207
RPL26 ribosomal protein L26 0.0534989
APLP2 amyloid beta (A4) precursor-like protein 2 0.0525686
NAP1L1 nucleosome assembly protein 1-like 1 0.0519442
SMYD3 SET and MYND domain containing 3 0.0495597
EEF2 eukaryotic translation elongation factor 2 0.0491895
RPS8 ribosomal protein S8 0.0488615
ASPH aspartate beta-hydroxylase 0.0487905
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.048362
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.048337
RPL37A ribosomal protein L37a 0.0478837
ENO1 enolase 1, (alpha) 0.0469028
SEPTIN9 septin 9 0.0464815
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0459796
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0446334
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0444326
FTL ferritin, light polypeptide 0.0443476
POTEF POTE ankyrin domain family, member F 0.0443042
MYH9 myosin, heavy chain 9, non-muscle 0.0440294
SLIT2 slit homolog 2 (Drosophila) 0.0439859
RPS27A ribosomal protein S27a 0.0425285
CANX calnexin 0.0419821
B2M beta-2-microglobulin 0.0410491
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0408725
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0406357
TIMP3 TIMP metallopeptidase inhibitor 3 0.0405746
RPL4 ribosomal protein L4 0.0403533
RPS25 ribosomal protein S25 0.0400328
NPAS2 neuronal PAS domain protein 2 0.0397332
MCL1 myeloid cell leukemia 1 0.039016
RPS23 ribosomal protein S23 0.0376657
TPM1 tropomyosin 1 (alpha) 0.0376607
RPS27 ribosomal protein S27 0.0373747
PTPRK protein tyrosine phosphatase, receptor type, K 0.0372029
MYO1E myosin IE 0.0360554
LIMA1 LIM domain and actin binding 1 0.035935
RPS29 ribosomal protein S29 0.0358585
FN1 fibronectin 1 0.0352686
INTS6 integrator complex subunit 6 0.0347741
H3-3B H3.3 histone B 0.0345972
TPM3 tropomyosin 3 0.0344403
RPS14 ribosomal protein S14 0.0342476
RPLP2 ribosomal protein, large, P2 0.0342337
RPL35 ribosomal protein L35 0.0340355
TLE4 transducin-like enhancer of split 4 0.0338309
RPL32 ribosomal protein L32 0.0337687
RPS17 ribosomal protein S17 0.0335898
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0332847
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0332313
RPL7A ribosomal protein L7a 0.033138
PGK1 phosphoglycerate kinase 1 0.0327592
RPL5 ribosomal protein L5 0.0327245
RPL13A ribosomal protein L13a 0.0326821
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0325823
LMNA lamin A/C 0.0325772
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0325589
RAD51B RAD51 paralog B 0.0324841
RPL12 ribosomal protein L12 0.0323653
ACTN4 actinin, alpha 4 0.0321796
RPS13 ribosomal protein S13 0.0319544
GOLGB1 golgin B1 0.0319494
LDHA lactate dehydrogenase A 0.0317203
BPTF bromodomain PHD finger transcription factor 0.0316627
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0314608
RAB7A RAB7A, member RAS oncogene family 0.0314016
RPS19 ribosomal protein S19 0.0313446
MBNL1 muscleblind-like splicing regulator 1 0.0312634
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0311852

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.124708
FAM13A family with sequence similarity 13, member A -0.0673884
MEIS2 Meis homeobox 2 -0.0579648
FNDC3B fibronectin type III domain containing 3B -0.0536319
NPEPPS aminopeptidase puromycin sensitive -0.0525939
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0520509
SOS1 son of sevenless homolog 1 (Drosophila) -0.0510905
NAMPT nicotinamide phosphoribosyltransferase -0.0469086
TENT5A terminal nucleotidyltransferase 5A -0.0427799
ADGRG6 adhesion G protein-coupled receptor G6 -0.0424113
ITPRID2 ITPR interacting domain containing 2 -0.0379029
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0366064
MARCHF6 membrane associated ring-CH-type finger 6 -0.0363339
TRIO trio Rho guanine nucleotide exchange factor -0.035641
FNBP1 formin binding protein 1 -0.0355599
HELZ helicase with zinc finger -0.0336102
ZMYM2 zinc finger, MYM-type 2 -0.0328568
FMN1 formin 1 -0.0316608
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.02941
ZNF292 zinc finger protein 292 -0.0233847
HAND2 heart and neural crest derivatives expressed 2 -0.0228169
MIS18BP1 MIS18 binding protein 1 -0.0228022
HAS2 hyaluronan synthase 2 -0.0224553
SCAF11 SR-related CTD-associated factor 11 -0.0220898
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0219376
SRP54 signal recognition particle 54kDa -0.02174
TET2 tet methylcytosine dioxygenase 2 -0.0212595
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0209282
LIMCH1 LIM and calponin homology domains 1 -0.0208435
TOB1 transducer of ERBB2, 1 -0.0206605
GNG2 guanine nucleotide binding protein (G protein), gamma 2 -0.0204623
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0204464
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.0201774
PCTP phosphatidylcholine transfer protein -0.0199639
INTS2 integrator complex subunit 2 -0.0196724
XPO1 exportin 1 -0.0195468
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -0.0192918
NEK7 NIMA-related kinase 7 -0.0192419
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0190275
CEP95 centrosomal protein 95kDa -0.0190066
KCTD3 potassium channel tetramerization domain containing 3 -0.0189038
USP9Y ubiquitin specific peptidase 9, Y-linked -0.0188673
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0188574
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked -0.0188561
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0187139
CDC27 cell division cycle 27 -0.0184606
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.0184401
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.018348
RAB30 RAB30, member RAS oncogene family -0.0182798
MBNL2 muscleblind-like splicing regulator 2 -0.0182583
CASC3 cancer susceptibility candidate 3 -0.0180736
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.0180688
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0179767
SNX13 sorting nexin 13 -0.0177831
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0176437
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0174727
CLTC clathrin, heavy chain (Hc) -0.0174258
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0173174
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0172141
CDC73 cell division cycle 73 -0.0171646
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0171438
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0171376
NRIP1 nuclear receptor interacting protein 1 -0.0170712
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0169957
NUP58 nucleoporin 58 -0.0168217
INSIG2 insulin induced gene 2 -0.0167482
TNRC6A trinucleotide repeat containing 6A -0.0167391
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0166719
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0164409
CLINT1 clathrin interactor 1 -0.0163672
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -0.0162086
UBQLN1 ubiquilin 1 -0.0161959
PCNX1 pecanex 1 -0.0161412
CENPC centromere protein C -0.0161335
USP12 ubiquitin specific peptidase 12 -0.0159464
MEF2A myocyte enhancer factor 2A -0.015928
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0159279
MBD5 methyl-CpG binding domain protein 5 -0.0158942
PHIP pleckstrin homology domain interacting protein -0.0158825
MXI1 MAX interactor 1, dimerization protein -0.0158436
PRPF8 pre-mRNA processing factor 8 -0.015669
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0156169
TFG TRK-fused gene -0.0155035
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0153312
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0151691
SCAF8 SR-related CTD-associated factor 8 -0.0150329
TPST1 tyrosylprotein sulfotransferase 1 -0.0150118
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0149489
HOOK2 hook microtubule-tethering protein 2 -0.0147876
NF1 neurofibromin 1 -0.0147396
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0147377
PDS5B PDS5 cohesin associated factor B -0.014733
ARPP19 cAMP-regulated phosphoprotein, 19kDa -0.0147145
AHR aryl hydrocarbon receptor -0.0147075
DSCAM Down syndrome cell adhesion molecule -0.0146388
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0146229
SLITRK6 SLIT and NTRK-like family, member 6 -0.0145102
SETD5 SET domain containing 5 -0.0143964
EIF2A eukaryotic translation initiation factor 2A, 65kDa -0.0143627
H1-4 H1.4 linker histone, cluster member -0.0143485