Brivudine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brivudine perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brivudine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin 0.174711
GCLC glutamate-cysteine ligase, catalytic subunit 0.10129
FTL ferritin, light polypeptide 0.0975555
AKAP13 A kinase (PRKA) anchor protein 13 0.0960329
LMO7 LIM domain 7 0.0902403
EXT1 exostosin glycosyltransferase 1 0.0854212
TPT1 tumor protein, translationally-controlled 1 0.0754731
LCN2 lipocalin 2 0.0682738
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0642556
MACC1 metastasis associated in colon cancer 1 0.0625687
ZNF292 zinc finger protein 292 0.0598311
RPS6 ribosomal protein S6 0.0534154
SFTPA2 surfactant protein A2 0.0523175
HLA-A major histocompatibility complex, class I, A 0.0511608
DST dystonin 0.0511514
GOLGB1 golgin B1 0.0507646
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0457175
RPL34 ribosomal protein L34 0.044935
TMC5 transmembrane channel-like 5 0.0446533
RPL35A ribosomal protein L35a 0.0411583
ACTG1 actin gamma 1 0.0409693
PTMA prothymosin, alpha 0.0406591
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0406512
RPS8 ribosomal protein S8 0.0403332
IFI27 interferon, alpha-inducible protein 27 0.0400501
SIK3 SIK family kinase 3 0.0389597
MT2A metallothionein 2A 0.0389232
VEGFA vascular endothelial growth factor A 0.0385753
RAB7A RAB7A, member RAS oncogene family 0.0383958
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0383851
HLA-B major histocompatibility complex, class I, B 0.0381154
FNIP1 folliculin interacting protein 1 0.0378565
HKDC1 hexokinase domain containing 1 0.0376253
RPL37 ribosomal protein L37 0.0374545
MAP7 microtubule-associated protein 7 0.0371649
RPL19 ribosomal protein L19 0.0371028
FTH1 ferritin, heavy polypeptide 1 0.0363127
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0352634
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0344353
PIBF1 progesterone immunomodulatory binding factor 1 0.0340061
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0338389
EPS8 epidermal growth factor receptor pathway substrate 8 0.0334316
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0333967
RPL23 ribosomal protein L23 0.0333242
RPS13 ribosomal protein S13 0.0333041
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0331341
SAMD4A sterile alpha motif domain containing 4A 0.0329795
RPS3 ribosomal protein S3 0.0324754
PABPC1 poly(A) binding protein, cytoplasmic 1 0.031802
RACK1 receptor for activated C kinase 1 0.0312063
RPS27 ribosomal protein S27 0.031144
RPL26 ribosomal protein L26 0.0310614
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0310065
RPLP0 ribosomal protein, large, P0 0.0306523
EGR1 early growth response 1 0.0301907
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0298621
RPLP1 ribosomal protein, large, P1 0.0298535
KYNU kynureninase 0.0286177
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0284256
RPL9 ribosomal protein L9 0.0281136
ANKHD1 ankyrin repeat and KH domain containing 1 0.0279972
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0277181
CSTB cystatin B (stefin B) 0.0275166
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0274767
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0274648
RPS16 ribosomal protein S16 0.0273688
TTC3 tetratricopeptide repeat domain 3 0.0271506
GOLGA4 golgin A4 0.0270759
IFI6 interferon, alpha-inducible protein 6 0.0267738
POTEF POTE ankyrin domain family, member F 0.0267587
EIF1 eukaryotic translation initiation factor 1 0.0266713
SMAD3 SMAD family member 3 0.0266539
RPS24 ribosomal protein S24 0.0266067
RPL31 ribosomal protein L31 0.0265223
ATF4 activating transcription factor 4 0.0262499
DSTN destrin (actin depolymerizing factor) 0.0260847
HSPH1 heat shock 105kDa/110kDa protein 1 0.0259857
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0254359
IFITM3 interferon induced transmembrane protein 3 0.0253298
DUSP10 dual specificity phosphatase 10 0.025245
MCU mitochondrial calcium uniporter 0.0251814
FRMD5 FERM domain containing 5 0.0251134
SERINC5 serine incorporator 5 0.0250551
MCTP1 multiple C2 domains, transmembrane 1 0.0247109
SEPTIN9 septin 9 0.024638
SEC24A SEC24 family member A 0.0246256
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.024613
RPL7A ribosomal protein L7a 0.0243081
RPS19 ribosomal protein S19 0.0242732
SEC31A SEC31 homolog A (S. cerevisiae) 0.0241358
MON2 MON2 homolog (S. cerevisiae) 0.0241026
ZFP36L1 ZFP36 ring finger protein-like 1 0.0238578
COG6 component of oligomeric golgi complex 6 0.0237579
ADAR adenosine deaminase, RNA-specific 0.0237424
KRT19 keratin 19, type I 0.0236127
RPS29 ribosomal protein S29 0.0235803
TRERF1 transcriptional regulating factor 1 0.0233426
RPS12 ribosomal protein S12 0.0232722
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.023219
N4BP2L2 NEDD4 binding protein 2-like 2 0.0231275

decreased expression

Symbol Name Standardized Value
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.143499
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.118351
ARHGAP26 Rho GTPase activating protein 26 -0.105669
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0926425
GMDS GDP-mannose 4,6-dehydratase -0.0844927
UBC ubiquitin C -0.0768034
AHNAK AHNAK nucleoprotein -0.0742521
BTBD9 BTB (POZ) domain containing 9 -0.0737413
RUNX1 runt-related transcription factor 1 -0.0736884
RNF43 ring finger protein 43 -0.0690817
PRKCA protein kinase C, alpha -0.0660895
TXNIP thioredoxin interacting protein -0.0656601
ZMYND8 zinc finger, MYND-type containing 8 -0.0648265
SQSTM1 sequestosome 1 -0.0645021
STS steroid sulfatase (microsomal), isozyme S -0.0640366
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0605969
NPSR1 neuropeptide S receptor 1 -0.0550318
PRELID2 PRELI domain containing 2 -0.0527584
STK24 serine/threonine kinase 24 -0.0507838
ACTN4 actinin, alpha 4 -0.0483216
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0481822
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0481458
ANXA2 annexin A2 -0.0472018
EHF ets homologous factor -0.0467253
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0457509
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0453109
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0441331
ITGA6 integrin, alpha 6 -0.0440696
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0433152
ATP10B ATPase, class V, type 10B -0.0432149
PLSCR2 phospholipid scramblase 2 -0.0430577
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0425018
JUN jun proto-oncogene -0.0419173
ANKRD10 ankyrin repeat domain 10 -0.0412042
EZR ezrin -0.0393882
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.039041
IGF1R insulin-like growth factor 1 receptor -0.0387711
SORBS1 sorbin and SH3 domain containing 1 -0.0386252
PDIA4 protein disulfide isomerase family A, member 4 -0.0384061
DIAPH3 diaphanous-related formin 3 -0.0364687
SSH2 slingshot protein phosphatase 2 -0.0359072
TRIO trio Rho guanine nucleotide exchange factor -0.0352844
MLPH melanophilin -0.0350948
SH3PXD2A SH3 and PX domains 2A -0.0350055
TMEM62 transmembrane protein 62 -0.0349943
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0347948
EPHB2 EPH receptor B2 -0.0344752
EFNB2 ephrin-B2 -0.034206
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0341806
MEIS2 Meis homeobox 2 -0.034144
PTBP3 polypyrimidine tract binding protein 3 -0.0340424
VMP1 vacuole membrane protein 1 -0.0329723
MSI2 musashi RNA-binding protein 2 -0.032508
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0322516
UBAC2 UBA domain containing 2 -0.0318937
PLSCR1 phospholipid scramblase 1 -0.031893
NCOA7 nuclear receptor coactivator 7 -0.0312627
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0309926
TUFT1 tuftelin 1 -0.030757
HDAC4 histone deacetylase 4 -0.0302468
ATP11A ATPase, class VI, type 11A -0.0301917
NRIP1 nuclear receptor interacting protein 1 -0.0301499
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0296499
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0295828
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0295637
FMN1 formin 1 -0.0287311
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -0.0282712
NKD1 naked cuticle homolog 1 (Drosophila) -0.0282414
RFC3 replication factor C (activator 1) 3, 38kDa -0.0278985
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0278011
ZNF207 zinc finger protein 207 -0.027656
MX1 MX dynamin-like GTPase 1 -0.0274081
PRKCE protein kinase C, epsilon -0.0272328
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0271596
FAT1 FAT atypical cadherin 1 -0.0267785
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0263787
BICRAL BICRA like chromatin remodeling complex associated protein -0.026368
TNS4 tensin 4 -0.0260591
STK39 serine threonine kinase 39 -0.0258588
MECOM MDS1 and EVI1 complex locus -0.0253061
ZNRF3 zinc and ring finger 3 -0.0251977
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase -0.0248197
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0245682
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0242697
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0241784
WDR1 WD repeat domain 1 -0.0240691
MYH9 myosin, heavy chain 9, non-muscle -0.0239886
SAMD12 sterile alpha motif domain containing 12 -0.0239151
DOCK1 dedicator of cytokinesis 1 -0.0239018
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0238816
WDR26 WD repeat domain 26 -0.0238277
MAP2K6 mitogen-activated protein kinase kinase 6 -0.0237272
NIBAN2 niban apoptosis regulator 2 -0.0234985
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0234946
COPB1 coatomer protein complex, subunit beta 1 -0.0233637
FNDC3B fibronectin type III domain containing 3B -0.0232005
CCDC146 coiled-coil domain containing 146 -0.0230935
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0230073
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0226299
ZBTB20 zinc finger and BTB domain containing 20 -0.0226131