| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Brivudine perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Brivudine_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.36117 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.168389 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.141587 |
| FN1 | fibronectin 1 | 0.141147 |
| CALR | calreticulin | 0.123223 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.104196 |
| ENO1 | enolase 1, (alpha) | 0.101082 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.096586 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0924654 |
| CANX | calnexin | 0.0885971 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.081213 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0807872 |
| TMSB4X | thymosin beta 4, X-linked | 0.0616985 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0536984 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0515447 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0496144 |
| CD44 | CD44 molecule (Indian blood group) | 0.048936 |
| LDHA | lactate dehydrogenase A | 0.0487468 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0485599 |
| ASPH | aspartate beta-hydroxylase | 0.0446906 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0436544 |
| AHNAK | AHNAK nucleoprotein | 0.0433626 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0425281 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0425231 |
| APP | amyloid beta (A4) precursor protein | 0.042376 |
| CADM1 | cell adhesion molecule 1 | 0.0416703 |
| UBC | ubiquitin C | 0.0416359 |
| ARRDC3 | arrestin domain containing 3 | 0.0413211 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0407471 |
| NAV2 | neuron navigator 2 | 0.0404403 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.038967 |
| IER3 | immediate early response 3 | 0.0388779 |
| VEGFA | vascular endothelial growth factor A | 0.0388363 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0385535 |
| PTK2 | protein tyrosine kinase 2 | 0.0378897 |
| COL3A1 | collagen, type III, alpha 1 | 0.0367345 |
| CALU | calumenin | 0.036 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0359018 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0342882 |
| RUNX1 | runt-related transcription factor 1 | 0.0341253 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0330654 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0320878 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0316776 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.03158 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.031126 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0309033 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.030794 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0299014 |
| RPL3 | ribosomal protein L3 | 0.0296528 |
| RPS3 | ribosomal protein S3 | 0.0295905 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0289217 |
| SMAD3 | SMAD family member 3 | 0.0288526 |
| MYO10 | myosin X | 0.0288248 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.02877 |
| POSTN | periostin, osteoblast specific factor | 0.0287347 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0284646 |
| IL6ST | interleukin 6 signal transducer | 0.0281586 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0279244 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0277525 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0276708 |
| SQSTM1 | sequestosome 1 | 0.026631 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0266114 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0266024 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0263963 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0260265 |
| RACK1 | receptor for activated C kinase 1 | 0.0259191 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0256803 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0256593 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0250096 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0248584 |
| SPAG9 | sperm associated antigen 9 | 0.024702 |
| ANXA2 | annexin A2 | 0.0242876 |
| ANKRD11 | ankyrin repeat domain 11 | 0.023429 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0234085 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0231238 |
| ATP13A3 | ATPase type 13A3 | 0.022804 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0224671 |
| INHBA | inhibin, beta A | 0.0224039 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0223919 |
| SFTPA2 | surfactant protein A2 | 0.0223666 |
| RPS2 | ribosomal protein S2 | 0.0221253 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0221049 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0220554 |
| MAP4 | microtubule-associated protein 4 | 0.0220539 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0220462 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0218488 |
| H1-0 | H1.0 linker histone | 0.0214302 |
| HIP1 | huntingtin interacting protein 1 | 0.0213683 |
| YBX1 | Y box binding protein 1 | 0.021252 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0211841 |
| RRBP1 | ribosome binding protein 1 | 0.0211535 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0210534 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0210287 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0208057 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.0207705 |
| GOLGB1 | golgin B1 | 0.0206287 |
| HDAC9 | histone deacetylase 9 | 0.0204478 |
| MLF1 | myeloid leukemia factor 1 | 0.0204375 |
| DSPP | dentin sialophosphoprotein | 0.02038 |
| JUN | jun proto-oncogene | 0.0202901 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.453494 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0933755 |
| COL1A1 | collagen, type I, alpha 1 | -0.0845894 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0825452 |
| NDRG1 | N-myc downstream regulated 1 | -0.0794417 |
| TMSB10 | thymosin beta 10 | -0.0724465 |
| VIM | vimentin | -0.0555353 |
| GLIS3 | GLIS family zinc finger 3 | -0.052771 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0518715 |
| RPL35A | ribosomal protein L35a | -0.0503707 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0495286 |
| FTL | ferritin, light polypeptide | -0.0473986 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0446033 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0429812 |
| HMGA2 | high mobility group AT-hook 2 | -0.0423839 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0413901 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0406821 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0377625 |
| PALLD | palladin, cytoskeletal associated protein | -0.0368823 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0321581 |
| HLA-B | major histocompatibility complex, class I, B | -0.0320734 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0262848 |
| VCL | vinculin | -0.0253033 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0250195 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0240661 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0239121 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0234464 |
| LOX | lysyl oxidase | -0.0234037 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0233177 |
| HLA-A | major histocompatibility complex, class I, A | -0.0230546 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0219738 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0217535 |
| ZNF644 | zinc finger protein 644 | -0.0212264 |
| FBN1 | fibrillin 1 | -0.0207678 |
| PFN1 | profilin 1 | -0.0203787 |
| RSU1 | Ras suppressor protein 1 | -0.0195794 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0193737 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0191013 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0190928 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0188384 |
| CLMP | CXADR-like membrane protein | -0.0186984 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0186303 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0184616 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0184051 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0181943 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0180619 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0179402 |
| VMP1 | vacuole membrane protein 1 | -0.0178893 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0177605 |
| ADM | adrenomedullin | -0.0176091 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0170957 |
| EGR1 | early growth response 1 | -0.0168734 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.016415 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0163719 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0162617 |
| OSMR | oncostatin M receptor | -0.0162089 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0161168 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0156122 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0155346 |
| PRR16 | proline rich 16 | -0.0153727 |
| RPL37A | ribosomal protein L37a | -0.0150787 |
| RBPMS | RNA binding protein with multiple splicing | -0.0148061 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0146923 |
| LIMA1 | LIM domain and actin binding 1 | -0.0146626 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.014565 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.014289 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0142211 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0141864 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0141486 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0139959 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0137124 |
| FRMD4A | FERM domain containing 4A | -0.013569 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0135075 |
| LOXL2 | lysyl oxidase-like 2 | -0.0133576 |
| LAMA5 | laminin, alpha 5 | -0.0132549 |
| NABP1 | nucleic acid binding protein 1 | -0.0132159 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0129348 |
| S100A9 | S100 calcium binding protein A9 | -0.0128968 |
| TNS3 | tensin 3 | -0.0128786 |
| ATM | ATM serine/threonine kinase | -0.0126895 |
| SLC30A7 | solute carrier family 30 (zinc transporter), member 7 | -0.0126177 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0123782 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0123454 |
| CALD1 | caldesmon 1 | -0.012315 |
| HEATR5A | HEAT repeat containing 5A | -0.0121305 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -0.0119613 |
| CST3 | cystatin C | -0.011857 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0117358 |
| HMGA1 | high mobility group AT-hook 1 | -0.011703 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0116716 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0116545 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0115895 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0115375 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0115328 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0115287 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.011416 |
| SLC25A51 | solute carrier family 25, member 51 | -0.0113856 |
| RASAL2 | RAS protein activator like 2 | -0.0113118 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0112124 |
| RPS6 | ribosomal protein S6 | -0.0112021 |
