| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Brivudine perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Brivudine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.186524 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.184643 |
| DSPP | dentin sialophosphoprotein | 0.157919 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.143861 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.129991 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.128267 |
| VEGFA | vascular endothelial growth factor A | 0.104133 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0984921 |
| SVIL | supervillin | 0.0955585 |
| ENO1 | enolase 1, (alpha) | 0.094673 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0874157 |
| DTNA | dystrobrevin, alpha | 0.0822853 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0817073 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0793546 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0759628 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0711278 |
| RPL3 | ribosomal protein L3 | 0.0704869 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0702789 |
| UBC | ubiquitin C | 0.0689252 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0671267 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0633973 |
| FAM107B | family with sequence similarity 107, member B | 0.0608287 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0606663 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0558055 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.054263 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0513299 |
| KYNU | kynureninase | 0.0495664 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0492752 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0487828 |
| ATXN1 | ataxin 1 | 0.0486818 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0484943 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0466115 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0460734 |
| RPS3 | ribosomal protein S3 | 0.0452311 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0450443 |
| RACK1 | receptor for activated C kinase 1 | 0.0434649 |
| RPS12 | ribosomal protein S12 | 0.0433663 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0433093 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0432841 |
| SDC4 | syndecan 4 | 0.0429086 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0427797 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0424361 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.041842 |
| INTS6 | integrator complex subunit 6 | 0.0406735 |
| TF | transferrin | 0.0404828 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0404259 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0402426 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0400953 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0399856 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0398018 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0384188 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0381099 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0371373 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0365657 |
| ASPH | aspartate beta-hydroxylase | 0.0358893 |
| FOXP1 | forkhead box P1 | 0.0352212 |
| TNS1 | tensin 1 | 0.0351177 |
| PALLD | palladin, cytoskeletal associated protein | 0.0349233 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0347682 |
| FERMT2 | fermitin family member 2 | 0.034596 |
| DST | dystonin | 0.0343944 |
| SERTAD2 | SERTA domain containing 2 | 0.0334517 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0333989 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0333167 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0328267 |
| RPL37A | ribosomal protein L37a | 0.0323344 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0321813 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0321348 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.032025 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0317084 |
| SIK3 | SIK family kinase 3 | 0.0304023 |
| DIAPH1 | diaphanous-related formin 1 | 0.0299814 |
| CANX | calnexin | 0.0299364 |
| CCDC88A | coiled-coil domain containing 88A | 0.0297605 |
| SMAD3 | SMAD family member 3 | 0.0292604 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0291905 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0290587 |
| RPS18 | ribosomal protein S18 | 0.0288917 |
| LDHA | lactate dehydrogenase A | 0.0287434 |
| CALR | calreticulin | 0.0287348 |
| FAM13A | family with sequence similarity 13, member A | 0.0283636 |
| QKI | QKI, KH domain containing, RNA binding | 0.0283524 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0283191 |
| MYO6 | myosin VI | 0.0273406 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0272061 |
| POTEF | POTE ankyrin domain family, member F | 0.0271128 |
| GOLGA4 | golgin A4 | 0.0268707 |
| FAT1 | FAT atypical cadherin 1 | 0.0267357 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0267259 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0265784 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0265241 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0265095 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.026275 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0261879 |
| CPE | carboxypeptidase E | 0.0261613 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0260583 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0260009 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0259885 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0259207 |
| RPL14 | ribosomal protein L14 | 0.0259092 |
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | -0.206928 |
| FN1 | fibronectin 1 | -0.184019 |
| APOA2 | apolipoprotein A-II | -0.109495 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.101532 |
| EHBP1 | EH domain binding protein 1 | -0.10005 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.097659 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.085559 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0792766 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.075041 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0719639 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0712746 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0662719 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0660777 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0637194 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0623898 |
| A2M | alpha-2-macroglobulin | -0.0616012 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0554439 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0550819 |
| TMEM123 | transmembrane protein 123 | -0.0523571 |
| TRIM26 | tripartite motif containing 26 | -0.0521128 |
| CP | ceruloplasmin (ferroxidase) | -0.0518717 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0486534 |
| TMSB10 | thymosin beta 10 | -0.0475442 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0469854 |
| CFB | complement factor B | -0.0466292 |
| PTCHD4 | patched domain containing 4 | -0.0460244 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0459243 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0450996 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0448849 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0441492 |
| OSMR | oncostatin M receptor | -0.0440563 |
| GNAS | GNAS complex locus | -0.0431698 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0418081 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.041512 |
| HMGA1 | high mobility group AT-hook 1 | -0.041484 |
| FRMD5 | FERM domain containing 5 | -0.0413799 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0387113 |
| ITGA1 | integrin, alpha 1 | -0.0385399 |
| RPS21 | ribosomal protein S21 | -0.0381273 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0380048 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0376017 |
| ATP10A | ATPase, class V, type 10A | -0.0373117 |
| LYZ | lysozyme | -0.0366138 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0363025 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0359114 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0354781 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0353725 |
| RNF213 | ring finger protein 213 | -0.0351306 |
| RPL35A | ribosomal protein L35a | -0.0348166 |
| TPM4 | tropomyosin 4 | -0.0345504 |
| APOE | apolipoprotein E | -0.0334995 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0333627 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0331559 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0327837 |
| PEG3 | paternally expressed 3 | -0.0326801 |
| RPL11 | ribosomal protein L11 | -0.0321422 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.0320368 |
| IGF2 | insulin-like growth factor 2 | -0.0307343 |
| VCL | vinculin | -0.0304836 |
| MX2 | MX dynamin-like GTPase 2 | -0.0304663 |
| ZFHX3 | zinc finger homeobox 3 | -0.0301903 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0299911 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0297563 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0294102 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0292642 |
| EGR1 | early growth response 1 | -0.029213 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0289175 |
| MALT1 | MALT1 paracaspase | -0.0288655 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0286997 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.028531 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0283602 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | -0.0278467 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0277833 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0277252 |
| HMGA2 | high mobility group AT-hook 2 | -0.0276758 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0275684 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0275254 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | -0.0270176 |
| DOK6 | docking protein 6 | -0.0269878 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | -0.0264909 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0263992 |
| ANGPTL8 | angiopoietin like 8 | -0.026127 |
| GPC3 | glypican 3 | -0.0258736 |
| KRT18 | keratin 18, type I | -0.025785 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0256572 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.02558 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0241244 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.024084 |
| METTL9 | methyltransferase like 9 | -0.0239274 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0236897 |
| CRLS1 | cardiolipin synthase 1 | -0.0231772 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0229424 |
| CCDC146 | coiled-coil domain containing 146 | -0.0227949 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0227662 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0225616 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0225507 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0223978 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0223237 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.022231 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0222175 |
