Brivudine_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brivudine perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brivudine_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.0994532
B2M beta-2-microglobulin 0.0852567
RPS8 ribosomal protein S8 0.079469
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0636066
RPS13 ribosomal protein S13 0.0624978
ENO1 enolase 1, (alpha) 0.0622953
INTS6 integrator complex subunit 6 0.0607799
RPS3 ribosomal protein S3 0.0602728
RPL37 ribosomal protein L37 0.0591565
RPS6 ribosomal protein S6 0.0578211
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0541268
UBC ubiquitin C 0.0528528
SQSTM1 sequestosome 1 0.052404
RPLP2 ribosomal protein, large, P2 0.0516705
LMO7 LIM domain 7 0.0516422
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0510832
APLP2 amyloid beta (A4) precursor-like protein 2 0.0503013
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0492451
RPS12 ribosomal protein S12 0.048946
MT1E metallothionein 1E 0.0474267
CD44 CD44 molecule (Indian blood group) 0.0444678
MYOF myoferlin 0.043117
RPL23 ribosomal protein L23 0.0414859
TPT1 tumor protein, translationally-controlled 1 0.0411057
RPL37A ribosomal protein L37a 0.0391226
RPLP1 ribosomal protein, large, P1 0.0388334
FTH1 ferritin, heavy polypeptide 1 0.0387072
RPL31 ribosomal protein L31 0.0384279
FTL ferritin, light polypeptide 0.0379343
EXT1 exostosin glycosyltransferase 1 0.0376874
RAI14 retinoic acid induced 14 0.037197
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0364303
RPS27 ribosomal protein S27 0.0360522
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0353744
RPS25 ribosomal protein S25 0.035296
RPS29 ribosomal protein S29 0.0348086
RPS19 ribosomal protein S19 0.0328897
NAV2 neuron navigator 2 0.0328468
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0323684
RPL5 ribosomal protein L5 0.0323504
DSCAM Down syndrome cell adhesion molecule 0.0323136
RPL12 ribosomal protein L12 0.0308118
KTN1 kinectin 1 (kinesin receptor) 0.0302305
RACK1 receptor for activated C kinase 1 0.0300861
MBNL2 muscleblind-like splicing regulator 2 0.0300481
RPS11 ribosomal protein S11 0.0299604
RPL8 ribosomal protein L8 0.0299297
MTSS1 metastasis suppressor 1 0.0298072
ANXA1 annexin A1 0.0294469
VEGFA vascular endothelial growth factor A 0.0293012
RPS17 ribosomal protein S17 0.0292082
NAP1L1 nucleosome assembly protein 1-like 1 0.028157
PCDH1 protocadherin 1 0.0281387
RPL3 ribosomal protein L3 0.027813
SRRM2 serine/arginine repetitive matrix 2 0.0277926
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0275071
RPL11 ribosomal protein L11 0.0274581
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0269658
LDHA lactate dehydrogenase A 0.025898
HLA-B major histocompatibility complex, class I, B 0.0258895
RPS23 ribosomal protein S23 0.0252367
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0251947
STC1 stanniocalcin 1 0.0251042
FNDC3B fibronectin type III domain containing 3B 0.0248706
DOK5 docking protein 5 0.0245592
PTMA prothymosin, alpha 0.0245578
CANX calnexin 0.0245341
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0245114
N4BP2L2 NEDD4 binding protein 2-like 2 0.024448
RPL35 ribosomal protein L35 0.0243697
ZSWIM6 zinc finger, SWIM-type containing 6 0.0243601
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0242594
POTEF POTE ankyrin domain family, member F 0.0241013
RPL7A ribosomal protein L7a 0.0240404
TPM3 tropomyosin 3 0.0240293
TTC3 tetratricopeptide repeat domain 3 0.0237137
TGM2 transglutaminase 2 0.0236194
RPS27A ribosomal protein S27a 0.0234453
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0232912
CALR calreticulin 0.0230082
RPL36 ribosomal protein L36 0.0228162
RPS2 ribosomal protein S2 0.0228107
RPL26 ribosomal protein L26 0.0227839
RPL13A ribosomal protein L13a 0.0227317
RPL28 ribosomal protein L28 0.0227012
RPL19 ribosomal protein L19 0.0225943
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.022313
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0222118
HSPA8 heat shock 70kDa protein 8 0.0221845
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0221094
PEAK1 pseudopodium-enriched atypical kinase 1 0.0219989
ARRDC3 arrestin domain containing 3 0.0219015
EEF2 eukaryotic translation elongation factor 2 0.0217732
IFITM3 interferon induced transmembrane protein 3 0.0216499
AKAP13 A kinase (PRKA) anchor protein 13 0.0216371
SQLE squalene epoxidase 0.0215959
EIF4A2 eukaryotic translation initiation factor 4A2 0.0215327
ANGPTL4 angiopoietin-like 4 0.021447
FNIP1 folliculin interacting protein 1 0.0209704
PABPC1 poly(A) binding protein, cytoplasmic 1 0.020862

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.23633
FLNB filamin B, beta -0.171851
TIMP3 TIMP metallopeptidase inhibitor 3 -0.164632
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.10878
DPYD dihydropyrimidine dehydrogenase -0.0816338
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0685809
NDRG1 N-myc downstream regulated 1 -0.0659111
SULF1 sulfatase 1 -0.05725
ITGA6 integrin, alpha 6 -0.0491509
NAMPT nicotinamide phosphoribosyltransferase -0.0483127
BCL2L1 BCL2-like 1 -0.0465936
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0465275
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0440047
FOXO1 forkhead box O1 -0.042209
IGF2 insulin-like growth factor 2 -0.0395089
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0393194
PODXL podocalyxin-like -0.0373103
DOCK5 dedicator of cytokinesis 5 -0.0345251
NEK7 NIMA-related kinase 7 -0.0322804
MECOM MDS1 and EVI1 complex locus -0.03225
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0321747
OSMR oncostatin M receptor -0.0316879
LMNA lamin A/C -0.0313466
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0297976
RIN2 Ras and Rab interactor 2 -0.0294362
GNAS GNAS complex locus -0.028471
AHNAK AHNAK nucleoprotein -0.0276026
FOXP1 forkhead box P1 -0.0267298
EMP1 epithelial membrane protein 1 -0.0265826
PRELID2 PRELI domain containing 2 -0.0245925
PALLD palladin, cytoskeletal associated protein -0.0240972
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.023954
HSPG2 heparan sulfate proteoglycan 2 -0.0233484
SAMD9 sterile alpha motif domain containing 9 -0.0233371
MYO10 myosin X -0.0233215
ANXA2 annexin A2 -0.02318
ACTN4 actinin, alpha 4 -0.0228216
RBM39 RNA binding motif protein 39 -0.0225921
ANLN anillin, actin binding protein -0.0222523
NRG1 neuregulin 1 -0.0215115
FN1 fibronectin 1 -0.0215079
MARCHF6 membrane associated ring-CH-type finger 6 -0.0211764
F3 coagulation factor III (thromboplastin, tissue factor) -0.0211549
ARHGAP29 Rho GTPase activating protein 29 -0.0210581
C4BPB complement component 4 binding protein, beta -0.0202701
BLCAP bladder cancer associated protein -0.019862
CAVIN1 caveolae associated protein 1 -0.019809
SMYD3 SET and MYND domain containing 3 -0.0194645
CEMIP cell migration inducing protein, hyaluronan binding -0.0191342
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0188886
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0188587
BMAL2 basic helix-loop-helix ARNT like 2 -0.0182547
TNS4 tensin 4 -0.0181718
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.017988
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.01782
ANKRD33B ankyrin repeat domain 33B -0.0177351
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0173836
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0172486
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0172355
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0171012
ZEB1 zinc finger E-box binding homeobox 1 -0.0169768
LUZP1 leucine zipper protein 1 -0.0168993
PDLIM5 PDZ and LIM domain 5 -0.0168557
THBD thrombomodulin -0.0165678
CD59 CD59 molecule, complement regulatory protein -0.0161796
LDLR low density lipoprotein receptor -0.0160945
NDE1 nudE neurodevelopment protein 1 -0.0159467
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0158241
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0157325
IFI16 interferon, gamma-inducible protein 16 -0.0156096
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0154564
COL17A1 collagen, type XVII, alpha 1 -0.0153941
DSG2 desmoglein 2 -0.0153048
PLAT plasminogen activator, tissue -0.0152109
ITGB4 integrin, beta 4 -0.0151905
EHF ets homologous factor -0.0151109
ITSN1 intersectin 1 (SH3 domain protein) -0.0151012
NF1 neurofibromin 1 -0.0150667
OSBPL3 oxysterol binding protein-like 3 -0.0150046
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0149895
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0149733
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0149163
EPHA2 EPH receptor A2 -0.0148832
METTL15 methyltransferase like 15 -0.0148797
S100A4 S100 calcium binding protein A4 -0.014788
KRT6A keratin 6A, type II -0.0147776
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -0.0147062
ANXA11 annexin A11 -0.0145015
SLC45A4 solute carrier family 45, member 4 -0.0143705
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.014334
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0143167
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0143113
CAPRIN2 caprin family member 2 -0.0141462
CDK6 cyclin-dependent kinase 6 -0.0140056
NDFIP1 Nedd4 family interacting protein 1 -0.0138214
ZNFX1 zinc finger, NFX1-type containing 1 -0.0138069
DAAM1 dishevelled associated activator of morphogenesis 1 -0.0137979
TXNRD1 thioredoxin reductase 1 -0.0136638
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0136411
ARF1 ADP-ribosylation factor 1 -0.0136271