Brivudine_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brivudine perturbation in LS 180 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Brivudine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.222062
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.158354
PTMA prothymosin, alpha 0.132489
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.11856
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.116268
TPT1 tumor protein, translationally-controlled 1 0.100767
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0969017
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0951223
B2M beta-2-microglobulin 0.0885911
RPS8 ribosomal protein S8 0.0866303
RPS6 ribosomal protein S6 0.0840506
FTL ferritin, light polypeptide 0.0838375
CALR calreticulin 0.0820043
ENO1 enolase 1, (alpha) 0.0781493
RPS12 ribosomal protein S12 0.0748144
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0724162
RPLP2 ribosomal protein, large, P2 0.0630093
RPL12 ribosomal protein L12 0.0623365
RPS19 ribosomal protein S19 0.0621572
RPLP1 ribosomal protein, large, P1 0.0616222
AREG amphiregulin 0.0603734
RPS3 ribosomal protein S3 0.0579873
RPL23 ribosomal protein L23 0.0566953
RPL26 ribosomal protein L26 0.055798
EEF2 eukaryotic translation elongation factor 2 0.0554313
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0542238
VEGFA vascular endothelial growth factor A 0.0537022
LDHA lactate dehydrogenase A 0.0529624
DSPP dentin sialophosphoprotein 0.0528801
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0518753
UBC ubiquitin C 0.0512944
PKM pyruvate kinase, muscle 0.048691
HSPA8 heat shock 70kDa protein 8 0.0483879
RPS13 ribosomal protein S13 0.0479894
RPL34 ribosomal protein L34 0.0475307
EXT1 exostosin glycosyltransferase 1 0.0473715
APLP2 amyloid beta (A4) precursor-like protein 2 0.0464516
RPL3 ribosomal protein L3 0.0463186
LMO7 LIM domain 7 0.0461385
H1-0 H1.0 linker histone 0.0450175
RPL19 ribosomal protein L19 0.0446442
RPL37 ribosomal protein L37 0.044493
ACTG1 actin gamma 1 0.0439075
RPS27A ribosomal protein S27a 0.0438565
RPL31 ribosomal protein L31 0.0437856
RPS17 ribosomal protein S17 0.0425949
AFF1 AF4/FMR2 family, member 1 0.0424564
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0417082
RPL9 ribosomal protein L9 0.0413771
RPS27 ribosomal protein S27 0.0408886
EEF1G eukaryotic translation elongation factor 1 gamma 0.03951
CANX calnexin 0.0386465
KTN1 kinectin 1 (kinesin receptor) 0.0383187
RACK1 receptor for activated C kinase 1 0.038175
EIF1 eukaryotic translation initiation factor 1 0.037788
RPL8 ribosomal protein L8 0.0377704
RPL4 ribosomal protein L4 0.0371923
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0364184
MUC13 mucin 13, cell surface associated 0.0362163
RPS23 ribosomal protein S23 0.0354283
RPL37A ribosomal protein L37a 0.0353765
MT2A metallothionein 2A 0.0346831
RPL11 ribosomal protein L11 0.0346245
RPL7A ribosomal protein L7a 0.0345614
RPS29 ribosomal protein S29 0.0345437
RPLP0 ribosomal protein, large, P0 0.0345422
RPL7 ribosomal protein L7 0.0337375
RPS25 ribosomal protein S25 0.0326994
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0324598
RPL18 ribosomal protein L18 0.032433
RPS24 ribosomal protein S24 0.0323584
RPL5 ribosomal protein L5 0.0321757
RPS16 ribosomal protein S16 0.0319747
TXNIP thioredoxin interacting protein 0.0318755
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0311858
RPL28 ribosomal protein L28 0.0308461
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0306991
RPS2 ribosomal protein S2 0.0306197
RPL36 ribosomal protein L36 0.0305151
RPL32 ribosomal protein L32 0.0301455
RPS4X ribosomal protein S4, X-linked 0.0297165
RPL27A ribosomal protein L27a 0.0296424
SFTPA2 surfactant protein A2 0.0296036
RPL35 ribosomal protein L35 0.0294294
RPS14 ribosomal protein S14 0.0293265
ZSWIM6 zinc finger, SWIM-type containing 6 0.0292941
RPL13A ribosomal protein L13a 0.0291961
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0291245
NEBL nebulette 0.028647
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0279514
ISG15 ISG15 ubiquitin-like modifier 0.0277957
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0276356
TPM3 tropomyosin 3 0.0274783
PDIA4 protein disulfide isomerase family A, member 4 0.0270299
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0269137
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0263975
RPS11 ribosomal protein S11 0.02601
PDZD8 PDZ domain containing 8 0.0259801
RPS5 ribosomal protein S5 0.0258945
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0255055

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.25054
CEMIP cell migration inducing protein, hyaluronan binding -0.127146
NALF1 NALCN channel auxiliary factor 1 -0.123839
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0907063
GREB1L growth regulation by estrogen in breast cancer-like -0.0893586
FLNB filamin B, beta -0.0817428
ITGA6 integrin, alpha 6 -0.0802912
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0671587
ANTXR2 anthrax toxin receptor 2 -0.0667939
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0632339
GMDS GDP-mannose 4,6-dehydratase -0.0629011
MUC6 mucin 6, oligomeric mucus/gel-forming -0.062164
GPHN gephyrin -0.0609487
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0566394
ANXA2 annexin A2 -0.0558447
VCL vinculin -0.0519853
RNF217 ring finger protein 217 -0.0517556
TNS4 tensin 4 -0.050256
CALB1 calbindin 1, 28kDa -0.0493906
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0482048
LAMA4 laminin, alpha 4 -0.0480457
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0475722
MAML2 mastermind-like 2 (Drosophila) -0.0467409
PPARG peroxisome proliferator-activated receptor gamma -0.0454045
ONECUT3 one cut homeobox 3 -0.0453957
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.044427
SLC35F3 solute carrier family 35, member F3 -0.0442585
ITGB4 integrin, beta 4 -0.0431282
NCOR1 nuclear receptor corepressor 1 -0.0424871
PRELID2 PRELI domain containing 2 -0.0420346
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0416554
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0413115
EHBP1 EH domain binding protein 1 -0.0388991
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.03856
RIN2 Ras and Rab interactor 2 -0.0382788
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0381052
NDRG1 N-myc downstream regulated 1 -0.0381028
MSI2 musashi RNA-binding protein 2 -0.0378193
PRSS3 protease, serine, 3 -0.0374759
ARHGAP6 Rho GTPase activating protein 6 -0.0374205
PTPRK protein tyrosine phosphatase, receptor type, K -0.0373434
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0349967
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0346143
FERMT1 fermitin family member 1 -0.0343886
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0341974
SH3D19 SH3 domain containing 19 -0.0323999
ALCAM activated leukocyte cell adhesion molecule -0.0316146
FAT1 FAT atypical cadherin 1 -0.03149
NFIA nuclear factor I/A -0.0313153
MAML3 mastermind-like 3 (Drosophila) -0.0304325
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0303868
RNF43 ring finger protein 43 -0.0302838
MUC17 mucin 17, cell surface associated -0.029484
CADPS Ca++-dependent secretion activator -0.029321
PTPRR protein tyrosine phosphatase, receptor type, R -0.0293099
PDLIM5 PDZ and LIM domain 5 -0.0288174
ESYT2 extended synaptotagmin-like protein 2 -0.0287031
PARD3 par-3 family cell polarity regulator -0.0283612
CCNY cyclin Y -0.0282501
BIRC6 baculoviral IAP repeat containing 6 -0.0280742
PTPRB protein tyrosine phosphatase, receptor type, B -0.0278455
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0276666
DENND1A DENN/MADD domain containing 1A -0.0275884
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0273936
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0268861
CLOCK clock circadian regulator -0.0263335
LPP LIM domain containing preferred translocation partner in lipoma -0.0262734
PATJ PATJ crumbs cell polarity complex component -0.0260876
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0259748
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0257675
MED13L mediator complex subunit 13-like -0.0256644
DLG1 discs, large homolog 1 (Drosophila) -0.0254709
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0252017
DIAPH2 diaphanous-related formin 2 -0.025198
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0251329
FAM13A family with sequence similarity 13, member A -0.0250972
POF1B premature ovarian failure, 1B -0.0250172
MBD5 methyl-CpG binding domain protein 5 -0.0248871
SAMD5 sterile alpha motif domain containing 5 -0.0248761
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0247266
MON2 MON2 homolog (S. cerevisiae) -0.024671
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0245006
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0243031
ACTN4 actinin, alpha 4 -0.0241115
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0239797
PSD3 pleckstrin and Sec7 domain containing 3 -0.0232303
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0228445
THSD4 thrombospondin, type I, domain containing 4 -0.0227646
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.0225757
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0224689
CCSER1 coiled-coil serine-rich protein 1 -0.0224127
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0220347
TBC1D22A TBC1 domain family, member 22A -0.0220307
FHL2 four and a half LIM domains 2 -0.0220249
RAP1B RAP1B, member of RAS oncogene family -0.0219985
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0218913
PTPRE protein tyrosine phosphatase, receptor type, E -0.021849
BRWD1 bromodomain and WD repeat domain containing 1 -0.0216747
ANXA3 annexin A3 -0.0216744
PDE4D phosphodiesterase 4D, cAMP-specific -0.0213985