Brivudine_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brivudine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brivudine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 0.137061
DST dystonin 0.127956
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0969069
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0887708
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0686457
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0611549
TMSB4X thymosin beta 4, X-linked 0.0609608
MACF1 microtubule-actin crosslinking factor 1 0.0575926
CD44 CD44 molecule (Indian blood group) 0.0568406
CANX calnexin 0.056527
TM4SF1 transmembrane 4 L six family member 1 0.0548091
FMNL2 formin-like 2 0.052488
AHNAK AHNAK nucleoprotein 0.0505306
DPYD dihydropyrimidine dehydrogenase 0.0486204
CAPRIN2 caprin family member 2 0.0471266
VCL vinculin 0.0453634
WWTR1 WW domain containing transcription regulator 1 0.0452279
KTN1 kinectin 1 (kinesin receptor) 0.0451201
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0425577
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0419749
RUNX1 runt-related transcription factor 1 0.0409201
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0400347
BCAR3 breast cancer anti-estrogen resistance 3 0.0395441
BIRC3 baculoviral IAP repeat containing 3 0.0389951
ERRFI1 ERBB receptor feedback inhibitor 1 0.0383608
SPAG9 sperm associated antigen 9 0.0377907
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0375113
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0366198
APP amyloid beta (A4) precursor protein 0.0363726
HDAC9 histone deacetylase 9 0.0360783
TP63 tumor protein p63 0.0359978
UBC ubiquitin C 0.0354865
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0351506
CALR calreticulin 0.035047
SP100 SP100 nuclear antigen 0.0347544
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0347284
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0342257
SDCCAG8 serologically defined colon cancer antigen 8 0.0330409
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0321169
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0320713
APLP2 amyloid beta (A4) precursor-like protein 2 0.0316679
PDIA4 protein disulfide isomerase family A, member 4 0.0315099
TTC3 tetratricopeptide repeat domain 3 0.0313289
DOCK11 dedicator of cytokinesis 11 0.031269
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0312499
HDLBP high density lipoprotein binding protein 0.0311616
CADM2 cell adhesion molecule 2 0.0300443
ENO1 enolase 1, (alpha) 0.0299291
RAB27B RAB27B, member RAS oncogene family 0.0299042
PRELID2 PRELI domain containing 2 0.0295265
RAD51B RAD51 paralog B 0.0292993
RAI1 retinoic acid induced 1 0.0284429
SDC4 syndecan 4 0.0284248
SMYD3 SET and MYND domain containing 3 0.0279654
RPL26 ribosomal protein L26 0.0270788
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0269333
GOLGB1 golgin B1 0.0267385
TPM3 tropomyosin 3 0.026542
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0264686
MYH9 myosin, heavy chain 9, non-muscle 0.0261416
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0260648
BIRC2 baculoviral IAP repeat containing 2 0.0260531
NAP1L1 nucleosome assembly protein 1-like 1 0.0256049
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0255425
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0252892
DSCAM Down syndrome cell adhesion molecule 0.0252521
RNF213 ring finger protein 213 0.0250787
ARHGAP5 Rho GTPase activating protein 5 0.0248984
CXCL8 chemokine (C-X-C motif) ligand 8 0.0246472
SFTPA2 surfactant protein A2 0.0245707
H1-0 H1.0 linker histone 0.0238449
PDE10A phosphodiesterase 10A 0.0236369
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0230215
ZSWIM6 zinc finger, SWIM-type containing 6 0.0229056
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0228647
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0227885
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0226269
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0226205
RPS3 ribosomal protein S3 0.022612
ANKRD36 ankyrin repeat domain 36 0.0221315
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0216737
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0214247
MYOF myoferlin 0.0213588
HSPA8 heat shock 70kDa protein 8 0.0209891
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0209319
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0206451
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0206335
KDM3A lysine (K)-specific demethylase 3A 0.0204339
CSNK1A1 casein kinase 1, alpha 1 0.0200378
DNAH14 dynein, axonemal, heavy chain 14 0.0199001
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0198005
ANKIB1 ankyrin repeat and IBR domain containing 1 0.019754
RAP2B RAP2B, member of RAS oncogene family 0.0196832
SET SET nuclear proto-oncogene 0.0195656
EIF4A2 eukaryotic translation initiation factor 4A2 0.0194042
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0193455
EHBP1 EH domain binding protein 1 0.0191742
RIGI RNA sensor RIG-I 0.0191337
ZEB1 zinc finger E-box binding homeobox 1 0.0191252
EZR ezrin 0.0189923

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.354647
VIM vimentin -0.172067
TMSB10 thymosin beta 10 -0.122148
FTL ferritin, light polypeptide -0.0913499
MT2A metallothionein 2A -0.0832141
RPL35A ribosomal protein L35a -0.0796649
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0585845
HLA-B major histocompatibility complex, class I, B -0.0557544
POTEF POTE ankyrin domain family, member F -0.0527255
PTMA prothymosin, alpha -0.0498784
RPS19 ribosomal protein S19 -0.037017
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0342392
HMGA1 high mobility group AT-hook 1 -0.0321402
S100A9 S100 calcium binding protein A9 -0.0314699
IFITM1 interferon induced transmembrane protein 1 -0.0297823
RPL28 ribosomal protein L28 -0.0281215
RPS23 ribosomal protein S23 -0.0276581
RPL36 ribosomal protein L36 -0.0265728
ENO2 enolase 2 (gamma, neuronal) -0.0254589
EGR1 early growth response 1 -0.0252723
LOC112694756 uncharaterized LOC112694756 -0.024291
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0241345
RPL37A ribosomal protein L37a -0.0239015
RPS6 ribosomal protein S6 -0.0238371
RPL11 ribosomal protein L11 -0.023147
EIF1 eukaryotic translation initiation factor 1 -0.0227158
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0227099
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0225034
HLA-A major histocompatibility complex, class I, A -0.0222654
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0221209
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0217356
FOSL1 FOS-like antigen 1 -0.0214853
RPL31 ribosomal protein L31 -0.0210935
SRGN serglycin -0.0208755
RPS25 ribosomal protein S25 -0.0207685
RPS14 ribosomal protein S14 -0.0205642
FTH1 ferritin, heavy polypeptide 1 -0.0200521
VDAC1 voltage-dependent anion channel 1 -0.019798
RPS29 ribosomal protein S29 -0.0197232
ACTG1 actin gamma 1 -0.0194806
WARS1 tryptophanyl-tRNA synthetase 1 -0.0190532
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0189848
PFN1 profilin 1 -0.0189213
RPL9 ribosomal protein L9 -0.0189082
RPLP2 ribosomal protein, large, P2 -0.0185298
MT1E metallothionein 1E -0.0184165
RPS15 ribosomal protein S15 -0.01793
RPLP1 ribosomal protein, large, P1 -0.0179105
TUBB4B tubulin, beta 4B class IVb -0.0176818
KPNB1 karyopherin (importin) beta 1 -0.0171615
WASF2 WAS protein family, member 2 -0.016894
CENPF centromere protein F, 350/400kDa -0.0163806
PCBP2 poly(rC) binding protein 2 -0.0162989
RPS10 ribosomal protein S10 -0.0160847
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0159311
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0158966
RPL23 ribosomal protein L23 -0.0158293
LOXL2 lysyl oxidase-like 2 -0.0156308
ISG15 ISG15 ubiquitin-like modifier -0.0152263
RPL8 ribosomal protein L8 -0.0152078
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.014965
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0144167
S100A6 S100 calcium binding protein A6 -0.014357
YBX1 Y box binding protein 1 -0.014313
PNISR PNN-interacting serine/arginine-rich protein -0.0141559
ATP5F1B ATP synthase F1 subunit beta -0.0140876
IFITM3 interferon induced transmembrane protein 3 -0.0139823
RTN4 reticulon 4 -0.0137311
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0135259
RPL36A ribosomal protein L36a -0.0134131
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0133905
IFI6 interferon, alpha-inducible protein 6 -0.0133877
EIF5B eukaryotic translation initiation factor 5B -0.0128228
GNAS GNAS complex locus -0.0125309
RBM25 RNA binding motif protein 25 -0.0125
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0123005
PRDX1 peroxiredoxin 1 -0.0122788
MIS18BP1 MIS18 binding protein 1 -0.0121282
TP53 tumor protein p53 -0.01208
SRSF11 serine/arginine-rich splicing factor 11 -0.0119638
RPS21 ribosomal protein S21 -0.0116496
RPS28 ribosomal protein S28 -0.011578
HSPG2 heparan sulfate proteoglycan 2 -0.01152
WSB1 WD repeat and SOCS box containing 1 -0.0113499
TUBA1C tubulin, alpha 1c -0.0112478
RPL38 ribosomal protein L38 -0.0112097
RPS13 ribosomal protein S13 -0.0111758
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0110615
BRWD1 bromodomain and WD repeat domain containing 1 -0.0109411
RPS20 ribosomal protein S20 -0.0107955
PDCD5 programmed cell death 5 -0.0107289
UBE2B ubiquitin-conjugating enzyme E2B -0.0107149
ATN1 atrophin 1 -0.0107046
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0106136
TNS3 tensin 3 -0.0105807
ATF4 activating transcription factor 4 -0.0104637
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0103737
FNBP4 formin binding protein 4 -0.01033
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0102737
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.010203