Brivudine_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brivudine perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Brivudine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.179837
VIM vimentin 0.106479
EGFR epidermal growth factor receptor 0.0995743
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0959402
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0934251
KRT17 keratin 17, type I 0.0722035
CALR calreticulin 0.0720143
B2M beta-2-microglobulin 0.0709453
ZBTB20 zinc finger and BTB domain containing 20 0.0677256
ASPH aspartate beta-hydroxylase 0.0675492
UBC ubiquitin C 0.0671964
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0656302
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0599981
RPS3 ribosomal protein S3 0.0599012
ZSWIM6 zinc finger, SWIM-type containing 6 0.0592325
MYOF myoferlin 0.0587036
MT2A metallothionein 2A 0.0584068
TXNRD1 thioredoxin reductase 1 0.0582782
CANX calnexin 0.057082
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0532243
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0530211
GOLGA4 golgin A4 0.0523178
PKM pyruvate kinase, muscle 0.0518261
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.051657
EEF2 eukaryotic translation elongation factor 2 0.0507557
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0504009
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0493957
KTN1 kinectin 1 (kinesin receptor) 0.0486727
ALCAM activated leukocyte cell adhesion molecule 0.0482081
ARHGAP26 Rho GTPase activating protein 26 0.0480043
TMSB10 thymosin beta 10 0.0476984
SLC38A1 solute carrier family 38, member 1 0.046199
OGA O-GlcNAcase 0.0461427
PSD3 pleckstrin and Sec7 domain containing 3 0.0452285
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0439527
CTBP2 C-terminal binding protein 2 0.0432095
LDHA lactate dehydrogenase A 0.0431612
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0419635
POTEF POTE ankyrin domain family, member F 0.0419361
SFTPA2 surfactant protein A2 0.0416656
SMAD3 SMAD family member 3 0.0413837
RPS13 ribosomal protein S13 0.040853
BIRC3 baculoviral IAP repeat containing 3 0.0407827
TPT1 tumor protein, translationally-controlled 1 0.0399362
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0397084
RABGAP1L RAB GTPase activating protein 1-like 0.0395212
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0394696
MBNL1 muscleblind-like splicing regulator 1 0.0388742
SEPTIN9 septin 9 0.0385139
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0377061
ENO1 enolase 1, (alpha) 0.0376592
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0376416
AKAP9 A kinase (PRKA) anchor protein 9 0.0368735
MYO10 myosin X 0.0368209
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0367753
BIRC6 baculoviral IAP repeat containing 6 0.0364252
LOC112694756 uncharaterized LOC112694756 0.0360375
DSCAM Down syndrome cell adhesion molecule 0.0358755
MYO5B myosin VB 0.0358427
SEC31A SEC31 homolog A (S. cerevisiae) 0.0357713
AFF1 AF4/FMR2 family, member 1 0.0355658
RPLP1 ribosomal protein, large, P1 0.035377
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0349689
FAM13A family with sequence similarity 13, member A 0.0348752
RPL26 ribosomal protein L26 0.0347517
MYO9A myosin IXA 0.034569
ISG15 ISG15 ubiquitin-like modifier 0.0345433
RPS8 ribosomal protein S8 0.0344644
RACK1 receptor for activated C kinase 1 0.0344297
EFNA5 ephrin-A5 0.0342488
MYL12B myosin, light chain 12B, regulatory 0.0339272
ZNF106 zinc finger protein 106 0.0337463
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0336344
ARHGAP21 Rho GTPase activating protein 21 0.0334754
VEGFA vascular endothelial growth factor A 0.0334563
RTN3 reticulon 3 0.0334524
ESYT2 extended synaptotagmin-like protein 2 0.0333609
FLNB filamin B, beta 0.033313
RPL35A ribosomal protein L35a 0.0332503
CTNND1 catenin (cadherin-associated protein), delta 1 0.0331029
TNRC6B trinucleotide repeat containing 6B 0.032824
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0323874
RPL7A ribosomal protein L7a 0.0323768
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0322795
PACS1 phosphofurin acidic cluster sorting protein 1 0.0321393
VMP1 vacuole membrane protein 1 0.0318586
PRKCE protein kinase C, epsilon 0.0318116
FNDC3A fibronectin type III domain containing 3A 0.0317797
MAP7 microtubule-associated protein 7 0.0317383
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0311338
JARID2 jumonji, AT rich interactive domain 2 0.0310698
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0309658
ATXN1 ataxin 1 0.0305007
SRRM1 serine/arginine repetitive matrix 1 0.0304421
PDIA4 protein disulfide isomerase family A, member 4 0.030306
PTMA prothymosin, alpha 0.0302811
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0301978
CALU calumenin 0.0301214
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0300242
RPS6 ribosomal protein S6 0.0299249

decreased expression

Symbol Name Standardized Value
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.137318
PDE4D phosphodiesterase 4D, cAMP-specific -0.126856
BACE2 beta-site APP-cleaving enzyme 2 -0.104615
PLAUR plasminogen activator, urokinase receptor -0.0991116
NDRG1 N-myc downstream regulated 1 -0.0987273
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0965037
LAMB3 laminin, beta 3 -0.0869304
LMO7 LIM domain 7 -0.0850538
IGF2 insulin-like growth factor 2 -0.0839852
PARD3 par-3 family cell polarity regulator -0.0824206
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0817618
ANXA2 annexin A2 -0.073806
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0724057
CEMIP cell migration inducing protein, hyaluronan binding -0.0718882
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0708112
ATOSA atos homolog A -0.0670681
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0658509
SAMD4A sterile alpha motif domain containing 4A -0.0627125
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0556513
FTH1 ferritin, heavy polypeptide 1 -0.0553811
SVIL supervillin -0.0534382
KLF5 Kruppel-like factor 5 (intestinal) -0.0534017
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.051294
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.051206
ZMYND8 zinc finger, MYND-type containing 8 -0.0507102
CAPN2 calpain 2, (m/II) large subunit -0.0486508
OCLN occludin -0.0486266
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0477546
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0477099
MCTP2 multiple C2 domains, transmembrane 2 -0.0465832
MEF2A myocyte enhancer factor 2A -0.0450044
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0445353
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0442198
CATSPERB catsper channel auxiliary subunit beta -0.0441734
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0441098
GRB10 growth factor receptor-bound protein 10 -0.0438821
FOXO3 forkhead box O3 -0.0435759
ABI1 abl-interactor 1 -0.0434478
FNDC3B fibronectin type III domain containing 3B -0.0433655
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0428342
ELL2 elongation factor, RNA polymerase II, 2 -0.0399358
BTG1 B-cell translocation gene 1, anti-proliferative -0.0388268
GOLPH3L golgi phosphoprotein 3-like -0.03861
TC2N tandem C2 domains, nuclear -0.0384952
MUC16 mucin 16, cell surface associated -0.038367
GLUL glutamate-ammonia ligase -0.0382187
TMCC3 transmembrane and coiled-coil domain family 3 -0.0380173
RB1CC1 RB1-inducible coiled-coil 1 -0.0379229
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0378563
SNX14 sorting nexin 14 -0.0376709
AFDN afadin, adherens junction formation factor -0.037397
MXD1 MAX dimerization protein 1 -0.0371634
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0368901
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -0.0367904
F3 coagulation factor III (thromboplastin, tissue factor) -0.0366818
DIDO1 death inducer-obliterator 1 -0.0358391
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0357163
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0352862
VRK2 vaccinia related kinase 2 -0.0352359
CDPF1 cysteine-rich, DPF motif domain containing 1 -0.0351019
NIBAN2 niban apoptosis regulator 2 -0.0350186
LAMC2 laminin, gamma 2 -0.0346942
DGKD diacylglycerol kinase, delta 130kDa -0.0338945
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0333761
FMN1 formin 1 -0.0332755
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0331454
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0329568
MBD5 methyl-CpG binding domain protein 5 -0.0322536
CDCP1 CUB domain containing protein 1 -0.0320599
ZNF217 zinc finger protein 217 -0.0320191
SOS2 son of sevenless homolog 2 (Drosophila) -0.0319642
ZC3H11A zinc finger CCCH-type containing 11A -0.0316864
FRMD6 FERM domain containing 6 -0.0316852
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.031604
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0315933
TUT4 terminal uridylyl transferase 4 -0.0315465
NECTIN2 nectin cell adhesion molecule 2 -0.0313846
RESF1 retroelement silencing factor 1 -0.0313742
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0312721
ZBTB43 zinc finger and BTB domain containing 43 -0.0305215
HBP1 HMG-box transcription factor 1 -0.0304801
IGF1R insulin-like growth factor 1 receptor -0.029879
MAML2 mastermind-like 2 (Drosophila) -0.0298217
DOCK4 dedicator of cytokinesis 4 -0.0298212
RPTOR regulatory associated protein of MTOR, complex 1 -0.0297935
SACK1A scaffolding CK1 anchoring protein A -0.029564
RGS20 regulator of G-protein signaling 20 -0.0295155
STRN3 striatin, calmodulin binding protein 3 -0.0294412
SMC4 structural maintenance of chromosomes 4 -0.0293269
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.0292955
YME1L1 YME1-like 1 ATPase -0.0292672
SDCBP2 syndecan binding protein (syntenin) 2 -0.029253
BMAL2 basic helix-loop-helix ARNT like 2 -0.0290171
FBXO11 F-box protein 11 -0.0289502
SMOC1 SPARC related modular calcium binding 1 -0.0289368
HOOK2 hook microtubule-tethering protein 2 -0.028859
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0286708
PCNX1 pecanex 1 -0.0285841
MCPH1 microcephalin 1 -0.0281864
SMC5 structural maintenance of chromosomes 5 -0.0281306