Brivudine_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brivudine perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brivudine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.105986
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.105884
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0766937
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0743934
PSD3 pleckstrin and Sec7 domain containing 3 0.07027
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0599247
ASPH aspartate beta-hydroxylase 0.0586119
DST dystonin 0.0570109
ENO1 enolase 1, (alpha) 0.0558332
MYOF myoferlin 0.0519045
SPTBN1 spectrin, beta, non-erythrocytic 1 0.046144
EEF2 eukaryotic translation elongation factor 2 0.0446013
LDHA lactate dehydrogenase A 0.0423405
ZSWIM6 zinc finger, SWIM-type containing 6 0.0421661
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0421358
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0418328
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0413869
AKAP13 A kinase (PRKA) anchor protein 13 0.0406346
EXT1 exostosin glycosyltransferase 1 0.0405983
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0403785
RPL3 ribosomal protein L3 0.0392713
UBC ubiquitin C 0.0386062
TPM3 tropomyosin 3 0.0371958
AGTPBP1 ATP/GTP binding protein 1 0.0354997
APLP2 amyloid beta (A4) precursor-like protein 2 0.0349871
PRKN parkin RBR E3 ubiquitin protein ligase 0.0347893
CANX calnexin 0.0344639
EZR ezrin 0.0333523
GRAMD1B GRAM domain containing 1B 0.032242
PDLIM5 PDZ and LIM domain 5 0.0316397
HSPA8 heat shock 70kDa protein 8 0.0310288
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0306295
KYNU kynureninase 0.0305983
SFTPA2 surfactant protein A2 0.0301955
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0299828
PM20D1 peptidase M20 domain containing 1 0.0293706
RAD51B RAD51 paralog B 0.0293475
RPL4 ribosomal protein L4 0.0285266
TXNRD1 thioredoxin reductase 1 0.0282001
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0279347
DNER delta/notch-like EGF repeat containing 0.0278823
RPS4X ribosomal protein S4, X-linked 0.0271347
DOCK4 dedicator of cytokinesis 4 0.0268067
SH3KBP1 SH3-domain kinase binding protein 1 0.0268029
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0265791
PKM pyruvate kinase, muscle 0.0259023
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0255167
FMNL2 formin-like 2 0.025401
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0252604
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0245777
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0244396
PTEN phosphatase and tensin homolog 0.0242746
RPL26 ribosomal protein L26 0.0240704
CALR calreticulin 0.0235225
ANXA1 annexin A1 0.023347
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0233288
SLC38A2 solute carrier family 38, member 2 0.0229739
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0229223
MCTP1 multiple C2 domains, transmembrane 1 0.0223059
FNIP1 folliculin interacting protein 1 0.0218075
MT2A metallothionein 2A 0.0217869
RABGAP1L RAB GTPase activating protein 1-like 0.0217039
PDE10A phosphodiesterase 10A 0.0216913
EEF1G eukaryotic translation elongation factor 1 gamma 0.0215988
RPS3 ribosomal protein S3 0.0215969
SMAD2 SMAD family member 2 0.0215338
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0214162
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0210451
ESYT2 extended synaptotagmin-like protein 2 0.0209915
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0208998
SET SET nuclear proto-oncogene 0.0206331
SMOC1 SPARC related modular calcium binding 1 0.0205591
SQSTM1 sequestosome 1 0.0203787
RACK1 receptor for activated C kinase 1 0.0201132
MYH9 myosin, heavy chain 9, non-muscle 0.0200703
LSAMP limbic system-associated membrane protein 0.0199651
CTIF CBP80/20-dependent translation initiation factor 0.019938
PDIA4 protein disulfide isomerase family A, member 4 0.0198586
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0196789
COL8A1 collagen, type VIII, alpha 1 0.0196479
TGFBR1 transforming growth factor, beta receptor 1 0.019517
SAMD4A sterile alpha motif domain containing 4A 0.0191321
CADM2 cell adhesion molecule 2 0.018807
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0187164
AHNAK AHNAK nucleoprotein 0.0185333
RPL14 ribosomal protein L14 0.018455
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0179296
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0179254
POTEF POTE ankyrin domain family, member F 0.0178344
NRXN3 neurexin 3 0.017694
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0176457
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0174465
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0171691
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0171681
RPS27 ribosomal protein S27 0.0171499
ITGA6 integrin, alpha 6 0.0169785
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0169
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0167885
IQGAP1 IQ motif containing GTPase activating protein 1 0.0165304
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0163483

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0574906
TMSB10 thymosin beta 10 -0.0567289
PTMA prothymosin, alpha -0.0343238
NAMPT nicotinamide phosphoribosyltransferase -0.0333375
RPL35A ribosomal protein L35a -0.031183
TFPI2 tissue factor pathway inhibitor 2 -0.0293039
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0278413
HLA-B major histocompatibility complex, class I, B -0.0238594
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0229779
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0223627
EIF1 eukaryotic translation initiation factor 1 -0.0221025
GNAS GNAS complex locus -0.019995
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0193209
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.019268
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0183771
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0182994
VDAC1 voltage-dependent anion channel 1 -0.0179879
FTL ferritin, light polypeptide -0.0176994
PNISR PNN-interacting serine/arginine-rich protein -0.0176073
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0170996
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0170783
KPNB1 karyopherin (importin) beta 1 -0.0168631
S100A6 S100 calcium binding protein A6 -0.0168155
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0164104
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.016188
ELL2 elongation factor, RNA polymerase II, 2 -0.0161332
ISG15 ISG15 ubiquitin-like modifier -0.0159222
TPT1 tumor protein, translationally-controlled 1 -0.0154522
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0150179
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0149345
TRA2A transformer 2 alpha homolog (Drosophila) -0.0149314
TGFBI transforming growth factor, beta-induced, 68kDa -0.0145632
IGFBP3 insulin-like growth factor binding protein 3 -0.0142745
RPS28 ribosomal protein S28 -0.0140825
RPL36 ribosomal protein L36 -0.014005
WSB1 WD repeat and SOCS box containing 1 -0.0134819
OGA O-GlcNAcase -0.0134138
TENT5A terminal nucleotidyltransferase 5A -0.0129837
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0121993
NT5C2 5'-nucleotidase, cytosolic II -0.0121314
USP3 ubiquitin specific peptidase 3 -0.0120739
CCL5 chemokine (C-C motif) ligand 5 -0.0119442
RBM39 RNA binding motif protein 39 -0.0117685
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0116955
PUM2 pumilio RNA-binding family member 2 -0.0116834
VIM vimentin -0.0115616
WDR43 WD repeat domain 43 -0.0115205
WARS1 tryptophanyl-tRNA synthetase 1 -0.0114616
STEAP1B STEAP family member 1B -0.0114425
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0112243
NPEPPS aminopeptidase puromycin sensitive -0.0111589
RPS21 ribosomal protein S21 -0.0109634
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0106565
NDRG1 N-myc downstream regulated 1 -0.0106531
PRSS23 protease, serine, 23 -0.0106149
RPS19 ribosomal protein S19 -0.0103556
STC1 stanniocalcin 1 -0.010295
TIMP1 TIMP metallopeptidase inhibitor 1 -0.00985339
FN1 fibronectin 1 -0.00978716
COL4A5 collagen, type IV, alpha 5 -0.00971854
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.00964371
SCN3A sodium channel, voltage gated, type III alpha subunit -0.00948341
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.00938886
QPCT glutaminyl-peptide cyclotransferase -0.00918959
WDR45B WD repeat domain 45B -0.00917691
NOP58 NOP58 ribonucleoprotein -0.00904731
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.008954
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.00893622
TSC22D2 TSC22 domain family, member 2 -0.00892675
ZMYND8 zinc finger, MYND-type containing 8 -0.00876592
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.00873833
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.00862719
RTN4 reticulon 4 -0.00860962
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.00857558
RAB31 RAB31, member RAS oncogene family -0.00847777
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.00843748
FAM193A family with sequence similarity 193, member A -0.00835721
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.00827819
NUP58 nucleoporin 58 -0.00825662
EFNA5 ephrin-A5 -0.00805357
BMERB1 bMERB domain containing 1 -0.00803412
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.00797185
RNF149 ring finger protein 149 -0.00793811
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.00790205
UQCRB ubiquinol-cytochrome c reductase binding protein -0.00785558
ZNF207 zinc finger protein 207 -0.00785231
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.00783814
UBE2B ubiquitin-conjugating enzyme E2B -0.00782647
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.00778772
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.00773238
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.00760598
IFITM3 interferon induced transmembrane protein 3 -0.00757943
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.00751537
FKBP10 FK506 binding protein 10, 65 kDa -0.00744004
IL6 interleukin 6 -0.0074389
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.00731891
SOX4 SRY (sex determining region Y)-box 4 -0.00721835
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.00718414
SOX6 SRY (sex determining region Y)-box 6 -0.00713747
MARCHF6 membrane associated ring-CH-type finger 6 -0.00713017