Brivudine_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brivudine perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brivudine_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.191178
VIM vimentin 0.169064
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.160113
MYH9 myosin, heavy chain 9, non-muscle 0.143915
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.119118
CALR calreticulin 0.110618
ENO1 enolase 1, (alpha) 0.102737
CD44 CD44 molecule (Indian blood group) 0.100482
LDHA lactate dehydrogenase A 0.0965589
EEF2 eukaryotic translation elongation factor 2 0.0948284
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0910626
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0896837
SFTPA2 surfactant protein A2 0.0829077
APLP2 amyloid beta (A4) precursor-like protein 2 0.0790556
NDRG1 N-myc downstream regulated 1 0.076694
TRIO trio Rho guanine nucleotide exchange factor 0.0764205
ASPH aspartate beta-hydroxylase 0.073959
IER3 immediate early response 3 0.0708934
STC1 stanniocalcin 1 0.0657454
SQSTM1 sequestosome 1 0.0647994
RPS12 ribosomal protein S12 0.0646754
PGK1 phosphoglycerate kinase 1 0.0637766
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0604471
MACF1 microtubule-actin crosslinking factor 1 0.0600069
TPT1 tumor protein, translationally-controlled 1 0.0586988
RPS6 ribosomal protein S6 0.0582571
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0572257
RPS3 ribosomal protein S3 0.0571235
DST dystonin 0.0569213
VEGFA vascular endothelial growth factor A 0.0564197
MT2A metallothionein 2A 0.0541246
B2M beta-2-microglobulin 0.0535807
CANX calnexin 0.0534041
RPS8 ribosomal protein S8 0.0518857
FTL ferritin, light polypeptide 0.0518193
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0512973
RPL23 ribosomal protein L23 0.0508009
PKM pyruvate kinase, muscle 0.047849
AKAP12 A kinase (PRKA) anchor protein 12 0.0462007
SPAG9 sperm associated antigen 9 0.0460564
RPLP2 ribosomal protein, large, P2 0.0456847
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0455908
IGFBP3 insulin-like growth factor binding protein 3 0.0451202
NAP1L1 nucleosome assembly protein 1-like 1 0.0448016
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0447968
RPL37A ribosomal protein L37a 0.0433475
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0432946
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0423756
ZSWIM6 zinc finger, SWIM-type containing 6 0.0422466
CDH13 cadherin 13 0.0421679
NAV2 neuron navigator 2 0.0417544
AKAP13 A kinase (PRKA) anchor protein 13 0.0417277
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.041105
SDC4 syndecan 4 0.0409807
PLIN2 perilipin 2 0.0408641
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0405486
EEF1G eukaryotic translation elongation factor 1 gamma 0.0401282
RPS13 ribosomal protein S13 0.0399167
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0394329
GOLGB1 golgin B1 0.0388755
EXT1 exostosin glycosyltransferase 1 0.0384716
RPL7A ribosomal protein L7a 0.0384345
RPL26 ribosomal protein L26 0.0382591
HLA-A major histocompatibility complex, class I, A 0.0380191
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.037905
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0378315
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0377644
KTN1 kinectin 1 (kinesin receptor) 0.0376249
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0376189
UBC ubiquitin C 0.0361338
LAMP2 lysosomal-associated membrane protein 2 0.0359242
OSBPL8 oxysterol binding protein-like 8 0.0355904
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0354497
COL5A1 collagen, type V, alpha 1 0.0353965
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0353757
RPL5 ribosomal protein L5 0.0353736
TIMP2 TIMP metallopeptidase inhibitor 2 0.0349628
EFNA5 ephrin-A5 0.0349466
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0344345
JARID2 jumonji, AT rich interactive domain 2 0.0343868
HDAC9 histone deacetylase 9 0.0339364
RACK1 receptor for activated C kinase 1 0.0338519
PTMA prothymosin, alpha 0.0335816
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0334521
TMSB4X thymosin beta 4, X-linked 0.033438
HLA-B major histocompatibility complex, class I, B 0.0333814
SDK1 sidekick cell adhesion molecule 1 0.0330177
EIF3A eukaryotic translation initiation factor 3, subunit A 0.032478
BIRC3 baculoviral IAP repeat containing 3 0.0323789
STC2 stanniocalcin 2 0.032231
RPS17 ribosomal protein S17 0.0318513
C3 complement component 3 0.0316381
RPS24 ribosomal protein S24 0.0316096
SEPTIN9 septin 9 0.0312159
FMNL2 formin-like 2 0.0307607
FLNB filamin B, beta 0.0306626
INSIG1 insulin induced gene 1 0.0305095
RPL3 ribosomal protein L3 0.0304647
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.030269
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0302608

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.106985
FN1 fibronectin 1 -0.0878646
NAMPT nicotinamide phosphoribosyltransferase -0.0848438
BICC1 BicC family RNA binding protein 1 -0.0745576
FRMD4A FERM domain containing 4A -0.0613058
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0528561
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0475536
GLIS3 GLIS family zinc finger 3 -0.0445656
KYNU kynureninase -0.0433835
FNDC3B fibronectin type III domain containing 3B -0.0432109
RIGI RNA sensor RIG-I -0.0420254
SMAD3 SMAD family member 3 -0.0409891
VCL vinculin -0.0392916
ELL2 elongation factor, RNA polymerase II, 2 -0.0389834
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0371207
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0363538
RBM39 RNA binding motif protein 39 -0.035102
TENT5A terminal nucleotidyltransferase 5A -0.035008
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0349583
SOD2 superoxide dismutase 2, mitochondrial -0.0334447
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0320087
NABP1 nucleic acid binding protein 1 -0.0316712
OSMR oncostatin M receptor -0.0313458
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0294739
THBS1 thrombospondin 1 -0.0292918
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0282701
BCAR3 breast cancer anti-estrogen resistance 3 -0.0274296
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0266653
WTAP Wilms tumor 1 associated protein -0.0266514
NT5C2 5'-nucleotidase, cytosolic II -0.0263999
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0261505
ZFAND3 zinc finger, AN1-type domain 3 -0.0257968
CDK17 cyclin-dependent kinase 17 -0.0251842
RNF213 ring finger protein 213 -0.0249754
GNAS GNAS complex locus -0.0247441
PNISR PNN-interacting serine/arginine-rich protein -0.0245483
EHBP1 EH domain binding protein 1 -0.0244469
PLSCR1 phospholipid scramblase 1 -0.0240822
RTN4 reticulon 4 -0.023509
MARCHF6 membrane associated ring-CH-type finger 6 -0.0232678
NCOA7 nuclear receptor coactivator 7 -0.0231712
TNS3 tensin 3 -0.0230759
DIAPH3 diaphanous-related formin 3 -0.0226482
FAM20C family with sequence similarity 20, member C -0.0226304
UGCG UDP-glucose ceramide glucosyltransferase -0.0224153
OGA O-GlcNAcase -0.0216116
WSB1 WD repeat and SOCS box containing 1 -0.0207962
ZNFX1 zinc finger, NFX1-type containing 1 -0.0207132
RUNX2 runt-related transcription factor 2 -0.0205055
PMP22 peripheral myelin protein 22 -0.0200098
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0197799
TRIP12 thyroid hormone receptor interactor 12 -0.0192175
DENND5A DENN/MADD domain containing 5A -0.019086
IFI6 interferon, alpha-inducible protein 6 -0.0189313
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0187844
NF1 neurofibromin 1 -0.0187497
BRWD3 bromodomain and WD repeat domain containing 3 -0.0185483
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0184256
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0183968
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0183631
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0182037
FAM3C family with sequence similarity 3, member C -0.0180981
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0179541
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0178923
PALLD palladin, cytoskeletal associated protein -0.017678
LPP LIM domain containing preferred translocation partner in lipoma -0.0175513
NRP1 neuropilin 1 -0.0174934
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0174101
IFI16 interferon, gamma-inducible protein 16 -0.0173838
MX1 MX dynamin-like GTPase 1 -0.0173492
TNNC1 troponin C type 1 (slow) -0.0172988
KIF4A kinesin family member 4A -0.0168751
ITCH itchy E3 ubiquitin protein ligase -0.0168482
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0166654
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0166525
PHIP pleckstrin homology domain interacting protein -0.0164304
ZNF644 zinc finger protein 644 -0.0163901
XAF1 XIAP associated factor 1 -0.016279
VMP1 vacuole membrane protein 1 -0.0162738
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0162419
SP100 SP100 nuclear antigen -0.0162224
EPSTI1 epithelial stromal interaction 1 (breast) -0.0161574
ATP13A3 ATPase type 13A3 -0.016109
MX2 MX dynamin-like GTPase 2 -0.0160596
NEK7 NIMA-related kinase 7 -0.0159767
CCNL1 cyclin L1 -0.0159041
QKI QKI, KH domain containing, RNA binding -0.0157664
STRN3 striatin, calmodulin binding protein 3 -0.0156941
SENP6 SUMO1/sentrin specific peptidase 6 -0.0156476
RASA2 RAS p21 protein activator 2 -0.0155464
NTN4 netrin 4 -0.0154503
ZBTB38 zinc finger and BTB domain containing 38 -0.0154486
VCAN versican -0.0154432
TRIM22 tripartite motif containing 22 -0.0154002
HDAC8 histone deacetylase 8 -0.0153587
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0153549
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0153302
DCBLD1 discoidin, CUB and LCCL domain containing 1 -0.0153156
ZNF292 zinc finger protein 292 -0.0152967
TFG TRK-fused gene -0.0150968