Brivudine_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brivudine perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brivudine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.135153
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.131133
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.11173
CALR calreticulin 0.104426
B2M beta-2-microglobulin 0.100823
MT2A metallothionein 2A 0.0980828
MYH9 myosin, heavy chain 9, non-muscle 0.093908
UBC ubiquitin C 0.0851291
FTL ferritin, light polypeptide 0.0810931
SDC4 syndecan 4 0.0790875
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0776139
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0721364
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0669166
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0605005
VEGFA vascular endothelial growth factor A 0.0576147
LDHA lactate dehydrogenase A 0.0574813
KYNU kynureninase 0.0554323
CD44 CD44 molecule (Indian blood group) 0.0530711
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0519989
PKM pyruvate kinase, muscle 0.0510029
APLP2 amyloid beta (A4) precursor-like protein 2 0.0499708
PTMA prothymosin, alpha 0.0495963
RAB1A RAB1A, member RAS oncogene family 0.0459526
PDIA6 protein disulfide isomerase family A, member 6 0.0450439
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0447301
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0442113
ARRDC3 arrestin domain containing 3 0.043687
ZSWIM6 zinc finger, SWIM-type containing 6 0.0406253
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0386265
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.038623
SOD2 superoxide dismutase 2, mitochondrial 0.0384453
KMT2E lysine (K)-specific methyltransferase 2E 0.0375124
CANX calnexin 0.0370346
PDIA4 protein disulfide isomerase family A, member 4 0.0369326
SHB Src homology 2 domain containing adaptor protein B 0.0364402
SMAD3 SMAD family member 3 0.0358909
H3-3B H3.3 histone B 0.0357226
ENO1 enolase 1, (alpha) 0.0356799
CSDE1 cold shock domain containing E1, RNA-binding 0.0354919
CALD1 caldesmon 1 0.0339307
PTN pleiotrophin 0.033814
RPS12 ribosomal protein S12 0.0334201
KTN1 kinectin 1 (kinesin receptor) 0.033006
FTH1 ferritin, heavy polypeptide 1 0.0328452
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0317472
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0315739
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0303856
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0302927
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0302438
FNDC3B fibronectin type III domain containing 3B 0.029829
RPN2 ribophorin II 0.0294887
UGCG UDP-glucose ceramide glucosyltransferase 0.0290541
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0290526
TPM3 tropomyosin 3 0.0290243
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0286664
MTPN myotrophin 0.0281804
RPL32 ribosomal protein L32 0.0279637
RND3 Rho family GTPase 3 0.0273154
ADM adrenomedullin 0.0271904
FOXJ3 forkhead box J3 0.0265004
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.026373
RPL23 ribosomal protein L23 0.0260575
RAP1B RAP1B, member of RAS oncogene family 0.025807
NF1 neurofibromin 1 0.0256072
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0255298
SKAP2 src kinase associated phosphoprotein 2 0.0251658
RPL3 ribosomal protein L3 0.0251165
SET SET nuclear proto-oncogene 0.024892
DSCAM Down syndrome cell adhesion molecule 0.0242613
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0241371
CD99 CD99 molecule 0.0240808
ANXA1 annexin A1 0.023882
EPAS1 endothelial PAS domain protein 1 0.0238768
MSN moesin 0.0238754
CSNK1A1 casein kinase 1, alpha 1 0.0238648
ANXA5 annexin A5 0.0238262
RACK1 receptor for activated C kinase 1 0.0237374
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 0.0235695
OSBPL8 oxysterol binding protein-like 8 0.0235301
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0232865
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0230922
FUS FUS RNA binding protein 0.0230885
IFI44 interferon-induced protein 44 0.0230618
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0230561
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0230275
RPS3 ribosomal protein S3 0.0230043
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0229981
RPS27A ribosomal protein S27a 0.0229092
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.022827
SEPTIN7 septin 7 0.0226963
EIF5B eukaryotic translation initiation factor 5B 0.0226725
RPS17 ribosomal protein S17 0.0226675
RPL9 ribosomal protein L9 0.0226091
EEF2 eukaryotic translation elongation factor 2 0.0224023
IQGAP1 IQ motif containing GTPase activating protein 1 0.0221661
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0220525
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.021867
ZNF638 zinc finger protein 638 0.0217599
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0217379
ANKRD12 ankyrin repeat domain 12 0.0217061

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.21757
IGFBP3 insulin-like growth factor binding protein 3 -0.159214
F3 coagulation factor III (thromboplastin, tissue factor) -0.110473
CDH13 cadherin 13 -0.11012
TIMP3 TIMP metallopeptidase inhibitor 3 -0.103057
HLA-B major histocompatibility complex, class I, B -0.0848818
LOX lysyl oxidase -0.0833758
TMSB10 thymosin beta 10 -0.0798791
ERRFI1 ERBB receptor feedback inhibitor 1 -0.074302
AHNAK AHNAK nucleoprotein -0.0737
VIM vimentin -0.0731174
COL6A3 collagen, type VI, alpha 3 -0.0723312
HMGA2 high mobility group AT-hook 2 -0.0713442
COL6A2 collagen, type VI, alpha 2 -0.0677747
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0640007
COL6A1 collagen, type VI, alpha 1 -0.0614953
PSD3 pleckstrin and Sec7 domain containing 3 -0.0611992
TGFBI transforming growth factor, beta-induced, 68kDa -0.057021
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0566186
HIPK2 homeodomain interacting protein kinase 2 -0.055081
RAI14 retinoic acid induced 14 -0.0542473
COL5A1 collagen, type V, alpha 1 -0.0538282
LOXL2 lysyl oxidase-like 2 -0.052396
HLA-C major histocompatibility complex, class I, C -0.0502863
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0501952
PRSS23 protease, serine, 23 -0.0487725
PRELID2 PRELI domain containing 2 -0.0460148
TPM4 tropomyosin 4 -0.0409064
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0408995
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0408047
FBXO11 F-box protein 11 -0.0408017
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0405748
TNS3 tensin 3 -0.040455
NRXN3 neurexin 3 -0.0360603
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0353605
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0347043
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0346468
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0342768
RAD51B RAD51 paralog B -0.0342515
KMT2C lysine (K)-specific methyltransferase 2C -0.0339742
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0339457
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0337801
COL1A2 collagen, type I, alpha 2 -0.0335207
TAS2R14 taste receptor, type 2, member 14 -0.0322184
ZMYND8 zinc finger, MYND-type containing 8 -0.0306922
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0294476
HDLBP high density lipoprotein binding protein -0.029242
EFNA5 ephrin-A5 -0.0289551
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0288914
CA12 carbonic anhydrase XII -0.0280383
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0276383
COL4A2 collagen, type IV, alpha 2 -0.0275541
KAZN kazrin, periplakin interacting protein -0.0274934
TMEM165 transmembrane protein 165 -0.0272726
SEC24D SEC24 family member D -0.0272507
GRB10 growth factor receptor-bound protein 10 -0.0272222
MAP4 microtubule-associated protein 4 -0.0264732
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0261622
PYGL phosphorylase, glycogen, liver -0.0258859
S100A6 S100 calcium binding protein A6 -0.0248361
CDK13 cyclin-dependent kinase 13 -0.0241609
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0240078
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0238913
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0238321
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0237344
OSMR oncostatin M receptor -0.0236851
GPR173 G protein-coupled receptor 173 -0.0231804
CLIP2 CAP-GLY domain containing linker protein 2 -0.0231536
CXCL8 chemokine (C-X-C motif) ligand 8 -0.023107
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0230809
COL7A1 collagen, type VII, alpha 1 -0.0225063
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0223835
NSD3 nuclear receptor binding SET domain protein 3 -0.0222677
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0218853
CHD9 chromodomain helicase DNA binding protein 9 -0.0218035
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0216613
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase -0.0216447
TPM1 tropomyosin 1 (alpha) -0.0214423
NUMB numb homolog (Drosophila) -0.0211931
CA9 carbonic anhydrase IX -0.0211555
PRKN parkin RBR E3 ubiquitin protein ligase -0.0208252
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0204888
CLMP CXADR-like membrane protein -0.020435
TMEM45A transmembrane protein 45A -0.0203697
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0202916
DNAH11 dynein, axonemal, heavy chain 11 -0.0202354
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0202012
APOLD1 apolipoprotein L domain containing 1 -0.020127
SMYD3 SET and MYND domain containing 3 -0.0199597
HM13 histocompatibility (minor) 13 -0.0198844
LPP LIM domain containing preferred translocation partner in lipoma -0.01985
GPX8 glutathione peroxidase 8 (putative) -0.0197683
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -0.0197635
SPDYA speedy/RINGO cell cycle regulator family member A -0.0197163
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0193753
AKAP12 A kinase (PRKA) anchor protein 12 -0.019286
ALK anaplastic lymphoma receptor tyrosine kinase -0.0190073
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0188982
PTPRF protein tyrosine phosphatase, receptor type, F -0.0187697
AFF3 AF4/FMR2 family, member 3 -0.018676