Brivudine_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brivudine perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brivudine_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.23891
TPT1 tumor protein, translationally-controlled 1 0.107757
RPLP1 ribosomal protein, large, P1 0.0882892
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0868131
B2M beta-2-microglobulin 0.0847084
ENO1 enolase 1, (alpha) 0.0797545
RPS12 ribosomal protein S12 0.0712102
RPS17 ribosomal protein S17 0.066018
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0658619
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0571188
GPC5 glypican 5 0.0534349
ACTG1 actin gamma 1 0.0520098
ASPH aspartate beta-hydroxylase 0.0499687
HLA-B major histocompatibility complex, class I, B 0.0480648
RPS3 ribosomal protein S3 0.0480432
RDX radixin 0.0476002
AKAP12 A kinase (PRKA) anchor protein 12 0.0461513
HLA-A major histocompatibility complex, class I, A 0.045997
FTL ferritin, light polypeptide 0.0457729
APLP2 amyloid beta (A4) precursor-like protein 2 0.0447231
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0435708
RPL12 ribosomal protein L12 0.0421998
RPS23 ribosomal protein S23 0.0409393
JARID2 jumonji, AT rich interactive domain 2 0.0399252
LOC102724023 ES1 protein homolog, mitochondrial 0.039733
SVIL supervillin 0.039482
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0391713
TNRC6B trinucleotide repeat containing 6B 0.0381534
CALR calreticulin 0.0381382
RPL9 ribosomal protein L9 0.0373569
POTEF POTE ankyrin domain family, member F 0.0372654
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0352286
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0348322
BICD1 bicaudal D homolog 1 (Drosophila) 0.0340588
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0339485
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0330095
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0329144
INTS6 integrator complex subunit 6 0.0329115
TRIO trio Rho guanine nucleotide exchange factor 0.0327659
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0323776
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0323406
MYO9B myosin IXB 0.0320515
RPL38 ribosomal protein L38 0.0318817
ZSWIM6 zinc finger, SWIM-type containing 6 0.0318805
RPS6 ribosomal protein S6 0.0318315
SLC38A2 solute carrier family 38, member 2 0.031239
RPS8 ribosomal protein S8 0.0312134
TTC1 tetratricopeptide repeat domain 1 0.0311084
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0310572
RPL31 ribosomal protein L31 0.0309257
RPS21 ribosomal protein S21 0.0300884
NDRG1 N-myc downstream regulated 1 0.029774
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0297169
RPL34 ribosomal protein L34 0.0295769
RPL15 ribosomal protein L15 0.029294
DENND5B DENN/MADD domain containing 5B 0.029277
ANKRD11 ankyrin repeat domain 11 0.0292552
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0288827
RHOBTB3 Rho-related BTB domain containing 3 0.0287736
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0286936
TPM3 tropomyosin 3 0.0286919
TMED3 transmembrane emp24 protein transport domain containing 3 0.0286658
SFTPA2 surfactant protein A2 0.0282883
GOLGB1 golgin B1 0.0279164
WWC1 WW and C2 domain containing 1 0.0278559
RPL4 ribosomal protein L4 0.0278545
RPL35A ribosomal protein L35a 0.0277616
NCAM1 neural cell adhesion molecule 1 0.0274814
SDC4 syndecan 4 0.027344
CCDC88A coiled-coil domain containing 88A 0.0272181
INSIG1 insulin induced gene 1 0.0269933
RPL7A ribosomal protein L7a 0.0268782
RPS5 ribosomal protein S5 0.0267422
SDK1 sidekick cell adhesion molecule 1 0.0266457
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.026597
RPL35 ribosomal protein L35 0.0265356
PCNX4 pecanex 4 0.0262725
NBEA neurobeachin 0.0262488
RPS14 ribosomal protein S14 0.026196
VEGFA vascular endothelial growth factor A 0.0259432
RPS25 ribosomal protein S25 0.0256968
WWC2 WW and C2 domain containing 2 0.025686
UBAP2 ubiquitin associated protein 2 0.0256447
CDK13 cyclin-dependent kinase 13 0.0256375
SEC62 SEC62 homolog (S. cerevisiae) 0.0254909
EGR1 early growth response 1 0.0252731
ARL15 ADP-ribosylation factor-like 15 0.0251241
PACS1 phosphofurin acidic cluster sorting protein 1 0.025027
RORA RAR-related orphan receptor A 0.0250165
MTDH metadherin 0.0245314
AGO2 argonaute RISC catalytic component 2 0.024464
RPL27 ribosomal protein L27 0.0244006
RPL26 ribosomal protein L26 0.0243478
EEF1G eukaryotic translation elongation factor 1 gamma 0.0243342
RPLP2 ribosomal protein, large, P2 0.0243121
PCLO piccolo presynaptic cytomatrix protein 0.0241042
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0240664
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0240221
HSPH1 heat shock 105kDa/110kDa protein 1 0.0239774
SKAP2 src kinase associated phosphoprotein 2 0.0239094

decreased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B -0.0767988
ZNF292 zinc finger protein 292 -0.0668927
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0661531
HMGA2 high mobility group AT-hook 2 -0.0621133
NUP58 nucleoporin 58 -0.0598071
WAC WW domain containing adaptor with coiled-coil -0.0565886
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0549514
TRIP12 thyroid hormone receptor interactor 12 -0.0538999
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0525081
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0517876
ANKRD28 ankyrin repeat domain 28 -0.051371
NF1 neurofibromin 1 -0.0510964
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0506064
MARCHF6 membrane associated ring-CH-type finger 6 -0.0503588
TAS2R14 taste receptor, type 2, member 14 -0.0490574
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0482129
YBX3 Y box binding protein 3 -0.0479041
GNAS GNAS complex locus -0.0476816
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0472817
TPX2 TPX2, microtubule-associated -0.047129
DIAPH3 diaphanous-related formin 3 -0.046949
MBNL1 muscleblind-like splicing regulator 1 -0.0459167
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0455274
RBM39 RNA binding motif protein 39 -0.0450696
NAMPT nicotinamide phosphoribosyltransferase -0.0449869
CENPF centromere protein F, 350/400kDa -0.0446741
MBD5 methyl-CpG binding domain protein 5 -0.0434953
PNISR PNN-interacting serine/arginine-rich protein -0.0427371
PCBP2 poly(rC) binding protein 2 -0.042708
TBC1D5 TBC1 domain family, member 5 -0.0415845
ATG7 autophagy related 7 -0.0415808
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0415412
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0412809
USP22 ubiquitin specific peptidase 22 -0.0402768
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0401276
NT5E 5'-nucleotidase, ecto (CD73) -0.0400889
AHNAK AHNAK nucleoprotein -0.0400144
PDE4D phosphodiesterase 4D, cAMP-specific -0.0396156
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0394757
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0394451
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0389174
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0372946
UBC ubiquitin C -0.0371681
TUBA1B tubulin, alpha 1b -0.0370068
THSD4 thrombospondin, type I, domain containing 4 -0.0366333
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0364451
PHIP pleckstrin homology domain interacting protein -0.0362237
ARB2A ARB2 cotranscriptional regulator A -0.0359853
TFG TRK-fused gene -0.0358002
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.035392
PRPF8 pre-mRNA processing factor 8 -0.0349
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0348336
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.034662
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0346154
MATR3 matrin 3 -0.0345469
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.034449
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0344134
STRN3 striatin, calmodulin binding protein 3 -0.0340371
NAV2 neuron navigator 2 -0.0337225
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0336892
SCAF8 SR-related CTD-associated factor 8 -0.0335415
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0333641
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0333225
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0327998
ATXN1 ataxin 1 -0.0327087
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0326639
HELZ helicase with zinc finger -0.0326254
SPDYA speedy/RINGO cell cycle regulator family member A -0.0325759
ATG10 autophagy related 10 -0.0323477
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.0321062
PARD3 par-3 family cell polarity regulator -0.0316866
TUT4 terminal uridylyl transferase 4 -0.0314552
DST dystonin -0.0312446
FMNL2 formin-like 2 -0.0311003
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -0.0310239
CLTC clathrin, heavy chain (Hc) -0.0308426
DENND1A DENN/MADD domain containing 1A -0.0307875
NAV3 neuron navigator 3 -0.0305286
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0304382
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0303393
RNF169 ring finger protein 169 -0.0303267
DLG1 discs, large homolog 1 (Drosophila) -0.0302641
ANLN anillin, actin binding protein -0.0301798
ERBIN erbb2 interacting protein -0.0298713
WDR48 WD repeat domain 48 -0.0298085
GLS2 glutaminase 2 (liver, mitochondrial) -0.0297824
RSRP1 arginine/serine-rich protein 1 -0.0297036
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0295916
SPAG9 sperm associated antigen 9 -0.0295546
CFDP1 craniofacial development protein 1 -0.0294641
DENND4A DENN/MADD domain containing 4A -0.0293792
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.0292423
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0292101
ACER3 alkaline ceramidase 3 -0.0289177
CREBRF CREB3 regulatory factor -0.0288652
RNF111 ring finger protein 111 -0.0288346
AARS1 alanyl-tRNA synthetase 1 -0.0288038
DPYD dihydropyrimidine dehydrogenase -0.0287339
RPRD1B regulation of nuclear pre-mRNA domain containing 1B -0.0286084
PRH1 proline-rich protein HaeIII subfamily 1 -0.0284957