Brivudine_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brivudine perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brivudine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.193543
ZSWIM6 zinc finger, SWIM-type containing 6 0.152664
FN1 fibronectin 1 0.148398
ASPH aspartate beta-hydroxylase 0.141173
SFTPA2 surfactant protein A2 0.126936
SQSTM1 sequestosome 1 0.10846
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.103268
APLP2 amyloid beta (A4) precursor-like protein 2 0.100529
VCL vinculin 0.090067
ENO1 enolase 1, (alpha) 0.070499
SMYD3 SET and MYND domain containing 3 0.0672674
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0667196
ACTG1 actin gamma 1 0.0647387
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0630172
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0626884
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0618092
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.060457
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0595447
CALR calreticulin 0.0592101
UBC ubiquitin C 0.0584288
RASAL2 RAS protein activator like 2 0.0577104
MYH9 myosin, heavy chain 9, non-muscle 0.0563522
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0556914
DST dystonin 0.0518594
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0511648
AKAP13 A kinase (PRKA) anchor protein 13 0.0495145
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0477701
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.047583
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0468821
STC2 stanniocalcin 2 0.0468009
TRIO trio Rho guanine nucleotide exchange factor 0.046143
CANX calnexin 0.0456389
SAMD4A sterile alpha motif domain containing 4A 0.0453988
RACK1 receptor for activated C kinase 1 0.0449903
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0446095
ERRFI1 ERBB receptor feedback inhibitor 1 0.0443357
BIRC3 baculoviral IAP repeat containing 3 0.0438919
TPM3 tropomyosin 3 0.0430701
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0427701
RABGAP1L RAB GTPase activating protein 1-like 0.0425024
LOXL2 lysyl oxidase-like 2 0.0421538
LYST lysosomal trafficking regulator 0.0420426
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0418191
GOLGB1 golgin B1 0.0415058
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0413836
AKAP12 A kinase (PRKA) anchor protein 12 0.0406535
LIMCH1 LIM and calponin homology domains 1 0.0402794
MCL1 myeloid cell leukemia 1 0.0400454
SYT1 synaptotagmin I 0.039835
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0393707
B2M beta-2-microglobulin 0.0384531
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0383112
GPATCH2L G patch domain containing 2-like 0.0383096
MAP1B microtubule-associated protein 1B 0.0374986
PDLIM5 PDZ and LIM domain 5 0.0374881
PALLD palladin, cytoskeletal associated protein 0.0374512
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0374446
INTS6 integrator complex subunit 6 0.0372653
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0372077
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0365785
ATF6 activating transcription factor 6 0.0365123
PRKCA protein kinase C, alpha 0.036018
EGR1 early growth response 1 0.0357804
CLIP2 CAP-GLY domain containing linker protein 2 0.0354815
VEGFA vascular endothelial growth factor A 0.0353198
RNF213 ring finger protein 213 0.0351631
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.035123
NTN4 netrin 4 0.0350927
ENAH enabled homolog (Drosophila) 0.0349564
POTEF POTE ankyrin domain family, member F 0.0346729
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0346179
SMAD3 SMAD family member 3 0.0345554
RANBP17 RAN binding protein 17 0.0340043
RPL37 ribosomal protein L37 0.033927
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0336848
NXN nucleoredoxin 0.0335772
ANKRD28 ankyrin repeat domain 28 0.0334465
GRB10 growth factor receptor-bound protein 10 0.03322
AHNAK AHNAK nucleoprotein 0.0329863
PSD3 pleckstrin and Sec7 domain containing 3 0.0326444
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0325307
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0324056
PCNX2 pecanex 2 0.0324004
MYOF myoferlin 0.0323355
HSPA8 heat shock 70kDa protein 8 0.0321469
BICD1 bicaudal D homolog 1 (Drosophila) 0.0319458
AEBP2 AE binding protein 2 0.0317741
RAB10 RAB10, member RAS oncogene family 0.0315634
DUSP6 dual specificity phosphatase 6 0.0315199
PEG10 paternally expressed 10 0.0314924
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0314374
DSCAM Down syndrome cell adhesion molecule 0.0313251
SVIL supervillin 0.0309023
RAD51B RAD51 paralog B 0.0308868
WNK1 WNK lysine deficient protein kinase 1 0.0308828
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0305683
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0304868
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0304574
NBEA neurobeachin 0.0304124
MYO1E myosin IE 0.030373

decreased expression

Symbol Name Standardized Value
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0833945
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0804553
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.066177
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0657311
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0601957
RNF145 ring finger protein 145 -0.0580118
NAMPT nicotinamide phosphoribosyltransferase -0.0558236
ZNF292 zinc finger protein 292 -0.0556492
NDRG1 N-myc downstream regulated 1 -0.0476007
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0465813
TFG TRK-fused gene -0.037746
NPEPPS aminopeptidase puromycin sensitive -0.0356139
MARCHF6 membrane associated ring-CH-type finger 6 -0.0327254
RBM25 RNA binding motif protein 25 -0.032263
NEK7 NIMA-related kinase 7 -0.0322158
LCORL ligand dependent nuclear receptor corepressor-like -0.0318375
PNISR PNN-interacting serine/arginine-rich protein -0.0311675
MIS18BP1 MIS18 binding protein 1 -0.0294482
RBM39 RNA binding motif protein 39 -0.0291388
WAC WW domain containing adaptor with coiled-coil -0.0290184
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0282289
RPL35A ribosomal protein L35a -0.0279399
PELO pelota homolog (Drosophila) -0.0276732
ZMYM2 zinc finger, MYM-type 2 -0.027549
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0274213
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0264079
CD109 CD109 molecule -0.0263672
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0252931
MT2A metallothionein 2A -0.0250713
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0247648
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -0.024392
RAB6A RAB6A, member RAS oncogene family -0.024346
CDC27 cell division cycle 27 -0.0238701
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0230847
NUP58 nucleoporin 58 -0.0230335
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0228826
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -0.0227182
USP3 ubiquitin specific peptidase 3 -0.0226524
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0222754
CENPF centromere protein F, 350/400kDa -0.0220366
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.021683
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0214779
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0214155
OGA O-GlcNAcase -0.0209423
KPNB1 karyopherin (importin) beta 1 -0.020863
KMT2E lysine (K)-specific methyltransferase 2E -0.0208243
HELZ helicase with zinc finger -0.0206592
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0206069
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0205182
PTBP3 polypyrimidine tract binding protein 3 -0.0204674
RLF rearranged L-myc fusion -0.0203465
FAM168B family with sequence similarity 168, member B -0.0203398
SOS1 son of sevenless homolog 1 (Drosophila) -0.0202141
ZFR zinc finger RNA binding protein -0.0201991
WDR45B WD repeat domain 45B -0.019733
TENT2 terminal nucleotidyltransferase 2 -0.0194547
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.018955
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0188602
PTMA prothymosin, alpha -0.0186596
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 -0.0186101
MATR3 matrin 3 -0.0185797
INSIG2 insulin induced gene 2 -0.0184238
UGCG UDP-glucose ceramide glucosyltransferase -0.0184222
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0184107
PUM2 pumilio RNA-binding family member 2 -0.0182903
SEC23A Sec23 homolog A (S. cerevisiae) -0.0181737
HMGA1 high mobility group AT-hook 1 -0.0179798
TM9SF3 transmembrane 9 superfamily member 3 -0.0179727
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0179688
MCTP2 multiple C2 domains, transmembrane 2 -0.017928
CDC73 cell division cycle 73 -0.0179051
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0178694
TRA2A transformer 2 alpha homolog (Drosophila) -0.0177235
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0176558
SETD5 SET domain containing 5 -0.0174977
QKI QKI, KH domain containing, RNA binding -0.0173623
SMOX spermine oxidase -0.0169909
SCAF11 SR-related CTD-associated factor 11 -0.0168948
GNAS GNAS complex locus -0.0167541
YME1L1 YME1-like 1 ATPase -0.016702
CLINT1 clathrin interactor 1 -0.0166125
NOP58 NOP58 ribonucleoprotein -0.016605
BIRC6 baculoviral IAP repeat containing 6 -0.0165093
RAB8B RAB8B, member RAS oncogene family -0.016439
RHEB Ras homolog enriched in brain -0.0164196
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0164072
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0163002
RAD21 RAD21 homolog (S. pombe) -0.0161541
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0160085
ECT2 epithelial cell transforming 2 -0.0159409
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -0.0158424
FNBP1 formin binding protein 1 -0.0157774
TMEM263 transmembrane protein 263 -0.015777
RUNX2 runt-related transcription factor 2 -0.0157689
DCAF5 DDB1 and CUL4 associated factor 5 -0.0156667
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0155307
KCTD9 potassium channel tetramerization domain containing 9 -0.0154586
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0154179
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0154031
NUF2 NUF2, NDC80 kinetochore complex component -0.0153364