| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | Amfenac in which the the hydrogen at the 4 position of the benzoyl group is substituted by bromine. It is used for the management of ocular pain and treatment of postoperative inflammation in patients who have undergone cataract extraction. It was withdrawn from the US market in 1998, following concerns over off-label abuse and hepatic failure. (Chemical Entities of Biological Interest Ontology, CHEBI_240107) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/60726 |
| Similar Terms | |
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198 proteins with high or low expression in Bromfenac relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TMEM64 | transmembrane protein 64 | 1.04 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 1.0 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | 0.93 |
| TSTD1 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 | 0.89 |
| ARFIP1 | ADP-ribosylation factor interacting protein 1 | 0.81 |
| ZNRD1 | zinc ribbon domain containing 1 | 0.73 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.64 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.64 |
| XIRP2 | xin actin binding repeat containing 2 | 0.63 |
| TBC1D14 | TBC1 domain family, member 14 | 0.53 |
| ZNF395 | zinc finger protein 395 | 0.47 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.46 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | 0.45 |
| WDR45 | WD repeat domain 45 | 0.44 |
| CD99 | CD99 molecule | 0.43 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.43 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | 0.42 |
| SPTBN5 | spectrin, beta, non-erythrocytic 5 | 0.42 |
| PLEKHA6 | pleckstrin homology domain containing, family A member 6 | 0.42 |
| MTERF1 | mitochondrial transcription termination factor 1 | 0.41 |
| NTHL1 | nth endonuclease III-like 1 (E. coli) | 0.41 |
| C2CD2L | C2CD2-like | 0.41 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.4 |
| RIOK3 | RIO kinase 3 | 0.4 |
| POLR2M | polymerase (RNA) II (DNA directed) polypeptide M | 0.4 |
| FUNDC1 | FUN14 domain containing 1 | 0.39 |
| RPLP2 | ribosomal protein, large, P2 | 0.39 |
| SLC39A3 | solute carrier family 39 (zinc transporter), member 3 | 0.39 |
| STMN2 | stathmin 2 | 0.39 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.39 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | 0.38 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | 0.38 |
| SPEG | SPEG complex locus | 0.38 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.38 |
| EHF | ets homologous factor | 0.38 |
| HPCAL4 | hippocalcin like 4 | 0.37 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.37 |
| TMEM39A | transmembrane protein 39A | 0.37 |
| CCNE2 | cyclin E2 | 0.37 |
| TMSB10 | thymosin beta 10 | 0.36 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 0.36 |
| SLC25A21 | solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 | 0.35 |
| TPM2 | tropomyosin 2 (beta) | 0.35 |
| ZNF714 | zinc finger protein 714 | 0.33 |
| TEPSIN | TEPSIN adaptor related protein complex 4 accessory protein | 0.33 |
| SOD1 | superoxide dismutase 1, soluble | 0.33 |
| DCAF10 | DDB1 and CUL4 associated factor 10 | 0.33 |
| UNC13D | unc-13 homolog D (C. elegans) | 0.32 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | 0.32 |
| ZCRB1 | zinc finger CCHC-type and RNA binding motif 1 | 0.32 |
| FGD1 | FYVE, RhoGEF and PH domain containing 1 | 0.32 |
| PFDN6 | prefoldin subunit 6 | 0.32 |
| MRPL12 | mitochondrial ribosomal protein L12 | 0.32 |
| PFDN1 | prefoldin subunit 1 | 0.32 |
| B2M | beta-2-microglobulin | 0.32 |
| SF3B5 | splicing factor 3b, subunit 5, 10kDa | 0.32 |
| COX5A | cytochrome c oxidase subunit Va | 0.32 |
| TLE5 | TLE family member 5, transcriptional modulator | 0.31 |
| PSAP | prosaposin | 0.31 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | 0.31 |
| UBQLN2 | ubiquilin 2 | 0.31 |
| STMN1 | stathmin 1 | 0.3 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | 0.3 |
| OTUD3 | OTU deubiquitinase 3 | 0.3 |
| MAGEA6 | melanoma antigen family A6 | 0.3 |
| PFDN5 | prefoldin subunit 5 | 0.3 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | 0.3 |
| XYLB | xylulokinase homolog (H. influenzae) | 0.3 |
| MDM4 | MDM4, p53 regulator | 0.3 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.3 |
| HECA | headcase homolog (Drosophila) | 0.3 |
| GINS4 | GINS complex subunit 4 (Sld5 homolog) | 0.29 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.29 |
| TMEM39B | transmembrane protein 39B | 0.29 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.29 |
| SET | SET nuclear proto-oncogene | 0.29 |
| LRRC45 | leucine rich repeat containing 45 | 0.29 |
| S100A6 | S100 calcium binding protein A6 | 0.28 |
| COX5B | cytochrome c oxidase subunit Vb | 0.28 |
| LZIC | leucine zipper and CTNNBIP1 domain containing | 0.28 |
| COQ6 | coenzyme Q6 monooxygenase | 0.28 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | 0.28 |
| SLC30A9 | solute carrier family 30 (zinc transporter), member 9 | 0.28 |
| RPL14 | ribosomal protein L14 | 0.28 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.27 |
| H1-5 | H1.5 linker histone, cluster member | 0.27 |
| BOLA3 | bolA family member 3 | 0.27 |
| KHSRP | KH-type splicing regulatory protein | 0.27 |
| CHCHD1 | coiled-coil-helix-coiled-coil-helix domain containing 1 | 0.27 |
| COX6B1 | cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) | 0.27 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | 0.27 |
| VSNL1 | visinin-like 1 | 0.27 |
| CDC25B | cell division cycle 25B | 0.27 |
| HSPB1 | heat shock 27kDa protein 1 | 0.27 |
| PPIL2 | peptidylprolyl isomerase (cyclophilin)-like 2 | 0.27 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.27 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | 0.27 |
| CROCC2 | ciliary rootlet coiled-coil, rootletin family member 2 | 0.26 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ADPRH | ADP-ribosylarginine hydrolase | -1.55 |
| PIP | prolactin-induced protein | -1.5 |
| TTN | titin | -1.26 |
| MYT1 | myelin transcription factor 1 | -1.23 |
| NEK4 | NIMA-related kinase 4 | -0.89 |
| UNC13C | unc-13 homolog C (C. elegans) | -0.85 |
| CCNYL1 | cyclin Y-like 1 | -0.81 |
| ZNF567 | zinc finger protein 567 | -0.75 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.73 |
| HACE1 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | -0.72 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.71 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.69 |
| NAA80 | N-alpha-acetyltransferase 80, NatH catalytic subunit | -0.68 |
| WDR19 | WD repeat domain 19 | -0.68 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.66 |
| TBC1D31 | TBC1 domain family, member 31 | -0.66 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | -0.66 |
| STK16 | serine/threonine kinase 16 | -0.61 |
| TRIM44 | tripartite motif containing 44 | -0.6 |
| PAQR4 | progestin and adipoQ receptor family member IV | -0.6 |
| POP5 | processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) | -0.58 |
| PRXL2C | peroxiredoxin like 2C | -0.55 |
| DIXDC1 | DIX domain containing 1 | -0.54 |
| KLHL42 | kelch-like family member 42 | -0.54 |
| CRBN | cereblon | -0.53 |
| TBC1D22B | TBC1 domain family, member 22B | -0.52 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | -0.52 |
| PHF1 | PHD finger protein 1 | -0.51 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.51 |
| GGT2 | gamma-glutamyltransferase 2 | -0.49 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.49 |
| PLEC | plectin | -0.49 |
| COX11 | COX11 cytochrome c oxidase copper chaperone | -0.48 |
| HOXB7 | homeobox B7 | -0.47 |
| PLPP3 | phospholipid phosphatase 3 | -0.46 |
| PLIN2 | perilipin 2 | -0.46 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | -0.44 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.43 |
| WDR25 | WD repeat domain 25 | -0.42 |
| ZNF518B | zinc finger protein 518B | -0.42 |
| DUSP4 | dual specificity phosphatase 4 | -0.42 |
| RAB29 | RAB29, member RAS oncogene family | -0.41 |
| ABHD14A | abhydrolase domain containing 14A | -0.41 |
| SIRT2 | sirtuin 2 | -0.41 |
| STK40 | serine/threonine kinase 40 | -0.41 |
| RUNX3 | runt-related transcription factor 3 | -0.41 |
| ZNF761 | zinc finger protein 761 | -0.41 |
| ALG5 | ALG5, dolichyl-phosphate beta-glucosyltransferase | -0.4 |
| SESN2 | sestrin 2 | -0.4 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | -0.4 |
| COMMD1 | copper metabolism (Murr1) domain containing 1 | -0.4 |
| EAPP | E2F-associated phosphoprotein | -0.38 |
| CES3 | carboxylesterase 3 | -0.37 |
| SPATA2 | spermatogenesis associated 2 | -0.37 |
| IFNGR1 | interferon gamma receptor 1 | -0.37 |
| DNAH12 | dynein, axonemal, heavy chain 12 | -0.37 |
| KIAA1109 | KIAA1109 | -0.36 |
| RAB12 | RAB12, member RAS oncogene family | -0.36 |
| ATP2A1 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | -0.36 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.36 |
| FAM20B | family with sequence similarity 20, member B | -0.36 |
| SLC15A4 | solute carrier family 15 (oligopeptide transporter), member 4 | -0.36 |
| LYRM4 | LYR motif containing 4 | -0.36 |
| ENPP5 | ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) | -0.35 |
| N4BP2 | NEDD4 binding protein 2 | -0.35 |
| GBA2 | glucosidase, beta (bile acid) 2 | -0.35 |
| GPN2 | GPN-loop GTPase 2 | -0.35 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -0.34 |
| ZNF267 | zinc finger protein 267 | -0.34 |
| RAB38 | RAB38, member RAS oncogene family | -0.34 |
| DIPK2A | divergent protein kinase domain 2A | -0.33 |
| KLF4 | Kruppel-like factor 4 (gut) | -0.33 |
| APBA3 | amyloid beta (A4) precursor protein-binding, family A, member 3 | -0.33 |
| KIFC3 | kinesin family member C3 | -0.33 |
| ACTR3B | ARP3 actin-related protein 3 homolog B (yeast) | -0.33 |
| DHRS11 | dehydrogenase/reductase (SDR family) member 11 | -0.33 |
| BAG1 | BCL2-associated athanogene | -0.33 |
| RNF14 | ring finger protein 14 | -0.33 |
| CYP2U1 | cytochrome P450, family 2, subfamily U, polypeptide 1 | -0.33 |
| L1RE1 | LINE1 retrotransposable element 1 | -0.33 |
| TK2 | thymidine kinase 2, mitochondrial | -0.32 |
| ANO8 | anoctamin 8 | -0.32 |
| TMEM120B | transmembrane protein 120B | -0.32 |
| OTUD6B | OTU domain containing 6B | -0.32 |
| BANF1 | barrier to autointegration factor 1 | -0.32 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -0.32 |
| POMGNT1 | protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | -0.31 |
| LNX2 | ligand of numb-protein X 2 | -0.31 |
| GDI1 | GDP dissociation inhibitor 1 | -0.31 |
| NPHP1 | nephronophthisis 1 (juvenile) | -0.31 |
| SEPTIN5 | septin 5 | -0.31 |
| ICAM5 | intercellular adhesion molecule 5, telencephalin | -0.31 |
| EEF2KMT | eukaryotic elongation factor 2 lysine methyltransferase | -0.31 |
| FAM76A | family with sequence similarity 76, member A | -0.3 |
| DONSON | downstream neighbor of SON | -0.3 |
| FBXO46 | F-box protein 46 | -0.3 |
| CPT1A | carnitine palmitoyltransferase 1A (liver) | -0.3 |
| PLEKHF2 | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | -0.3 |
| CDK8 | cyclin-dependent kinase 8 | -0.3 |
| AMMECR1L | AMMECR1-like | -0.3 |
