Bronchiectasis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances. (Human Disease Ontology, DOID_9563)
External Link https://www.disgenet.org/browser/0/1/0/C0006267
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Genes

184 genes associated with the disease Bronchiectasis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ADRB2 adrenoceptor beta 2, surface
ALB albumin
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARMC4 armadillo repeat containing 4
ATM ATM serine/threonine kinase
ATP11A ATPase, class VI, type 11A
AVP arginine vasopressin
B2M beta-2-microglobulin
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BLM Bloom syndrome, RecQ helicase-like
BLNK B-cell linker
BTNL2 butyrophilin-like 2
C11ORF70 chromosome 11 open reading frame 70
CA12 carbonic anhydrase XII
CALR calreticulin
CAMP cathelicidin antimicrobial peptide
CARMIL2 capping protein regulator and myosin 1 linker 2
CCDC103 coiled-coil domain containing 103
CCDC151 coiled-coil domain containing 151
CCDC39 coiled-coil domain containing 39
CCDC40 coiled-coil domain containing 40
CCDC65 coiled-coil domain containing 65
CCL17 chemokine (C-C motif) ligand 17
CCL20 chemokine (C-C motif) ligand 20
CCNO cyclin O
CD19 CD19 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CD81 CD81 molecule
CD8A CD8a molecule
CEL carboxyl ester lipase
CFAP298 cilia and flagella associated protein 298
CFI complement factor I
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRP C-reactive protein, pentraxin-related
CTSB cathepsin B
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DIAPH1 diaphanous-related formin 1
DNAAF1 dynein, axonemal, assembly factor 1
DNAAF2 dynein, axonemal, assembly factor 2
DNAAF3 dynein, axonemal, assembly factor 3
DNAAF4 dynein axonemal assembly factor 4
DNAAF5 dynein, axonemal, assembly factor 5
DNAH1 dynein, axonemal, heavy chain 1
DNAH11 dynein, axonemal, heavy chain 11
DNAH5 dynein, axonemal, heavy chain 5
DNAH7 dynein, axonemal, heavy chain 7
DNAI1 dynein, axonemal, intermediate chain 1
DNAI2 dynein, axonemal, intermediate chain 2
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13
DNAL1 dynein, axonemal, light chain 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPP9 dipeptidyl-peptidase 9
DRC1 dynein regulatory complex subunit 1
DSP desmoplakin
ELANE elastase, neutrophil expressed
ELN elastin
ENG endoglin
FAM13A family with sequence similarity 13, member A
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FLNB filamin B, beta
FLVCR1 feline leukemia virus subgroup C cellular receptor 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOXJ1 forkhead box J1
FOXP3 forkhead box P3
G6PC3 glucose 6 phosphatase, catalytic, 3
GAS2L2 growth arrest-specific 2 like 2
GAS8 growth arrest-specific 8
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HYDIN HYDIN, axonemal central pair apparatus protein
ICAM1 intercellular adhesion molecule 1
ICOS inducible T-cell co-stimulator
IFNG interferon, gamma
IGLL1 immunoglobulin lambda-like polypeptide 1
IL10 interleukin 10
IL13 interleukin 13
IL17A interleukin 17A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL21R interleukin 21 receptor
IL23A interleukin 23, alpha subunit p19
IL6 interleukin 6
IRF8 interferon regulatory factor 8
ISYNA1 inositol-3-phosphate synthase 1
JMJD6 jumonji domain containing 6
LCN1 lipocalin 1
LGALS9 lectin, galactoside-binding, soluble, 9
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRRC56 leucine rich repeat containing 56
LRRC6 leucine rich repeat containing 6
LRRC8A leucine rich repeat containing 8 family, member A
MBL2 mannose-binding lectin (protein C) 2, soluble
MCIDAS multiciliate differentiation and DNA synthesis associated cell cycle protein
MICA MHC class I polypeptide-related sequence A
MMP1 matrix metallopeptidase 1
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
NBN nibrin
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies)
NME8 NME/NM23 family member 8
NOS2 nitric oxide synthase 2, inducible
NTM neurotrimin
NXF1 nuclear RNA export factor 1
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
ODAD1 outer dynein arm docking complex subunit 1
OFD1 oral-facial-digital syndrome 1
PAEP progestagen-associated endometrial protein
PARN poly(A)-specific ribonuclease
PARP9 poly (ADP-ribose) polymerase family, member 9
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDCD1 programmed cell death 1
PGM3 phosphoglucomutase 3
PIH1D3 PIH1 domain containing 3
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPARG peroxisome proliferator-activated receptor gamma
PREP prolyl endopeptidase
PRKCD protein kinase C, delta
PRTN3 proteinase 3
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PZP pregnancy-zone protein
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGMA repulsive guidance molecule family member a
RGS6 regulator of G-protein signaling 6
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RPGR retinitis pigmentosa GTPase regulator
RSPH1 radial spoke head 1 homolog (Chlamydomonas)
RSPH3 radial spoke 3 homolog (Chlamydomonas)
RSPH4A radial spoke head 4 homolog A (Chlamydomonas)
RSPH9 radial spoke head 9 homolog (Chlamydomonas)
RTEL1 regulator of telomere elongation helicase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCNN1B sodium channel, non voltage gated 1 beta subunit
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SEC14L2 SEC14-like 2 (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPA1 surfactant protein A1
SFTPA2 surfactant protein A2
SFTPC surfactant protein C
SFTPD surfactant protein D
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
SLC26A9 solute carrier family 26 (anion exchanger), member 9
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SPAG1 sperm associated antigen 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK36 serine/threonine kinase 36
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TCF3 transcription factor 3
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLR2 toll-like receptor 2
TNF tumor necrosis factor
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TRAF3IP2 TRAF3 interacting protein 2
TRIM21 tripartite motif containing 21
TTC25 tetratricopeptide repeat domain 25
USO1 USO1 vesicle transport factor
USP11 ubiquitin specific peptidase 11
ZMYND10 zinc finger, MYND-type containing 10
ZNF341 zinc finger protein 341