Brucellosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue. (Human Disease Ontology, DOID_11077)
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Genes

300 genes co-occuring with the disease Brucellosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
MEFV Mediterranean fever 3.672
SYNJ2BP synaptojanin 2 binding protein 3.574
REV1 REV1, polymerase (DNA directed) 2.767
IFNG interferon, gamma 2.738
CRP C-reactive protein, pentraxin-related 2.687
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.466
IL1B interleukin 1, beta 2.441
TNF tumor necrosis factor 2.397
CD4 CD4 molecule 2.321
IL10 interleukin 10 2.297
IL6 interleukin 6 2.285
CD8A CD8a molecule 2.261
CASP1 caspase 1, apoptosis-related cysteine peptidase 2.235
MVK mevalonate kinase 2.23
NLRP3 NLR family, pyrin domain containing 3 2.226
IL4 interleukin 4 2.2
IL18 interleukin 18 2.183
TLR4 toll-like receptor 4 2.159
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.149
HSPD1 heat shock 60kDa protein 1 (chaperonin) 2.147
RAB2A RAB2A, member RAS oncogene family 2.111
TLR2 toll-like receptor 2 2.108
AIM2 absent in melanoma 2 2.091
ALB albumin 2.049
IL1A interleukin 1, alpha 2.016
MYD88 myeloid differentiation primary response 88 2.003
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.0
IL2 interleukin 2 1.995
NOD2 nucleotide-binding oligomerization domain containing 2 1.994
NLRC4 NLR family, CARD domain containing 4 1.955
LAMP1 lysosomal-associated membrane protein 1 1.943
IL17A interleukin 17A 1.869
SAA1 serum amyloid A1 1.854
YIPF5 Yip1 domain family, member 5 1.842
MAN2B1 mannosidase, alpha, class 2B, member 1 1.831
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.821
BDKRB2 bradykinin receptor B2 1.789
NLRP12 NLR family, pyrin domain containing 12 1.787
HTRA1 HtrA serine peptidase 1 1.77
SAA2 serum amyloid A2 1.769
NLRP1 NLR family, pyrin domain containing 1 1.761
PXDNL peroxidasin-like 1.737
PXDN peroxidasin 1.736
TLR9 toll-like receptor 9 1.734
CXCL8 chemokine (C-X-C motif) ligand 8 1.724
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 1.711
LPIN2 lipin 2 1.697
NDNF neuron-derived neurotrophic factor 1.696
GSDMD gasdermin D 1.686
IL1R1 interleukin 1 receptor, type I 1.672
IFNB1 interferon, beta 1, fibroblast 1.672
NOD1 nucleotide-binding oligomerization domain containing 1 1.667
TLR5 toll-like receptor 5 1.663
PRTN3 proteinase 3 1.655
SAA4 serum amyloid A4, constitutive 1.638
SAA2-SAA4 SAA2-SAA4 readthrough 1.636
USP45 ubiquitin specific peptidase 45 1.636
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 1.631
IFNA1 interferon, alpha 1 1.631
LY96 lymphocyte antigen 96 1.63
TLR1 toll-like receptor 1 1.607
IRF1 interferon regulatory factor 1 1.606
EEA1 early endosome antigen 1 1.605
CCL2 chemokine (C-C motif) ligand 2 1.601
ADA2 adenosine deaminase 2 1.593
IL1RN interleukin 1 receptor antagonist 1.574
HSPE1 heat shock 10kDa protein 1 1.573
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.572
CD86 CD86 molecule 1.565
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.558
ACE angiotensin I converting enzyme 1.548
PTPRT protein tyrosine phosphatase, receptor type, T 1.547
IL5 interleukin 5 1.546
ERVW-1 endogenous retrovirus group W, member 1 1.545
NLRP6 NLR family, pyrin domain containing 6 1.542
ADA adenosine deaminase 1.538
TGFB1 transforming growth factor, beta 1 1.531
PYCARD PYD and CARD domain containing 1.529
IZUMO1 izumo sperm-egg fusion 1 1.523
DSE dermatan sulfate epimerase 1.504
ERV3-1 endogenous retrovirus group 3, member 1 1.496
MRRF mitochondrial ribosome recycling factor 1.495
ERVFRD-1 endogenous retrovirus group FRD, member 1 1.495
ATG14 autophagy related 14 1.49
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.469
F2 coagulation factor II (thrombin) 1.464
GBP5 guanylate binding protein 5 1.459
CD40 CD40 molecule, TNF receptor superfamily member 5 1.459
NAIP NLR family, apoptosis inhibitory protein 1.455
ERN1 endoplasmic reticulum to nucleus signaling 1 1.453
CD80 CD80 molecule 1.447
EPYC epiphycan 1.446
ULK1 unc-51 like autophagy activating kinase 1 1.442
TLR7 toll-like receptor 7 1.441
IRF3 interferon regulatory factor 3 1.437
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.434
TLR3 toll-like receptor 3 1.432
RAB5A RAB5A, member RAS oncogene family 1.422
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.418
PKN1 protein kinase N1 1.415
PRF1 perforin 1 (pore forming protein) 1.405
TLR10 toll-like receptor 10 1.398
TLR6 toll-like receptor 6 1.396
GBP7 guanylate binding protein 7 1.393
NKIRAS2 NFKB inhibitor interacting Ras-like 2 1.391
PKN2 protein kinase N2 1.387
ACTB actin, beta 1.381
F3 coagulation factor III (thromboplastin, tissue factor) 1.378
CCL5 chemokine (C-C motif) ligand 5 1.369
IL13 interleukin 13 1.366
SERTAD3 SERTA domain containing 3 1.364
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.359
RAD51 RAD51 recombinase 1.351
TBL1X transducin (beta)-like 1X-linked 1.348
CANX calnexin 1.338
CXCL14 chemokine (C-X-C motif) ligand 14 1.338
IFNAR1 interferon (alpha, beta and omega) receptor 1 1.333
BECN1 beclin 1, autophagy related 1.33
CXCL10 chemokine (C-X-C motif) ligand 10 1.327
CTSD cathepsin D 1.326
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 1.326
CCL3 chemokine (C-C motif) ligand 3 1.324
STAT1 signal transducer and activator of transcription 1, 91kDa 1.317
R3HCC1L R3H domain and coiled-coil containing 1-like 1.31
CKB creatine kinase, brain 1.309
IL22 interleukin 22 1.305
GMDS GDP-mannose 4,6-dehydratase 1.303
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.301
ERAP1 endoplasmic reticulum aminopeptidase 1 1.301
CKM creatine kinase, muscle 1.292
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.289
MPO myeloperoxidase 1.288
CKMT1B creatine kinase, mitochondrial 1B 1.288
PRNP prion protein 1.287
SELL selectin L 1.284
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 1.277
IRAK4 interleukin-1 receptor-associated kinase 4 1.271
HLA-B major histocompatibility complex, class I, B 1.271
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.267
LTF lactotransferrin 1.263
CSF3 colony stimulating factor 3 (granulocyte) 1.261
CGAS cyclic GMP-AMP synthase 1.26
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta 1.257
HP haptoglobin 1.255
ICAM1 intercellular adhesion molecule 1 1.251
PACRG PARK2 co-regulated 1.249
ATG5 autophagy related 5 1.244
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 1.243
RIPK2 receptor-interacting serine-threonine kinase 2 1.242
RPS12 ribosomal protein S12 1.241
MAPK14 mitogen-activated protein kinase 14 1.238
LTA lymphotoxin alpha 1.233
GBP3 guanylate binding protein 3 1.23
CALR calreticulin 1.23
IFI16 interferon, gamma-inducible protein 16 1.229
VDAC1 voltage-dependent anion channel 1 1.226
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.22
CR2 complement component (3d/Epstein Barr virus) receptor 2 1.218
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 1.217
MAN2C1 mannosidase, alpha, class 2C, member 1 1.217
ADCY10 adenylate cyclase 10 (soluble) 1.209
IL18BP interleukin 18 binding protein 1.208
WDR1 WD repeat domain 1 1.208
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 1.206
FOXP3 forkhead box P3 1.202
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 1.201
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.2
MMP9 matrix metallopeptidase 9 1.196
CCL4 chemokine (C-C motif) ligand 4 1.195
CD163 CD163 molecule 1.193
CD69 CD69 molecule 1.189
IRF8 interferon regulatory factor 8 1.188
HSPA14 heat shock 70kDa protein 14 1.185
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.183
NLRP8 NLR family, pyrin domain containing 8 1.172
CRIP3 cysteine-rich protein 3 1.172
IL10RA interleukin 10 receptor, alpha 1.171
KLRC4 killer cell lectin-like receptor subfamily C, member 4 1.17
NUBPL nucleotide binding protein-like 1.168
FUT2 fucosyltransferase 2 (secretor status included) 1.167
IFIH1 interferon induced with helicase C domain 1 1.167
GBP1 guanylate binding protein 1, interferon-inducible 1.166
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.165
B2M beta-2-microglobulin 1.163
TYK2 tyrosine kinase 2 1.163
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 1.162
NRL neural retina leucine zipper 1.159
IRAK1 interleukin-1 receptor-associated kinase 1 1.158
PTPRC protein tyrosine phosphatase, receptor type, C 1.157
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 1.154
IL17RA interleukin 17 receptor A 1.154
RPL9 ribosomal protein L9 1.153
NEK7 NIMA-related kinase 7 1.152
IFNGR1 interferon gamma receptor 1 1.151
CD40LG CD40 ligand 1.149
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 1.149
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.146
IL2RA interleukin 2 receptor, alpha 1.143
TRAT1 T cell receptor associated transmembrane adaptor 1 1.143
IFNA2 interferon, alpha 2 1.142
LYZL6 lysozyme-like 6 1.142
TLR8 toll-like receptor 8 1.141
WAS Wiskott-Aldrich syndrome 1.141
CASP5 caspase 5, apoptosis-related cysteine peptidase 1.139
RAG1 recombination activating gene 1 1.138
GBP2 guanylate binding protein 2, interferon-inducible 1.132
CD19 CD19 molecule 1.127
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 1.125
CD209 CD209 molecule 1.124
ARF1 ADP-ribosylation factor 1 1.122
CD248 CD248 molecule, endosialin 1.121
IL36RN interleukin 36 receptor antagonist 1.121
MFSD11 major facilitator superfamily domain containing 11 1.119
IL15 interleukin 15 1.119
POMC proopiomelanocortin 1.118
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.117
CSF1 colony stimulating factor 1 (macrophage) 1.113
FN1 fibronectin 1 1.104
CIDEB cell death-inducing DFFA-like effector b 1.102
IL17F interleukin 17F 1.101
YBEY ybeY metallopeptidase (putative) 1.1
TXNIP thioredoxin interacting protein 1.098
NLRP7 NLR family, pyrin domain containing 7 1.095
ATG4B autophagy related 4B, cysteine peptidase 1.093
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.093
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.092
GNLY granulysin 1.091
NLRP10 NLR family, pyrin domain containing 10 1.089
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.085
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.085
ATP5IF1 ATP synthase inhibitory factor subunit 1 1.084
MID1 midline 1 1.084
KIAA0753 KIAA0753 1.084
IRF7 interferon regulatory factor 7 1.084
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 1.082
NOS2 nitric oxide synthase 2, inducible 1.082
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 1.08
IL37 interleukin 37 1.08
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.079
IGSF21 immunoglobin superfamily, member 21 1.075
INS insulin 1.075
CSN1S1 casein alpha s1 1.072
CCR7 chemokine (C-C motif) receptor 7 1.071
AVP arginine vasopressin 1.068
HLA-A major histocompatibility complex, class I, A 1.067
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.066
ATF6 activating transcription factor 6 1.066
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.064
HES7 hes family bHLH transcription factor 7 1.063
CYBB cytochrome b-245, beta polypeptide 1.062
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 1.062
JUN jun proto-oncogene 1.06
GLYATL1 glycine-N-acyltransferase-like 1 1.058
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.056
ATG7 autophagy related 7 1.055
MARS1 methionyl-tRNA synthetase 1 1.052
NELFCD negative elongation factor complex member C/D 1.052
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 1.048
NCSTN nicastrin 1.04
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.04
HAMP hepcidin antimicrobial peptide 1.04
ACE2 angiotensin I converting enzyme 2 1.038
CLEC7A C-type lectin domain family 7, member A 1.038
DNAL1 dynein, axonemal, light chain 1 1.035
MARS2 methionyl-tRNA synthetase 2, mitochondrial 1.034
ELANE elastase, neutrophil expressed 1.033
RILP Rab interacting lysosomal protein 1.03
NBPF15 neuroblastoma breakpoint family, member 15 1.029
CTSB cathepsin B 1.029
SPI1 Spi-1 proto-oncogene 1.027
IFNA17 interferon, alpha 17 1.027
FASLG Fas ligand (TNF superfamily, member 6) 1.027
IL18RAP interleukin 18 receptor accessory protein 1.025
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.025
IL36R interleukin 36 receptor 1.025
IFNA10 interferon, alpha 10 1.024
PRDX6 peroxiredoxin 6 1.024
IFNA13 interferon, alpha 13 1.021
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 1.018
BTN2A1 butyrophilin, subfamily 2, member A1 1.017
DUSP16 dual specificity phosphatase 16 1.014
CP ceruloplasmin (ferroxidase) 1.01
CXCL9 chemokine (C-X-C motif) ligand 9 1.01
HMGB1 high mobility group box 1 1.009
IFNA16 interferon, alpha 16 1.008
CA5A carbonic anhydrase VA, mitochondrial 1.008
IFNA7 interferon, alpha 7 1.008
IFNA14 interferon, alpha 14 1.007
IFNA21 interferon, alpha 21 1.007
IFNA6 interferon, alpha 6 1.007
IFNA8 interferon, alpha 8 1.007
NLRP4 NLR family, pyrin domain containing 4 1.007
IFNA5 interferon, alpha 5 1.005
C3 complement component 3 1.004
MX1 MX dynamin-like GTPase 1 1.003
CHIT1 chitinase 1 (chitotriosidase) 1.003
IFNA4 interferon, alpha 4 1.002
RHOA ras homolog family member A 1.002
MORN2 MORN repeat containing 2 1.001
NHLRC3 NHL repeat containing 3 1.0