Bruxism Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A sleep disorder that involves involuntarily grinding or clenching of the teeth while sleeping. (Human Disease Ontology, DOID_2846)
Similar Terms
Downloads & Tools

Genes

131 genes co-occuring with the disease Bruxism in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
MECP2 methyl CpG binding protein 2 2.786
CDKL5 cyclin-dependent kinase-like 5 2.529
FOXG1 forkhead box G1 2.238
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 2.187
STXBP1 syntaxin binding protein 1 2.061
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 2.04
IQSEC2 IQ motif and Sec7 domain 2 2.013
WDR45 WD repeat domain 45 1.99
TAC1 tachykinin, precursor 1 1.974
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.933
HCRT hypocretin (orexin) neuropeptide precursor 1.861
REM2 RAS (RAD and GEM)-like GTP binding 2 1.8
COMT catechol-O-methyltransferase 1.784
MAOB monoamine oxidase B 1.753
DRD2 dopamine receptor D2 1.74
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.732
MAOA monoamine oxidase A 1.708
AMY1B amylase, alpha 1B (salivary) 1.679
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.664
TMEM37 transmembrane protein 37 1.639
BDNF brain-derived neurotrophic factor 1.63
ANKK1 ankyrin repeat and kinase domain containing 1 1.627
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.621
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.621
ACTN3 actinin, alpha 3 (gene/pseudogene) 1.614
RNLS renalase, FAD-dependent amine oxidase 1.607
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 1.594
LAPTM4A lysosomal protein transmembrane 4 alpha 1.58
POMC proopiomelanocortin 1.57
BTBD9 BTB (POZ) domain containing 9 1.551
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.549
DRD1 dopamine receptor D1 1.535
IL1B interleukin 1, beta 1.532
MEF2C myocyte enhancer factor 2C 1.522
TRIM32 tripartite motif containing 32 1.515
DRD3 dopamine receptor D3 1.51
DRD5 dopamine receptor D5 1.504
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.492
REM1 RAS (RAD and GEM)-like GTP-binding 1 1.488
TMEM131 transmembrane protein 131 1.476
IL6 interleukin 6 1.471
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.466
CKM creatine kinase, muscle 1.448
UBE3A ubiquitin protein ligase E3A 1.446
SHANK3 SH3 and multiple ankyrin repeat domains 3 1.438
CKMT1B creatine kinase, mitochondrial 1B 1.404
CKB creatine kinase, brain 1.401
MBD5 methyl-CpG binding domain protein 5 1.399
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.392
OPN1MW2 opsin 1 (cone pigments), medium-wave-sensitive 2 1.37
TNF tumor necrosis factor 1.365
SNAP25 synaptosomal-associated protein, 25kDa 1.351
LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 1.341
EMG1 EMG1 N1-specific pseudouridine methyltransferase 1.333
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.328
NTNG2 netrin G2 1.314
NOXA1 NADPH oxidase activator 1 1.313
DRGX dorsal root ganglia homeobox 1.312
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.307
SCN1A sodium channel, voltage gated, type I alpha subunit 1.305
PISD phosphatidylserine decarboxylase 1.301
ZNF674 zinc finger protein 674 1.293
IL1A interleukin 1, alpha 1.286
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 1.282
CRP C-reactive protein, pentraxin-related 1.282
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 1.273
PRNP prion protein 1.256
FOS FBJ murine osteosarcoma viral oncogene homolog 1.254
LRRC75B leucine rich repeat containing 75B 1.246
INS insulin 1.244
BMP2 bone morphogenetic protein 2 1.241
KNG1 kininogen 1 1.241
RRAD Ras-related associated with diabetes 1.24
IGF1 insulin-like growth factor 1 (somatomedin C) 1.234
ALB albumin 1.233
GARNL3 GTPase activating Rap/RanGAP domain-like 3 1.226
RAI1 retinoic acid induced 1 1.225
SCN2A sodium channel, voltage gated, type II alpha subunit 1.222
FMR1 fragile X mental retardation 1 1.22
C22ORF15 chromosome 22 open reading frame 15 1.218
OXT oxytocin/neurophysin I prepropeptide 1.217
NPIPA5 nuclear pore complex interacting protein family, member A5 1.211
UNC80 unc-80 homolog (C. elegans) 1.207
RIMBP2 RIMS binding protein 2 1.199
CAPS2 calcyphosine 2 1.193
TH tyrosine hydroxylase 1.192
DNAH12 dynein, axonemal, heavy chain 12 1.178
TMEM161B transmembrane protein 161B 1.177
PEPD peptidase D 1.173
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.164
SKOR1 SKI family transcriptional corepressor 1 1.163
SHROOM4 shroom family member 4 1.158
GHRL ghrelin/obestatin prepropeptide 1.155
CHGA chromogranin A 1.155
MYO3B myosin IIIB 1.149
NGF nerve growth factor (beta polypeptide) 1.138
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 1.137
NPIPB11 nuclear pore complex interacting protein family, member B11 1.137
SATB2 SATB homeobox 2 1.13
SPINK7 serine peptidase inhibitor, Kazal type 7 (putative) 1.129
ADAM23 ADAM metallopeptidase domain 23 1.125
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 1.124
AVP arginine vasopressin 1.123
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 1.112
PER3 period circadian clock 3 1.108
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.097
LHFPL6 LHFPL tetraspan subfamily member 6 1.095
KLF7 Kruppel-like factor 7 (ubiquitous) 1.09
NTNG1 netrin G1 1.087
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 1.086
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 1.084
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 1.082
TAAR1 trace amine associated receptor 1 1.08
KCNT2 potassium channel, sodium activated subfamily T, member 2 1.078
THAP1 THAP domain containing, apoptosis associated protein 1 1.07
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 1.069
CNTNAP2 contactin associated protein-like 2 1.065
NPIPA2 nuclear pore complex interacting protein family, member A2 1.061
CPOX coproporphyrinogen oxidase 1.053
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 1.051
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.042
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 1.038
TAAR9 trace amine associated receptor 9 (gene/pseudogene) 1.037
RAB39B RAB39B, member RAS oncogene family 1.036
ANKRD33 ankyrin repeat domain 33 1.032
PMCH pro-melanin-concentrating hormone 1.025
TMEM11 transmembrane protein 11 1.021
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.02
CCDC144A coiled-coil domain containing 144A 1.011
BGLAP bone gamma-carboxyglutamate (gla) protein 1.007
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 1.007