Budesonide_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Budesonide_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.290195
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.139945
TRIO trio Rho guanine nucleotide exchange factor 0.112431
LOX lysyl oxidase 0.108976
COL5A1 collagen, type V, alpha 1 0.108534
ZMYND8 zinc finger, MYND-type containing 8 0.102268
NAV1 neuron navigator 1 0.0958435
PLAT plasminogen activator, tissue 0.0869954
PRELID2 PRELI domain containing 2 0.0863097
NAV2 neuron navigator 2 0.0720748
FN1 fibronectin 1 0.068041
PODXL podocalyxin-like 0.0668372
NCOR2 nuclear receptor corepressor 2 0.058277
FKBP5 FK506 binding protein 5 0.0493401
AHNAK AHNAK nucleoprotein 0.0478274
FTH1 ferritin, heavy polypeptide 1 0.0468704
EGFR epidermal growth factor receptor 0.0457666
FLNB filamin B, beta 0.0443458
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.042218
NEBL nebulette 0.0409056
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0406975
HIPK2 homeodomain interacting protein kinase 2 0.0406881
JCAD junctional cadherin 5 associated 0.0405923
ERRFI1 ERBB receptor feedback inhibitor 1 0.0397192
MT1X metallothionein 1X 0.038834
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0378119
CDH13 cadherin 13 0.0371188
FLNA filamin A, alpha 0.0367961
LENG8 leukocyte receptor cluster (LRC) member 8 0.0360326
SORBS2 sorbin and SH3 domain containing 2 0.0355277
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0354695
DCLK2 doublecortin-like kinase 2 0.0352221
ANTXR1 anthrax toxin receptor 1 0.0346873
FAM13A family with sequence similarity 13, member A 0.0345602
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0342855
MYOF myoferlin 0.0342067
SEPTIN9 septin 9 0.0340657
NFE2L1 nuclear factor, erythroid 2-like 1 0.0339968
TRAM2 translocation associated membrane protein 2 0.032908
GLIS3 GLIS family zinc finger 3 0.0328319
DNER delta/notch-like EGF repeat containing 0.0327447
LPP LIM domain containing preferred translocation partner in lipoma 0.031512
ABLIM3 actin binding LIM protein family, member 3 0.0312837
SH3RF3 SH3 domain containing ring finger 3 0.0312142
EFNA5 ephrin-A5 0.0311675
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0311176
TNS3 tensin 3 0.0309758
SRRM2 serine/arginine repetitive matrix 2 0.0304984
L1CAM L1 cell adhesion molecule 0.0300091
DST dystonin 0.0297528
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.028695
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0283063
RUNX1 runt-related transcription factor 1 0.0281058
YEATS2 YEATS domain containing 2 0.0276685
ANGPTL4 angiopoietin-like 4 0.0273331
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0267581
SLC39A11 solute carrier family 39, member 11 0.0263269
BCL2L1 BCL2-like 1 0.0254066
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0252799
SMYD3 SET and MYND domain containing 3 0.0250736
CUX1 cut-like homeobox 1 0.0250441
RNF213 ring finger protein 213 0.0245971
FNDC3B fibronectin type III domain containing 3B 0.0242551
RNF144A ring finger protein 144A 0.023682
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0236125
RAD51B RAD51 paralog B 0.0234779
SAA2 serum amyloid A2 0.023448
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 0.0234422
DHRSX dehydrogenase/reductase (SDR family) X-linked 0.0233916
FRMD4A FERM domain containing 4A 0.0232631
MMP12 matrix metallopeptidase 12 0.0230164
DEPP1 DEPP autophagy regulator 1 0.0230086
PTX3 pentraxin 3, long 0.0228845
PDE4D phosphodiesterase 4D, cAMP-specific 0.0225747
C1D C1D nuclear receptor corepressor 0.0224306
PER1 period circadian clock 1 0.0223968
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0213066
DDR2 discoidin domain receptor tyrosine kinase 2 0.0210891
PCDH7 protocadherin 7 0.0210825
MBD5 methyl-CpG binding domain protein 5 0.021035
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0207237
PRICKLE2 prickle homolog 2 (Drosophila) 0.0206241
GREB1L growth regulation by estrogen in breast cancer-like 0.0205966
GSE1 Gse1 coiled-coil protein 0.020227
ZNF292 zinc finger protein 292 0.0196875
PRKN parkin RBR E3 ubiquitin protein ligase 0.0191987
MEIS2 Meis homeobox 2 0.0191733
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0189461
PLEC plectin 0.0187342
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0186358
RERE arginine-glutamic acid dipeptide (RE) repeats 0.018049
BRD4 bromodomain containing 4 0.0180079
SVIL supervillin 0.0178333
ANKRD36 ankyrin repeat domain 36 0.0177685
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0177003
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.0176253
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0175621
ZBTB20 zinc finger and BTB domain containing 20 0.0172566
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0172388
SYTL3 synaptotagmin-like 3 0.0165106

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.258739
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.172321
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.160093
PTMA prothymosin, alpha -0.0973879
SQSTM1 sequestosome 1 -0.096919
TMSB10 thymosin beta 10 -0.0848771
S100A6 S100 calcium binding protein A6 -0.0798075
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.078882
CSTB cystatin B (stefin B) -0.0781902
DLG1 discs, large homolog 1 (Drosophila) -0.0722641
B2M beta-2-microglobulin -0.0688214
UBC ubiquitin C -0.0685931
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0659974
LMNA lamin A/C -0.0593465
COL3A1 collagen, type III, alpha 1 -0.0590216
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0583843
NDRG1 N-myc downstream regulated 1 -0.0569846
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0546504
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0530843
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0513441
HLA-B major histocompatibility complex, class I, B -0.0508375
TPT1 tumor protein, translationally-controlled 1 -0.0505707
NAP1L1 nucleosome assembly protein 1-like 1 -0.0488464
CCND1 cyclin D1 -0.0486954
EIF1 eukaryotic translation initiation factor 1 -0.0463196
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0457171
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0450692
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0438675
FTL ferritin, light polypeptide -0.0428055
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.042737
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0423119
TAGLN2 transgelin 2 -0.0417441
HLA-E major histocompatibility complex, class I, E -0.0409278
TM4SF1 transmembrane 4 L six family member 1 -0.03923
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0383863
ZEB1 zinc finger E-box binding homeobox 1 -0.0383079
IGFBP3 insulin-like growth factor binding protein 3 -0.0381213
THBS2 thrombospondin 2 -0.0371518
INSIG1 insulin induced gene 1 -0.0369094
VDAC1 voltage-dependent anion channel 1 -0.0367693
MT2A metallothionein 2A -0.0365381
ELL2 elongation factor, RNA polymerase II, 2 -0.036506
TMSB4X thymosin beta 4, X-linked -0.0363746
RND3 Rho family GTPase 3 -0.0358365
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0349384
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0341007
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0336504
ADM adrenomedullin -0.0335956
COL1A2 collagen, type I, alpha 2 -0.033545
CAVIN1 caveolae associated protein 1 -0.0335254
PRRC2C proline-rich coiled-coil 2C -0.0326077
S100A4 S100 calcium binding protein A4 -0.0322828
NT5C2 5'-nucleotidase, cytosolic II -0.0321121
WDFY1 WD repeat and FYVE domain containing 1 -0.0319035
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0317566
CD44 CD44 molecule (Indian blood group) -0.0317217
GNAS GNAS complex locus -0.0317042
RHOBTB3 Rho-related BTB domain containing 3 -0.0315751
PKM pyruvate kinase, muscle -0.0301507
STC1 stanniocalcin 1 -0.0298021
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0291405
OGA O-GlcNAcase -0.0288639
TAOK1 TAO kinase 1 -0.0286421
S100A10 S100 calcium binding protein A10 -0.028638
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0285574
RPS6 ribosomal protein S6 -0.0284959
RPS3 ribosomal protein S3 -0.0282742
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.027789
GARS1 glycyl-tRNA synthetase 1 -0.0277323
CYLD cylindromatosis (turban tumor syndrome) -0.0275018
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0274844
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0273182
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.0271414
PLAUR plasminogen activator, urokinase receptor -0.0270904
RPL34 ribosomal protein L34 -0.0270496
RAB1A RAB1A, member RAS oncogene family -0.0269194
CD99 CD99 molecule -0.0265479
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0265467
KDM3A lysine (K)-specific demethylase 3A -0.026515
RPL23 ribosomal protein L23 -0.0260718
RPL35A ribosomal protein L35a -0.0259286
SOX9 SRY (sex determining region Y)-box 9 -0.0257423
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0256515
FAM107B family with sequence similarity 107, member B -0.0253098
GOLGA4 golgin A4 -0.025223
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0251295
HLA-C major histocompatibility complex, class I, C -0.0248899
FRMD5 FERM domain containing 5 -0.024863
HMGB2 high mobility group box 2 -0.0245683
ACTG1 actin gamma 1 -0.0239045
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0238302
SLC38A1 solute carrier family 38, member 1 -0.0237859
ANKRD10 ankyrin repeat domain 10 -0.0229979
SPAG9 sperm associated antigen 9 -0.0228945
CTSB cathepsin B -0.0228523
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0227554
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0226799
ARL5B ADP-ribosylation factor-like 5B -0.0226783
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0226451
ANXA2 annexin A2 -0.0226175