Budesonide_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Budesonide_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.143938
NLGN1 neuroligin 1 0.137244
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.122098
NHSL1 NHS-like 1 0.0939472
DST dystonin 0.0871632
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0830963
H1-0 H1.0 linker histone 0.0809917
SRRM2 serine/arginine repetitive matrix 2 0.0726638
EGR1 early growth response 1 0.0684437
YAP1 Yes-associated protein 1 0.0671808
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0609741
YBX3 Y box binding protein 3 0.0540661
BRD4 bromodomain containing 4 0.0517962
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0515575
TRIO trio Rho guanine nucleotide exchange factor 0.0515
NEBL nebulette 0.0502184
JMJD1C jumonji domain containing 1C 0.0501584
TPI1 triosephosphate isomerase 1 0.0498305
MKI67 marker of proliferation Ki-67 0.0492309
POTEF POTE ankyrin domain family, member F 0.0491781
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0486018
PCDH7 protocadherin 7 0.047515
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0465087
MMP12 matrix metallopeptidase 12 0.0464426
MACF1 microtubule-actin crosslinking factor 1 0.0459492
AHNAK AHNAK nucleoprotein 0.0459227
CMIP c-Maf inducing protein 0.0456688
EIF4B eukaryotic translation initiation factor 4B 0.0452218
RAB7A RAB7A, member RAS oncogene family 0.0451159
DTNA dystrobrevin, alpha 0.0449928
USP34 ubiquitin specific peptidase 34 0.0448192
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0445778
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0442061
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0435736
EHBP1 EH domain binding protein 1 0.043454
NCOR2 nuclear receptor corepressor 2 0.0432834
CUX1 cut-like homeobox 1 0.0429074
WNK1 WNK lysine deficient protein kinase 1 0.0413243
ANKRD12 ankyrin repeat domain 12 0.0411277
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0402611
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0388556
PTK2 protein tyrosine kinase 2 0.0386669
PRRC2A proline-rich coiled-coil 2A 0.0382488
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0380362
RTN4 reticulon 4 0.0376072
RPS12 ribosomal protein S12 0.0373311
LMO7 LIM domain 7 0.0373056
PGK1 phosphoglycerate kinase 1 0.0372468
PFN1 profilin 1 0.0369052
TMSB10 thymosin beta 10 0.0367395
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0364478
TPM3 tropomyosin 3 0.0364405
AFF4 AF4/FMR2 family, member 4 0.0361719
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0360559
ATXN2L ataxin 2-like 0.0359677
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0354569
EEF2 eukaryotic translation elongation factor 2 0.0349157
SYNE2 spectrin repeat containing, nuclear envelope 2 0.034193
NRXN3 neurexin 3 0.0334578
NAP1L1 nucleosome assembly protein 1-like 1 0.0333021
DOCK1 dedicator of cytokinesis 1 0.032824
KMT2D lysine (K)-specific methyltransferase 2D 0.0328015
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0327819
NF1 neurofibromin 1 0.032108
MAP1B microtubule-associated protein 1B 0.032042
VMP1 vacuole membrane protein 1 0.0319914
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.0317026
BABAM2 BRISC and BRCA1 A complex member 2 0.0314524
PARD3 par-3 family cell polarity regulator 0.0310137
RPS3 ribosomal protein S3 0.0309442
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0309435
RNF213 ring finger protein 213 0.0307155
AKAP12 A kinase (PRKA) anchor protein 12 0.030447
FNDC3B fibronectin type III domain containing 3B 0.0303064
RPL19 ribosomal protein L19 0.0302979
PER1 period circadian clock 1 0.0302908
ADIPOR2 adiponectin receptor 2 0.0302356
LRRC23 leucine rich repeat containing 23 0.0301298
LPP LIM domain containing preferred translocation partner in lipoma 0.0300689
ARID1A AT rich interactive domain 1A (SWI-like) 0.029998
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0299877
ACLY ATP citrate lyase 0.029894
FOXM1 forkhead box M1 0.0298621
P4HB prolyl 4-hydroxylase, beta polypeptide 0.029664
SPRED2 sprouty-related, EVH1 domain containing 2 0.0294953
HSPA8 heat shock 70kDa protein 8 0.0292268
PRRC2C proline-rich coiled-coil 2C 0.0292114
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0291912
RAD51B RAD51 paralog B 0.0291533
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0290784
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0288781
YEATS2 YEATS domain containing 2 0.0288649
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0288049
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0286867
FNIP1 folliculin interacting protein 1 0.0284735
PACS1 phosphofurin acidic cluster sorting protein 1 0.0284598
L3MBTL4 l(3)mbt-like 4 (Drosophila) 0.0282673
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0278149
R3HDM2 R3H domain containing 2 0.0273734
KDM5A lysine (K)-specific demethylase 5A 0.0273623

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.151432
AREG amphiregulin -0.109675
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0976391
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0685915
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0578199
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0554481
MYL12B myosin, light chain 12B, regulatory -0.0527778
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0524586
ATP5F1B ATP synthase F1 subunit beta -0.0507708
CPOX coproporphyrinogen oxidase -0.0462048
OXR1 oxidation resistance 1 -0.0399866
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0396132
MGAT4C MGAT4 family, member C -0.0394096
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0365136
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0359922
TXNRD1 thioredoxin reductase 1 -0.0353621
RPL35A ribosomal protein L35a -0.0352372
GCG glucagon -0.0343158
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0341491
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0328562
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0318816
EDN1 endothelin 1 -0.0315423
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0308064
CXADR coxsackie virus and adenovirus receptor -0.0285594
BIRC3 baculoviral IAP repeat containing 3 -0.0277954
RAD21 RAD21 homolog (S. pombe) -0.0274601
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0273163
CHD1 chromodomain helicase DNA binding protein 1 -0.0271783
NIPBL Nipped-B homolog (Drosophila) -0.0262443
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0255716
GJA1 gap junction protein, alpha 1, 43kDa -0.0251882
CBX3 chromobox homolog 3 -0.0249846
RPLP0 ribosomal protein, large, P0 -0.024826
RPL8 ribosomal protein L8 -0.024628
LMAN1 lectin, mannose-binding, 1 -0.0245232
BIRC2 baculoviral IAP repeat containing 2 -0.0240935
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0238958
PDE4B phosphodiesterase 4B, cAMP-specific -0.0237104
KIF5B kinesin family member 5B -0.0235253
WDR43 WD repeat domain 43 -0.0234684
TCP1 t-complex 1 -0.0233766
LDHB lactate dehydrogenase B -0.0224528
BTG3 BTG family, member 3 -0.0221912
SLC38A1 solute carrier family 38, member 1 -0.0215884
PRKCI protein kinase C, iota -0.0215734
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.021333
PNISR PNN-interacting serine/arginine-rich protein -0.0213128
NSUN6 NOP2/Sun domain family, member 6 -0.0200611
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.019923
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0199145
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0195977
SCAF11 SR-related CTD-associated factor 11 -0.0195363
IPO7 importin 7 -0.0194679
ADAM9 ADAM metallopeptidase domain 9 -0.0188548
MARCHF6 membrane associated ring-CH-type finger 6 -0.0187766
TMEM47 transmembrane protein 47 -0.0187035
HMGB2 high mobility group box 2 -0.0186257
DKC1 dyskeratosis congenita 1, dyskerin -0.0182881
ATP5F1E ATP synthase F1 subunit epsilon -0.0179873
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0177527
LARS1 leucyl-tRNA synthetase 1 -0.0175576
TNPO1 transportin 1 -0.0175314
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.0174666
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0174551
SRSF11 serine/arginine-rich splicing factor 11 -0.0173815
MRPL3 mitochondrial ribosomal protein L3 -0.0173669
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase -0.0169895
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0168854
MATR3 matrin 3 -0.0167282
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0167069
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.016648
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0165276
ZC3H15 zinc finger CCCH-type containing 15 -0.0165208
QKI QKI, KH domain containing, RNA binding -0.0165051
HSPA4 heat shock 70kDa protein 4 -0.0163385
GGNBP2 gametogenetin binding protein 2 -0.0161984
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0159683
RPL27A ribosomal protein L27a -0.0159296
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0158454
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0157462
RNF145 ring finger protein 145 -0.0154094
PARK7 parkinson protein 7 -0.0153762
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.015309
WDR36 WD repeat domain 36 -0.0153051
NDFIP1 Nedd4 family interacting protein 1 -0.015283
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.015148
USP15 ubiquitin specific peptidase 15 -0.0151037
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -0.0150953
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0150405
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.014997
RPS21 ribosomal protein S21 -0.0148058
IL6ST interleukin 6 signal transducer -0.0147174
TSNAX translin-associated factor X -0.0147093
PDK4 pyruvate dehydrogenase kinase, isozyme 4 -0.0147045
COG5 component of oligomeric golgi complex 5 -0.014695
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0146934
RARS1 arginyl-tRNA synthetase 1 -0.0146885
VDAC1 voltage-dependent anion channel 1 -0.0146073
CCNL1 cyclin L1 -0.0144459
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0143337