Budesonide_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Budesonide_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
H1-0 H1.0 linker histone 0.168851
ZMYND8 zinc finger, MYND-type containing 8 0.146141
SRRM2 serine/arginine repetitive matrix 2 0.0937388
NDRG1 N-myc downstream regulated 1 0.0848926
MBNL2 muscleblind-like splicing regulator 2 0.0815078
RNF43 ring finger protein 43 0.0688433
TXNIP thioredoxin interacting protein 0.0646429
NRIP1 nuclear receptor interacting protein 1 0.0581177
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0530716
SREBF2 sterol regulatory element binding transcription factor 2 0.0515907
RUNX1 runt-related transcription factor 1 0.0475045
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0471569
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0466446
PTPRF protein tyrosine phosphatase, receptor type, F 0.0459677
NCOR2 nuclear receptor corepressor 2 0.0453213
TMPRSS4 transmembrane protease, serine 4 0.0452415
SPATA13 spermatogenesis associated 13 0.0442728
AHNAK AHNAK nucleoprotein 0.0427858
USP54 ubiquitin specific peptidase 54 0.041336
BHLHE40 basic helix-loop-helix family, member e40 0.0411818
ARGLU1 arginine and glutamate rich 1 0.0410145
AFF1 AF4/FMR2 family, member 1 0.040324
IGF1R insulin-like growth factor 1 receptor 0.0396789
SERINC5 serine incorporator 5 0.0393764
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0385222
TSC22D2 TSC22 domain family, member 2 0.0385184
MLPH melanophilin 0.0382334
PGK1 phosphoglycerate kinase 1 0.0381958
SEC24D SEC24 family member D 0.0380431
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0380214
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0377704
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0374051
DSCAM Down syndrome cell adhesion molecule 0.0372454
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0372013
DNM2 dynamin 2 0.0364746
SBF2 SET binding factor 2 0.0364199
HDLBP high density lipoprotein binding protein 0.0364016
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0363959
NEBL nebulette 0.0362067
CMIP c-Maf inducing protein 0.0350036
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0349702
MUC1 mucin 1, cell surface associated 0.0346639
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0342865
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.0341675
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0340707
NCKAP5 NCK-associated protein 5 0.0337497
YEATS2 YEATS domain containing 2 0.0336901
AOPEP aminopeptidase O (putative) 0.0334735
TC2N tandem C2 domains, nuclear 0.0333452
RBM39 RNA binding motif protein 39 0.0332384
AGR2 anterior gradient 2 0.0329647
MYH9 myosin, heavy chain 9, non-muscle 0.0328475
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0325969
ACTN4 actinin, alpha 4 0.0325062
CHD9 chromodomain helicase DNA binding protein 9 0.0324634
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0323157
RNF149 ring finger protein 149 0.0323079
SH3PXD2A SH3 and PX domains 2A 0.0320558
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0319976
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.0319129
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.031371
SCARB1 scavenger receptor class B, member 1 0.0313146
PADI1 peptidyl arginine deiminase, type I 0.0311888
PER2 period circadian clock 2 0.0311748
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0310013
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0309111
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0306626
TMC5 transmembrane channel-like 5 0.0304481
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0301977
SORBS1 sorbin and SH3 domain containing 1 0.0301719
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0300949
ZFP36L1 ZFP36 ring finger protein-like 1 0.0297357
KMT2C lysine (K)-specific methyltransferase 2C 0.0297349
FOSL2 FOS-like antigen 2 0.0296357
PMM2 phosphomannomutase 2 0.0295902
CCNL1 cyclin L1 0.0294862
PRRC2C proline-rich coiled-coil 2C 0.0293118
ZNRF3 zinc and ring finger 3 0.0291294
FAM13A family with sequence similarity 13, member A 0.028853
DYNC2I1 dynein 2 intermediate chain 1 0.0287617
HDAC4 histone deacetylase 4 0.0286104
PRELID2 PRELI domain containing 2 0.028593
ATP10B ATPase, class V, type 10B 0.0280153
IL20RA interleukin 20 receptor, alpha 0.0279541
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0278512
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0278198
BCLAF1 BCL2-associated transcription factor 1 0.0273482
BABAM2 BRISC and BRCA1 A complex member 2 0.0270264
SPRED2 sprouty-related, EVH1 domain containing 2 0.026952
TMEM51 transmembrane protein 51 0.0267147
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0267023
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0266323
MINK1 misshapen-like kinase 1 0.026621
ERCC5 excision repair cross-complementation group 5 0.0265417
BICRAL BICRA like chromatin remodeling complex associated protein 0.0265216
MKI67 marker of proliferation Ki-67 0.0264944
GOLGB1 golgin B1 0.026469
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0264563
OGA O-GlcNAcase 0.0261906
LASP1 LIM and SH3 protein 1 0.0261617

decreased expression

Symbol Name Standardized Value
RNF213 ring finger protein 213 -0.141701
LYZ lysozyme -0.135792
INTS6 integrator complex subunit 6 -0.129005
B2M beta-2-microglobulin -0.123127
EPSTI1 epithelial stromal interaction 1 (breast) -0.122237
ANXA2 annexin A2 -0.101875
GCLC glutamate-cysteine ligase, catalytic subunit -0.0938221
PLSCR2 phospholipid scramblase 2 -0.0932137
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0924866
TPT1 tumor protein, translationally-controlled 1 -0.088574
MX1 MX dynamin-like GTPase 1 -0.081481
PERP PERP, TP53 apoptosis effector -0.0811796
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0803183
SP100 SP100 nuclear antigen -0.0793396
LAMA4 laminin, alpha 4 -0.0781572
AREG amphiregulin -0.0774958
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0743495
RIGI RNA sensor RIG-I -0.072481
LMO7 LIM domain 7 -0.0723511
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0722396
TM4SF19 transmembrane 4 L six family member 19 -0.0719775
RAB7A RAB7A, member RAS oncogene family -0.0713673
MX2 MX dynamin-like GTPase 2 -0.068817
STS steroid sulfatase (microsomal), isozyme S -0.0687064
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0635368
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0625435
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0601387
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0548236
TJP1 tight junction protein 1 -0.0517945
MAP7 microtubule-associated protein 7 -0.0514336
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0502741
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0496898
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0484373
NPSR1 neuropeptide S receptor 1 -0.0482574
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0469945
XAF1 XIAP associated factor 1 -0.0464916
IGFBP3 insulin-like growth factor binding protein 3 -0.0461805
RPL35A ribosomal protein L35a -0.0454152
MCL1 myeloid cell leukemia 1 -0.0440358
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0438686
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0434793
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0428743
HKDC1 hexokinase domain containing 1 -0.0419709
PKM pyruvate kinase, muscle -0.0397534
UBC ubiquitin C -0.0395864
TSHZ2 teashirt zinc finger homeobox 2 -0.0388985
SAMD9 sterile alpha motif domain containing 9 -0.0386637
MAML2 mastermind-like 2 (Drosophila) -0.0378148
GMDS GDP-mannose 4,6-dehydratase -0.0377382
PMP22 peripheral myelin protein 22 -0.0375332
IFIH1 interferon induced with helicase C domain 1 -0.036321
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0361239
SLC38A1 solute carrier family 38, member 1 -0.0350744
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0349605
SPDYA speedy/RINGO cell cycle regulator family member A -0.0348832
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0348071
NABP1 nucleic acid binding protein 1 -0.0347418
C6ORF132 chromosome 6 open reading frame 132 -0.0343652
LCN2 lipocalin 2 -0.0343431
UBAP2 ubiquitin associated protein 2 -0.0342684
ACTG1 actin gamma 1 -0.0337634
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.033492
LPP LIM domain containing preferred translocation partner in lipoma -0.0332582
RPS6 ribosomal protein S6 -0.0332258
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0323001
PARD3 par-3 family cell polarity regulator -0.0319146
FTL ferritin, light polypeptide -0.0316615
TXNRD1 thioredoxin reductase 1 -0.0316094
CANX calnexin -0.0306564
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0305355
CATSPERB catsper channel auxiliary subunit beta -0.0305228
FBXO39 F-box protein 39 -0.0303646
LAP3 leucine aminopeptidase 3 -0.0303035
SLC38A2 solute carrier family 38, member 2 -0.0302619
ENO1 enolase 1, (alpha) -0.0301681
RPLP0 ribosomal protein, large, P0 -0.0301593
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0300327
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0299972
IFITM3 interferon induced transmembrane protein 3 -0.0298666
SETX senataxin -0.029734
GK glycerol kinase -0.0295152
SIK3 SIK family kinase 3 -0.0294349
MCTP1 multiple C2 domains, transmembrane 1 -0.029191
NCOA7 nuclear receptor coactivator 7 -0.0289625
RB1 retinoblastoma 1 -0.0287592
POU2F2 POU class 2 homeobox 2 -0.0285879
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0285434
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0281954
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0273205
ISG15 ISG15 ubiquitin-like modifier -0.027281
SAMHD1 SAM domain and HD domain 1 -0.0268177
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0266755
FOSL1 FOS-like antigen 1 -0.0262399
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0261893
VCL vinculin -0.0259589
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.0251255
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0248805
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0248426
RPS24 ribosomal protein S24 -0.024815
RPS8 ribosomal protein S8 -0.0245619