Budesonide_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Budesonide_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.406825
FN1 fibronectin 1 0.269123
TGFBI transforming growth factor, beta-induced, 68kDa 0.137321
LOX lysyl oxidase 0.114001
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.103016
HIPK2 homeodomain interacting protein kinase 2 0.0987986
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.097078
LTBP1 latent transforming growth factor beta binding protein 1 0.0912574
ERRFI1 ERBB receptor feedback inhibitor 1 0.0892285
HMGA2 high mobility group AT-hook 2 0.0848742
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0775059
MAML2 mastermind-like 2 (Drosophila) 0.0760106
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0749568
F3 coagulation factor III (thromboplastin, tissue factor) 0.072238
FTH1 ferritin, heavy polypeptide 1 0.0683224
PRELID2 PRELI domain containing 2 0.0618422
DPYD dihydropyrimidine dehydrogenase 0.0593639
PTPRG protein tyrosine phosphatase, receptor type, G 0.0576492
LPP LIM domain containing preferred translocation partner in lipoma 0.0513792
SORBS2 sorbin and SH3 domain containing 2 0.0497398
NAV2 neuron navigator 2 0.0488992
MBNL1 muscleblind-like splicing regulator 1 0.0483402
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0477905
AKAP12 A kinase (PRKA) anchor protein 12 0.0469369
PID1 phosphotyrosine interaction domain containing 1 0.0453707
LDHA lactate dehydrogenase A 0.0440654
DOCK5 dedicator of cytokinesis 5 0.0440435
ANKRD28 ankyrin repeat domain 28 0.0439872
COL5A1 collagen, type V, alpha 1 0.0436211
NRP1 neuropilin 1 0.0423697
GLIS3 GLIS family zinc finger 3 0.0421934
ABLIM3 actin binding LIM protein family, member 3 0.041684
NAV1 neuron navigator 1 0.0411976
PSD3 pleckstrin and Sec7 domain containing 3 0.0378403
COL7A1 collagen, type VII, alpha 1 0.0377152
AHNAK AHNAK nucleoprotein 0.0374021
EPS8 epidermal growth factor receptor pathway substrate 8 0.037242
MYO1B myosin IB 0.0369378
JAK2 Janus kinase 2 0.0368395
SLC38A2 solute carrier family 38, member 2 0.0362911
ZMYND8 zinc finger, MYND-type containing 8 0.0358402
ZFHX3 zinc finger homeobox 3 0.034763
IL1R1 interleukin 1 receptor, type I 0.0344618
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0338863
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0328725
DNER delta/notch-like EGF repeat containing 0.0321889
CNTN5 contactin 5 0.0318462
SH3RF3 SH3 domain containing ring finger 3 0.0314657
GRB10 growth factor receptor-bound protein 10 0.0313965
TOP1 topoisomerase (DNA) I 0.0312548
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0309701
PTEN phosphatase and tensin homolog 0.0306235
TRAM2 translocation associated membrane protein 2 0.0288748
CCN4 cellular communication network factor 4 0.027889
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0276985
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.027425
ZBTB20 zinc finger and BTB domain containing 20 0.0256086
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0255099
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0250908
FKBP5 FK506 binding protein 5 0.0247906
PLEC plectin 0.0246194
MED13L mediator complex subunit 13-like 0.0243702
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0239608
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0238682
ANGPTL4 angiopoietin-like 4 0.023394
CD109 CD109 molecule 0.0233852
FOXO3 forkhead box O3 0.023077
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.022789
FGD4 FYVE, RhoGEF and PH domain containing 4 0.022585
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0224425
PRICKLE2 prickle homolog 2 (Drosophila) 0.0224231
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0224197
FOXP1 forkhead box P1 0.0223294
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0223252
AKAP13 A kinase (PRKA) anchor protein 13 0.0218368
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0215747
TGFBR3 transforming growth factor, beta receptor III 0.0213751
MACF1 microtubule-actin crosslinking factor 1 0.0212141
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0211039
OXR1 oxidation resistance 1 0.0210842
OSMR oncostatin M receptor 0.0209765
BCL2L1 BCL2-like 1 0.0205239
TRPS1 trichorhinophalangeal syndrome I 0.0200288
CUX1 cut-like homeobox 1 0.0199652
POTEF POTE ankyrin domain family, member F 0.0198538
COL6A2 collagen, type VI, alpha 2 0.019617
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0195112
ANKRD12 ankyrin repeat domain 12 0.0194294
STC1 stanniocalcin 1 0.0194222
TNS1 tensin 1 0.0194157
UTRN utrophin 0.0192341
TMSB10 thymosin beta 10 0.0192072
EFNA5 ephrin-A5 0.0191294
NCOR2 nuclear receptor corepressor 2 0.0190525
PRRX1 paired related homeobox 1 0.0189569
SVIL supervillin 0.0189413
ESYT2 extended synaptotagmin-like protein 2 0.0185476
VEGFA vascular endothelial growth factor A 0.0185142
WNT5A wingless-type MMTV integration site family, member 5A 0.0184039
COL8A1 collagen, type VIII, alpha 1 0.0180433

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.292609
IGFBP3 insulin-like growth factor binding protein 3 -0.1647
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.12926
CXCL8 chemokine (C-X-C motif) ligand 8 -0.106468
CADM1 cell adhesion molecule 1 -0.102992
TRIO trio Rho guanine nucleotide exchange factor -0.0803595
CD44 CD44 molecule (Indian blood group) -0.0658528
PTMA prothymosin, alpha -0.0644988
IER3 immediate early response 3 -0.0624736
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0570538
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0557363
CANX calnexin -0.0524168
EXT1 exostosin glycosyltransferase 1 -0.049169
ATP13A3 ATPase type 13A3 -0.0484571
NDRG1 N-myc downstream regulated 1 -0.0454781
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0438864
TM4SF1 transmembrane 4 L six family member 1 -0.042153
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0403195
PDE10A phosphodiesterase 10A -0.0401107
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0390157
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0388566
NAMPT nicotinamide phosphoribosyltransferase -0.0388457
BHLHE40 basic helix-loop-helix family, member e40 -0.0364166
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0347352
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0334085
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0311689
ZFAND3 zinc finger, AN1-type domain 3 -0.0309932
ICAM1 intercellular adhesion molecule 1 -0.0306701
RPS8 ribosomal protein S8 -0.0301673
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.029973
LMAN1 lectin, mannose-binding, 1 -0.0291519
RPS6 ribosomal protein S6 -0.0279971
FTL ferritin, light polypeptide -0.0278836
DLG1 discs, large homolog 1 (Drosophila) -0.0275918
SPAG9 sperm associated antigen 9 -0.0268817
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0267947
USP3 ubiquitin specific peptidase 3 -0.0267466
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0266533
RLF rearranged L-myc fusion -0.0261765
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0260685
QKI QKI, KH domain containing, RNA binding -0.0260596
ARRDC3 arrestin domain containing 3 -0.0249994
SQSTM1 sequestosome 1 -0.0245469
MARCKS myristoylated alanine-rich protein kinase C substrate -0.024165
EIF1 eukaryotic translation initiation factor 1 -0.0239729
UBC ubiquitin C -0.0239344
RPL35A ribosomal protein L35a -0.0232655
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0231123
CLINT1 clathrin interactor 1 -0.0229683
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0227465
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0227368
SMAD3 SMAD family member 3 -0.0226343
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0225992
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0225559
WSB1 WD repeat and SOCS box containing 1 -0.0219889
LOXL2 lysyl oxidase-like 2 -0.0218277
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0215272
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0212742
B2M beta-2-microglobulin -0.0212272
CALR calreticulin -0.0211305
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0207789
TFG TRK-fused gene -0.0206721
YBX1 Y box binding protein 1 -0.0202411
INHBA inhibin, beta A -0.020148
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0199606
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0199399
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0198691
TNIP1 TNFAIP3 interacting protein 1 -0.0197776
RPL7 ribosomal protein L7 -0.0197122
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0196732
RASA2 RAS p21 protein activator 2 -0.0196588
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0195616
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0195109
CLIC4 chloride intracellular channel 4 -0.0192914
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0192912
EEF2 eukaryotic translation elongation factor 2 -0.0190725
ANTXR2 anthrax toxin receptor 2 -0.0188562
SQLE squalene epoxidase -0.0186811
RAD21 RAD21 homolog (S. pombe) -0.0186346
ADAM17 ADAM metallopeptidase domain 17 -0.018631
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0185438
PDIA3 protein disulfide isomerase family A, member 3 -0.0183909
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0182066
NAP1L1 nucleosome assembly protein 1-like 1 -0.018176
KDM3A lysine (K)-specific demethylase 3A -0.0180562
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0177132
PDIA6 protein disulfide isomerase family A, member 6 -0.017692
HILPDA hypoxia inducible lipid droplet-associated -0.0176815
RYBP RING1 and YY1 binding protein -0.0176512
FXR1 fragile X mental retardation, autosomal homolog 1 -0.017595
RPL12 ribosomal protein L12 -0.0175353
PDE8A phosphodiesterase 8A -0.017513
DDIT4 DNA-damage-inducible transcript 4 -0.0174676
RHEB Ras homolog enriched in brain -0.0170979
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0170573
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0170367
CDH13 cadherin 13 -0.0170334
TRAM1 translocation associated membrane protein 1 -0.0170215
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.016568
SP100 SP100 nuclear antigen -0.0164977