Budesonide_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Budesonide_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.232997
FKBP5 FK506 binding protein 5 0.183201
TXNIP thioredoxin interacting protein 0.15723
AHNAK AHNAK nucleoprotein 0.144475
MT1X metallothionein 1X 0.126253
KRT6A keratin 6A, type II 0.126139
POTEF POTE ankyrin domain family, member F 0.120839
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.116516
ZMYND8 zinc finger, MYND-type containing 8 0.115895
ESYT2 extended synaptotagmin-like protein 2 0.102898
NIBAN2 niban apoptosis regulator 2 0.080058
CAPRIN2 caprin family member 2 0.0797844
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.071031
FLNB filamin B, beta 0.069774
TGM2 transglutaminase 2 0.0680796
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0677859
TMSB10 thymosin beta 10 0.0669108
BCL2L1 BCL2-like 1 0.0661356
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0641633
TRIO trio Rho guanine nucleotide exchange factor 0.0635038
ZFP36L1 ZFP36 ring finger protein-like 1 0.0614857
EZR ezrin 0.0609913
ITGB4 integrin, beta 4 0.0585891
H1-0 H1.0 linker histone 0.0543208
ABLIM3 actin binding LIM protein family, member 3 0.0535269
TNS4 tensin 4 0.0527959
AKAP13 A kinase (PRKA) anchor protein 13 0.0521335
ZFHX3 zinc finger homeobox 3 0.0517884
VCL vinculin 0.0511141
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0510841
PID1 phosphotyrosine interaction domain containing 1 0.049696
LAMB1 laminin, beta 1 0.0496448
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0494142
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0489026
FTH1 ferritin, heavy polypeptide 1 0.0474038
NAMPT nicotinamide phosphoribosyltransferase 0.0471451
GLUL glutamate-ammonia ligase 0.0470646
EFNA5 ephrin-A5 0.0468567
HMGA2 high mobility group AT-hook 2 0.0459948
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0459893
EGR1 early growth response 1 0.0453174
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0448257
YAP1 Yes-associated protein 1 0.0442844
LAMA5 laminin, alpha 5 0.0405251
IRS2 insulin receptor substrate 2 0.0396771
MCL1 myeloid cell leukemia 1 0.0376852
HIPK2 homeodomain interacting protein kinase 2 0.0361152
NRCAM neuronal cell adhesion molecule 0.0354886
ZHX3 zinc fingers and homeoboxes 3 0.0353677
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0349855
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.034891
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0344091
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0342692
DOCK5 dedicator of cytokinesis 5 0.0341556
MT1E metallothionein 1E 0.0340902
PLEC plectin 0.0338546
NDRG1 N-myc downstream regulated 1 0.033527
GRID1 glutamate receptor, ionotropic, delta 1 0.0316725
RREB1 ras responsive element binding protein 1 0.0316507
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0308328
ERRFI1 ERBB receptor feedback inhibitor 1 0.0297818
FN1 fibronectin 1 0.0297163
RTN4 reticulon 4 0.029715
IRAK3 interleukin-1 receptor-associated kinase 3 0.0290487
FMNL2 formin-like 2 0.0288628
ALCAM activated leukocyte cell adhesion molecule 0.028542
JPH2 junctophilin 2 0.02841
BCL9L B-cell CLL/lymphoma 9-like 0.0282387
SASH1 SAM and SH3 domain containing 1 0.0276434
MLKL mixed lineage kinase domain-like 0.027577
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0271108
EPS8 epidermal growth factor receptor pathway substrate 8 0.0265754
CAVIN2 caveolae associated protein 2 0.0263632
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0263134
KRT17 keratin 17, type I 0.0260833
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.026025
DDIT4 DNA-damage-inducible transcript 4 0.0257898
BIRC3 baculoviral IAP repeat containing 3 0.0254866
PER1 period circadian clock 1 0.0252949
PHF20 PHD finger protein 20 0.0252645
RBM39 RNA binding motif protein 39 0.0252057
CDKL5 cyclin-dependent kinase-like 5 0.0251859
ABLIM2 actin binding LIM protein family, member 2 0.0250933
ELL2 elongation factor, RNA polymerase II, 2 0.0243349
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.0240874
CLMB calcimembrin 0.023986
GSN gelsolin 0.0236166
SOD2 superoxide dismutase 2, mitochondrial 0.0230178
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0225728
SKI SKI proto-oncogene 0.0225026
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.0223724
ITGA10 integrin, alpha 10 0.0220981
AGTPBP1 ATP/GTP binding protein 1 0.0218236
NAV2 neuron navigator 2 0.0214357
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.021254
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0211082
AFAP1L1 actin filament associated protein 1-like 1 0.0207937
ZBTB38 zinc finger and BTB domain containing 38 0.0207926
JARID2 jumonji, AT rich interactive domain 2 0.0204033
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0203482

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.221777
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.161448
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.14703
CD44 CD44 molecule (Indian blood group) -0.115478
B2M beta-2-microglobulin -0.0992385
SLC35F3 solute carrier family 35, member F3 -0.0897354
ITGA6 integrin, alpha 6 -0.0841066
PTMA prothymosin, alpha -0.0823115
DPYD dihydropyrimidine dehydrogenase -0.0756722
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0753058
CLU clusterin -0.0737379
EXT1 exostosin glycosyltransferase 1 -0.0734006
STC1 stanniocalcin 1 -0.0730934
MEF2A myocyte enhancer factor 2A -0.0730704
ASPH aspartate beta-hydroxylase -0.0682312
SULF1 sulfatase 1 -0.0663595
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0655851
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0640585
RAI14 retinoic acid induced 14 -0.0625932
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0594693
TMSB4X thymosin beta 4, X-linked -0.0574907
TPT1 tumor protein, translationally-controlled 1 -0.0557301
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0553266
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0524667
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0523546
NRIP1 nuclear receptor interacting protein 1 -0.0515806
KIAA1217 KIAA1217 -0.0492592
MTSS1 metastasis suppressor 1 -0.0492118
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0481355
DST dystonin -0.0466991
SAMD9 sterile alpha motif domain containing 9 -0.046139
PODXL podocalyxin-like -0.0460735
HLA-B major histocompatibility complex, class I, B -0.0460532
DOK5 docking protein 5 -0.0452663
MBNL1 muscleblind-like splicing regulator 1 -0.0452282
AOPEP aminopeptidase O (putative) -0.0451137
SULF2 sulfatase 2 -0.0444038
PRSS23 protease, serine, 23 -0.0443991
RPS8 ribosomal protein S8 -0.0437704
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0433887
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.043018
RPS6 ribosomal protein S6 -0.0422019
MACF1 microtubule-actin crosslinking factor 1 -0.0414553
MECOM MDS1 and EVI1 complex locus -0.0402695
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0401409
NRG1 neuregulin 1 -0.0398073
SQSTM1 sequestosome 1 -0.0393767
ENO1 enolase 1, (alpha) -0.0392141
ZEB1 zinc finger E-box binding homeobox 1 -0.0391932
GRB10 growth factor receptor-bound protein 10 -0.0391632
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0386929
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0383877
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0382354
CANX calnexin -0.0371738
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0369662
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0355843
KTN1 kinectin 1 (kinesin receptor) -0.0354401
CAV1 caveolin 1, caveolae protein, 22kDa -0.0354147
JMJD1C jumonji domain containing 1C -0.0353798
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0341904
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0339423
LAMC2 laminin, gamma 2 -0.0338722
CAPN2 calpain 2, (m/II) large subunit -0.0335671
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0331539
LMNA lamin A/C -0.0326789
CDK6 cyclin-dependent kinase 6 -0.0326782
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.032566
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0323948
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0321364
ECE1 endothelin converting enzyme 1 -0.0319324
PLS3 plastin 3 -0.0313785
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0313638
LMO7 LIM domain 7 -0.031267
HLA-E major histocompatibility complex, class I, E -0.0312641
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0310344
IFITM1 interferon induced transmembrane protein 1 -0.0306789
RIGI RNA sensor RIG-I -0.0302721
SYNJ2 synaptojanin 2 -0.0301667
DSTN destrin (actin depolymerizing factor) -0.0299971
HDAC9 histone deacetylase 9 -0.029931
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0296439
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0295976
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0295425
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.029101
RPS13 ribosomal protein S13 -0.02902
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0288751
MYO10 myosin X -0.0285209
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0284551
PSD3 pleckstrin and Sec7 domain containing 3 -0.0281661
RPS21 ribosomal protein S21 -0.0279756
PDLIM5 PDZ and LIM domain 5 -0.02796
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0276845
CEMIP cell migration inducing protein, hyaluronan binding -0.027523
ABI3BP ABI family, member 3 (NESH) binding protein -0.0273164
FRMD5 FERM domain containing 5 -0.0272544
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0271578
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0270848
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0266764
SMAD3 SMAD family member 3 -0.0266761
PKM pyruvate kinase, muscle -0.0259115