Budesonide_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Budesonide_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.124774
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.121435
CEMIP cell migration inducing protein, hyaluronan binding 0.110506
SRRM2 serine/arginine repetitive matrix 2 0.10958
NDRG1 N-myc downstream regulated 1 0.0991191
H1-0 H1.0 linker histone 0.0966185
ONECUT3 one cut homeobox 3 0.0960834
FLNB filamin B, beta 0.091678
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.090537
RNF43 ring finger protein 43 0.085614
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0847855
TNS4 tensin 4 0.0817137
FAM13A family with sequence similarity 13, member A 0.0751652
GOLGA4 golgin A4 0.0726107
AHNAK AHNAK nucleoprotein 0.0699477
MACF1 microtubule-actin crosslinking factor 1 0.0678199
PTPRR protein tyrosine phosphatase, receptor type, R 0.0642246
TXNIP thioredoxin interacting protein 0.0640667
TMSB10 thymosin beta 10 0.0589239
ZFAND3 zinc finger, AN1-type domain 3 0.0587358
ESYT2 extended synaptotagmin-like protein 2 0.0573861
PDIA4 protein disulfide isomerase family A, member 4 0.0551658
LMO7 LIM domain 7 0.0543237
ANKRD11 ankyrin repeat domain 11 0.0541591
RBM39 RNA binding motif protein 39 0.0540392
GPHN gephyrin 0.0537157
OGA O-GlcNAcase 0.0535616
EEF2 eukaryotic translation elongation factor 2 0.0532131
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0530972
ACTN4 actinin, alpha 4 0.0525846
PGK1 phosphoglycerate kinase 1 0.0514862
SEC31A SEC31 homolog A (S. cerevisiae) 0.0506652
ZNF292 zinc finger protein 292 0.0505516
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0488683
CADPS Ca++-dependent secretion activator 0.0487315
NCOR1 nuclear receptor corepressor 1 0.0485373
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0479127
EWSR1 EWS RNA-binding protein 1 0.0472122
PRSS3 protease, serine, 3 0.0467127
MON2 MON2 homolog (S. cerevisiae) 0.0457533
FTH1 ferritin, heavy polypeptide 1 0.0452309
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0450653
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0448262
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0428928
KDM4B lysine (K)-specific demethylase 4B 0.0427031
NCOR2 nuclear receptor corepressor 2 0.0418993
CTBP2 C-terminal binding protein 2 0.0418183
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0415201
FNDC3B fibronectin type III domain containing 3B 0.0413648
DNM2 dynamin 2 0.0413571
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0413088
MED13L mediator complex subunit 13-like 0.0405397
ARHGAP32 Rho GTPase activating protein 32 0.0402727
SREBF2 sterol regulatory element binding transcription factor 2 0.0400159
GAK cyclin G associated kinase 0.0393554
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0392411
CTNND1 catenin (cadherin-associated protein), delta 1 0.0387867
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0384153
HDLBP high density lipoprotein binding protein 0.0383915
PRRC2C proline-rich coiled-coil 2C 0.0383038
ABHD2 abhydrolase domain containing 2 0.0375106
PNISR PNN-interacting serine/arginine-rich protein 0.0374702
SBF2 SET binding factor 2 0.0373671
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0373222
MYH9 myosin, heavy chain 9, non-muscle 0.0370853
RREB1 ras responsive element binding protein 1 0.0370328
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0364373
ZC3H11A zinc finger CCCH-type containing 11A 0.0364328
DGKD diacylglycerol kinase, delta 130kDa 0.0363374
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0362787
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0362691
DERA deoxyribose-phosphate aldolase (putative) 0.0361643
CSNK1A1 casein kinase 1, alpha 1 0.036084
MINK1 misshapen-like kinase 1 0.0359946
LENG8 leukocyte receptor cluster (LRC) member 8 0.0359374
ABHD17C abhydrolase domain containing 17C 0.0357547
KDM3A lysine (K)-specific demethylase 3A 0.0355412
ITGA6 integrin, alpha 6 0.0354962
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0346869
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0344784
SHROOM3 shroom family member 3 0.0344558
FAT1 FAT atypical cadherin 1 0.0337752
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0333204
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0329427
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0327485
BIRC6 baculoviral IAP repeat containing 6 0.0322722
COPA coatomer protein complex, subunit alpha 0.0322362
DSCAM Down syndrome cell adhesion molecule 0.0322076
RNF145 ring finger protein 145 0.0321957
BRD4 bromodomain containing 4 0.0321915
NF1 neurofibromin 1 0.0319068
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.031742
DENND4C DENN/MADD domain containing 4C 0.0316828
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0316809
PPARG peroxisome proliferator-activated receptor gamma 0.0316637
EREG epiregulin 0.0315771
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0315574
SETD5 SET domain containing 5 0.0313587
KLF3 Kruppel-like factor 3 (basic) 0.0311946
SHB Src homology 2 domain containing adaptor protein B 0.0309412

decreased expression

Symbol Name Standardized Value
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.168921
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.155124
NPSR1 neuropeptide S receptor 1 -0.0646191
RPS6 ribosomal protein S6 -0.0608306
ACTG1 actin gamma 1 -0.0564018
PTPRK protein tyrosine phosphatase, receptor type, K -0.0444757
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0420868
ALCAM activated leukocyte cell adhesion molecule -0.0392035
TFF1 trefoil factor 1 -0.0388646
RPL35A ribosomal protein L35a -0.0383469
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0383239
EGFR epidermal growth factor receptor -0.037852
RPS8 ribosomal protein S8 -0.0376743
S100A6 S100 calcium binding protein A6 -0.0373484
PSD3 pleckstrin and Sec7 domain containing 3 -0.0369177
LOC102724023 ES1 protein homolog, mitochondrial -0.0358436
TPM4 tropomyosin 4 -0.0357763
PDE4D phosphodiesterase 4D, cAMP-specific -0.0335015
RNF217 ring finger protein 217 -0.0328239
TPT1 tumor protein, translationally-controlled 1 -0.0326212
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0322456
MARCHF3 membrane associated ring-CH-type finger 3 -0.031803
MAML3 mastermind-like 3 (Drosophila) -0.0308193
SLC38A2 solute carrier family 38, member 2 -0.0306695
RPLP0 ribosomal protein, large, P0 -0.0306554
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0298565
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0296587
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0293286
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0288267
LAMA4 laminin, alpha 4 -0.027356
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0273002
F3 coagulation factor III (thromboplastin, tissue factor) -0.0266086
MUC17 mucin 17, cell surface associated -0.0264567
GREB1L growth regulation by estrogen in breast cancer-like -0.026359
KRT18 keratin 18, type I -0.0261067
FHIT fragile histidine triad -0.0259928
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0258042
SOX4 SRY (sex determining region Y)-box 4 -0.025675
B2M beta-2-microglobulin -0.0256423
TUBA1B tubulin, alpha 1b -0.0255122
MBNL1 muscleblind-like splicing regulator 1 -0.0254544
SLC35F3 solute carrier family 35, member F3 -0.0249895
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0243352
RPS13 ribosomal protein S13 -0.0242021
PTPRB protein tyrosine phosphatase, receptor type, B -0.0240364
GLS2 glutaminase 2 (liver, mitochondrial) -0.0239381
ATP5F1B ATP synthase F1 subunit beta -0.0238779
BTG1 B-cell translocation gene 1, anti-proliferative -0.0237427
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0236493
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0231244
INTS6 integrator complex subunit 6 -0.0226687
MRPS6 mitochondrial ribosomal protein S6 -0.0225178
KTN1 kinectin 1 (kinesin receptor) -0.0214922
PTMA prothymosin, alpha -0.0212125
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.02075
SPDYA speedy/RINGO cell cycle regulator family member A -0.0206252
HMGA1 high mobility group AT-hook 1 -0.0202953
SIK3 SIK family kinase 3 -0.0200545
CLOCK clock circadian regulator -0.0199996
DSTN destrin (actin depolymerizing factor) -0.0199647
PATJ PATJ crumbs cell polarity complex component -0.0197748
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0195988
CATSPERB catsper channel auxiliary subunit beta -0.0195252
AFF1 AF4/FMR2 family, member 1 -0.0195025
RPS25 ribosomal protein S25 -0.0185732
RPS5 ribosomal protein S5 -0.0182708
FBXO11 F-box protein 11 -0.0180722
RPL31 ribosomal protein L31 -0.0176666
LDHB lactate dehydrogenase B -0.017654
RPL7A ribosomal protein L7a -0.0174455
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0172237
SERBP1 SERPINE1 mRNA binding protein 1 -0.0172055
RND3 Rho family GTPase 3 -0.0171808
CCND1 cyclin D1 -0.0170007
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0169975
UBC ubiquitin C -0.0167079
LDHA lactate dehydrogenase A -0.0166614
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0166372
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.01653
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0159621
LSAMP limbic system-associated membrane protein -0.0158856
EMP1 epithelial membrane protein 1 -0.0158526
DEK DEK proto-oncogene -0.0157204
ZBTB20 zinc finger and BTB domain containing 20 -0.0156677
UNC13B unc-13 homolog B (C. elegans) -0.0156334
TES testin LIM domain protein -0.0155929
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0155926
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0155304
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0155075
RPL9 ribosomal protein L9 -0.0151981
RPS19 ribosomal protein S19 -0.0151761
TWF1 twinfilin actin binding protein 1 -0.0150251
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0149109
PCDH9 protocadherin 9 -0.0149079
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0148452
PA2G4 proliferation-associated 2G4, 38kDa -0.0148236
TUBB4B tubulin, beta 4B class IVb -0.0148024
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0147243
PERP PERP, TP53 apoptosis effector -0.0146983
PDIA3 protein disulfide isomerase family A, member 3 -0.0146571