Budesonide_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Budesonide_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.222638
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.119098
MT1X metallothionein 1X 0.10112
MT1E metallothionein 1E 0.098904
TOP1 topoisomerase (DNA) I 0.08814
RUNX1 runt-related transcription factor 1 0.0615924
ZMYND8 zinc finger, MYND-type containing 8 0.0584385
FKBP5 FK506 binding protein 5 0.0542311
ESYT2 extended synaptotagmin-like protein 2 0.0499774
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0489245
EEF2 eukaryotic translation elongation factor 2 0.0425616
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0392523
POTEF POTE ankyrin domain family, member F 0.0379004
PTPRF protein tyrosine phosphatase, receptor type, F 0.0363494
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0359618
YEATS2 YEATS domain containing 2 0.0357002
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0354065
NPAS2 neuronal PAS domain protein 2 0.0334585
NIBAN2 niban apoptosis regulator 2 0.0328837
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0322911
TXNIP thioredoxin interacting protein 0.031795
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0315412
AHNAK AHNAK nucleoprotein 0.0314376
SRRM2 serine/arginine repetitive matrix 2 0.0313471
ITGB4 integrin, beta 4 0.030577
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0303137
PSD3 pleckstrin and Sec7 domain containing 3 0.02973
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0281999
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0281066
EGR1 early growth response 1 0.0280626
CAPRIN2 caprin family member 2 0.0279062
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0278624
FTH1 ferritin, heavy polypeptide 1 0.0276497
ZBTB38 zinc finger and BTB domain containing 38 0.0272569
RACK1 receptor for activated C kinase 1 0.0265139
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0261257
MYOF myoferlin 0.0260367
PRRC2A proline-rich coiled-coil 2A 0.0251091
RPS2 ribosomal protein S2 0.0250554
NCOR2 nuclear receptor corepressor 2 0.0250086
EMP1 epithelial membrane protein 1 0.0248451
NDRG1 N-myc downstream regulated 1 0.0245136
CABIN1 calcineurin binding protein 1 0.0244313
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0237047
WNK1 WNK lysine deficient protein kinase 1 0.0236435
ANGPTL4 angiopoietin-like 4 0.0234583
PER1 period circadian clock 1 0.0227951
DNER delta/notch-like EGF repeat containing 0.0222953
ANKRD28 ankyrin repeat domain 28 0.0222357
HDLBP high density lipoprotein binding protein 0.0220661
IGF1R insulin-like growth factor 1 receptor 0.0220172
EXOC4 exocyst complex component 4 0.021755
AKAP9 A kinase (PRKA) anchor protein 9 0.0215345
MYO9B myosin IXB 0.021463
H1-0 H1.0 linker histone 0.0212756
EHBP1 EH domain binding protein 1 0.0212129
BABAM2 BRISC and BRCA1 A complex member 2 0.0210334
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0209583
TRERF1 transcriptional regulating factor 1 0.0207191
TIMP2 TIMP metallopeptidase inhibitor 2 0.0203946
LENG8 leukocyte receptor cluster (LRC) member 8 0.0202114
MTCL1 microtubule crosslinking factor 1 0.020185
LOC112694756 uncharaterized LOC112694756 0.0201768
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0198451
GTF2IRD1 GTF2I repeat domain containing 1 0.0196508
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0196311
INTS6 integrator complex subunit 6 0.0196002
INF2 inverted formin, FH2 and WH2 domain containing 0.0195945
PYGB phosphorylase, glycogen; brain 0.0193034
ASXL2 additional sex combs like transcriptional regulator 2 0.0192437
ENO2 enolase 2 (gamma, neuronal) 0.019127
ZNF638 zinc finger protein 638 0.0191244
DOCK1 dedicator of cytokinesis 1 0.0190469
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.018939
DDIT4 DNA-damage-inducible transcript 4 0.0189227
EZR ezrin 0.0186942
SGK1 serum/glucocorticoid regulated kinase 1 0.0182619
CHD9 chromodomain helicase DNA binding protein 9 0.0181767
WWTR1 WW domain containing transcription regulator 1 0.0180888
HSPG2 heparan sulfate proteoglycan 2 0.0180826
POM121 POM121 transmembrane nucleoporin 0.0179289
MARK4 MAP/microtubule affinity-regulating kinase 4 0.0178478
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0177872
RPL18 ribosomal protein L18 0.0173074
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0170745
ZMIZ1 zinc finger, MIZ-type containing 1 0.0169618
ATN1 atrophin 1 0.0169536
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0167381
GYS1 glycogen synthase 1 (muscle) 0.0165753
CSNK1A1 casein kinase 1, alpha 1 0.0165395
TTC3 tetratricopeptide repeat domain 3 0.0164191
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0163372
FOXO3 forkhead box O3 0.016334
SEC24A SEC24 family member A 0.0161081
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0159952
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0159537
AGTPBP1 ATP/GTP binding protein 1 0.0159374
MAPT microtubule-associated protein tau 0.0157108
FLNB filamin B, beta 0.0156298
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0154474

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.183076
PTMA prothymosin, alpha -0.171195
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.155011
VIM vimentin -0.147014
TMSB4X thymosin beta 4, X-linked -0.108012
TM4SF1 transmembrane 4 L six family member 1 -0.0852754
TPT1 tumor protein, translationally-controlled 1 -0.0822911
HLA-B major histocompatibility complex, class I, B -0.0810514
CD44 CD44 molecule (Indian blood group) -0.0798068
DST dystonin -0.0746968
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0710505
CENPF centromere protein F, 350/400kDa -0.064901
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0632216
CANX calnexin -0.0627113
RPL35A ribosomal protein L35a -0.0624977
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0606766
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0605512
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0601241
SLC38A2 solute carrier family 38, member 2 -0.0588638
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0558978
WARS1 tryptophanyl-tRNA synthetase 1 -0.0539764
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0506982
RAI1 retinoic acid induced 1 -0.0503703
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0482523
TP63 tumor protein p63 -0.0470513
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0459422
ZNF217 zinc finger protein 217 -0.0458629
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0430265
RAB27B RAB27B, member RAS oncogene family -0.042649
ARHGAP5 Rho GTPase activating protein 5 -0.0417858
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0412386
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0412377
CADM2 cell adhesion molecule 2 -0.0401411
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0388111
SMC4 structural maintenance of chromosomes 4 -0.0382006
DEK DEK proto-oncogene -0.0371539
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0370617
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0369691
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.036808
VCL vinculin -0.0366343
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0364495
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.036285
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0360138
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0352193
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0349154
ADAM10 ADAM metallopeptidase domain 10 -0.0340559
RPS6 ribosomal protein S6 -0.0339096
VDAC1 voltage-dependent anion channel 1 -0.0337611
RPLP0 ribosomal protein, large, P0 -0.0332329
B2M beta-2-microglobulin -0.0326344
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0323177
KMT2E lysine (K)-specific methyltransferase 2E -0.0322035
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0318928
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.031628
SRPK2 SRSF protein kinase 2 -0.0315583
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0313728
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0312539
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0310387
MKI67 marker of proliferation Ki-67 -0.0309987
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0306614
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0305613
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0304602
MATR3 matrin 3 -0.03009
RBM39 RNA binding motif protein 39 -0.029657
DPYD dihydropyrimidine dehydrogenase -0.02907
EREG epiregulin -0.0285836
SETD5 SET domain containing 5 -0.0282185
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0281321
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0281112
TRIP12 thyroid hormone receptor interactor 12 -0.0279615
IFI6 interferon, alpha-inducible protein 6 -0.0275226
RPS24 ribosomal protein S24 -0.0274541
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0274048
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0272794
BIRC2 baculoviral IAP repeat containing 2 -0.0272602
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0269712
IPO7 importin 7 -0.0267481
ADGRG6 adhesion G protein-coupled receptor G6 -0.0263391
IFIH1 interferon induced with helicase C domain 1 -0.0262411
PTK2 protein tyrosine kinase 2 -0.0261445
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.026141
RPL34 ribosomal protein L34 -0.0260935
RPS8 ribosomal protein S8 -0.0257906
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0257567
ADAM17 ADAM metallopeptidase domain 17 -0.0253366
NAMPT nicotinamide phosphoribosyltransferase -0.0252977
IFITM1 interferon induced transmembrane protein 1 -0.0252506
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0252277
TMEM123 transmembrane protein 123 -0.0252036
PRELID2 PRELI domain containing 2 -0.0249267
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0246945
RPS19 ribosomal protein S19 -0.0246235
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0246226
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0243891
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0243876
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.024161
KIF5B kinesin family member 5B -0.0239763
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0239047
SRSF11 serine/arginine-rich splicing factor 11 -0.0238676
MYL12B myosin, light chain 12B, regulatory -0.0236803