Budesonide_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Budesonide_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.288408
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.190484
PDE4D phosphodiesterase 4D, cAMP-specific 0.164075
MT2A metallothionein 2A 0.102613
THSD4 thrombospondin, type I, domain containing 4 0.0873702
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0803326
MAML3 mastermind-like 3 (Drosophila) 0.0776806
EFNA5 ephrin-A5 0.0765071
MAP2K1 mitogen-activated protein kinase kinase 1 0.0758559
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0739268
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0670234
ATP11A ATPase, class VI, type 11A 0.0622062
MCTP1 multiple C2 domains, transmembrane 1 0.0587053
AHNAK AHNAK nucleoprotein 0.0543441
SMYD3 SET and MYND domain containing 3 0.0508263
DOCK5 dedicator of cytokinesis 5 0.0503208
TMSB10 thymosin beta 10 0.0494943
FOXP1 forkhead box P1 0.0493367
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0490841
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0468161
SCEL sciellin 0.0464127
LAMA4 laminin, alpha 4 0.0458086
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0449383
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0439259
RAD51B RAD51 paralog B 0.0434148
EGR1 early growth response 1 0.0431865
LMO7 LIM domain 7 0.043076
PTPRM protein tyrosine phosphatase, receptor type, M 0.0425638
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0412478
SRRM2 serine/arginine repetitive matrix 2 0.0410659
OSMR oncostatin M receptor 0.040659
MCL1 myeloid cell leukemia 1 0.0382528
LPP LIM domain containing preferred translocation partner in lipoma 0.0379481
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0373282
CMIP c-Maf inducing protein 0.0367325
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0365566
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0364327
DNER delta/notch-like EGF repeat containing 0.0364041
INTS6 integrator complex subunit 6 0.0355338
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0354965
EXT1 exostosin glycosyltransferase 1 0.0351574
SUMF1 sulfatase modifying factor 1 0.0347647
AKAP13 A kinase (PRKA) anchor protein 13 0.0347378
GPHN gephyrin 0.0341502
LRP12 low density lipoprotein receptor-related protein 12 0.0338987
MACF1 microtubule-actin crosslinking factor 1 0.0338654
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0335399
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0332664
TRAPPC9 trafficking protein particle complex 9 0.0331696
PDLIM5 PDZ and LIM domain 5 0.0328942
FAF1 Fas (TNFRSF6) associated factor 1 0.0325285
EPAS1 endothelial PAS domain protein 1 0.0322425
FRY furry homolog (Drosophila) 0.0319187
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.0317662
CUX1 cut-like homeobox 1 0.0314494
CES1 carboxylesterase 1 0.0313972
TES testin LIM domain protein 0.0311031
PLEC plectin 0.0303118
VCL vinculin 0.0298107
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.02974
DOCK1 dedicator of cytokinesis 1 0.0295959
TJP1 tight junction protein 1 0.0295539
ANKRD17 ankyrin repeat domain 17 0.0295417
BCAR3 breast cancer anti-estrogen resistance 3 0.0295209
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.029226
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0288122
PYGL phosphorylase, glycogen, liver 0.0276987
IGF1R insulin-like growth factor 1 receptor 0.0276262
CCSER1 coiled-coil serine-rich protein 1 0.0275579
BLZF1 basic leucine zipper nuclear factor 1 0.0273954
SEC61G Sec61 gamma subunit 0.0269197
SLTM SAFB-like, transcription modulator 0.0266517
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0265784
MLKL mixed lineage kinase domain-like 0.0265234
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0264554
BABAM2 BRISC and BRCA1 A complex member 2 0.0257816
HM13 histocompatibility (minor) 13 0.0256039
CST3 cystatin C 0.0254332
LGALS12 lectin, galactoside-binding, soluble, 12 0.0245751
TRIP12 thyroid hormone receptor interactor 12 0.0244224
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0241918
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0240701
JMJD1C jumonji domain containing 1C 0.0237994
ANKRD11 ankyrin repeat domain 11 0.023616
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0235013
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0234959
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0234609
TNRC6B trinucleotide repeat containing 6B 0.0232069
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0230588
RPLP1 ribosomal protein, large, P1 0.0230561
TAS2R14 taste receptor, type 2, member 14 0.0230414
FKBP5 FK506 binding protein 5 0.022879
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0227745
RABGAP1L RAB GTPase activating protein 1-like 0.0227725
NEBL nebulette 0.0226834
PTK2 protein tyrosine kinase 2 0.022398
FNDC3B fibronectin type III domain containing 3B 0.022315
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.022262
RNF149 ring finger protein 149 0.0221541
GOLGB1 golgin B1 0.0217665

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0733256
NDRG1 N-myc downstream regulated 1 -0.0425085
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0353205
ARRDC3 arrestin domain containing 3 -0.0286311
ASPH aspartate beta-hydroxylase -0.0274194
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0257471
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0244978
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0238026
TXNRD1 thioredoxin reductase 1 -0.0236057
FAM13A family with sequence similarity 13, member A -0.0228319
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0227248
NGLY1 N-glycanase 1 -0.0213407
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0201588
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0201301
OGA O-GlcNAcase -0.0198928
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0191762
CPE carboxypeptidase E -0.01749
IGFBP3 insulin-like growth factor binding protein 3 -0.0167878
H1-0 H1.0 linker histone -0.0165178
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0163892
ANKRD10 ankyrin repeat domain 10 -0.0162763
GRB10 growth factor receptor-bound protein 10 -0.0162296
LRP1B low density lipoprotein receptor-related protein 1B -0.016086
WDR45B WD repeat domain 45B -0.0158107
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0153016
ABLIM1 actin binding LIM protein 1 -0.0145639
MATR3 matrin 3 -0.0142528
UBC ubiquitin C -0.0141917
USP53 ubiquitin specific peptidase 53 -0.0141522
MSMO1 methylsterol monooxygenase 1 -0.0140732
PTMA prothymosin, alpha -0.0140649
RAB27B RAB27B, member RAS oncogene family -0.0140113
HOOK2 hook microtubule-tethering protein 2 -0.0137711
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0136846
KMT2E lysine (K)-specific methyltransferase 2E -0.0135198
UVRAG UV radiation resistance associated -0.0134006
NPTN neuroplastin -0.0133026
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0132856
TENT5A terminal nucleotidyltransferase 5A -0.0131875
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0131517
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0130232
TKT transketolase -0.0129138
HILPDA hypoxia inducible lipid droplet-associated -0.0128443
MARF1 meiosis regulator and mRNA stability factor 1 -0.0127568
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0125327
BMP7 bone morphogenetic protein 7 -0.0125249
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0123882
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0123678
DSCAM Down syndrome cell adhesion molecule -0.0123638
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0123465
HBP1 HMG-box transcription factor 1 -0.0122407
TPD52 tumor protein D52 -0.0122386
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0120793
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0118577
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0116062
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0115348
TMEM165 transmembrane protein 165 -0.011529
CEMIP cell migration inducing protein, hyaluronan binding -0.0112917
MXI1 MAX interactor 1, dimerization protein -0.0110076
PAPOLA poly(A) polymerase alpha -0.0109189
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0108383
UBE2O ubiquitin-conjugating enzyme E2O -0.010764
CYLD cylindromatosis (turban tumor syndrome) -0.0106348
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0105323
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0105021
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0104807
ARL8B ADP-ribosylation factor-like 8B -0.0104573
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0104446
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0104159
SOD2 superoxide dismutase 2, mitochondrial -0.01041
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) -0.0102461
GLS2 glutaminase 2 (liver, mitochondrial) -0.010165
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0101524
MPZL2 myelin protein zero-like 2 -0.0101211
KLRD1 killer cell lectin-like receptor subfamily D, member 1 -0.00992048
PDE8A phosphodiesterase 8A -0.00974044
GADD45A growth arrest and DNA-damage-inducible, alpha -0.00971229
WAC WW domain containing adaptor with coiled-coil -0.00970794
ZC3H15 zinc finger CCCH-type containing 15 -0.00970011
INSIG2 insulin induced gene 2 -0.00969721
KIAA1217 KIAA1217 -0.00968575
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.00961567
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.00960357
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.00960306
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.00922103
ZFC3H1 zinc finger, C3H1-type containing -0.0091815
GPBP1 GC-rich promoter binding protein 1 -0.00917313
ADGRF1 adhesion G protein-coupled receptor F1 -0.00912584
FXR1 fragile X mental retardation, autosomal homolog 1 -0.00907599
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -0.00890324
SQSTM1 sequestosome 1 -0.0088804
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.00884501
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.00882427
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.00881115
SLMAP sarcolemma associated protein -0.00877288
S100A6 S100 calcium binding protein A6 -0.00859718
AFF1 AF4/FMR2 family, member 1 -0.00858793
USP3 ubiquitin specific peptidase 3 -0.00852929
BHLHE40 basic helix-loop-helix family, member e40 -0.00850304
RYBP RING1 and YY1 binding protein -0.00846947