Budesonide_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Budesonide_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.388472
FN1 fibronectin 1 0.178205
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.16666
MT2A metallothionein 2A 0.127839
FKBP5 FK506 binding protein 5 0.109535
HIPK2 homeodomain interacting protein kinase 2 0.106841
TGM2 transglutaminase 2 0.102389
HMGA2 high mobility group AT-hook 2 0.0924537
IRAK3 interleukin-1 receptor-associated kinase 3 0.089722
ZMYND8 zinc finger, MYND-type containing 8 0.0876521
RAD51B RAD51 paralog B 0.0834498
ANKRD28 ankyrin repeat domain 28 0.0773419
NRCAM neuronal cell adhesion molecule 0.077183
LOX lysyl oxidase 0.0762718
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0716506
GPC6 glypican 6 0.0650697
NRG1 neuregulin 1 0.0609119
SORBS2 sorbin and SH3 domain containing 2 0.0597633
DPYD dihydropyrimidine dehydrogenase 0.0571072
AHNAK AHNAK nucleoprotein 0.0567667
ZBTB16 zinc finger and BTB domain containing 16 0.0483677
TSC22D3 TSC22 domain family, member 3 0.0478327
PID1 phosphotyrosine interaction domain containing 1 0.0471584
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.0465426
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0464391
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0460484
NAMPT nicotinamide phosphoribosyltransferase 0.0458373
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0457464
DNER delta/notch-like EGF repeat containing 0.0434636
ELL2 elongation factor, RNA polymerase II, 2 0.0430206
PCNX1 pecanex 1 0.0417277
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.041184
UGP2 UDP-glucose pyrophosphorylase 2 0.0400234
TRIO trio Rho guanine nucleotide exchange factor 0.0399143
MYO1E myosin IE 0.0397523
RUNX2 runt-related transcription factor 2 0.0395545
ACSL1 acyl-CoA synthetase long-chain family member 1 0.0394395
SH3RF3 SH3 domain containing ring finger 3 0.0383944
CLMP CXADR-like membrane protein 0.0377804
ZEB2 zinc finger E-box binding homeobox 2 0.0373807
ZC3H12C zinc finger CCCH-type containing 12C 0.0363384
ZHX3 zinc fingers and homeoboxes 3 0.035539
TLR2 toll-like receptor 2 0.0351276
FTH1 ferritin, heavy polypeptide 1 0.0348437
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0348435
ANGPTL4 angiopoietin-like 4 0.0345538
ZFHX3 zinc finger homeobox 3 0.0343491
CA12 carbonic anhydrase XII 0.0342855
USP34 ubiquitin specific peptidase 34 0.0341138
RAB27B RAB27B, member RAS oncogene family 0.0341087
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0335983
NCOR2 nuclear receptor corepressor 2 0.033426
ZFP36L1 ZFP36 ring finger protein-like 1 0.0332248
ESYT2 extended synaptotagmin-like protein 2 0.0330871
IL18R1 interleukin 18 receptor 1 0.0328618
PRELID2 PRELI domain containing 2 0.0328595
NEBL nebulette 0.0313839
MYOF myoferlin 0.0310723
OSMR oncostatin M receptor 0.0307312
SRRM2 serine/arginine repetitive matrix 2 0.0307177
ITGA10 integrin, alpha 10 0.030631
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.030474
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0303377
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0303292
ABLIM3 actin binding LIM protein family, member 3 0.0298407
FLNB filamin B, beta 0.0295898
EGR1 early growth response 1 0.0293485
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0292623
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0286372
ASPH aspartate beta-hydroxylase 0.0286189
YEATS2 YEATS domain containing 2 0.0277714
HDAC4 histone deacetylase 4 0.0273169
MT1X metallothionein 1X 0.0272262
NPAS2 neuronal PAS domain protein 2 0.0272107
MLPH melanophilin 0.0271186
MAML2 mastermind-like 2 (Drosophila) 0.0269976
LPP LIM domain containing preferred translocation partner in lipoma 0.0269503
NPC1 Niemann-Pick disease, type C1 0.0269088
DCN decorin 0.0268478
TPST1 tyrosylprotein sulfotransferase 1 0.0267821
LAMB1 laminin, beta 1 0.0267058
PLIN2 perilipin 2 0.0265166
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0261291
NNMT nicotinamide N-methyltransferase 0.0260159
SOD2 superoxide dismutase 2, mitochondrial 0.0256437
THSD4 thrombospondin, type I, domain containing 4 0.0253425
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0251999
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.025065
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0241378
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0240531
COPS8 COP9 signalosome subunit 8 0.0239635
BCL6 B-cell CLL/lymphoma 6 0.0237617
EGFR epidermal growth factor receptor 0.0234438
MBNL1 muscleblind-like splicing regulator 1 0.0234355
BABAM2 BRISC and BRCA1 A complex member 2 0.0230656
WDPCP WD repeat containing planar cell polarity effector 0.0230584
SAMD4A sterile alpha motif domain containing 4A 0.0229755
CABIN1 calcineurin binding protein 1 0.0229209
CD109 CD109 molecule 0.0227868
RPGR retinitis pigmentosa GTPase regulator 0.0226309

decreased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 -0.121164
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.11125
VIM vimentin -0.102021
RICTOR RPTOR independent companion of MTOR, complex 2 -0.090149
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0777562
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0760509
FTL ferritin, light polypeptide -0.0719818
GRB10 growth factor receptor-bound protein 10 -0.0706962
IGFBP3 insulin-like growth factor binding protein 3 -0.0613824
STC1 stanniocalcin 1 -0.0592127
PDE4D phosphodiesterase 4D, cAMP-specific -0.0590381
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0542768
PTMA prothymosin, alpha -0.0524276
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0514944
SMAD3 SMAD family member 3 -0.0507434
IER3 immediate early response 3 -0.0498782
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0493834
CD44 CD44 molecule (Indian blood group) -0.0473769
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0468403
BASP1 brain abundant, membrane attached signal protein 1 -0.0465192
LMAN1 lectin, mannose-binding, 1 -0.0463512
FAM107B family with sequence similarity 107, member B -0.0455126
C15ORF48 chromosome 15 open reading frame 48 -0.045283
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0452172
KDM2A lysine (K)-specific demethylase 2A -0.0444743
GOLGA4 golgin A4 -0.0441622
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0440653
PARD3 par-3 family cell polarity regulator -0.0439577
RPLP1 ribosomal protein, large, P1 -0.0434264
WAC WW domain containing adaptor with coiled-coil -0.0424515
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0423025
EIF1 eukaryotic translation initiation factor 1 -0.0410836
RIOK3 RIO kinase 3 -0.0409573
NAP1L1 nucleosome assembly protein 1-like 1 -0.0407742
EXT1 exostosin glycosyltransferase 1 -0.0400873
KDM3A lysine (K)-specific demethylase 3A -0.0396645
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0386276
USP3 ubiquitin specific peptidase 3 -0.0380438
WDR45B WD repeat domain 45B -0.037824
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0369762
SPAG9 sperm associated antigen 9 -0.0361552
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0355733
B2M beta-2-microglobulin -0.0354695
DLG1 discs, large homolog 1 (Drosophila) -0.0347574
TFPI2 tissue factor pathway inhibitor 2 -0.0331645
ZFAND3 zinc finger, AN1-type domain 3 -0.0328909
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0324605
RAB1A RAB1A, member RAS oncogene family -0.0324427
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0323594
VDAC1 voltage-dependent anion channel 1 -0.0318617
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0316703
TMSB4X thymosin beta 4, X-linked -0.0314336
RAP1B RAP1B, member of RAS oncogene family -0.0313049
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.031046
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0308143
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0294528
GNAS GNAS complex locus -0.029386
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0289661
RPL35A ribosomal protein L35a -0.0286523
NCOA7 nuclear receptor coactivator 7 -0.0281366
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0278156
TMEM263 transmembrane protein 263 -0.0275716
PDGFA platelet-derived growth factor alpha polypeptide -0.0273989
RPLP0 ribosomal protein, large, P0 -0.0272023
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0268706
PRRC2C proline-rich coiled-coil 2C -0.0267535
KTN1 kinectin 1 (kinesin receptor) -0.026746
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0266308
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0266198
RAI14 retinoic acid induced 14 -0.0265008
MRPS6 mitochondrial ribosomal protein S6 -0.0264884
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0263053
TPT1 tumor protein, translationally-controlled 1 -0.0261318
HILPDA hypoxia inducible lipid droplet-associated -0.0260358
UGCG UDP-glucose ceramide glucosyltransferase -0.0257148
MARCHF6 membrane associated ring-CH-type finger 6 -0.0254975
MYO10 myosin X -0.0253955
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0251153
ITCH itchy E3 ubiquitin protein ligase -0.0249284
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0248096
FNDC3B fibronectin type III domain containing 3B -0.0244375
RNF145 ring finger protein 145 -0.0243966
DSCAM Down syndrome cell adhesion molecule -0.0242204
BTG1 B-cell translocation gene 1, anti-proliferative -0.0240295
KIF5B kinesin family member 5B -0.023982
SLC38A1 solute carrier family 38, member 1 -0.0238551
ANXA2 annexin A2 -0.0237832
ZSWIM6 zinc finger, SWIM-type containing 6 -0.023709
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0236809
HELZ helicase with zinc finger -0.023596
RPS19 ribosomal protein S19 -0.0235154
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0235051
COG5 component of oligomeric golgi complex 5 -0.0234419
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0232085
HMGA1 high mobility group AT-hook 1 -0.0231288
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0229353
HDAC9 histone deacetylase 9 -0.0229002
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0228912
RPS21 ribosomal protein S21 -0.0222176
RPL27A ribosomal protein L27a -0.0221658