Budesonide_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Budesonide_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.260281
PM20D1 peptidase M20 domain containing 1 0.208902
TMSB10 thymosin beta 10 0.202198
PDE4D phosphodiesterase 4D, cAMP-specific 0.128372
FGA fibrinogen alpha chain 0.0885782
NNMT nicotinamide N-methyltransferase 0.0755398
SRGN serglycin 0.0738736
SYNE2 spectrin repeat containing, nuclear envelope 2 0.06708
AKAP13 A kinase (PRKA) anchor protein 13 0.0644466
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0588347
FGB fibrinogen beta chain 0.0551231
AHNAK AHNAK nucleoprotein 0.0547683
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0512952
TPD52 tumor protein D52 0.0506762
NEBL nebulette 0.0495984
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0481118
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0474732
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0463374
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0457543
RAD51B RAD51 paralog B 0.0440792
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.0418204
UTRN utrophin 0.0414464
FAM135A family with sequence similarity 135, member A 0.0404835
EWSR1 EWS RNA-binding protein 1 0.0401353
PER1 period circadian clock 1 0.0399714
ANKRD11 ankyrin repeat domain 11 0.0396628
FTH1 ferritin, heavy polypeptide 1 0.0392712
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0381174
FNDC3B fibronectin type III domain containing 3B 0.0374971
SRRM2 serine/arginine repetitive matrix 2 0.0374325
PDE8A phosphodiesterase 8A 0.0364669
ZMYND8 zinc finger, MYND-type containing 8 0.0356816
FGG fibrinogen gamma chain 0.0356681
EFNA5 ephrin-A5 0.0354239
ANXA1 annexin A1 0.0352515
LDHA lactate dehydrogenase A 0.0347589
CYRIB CYFIP related Rac1 interactor B 0.0344514
CABIN1 calcineurin binding protein 1 0.0344315
PHF20 PHD finger protein 20 0.0341748
CAVIN2 caveolae associated protein 2 0.0334706
APP amyloid beta (A4) precursor protein 0.033309
TRIO trio Rho guanine nucleotide exchange factor 0.0326601
KDM3A lysine (K)-specific demethylase 3A 0.0323236
UBAP2L ubiquitin associated protein 2-like 0.031775
FNBP1L formin binding protein 1-like 0.031558
EGR1 early growth response 1 0.0314755
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0314132
RBM39 RNA binding motif protein 39 0.0308962
POTEF POTE ankyrin domain family, member F 0.0305205
MT1X metallothionein 1X 0.0304799
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0296709
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0296623
SIK3 SIK family kinase 3 0.0291806
ZNF292 zinc finger protein 292 0.0290047
EGFR epidermal growth factor receptor 0.0289468
SLC38A2 solute carrier family 38, member 2 0.0287898
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0285206
FLNA filamin A, alpha 0.0284189
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0283445
ERRFI1 ERBB receptor feedback inhibitor 1 0.0277761
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.027642
EEF2 eukaryotic translation elongation factor 2 0.0273469
THSD4 thrombospondin, type I, domain containing 4 0.0272934
ATXN2L ataxin 2-like 0.0270815
YAP1 Yes-associated protein 1 0.0264866
MTUS1 microtubule associated tumor suppressor 1 0.0264498
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0264431
PUM1 pumilio RNA-binding family member 1 0.0261171
WDR43 WD repeat domain 43 0.0256001
RPS20 ribosomal protein S20 0.0251272
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0250289
DOCK5 dedicator of cytokinesis 5 0.0248837
TSC22D3 TSC22 domain family, member 3 0.0248482
MRTFA myocardin related transcription factor A 0.024735
UBASH3B ubiquitin associated and SH3 domain containing B 0.0246389
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.024585
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0241909
ZFHX3 zinc finger homeobox 3 0.0241766
TNRC6B trinucleotide repeat containing 6B 0.0241224
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.024118
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0236151
NEK7 NIMA-related kinase 7 0.0234047
YBX1 Y box binding protein 1 0.0233163
ARHGAP17 Rho GTPase activating protein 17 0.022854
PYGB phosphorylase, glycogen; brain 0.0226477
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0225931
SPIDR scaffolding protein involved in DNA repair 0.0225679
PRRC2A proline-rich coiled-coil 2A 0.0219708
CCN2 cellular communication network factor 2 0.0219054
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0216998
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0212459
RPS2 ribosomal protein S2 0.021238
MATR3 matrin 3 0.0210942
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.021026
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0210134
S100A10 S100 calcium binding protein A10 0.0206868
H1-0 H1.0 linker histone 0.0205931
TPM3 tropomyosin 3 0.0205331
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0203734
RPL32 ribosomal protein L32 0.020213

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.180319
TM4SF1 transmembrane 4 L six family member 1 -0.174837
TFPI2 tissue factor pathway inhibitor 2 -0.13522
VIM vimentin -0.133102
IER3 immediate early response 3 -0.104519
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.102798
TXNRD1 thioredoxin reductase 1 -0.0855736
FTL ferritin, light polypeptide -0.0824874
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0676088
C15ORF48 chromosome 15 open reading frame 48 -0.0562049
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0560033
EIF1 eukaryotic translation initiation factor 1 -0.0523458
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0518126
DENND4A DENN/MADD domain containing 4A -0.0517407
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0514973
SLC38A1 solute carrier family 38, member 1 -0.050651
S100A6 S100 calcium binding protein A6 -0.0460189
ASPH aspartate beta-hydroxylase -0.0452233
RPL35A ribosomal protein L35a -0.0398694
SAMD4A sterile alpha motif domain containing 4A -0.0357422
GRAMD1B GRAM domain containing 1B -0.0354367
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0354158
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0348396
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0337317
IL6 interleukin 6 -0.0337108
NAV3 neuron navigator 3 -0.0335882
UPP1 uridine phosphorylase 1 -0.0329613
PTMA prothymosin, alpha -0.0323709
DOCK4 dedicator of cytokinesis 4 -0.0318078
TPT1 tumor protein, translationally-controlled 1 -0.0316011
FAM107B family with sequence similarity 107, member B -0.0308866
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0305974
HMGA1 high mobility group AT-hook 1 -0.0301877
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0301203
B2M beta-2-microglobulin -0.0294219
RBM25 RNA binding motif protein 25 -0.0293235
PKM pyruvate kinase, muscle -0.0289913
IGFBP3 insulin-like growth factor binding protein 3 -0.0281355
RPLP1 ribosomal protein, large, P1 -0.0277247
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0273467
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0272435
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.026139
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0260353
AREG amphiregulin -0.0260097
HLA-B major histocompatibility complex, class I, B -0.0259571
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0257468
LOC102724023 ES1 protein homolog, mitochondrial -0.02574
SQSTM1 sequestosome 1 -0.0249417
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0246702
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0245169
CD44 CD44 molecule (Indian blood group) -0.024187
GLS2 glutaminase 2 (liver, mitochondrial) -0.0238843
MYL12B myosin, light chain 12B, regulatory -0.0236482
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0235224
CMIP c-Maf inducing protein -0.023288
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0232766
ATP5F1B ATP synthase F1 subunit beta -0.0231799
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0229276
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.022794
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0226565
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0218244
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0216754
TIMP1 TIMP metallopeptidase inhibitor 1 -0.021604
SOD2 superoxide dismutase 2, mitochondrial -0.0215143
RPL31 ribosomal protein L31 -0.0211924
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0211424
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0209694
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.02093
MARCHF4 membrane associated ring-CH-type finger 4 -0.0207092
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0204604
UBC ubiquitin C -0.0203589
COTL1 coactosin-like F-actin binding protein 1 -0.0203508
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -0.0200311
EXT1 exostosin glycosyltransferase 1 -0.0199009
SOX4 SRY (sex determining region Y)-box 4 -0.0198912
HLA-A major histocompatibility complex, class I, A -0.0197413
CTSL cathepsin L -0.0195535
DSE dermatan sulfate epimerase -0.0195269
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0193155
ALCAM activated leukocyte cell adhesion molecule -0.0193001
NIPBL Nipped-B homolog (Drosophila) -0.0192511
PRRC2C proline-rich coiled-coil 2C -0.0191707
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0191302
RRM2 ribonucleotide reductase M2 -0.0190525
TPM4 tropomyosin 4 -0.0188934
KPNB1 karyopherin (importin) beta 1 -0.0187918
SMAD3 SMAD family member 3 -0.0186844
SPAG9 sperm associated antigen 9 -0.0186583
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0185346
BHLHE40 basic helix-loop-helix family, member e40 -0.0184115
KIF5B kinesin family member 5B -0.0183879
ICAM1 intercellular adhesion molecule 1 -0.0181411
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.01807
PRDX1 peroxiredoxin 1 -0.0179483
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0179038
VDAC1 voltage-dependent anion channel 1 -0.017761
CXCL2 chemokine (C-X-C motif) ligand 2 -0.0177234
SDC4 syndecan 4 -0.0176683
CDCP1 CUB domain containing protein 1 -0.0175672
DEK DEK proto-oncogene -0.0175249