Budesonide_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Budesonide_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.132439
FN1 fibronectin 1 0.0946933
ERRFI1 ERBB receptor feedback inhibitor 1 0.0940882
ELL2 elongation factor, RNA polymerase II, 2 0.0813952
MT2A metallothionein 2A 0.0742865
PDE10A phosphodiesterase 10A 0.0712441
AKAP12 A kinase (PRKA) anchor protein 12 0.0697259
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0636499
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0614154
DDIT4 DNA-damage-inducible transcript 4 0.0597532
ESYT2 extended synaptotagmin-like protein 2 0.0585574
CCNY cyclin Y 0.0573186
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0542277
NCOA3 nuclear receptor coactivator 3 0.0521582
VIM vimentin 0.050164
POTEF POTE ankyrin domain family, member F 0.0494961
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0489681
MAML3 mastermind-like 3 (Drosophila) 0.0488163
TBC1D22A TBC1 domain family, member 22A 0.0473593
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0466329
PRRC2C proline-rich coiled-coil 2C 0.0463957
MT1X metallothionein 1X 0.0463661
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0457455
AVL9 AVL9 homolog (S. cerevisiase) 0.0446003
ZNF654 zinc finger protein 654 0.0444146
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0430658
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0419553
AREG amphiregulin 0.0417841
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0415829
SETD5 SET domain containing 5 0.0412866
RPL26 ribosomal protein L26 0.0404169
GNPDA1 glucosamine-6-phosphate deaminase 1 0.040309
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0399882
SMAD3 SMAD family member 3 0.0399158
ENO1 enolase 1, (alpha) 0.0398328
DTNA dystrobrevin, alpha 0.0379899
ZFAND3 zinc finger, AN1-type domain 3 0.0379718
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0366654
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0365881
NCKAP1 NCK-associated protein 1 0.0365645
GARS1 glycyl-tRNA synthetase 1 0.0362766
PRKCA protein kinase C, alpha 0.0357685
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0356376
SACK1A scaffolding CK1 anchoring protein A 0.0355609
CANX calnexin 0.0355295
MKI67 marker of proliferation Ki-67 0.0351811
HSPG2 heparan sulfate proteoglycan 2 0.0348962
SMYD3 SET and MYND domain containing 3 0.0341952
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0341045
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0339904
HLA-B major histocompatibility complex, class I, B 0.0339556
PDLIM5 PDZ and LIM domain 5 0.0339251
BTBD9 BTB (POZ) domain containing 9 0.0337783
HOMER2 homer scaffolding protein 2 0.0337315
RPS16 ribosomal protein S16 0.0336654
HELZ helicase with zinc finger 0.033516
RNF213 ring finger protein 213 0.0333612
TMEM165 transmembrane protein 165 0.0333298
RRBP1 ribosome binding protein 1 0.0326931
COG6 component of oligomeric golgi complex 6 0.0325088
ARHGAP5 Rho GTPase activating protein 5 0.032498
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.032495
RIGI RNA sensor RIG-I 0.0324616
YBX1 Y box binding protein 1 0.0324508
EMP1 epithelial membrane protein 1 0.0322962
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0321435
APLP2 amyloid beta (A4) precursor-like protein 2 0.0321106
ZNF638 zinc finger protein 638 0.0320711
DCAF7 DDB1 and CUL4 associated factor 7 0.0313412
DIAPH2 diaphanous-related formin 2 0.0312154
ZFP36L1 ZFP36 ring finger protein-like 1 0.0310085
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0310068
BRD4 bromodomain containing 4 0.0308732
CD44 CD44 molecule (Indian blood group) 0.030701
EGR1 early growth response 1 0.0304455
CLIC4 chloride intracellular channel 4 0.0303182
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0303173
UBE2K ubiquitin-conjugating enzyme E2K 0.0302384
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0300767
CLASP1 cytoplasmic linker associated protein 1 0.029827
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0298249
GMDS GDP-mannose 4,6-dehydratase 0.0297681
LSAMP limbic system-associated membrane protein 0.0296179
NPAS2 neuronal PAS domain protein 2 0.0295768
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0295573
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0294467
FUBP1 far upstream element (FUSE) binding protein 1 0.0294354
WSB1 WD repeat and SOCS box containing 1 0.0293427
NEMF nuclear export mediator factor 0.0292566
SEC31A SEC31 homolog A (S. cerevisiae) 0.0291959
SRRM1 serine/arginine repetitive matrix 1 0.0291615
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0290335
OSBPL8 oxysterol binding protein-like 8 0.0290275
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0288398
COL5A1 collagen, type V, alpha 1 0.0285378
FNDC3B fibronectin type III domain containing 3B 0.0283992
ANKRD33B ankyrin repeat domain 33B 0.02839
SFMBT2 Scm-like with four mbt domains 2 0.0279931
EWSR1 EWS RNA-binding protein 1 0.0279305
RUNX1 runt-related transcription factor 1 0.0278151

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.121192
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.116414
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.11187
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.101602
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.101329
LAMB3 laminin, beta 3 -0.0945581
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.093201
SLC38A1 solute carrier family 38, member 1 -0.0864954
IFIH1 interferon induced with helicase C domain 1 -0.0861491
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0818041
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0812502
NPTN neuroplastin -0.0784562
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0781461
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0756048
DSCAM Down syndrome cell adhesion molecule -0.0732339
SRPK2 SRSF protein kinase 2 -0.0724045
KRT17 keratin 17, type I -0.0691327
BACE2 beta-site APP-cleaving enzyme 2 -0.066931
RPS19 ribosomal protein S19 -0.066872
H3-3B H3.3 histone B -0.0668338
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0659913
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0658754
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0628312
ACVR1 activin A receptor, type I -0.0627494
DICER1 dicer 1, ribonuclease type III -0.0626954
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.060999
GOLGA4 golgin A4 -0.0605302
NAMPT nicotinamide phosphoribosyltransferase -0.0596606
RAB8B RAB8B, member RAS oncogene family -0.0567639
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0554761
KDM6A lysine (K)-specific demethylase 6A -0.053512
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.053105
OGA O-GlcNAcase -0.0521417
PTMA prothymosin, alpha -0.0517205
NEK7 NIMA-related kinase 7 -0.0515523
RPS24 ribosomal protein S24 -0.0504967
GCLC glutamate-cysteine ligase, catalytic subunit -0.0492303
RNF149 ring finger protein 149 -0.0491473
RAB1A RAB1A, member RAS oncogene family -0.0484756
RBM39 RNA binding motif protein 39 -0.0470828
RAP1B RAP1B, member of RAS oncogene family -0.0469757
UBC ubiquitin C -0.0459173
MYO5B myosin VB -0.0454367
PLAUR plasminogen activator, urokinase receptor -0.0448462
RPL35A ribosomal protein L35a -0.0438054
S100A6 S100 calcium binding protein A6 -0.0435392
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0432847
TRA2A transformer 2 alpha homolog (Drosophila) -0.043272
SAR1A secretion associated, Ras related GTPase 1A -0.0431014
STC1 stanniocalcin 1 -0.0425859
TNIP1 TNFAIP3 interacting protein 1 -0.0421204
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0419678
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0413516
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0405701
KTN1 kinectin 1 (kinesin receptor) -0.0404981
EML4 echinoderm microtubule associated protein like 4 -0.0404006
NPEPPS aminopeptidase puromycin sensitive -0.0393041
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0390368
AKAP9 A kinase (PRKA) anchor protein 9 -0.0390358
MXD1 MAX dimerization protein 1 -0.0389644
RPS29 ribosomal protein S29 -0.0386501
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0384865
OASL 2'-5'-oligoadenylate synthetase-like -0.0376978
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0376157
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0375143
JUN jun proto-oncogene -0.0374917
MARCHF6 membrane associated ring-CH-type finger 6 -0.0367971
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0365654
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0364722
RPLP2 ribosomal protein, large, P2 -0.0364342
RNASE3 ribonuclease, RNase A family, 3 -0.036423
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.0364073
CDK6 cyclin-dependent kinase 6 -0.0362674
CXXC1 CXXC finger protein 1 -0.0360575
SNX9 sorting nexin 9 -0.0359135
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0356104
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0353784
B2M beta-2-microglobulin -0.0348994
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0348788
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0345738
KYNU kynureninase -0.0342693
REPS1 RALBP1 associated Eps domain containing 1 -0.0339058
RB1CC1 RB1-inducible coiled-coil 1 -0.0338966
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0335936
MAP1B microtubule-associated protein 1B -0.0329636
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0325774
AFF4 AF4/FMR2 family, member 4 -0.0324461
TPT1 tumor protein, translationally-controlled 1 -0.032417
MUC16 mucin 16, cell surface associated -0.03237
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0322646
GPBP1L1 GC-rich promoter binding protein 1-like 1 -0.0316052
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0313431
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0309462
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0301794
ABLIM1 actin binding LIM protein 1 -0.0301504
PICALM phosphatidylinositol binding clathrin assembly protein -0.0300017
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.029795
AFAP1 actin filament associated protein 1 -0.0295193
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0294776
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0285323