Budesonide_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Budesonide_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.212837
RAD51B RAD51 paralog B 0.164569
PDE4D phosphodiesterase 4D, cAMP-specific 0.158635
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.148067
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.117761
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.116722
EGR1 early growth response 1 0.09031
THSD4 thrombospondin, type I, domain containing 4 0.0817946
PER1 period circadian clock 1 0.0673569
ELL2 elongation factor, RNA polymerase II, 2 0.0658226
POTEF POTE ankyrin domain family, member F 0.0575654
SRRM2 serine/arginine repetitive matrix 2 0.0570997
PRRC2A proline-rich coiled-coil 2A 0.056808
H1-0 H1.0 linker histone 0.0528438
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0494508
PDE10A phosphodiesterase 10A 0.0490896
EXOC4 exocyst complex component 4 0.048906
TLN1 talin 1 0.0466986
GRAMD1B GRAM domain containing 1B 0.0443238
FLNA filamin A, alpha 0.0385407
KMT2D lysine (K)-specific methyltransferase 2D 0.0358033
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0353123
ZMYND8 zinc finger, MYND-type containing 8 0.0352011
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.035192
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0344878
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0341143
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0334391
PDIA4 protein disulfide isomerase family A, member 4 0.0325836
NCOR2 nuclear receptor corepressor 2 0.0323815
KDM4B lysine (K)-specific demethylase 4B 0.0316735
CABIN1 calcineurin binding protein 1 0.0309701
RPS20 ribosomal protein S20 0.0304415
EEF2 eukaryotic translation elongation factor 2 0.0304334
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0297897
EIF4B eukaryotic translation initiation factor 4B 0.0297006
TRIO trio Rho guanine nucleotide exchange factor 0.0296966
PTPRF protein tyrosine phosphatase, receptor type, F 0.0288734
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0286841
SEPTIN2 septin 2 0.0284834
KIAA1328 KIAA1328 0.0279525
PABPC1 poly(A) binding protein, cytoplasmic 1 0.027853
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0273338
ATXN2L ataxin 2-like 0.0273319
INTS1 integrator complex subunit 1 0.027093
BABAM2 BRISC and BRCA1 A complex member 2 0.0267395
CTIF CBP80/20-dependent translation initiation factor 0.0266142
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0262241
FOXM1 forkhead box M1 0.0255395
SMYD3 SET and MYND domain containing 3 0.0254973
ACTG1 actin gamma 1 0.0253606
INTS3 integrator complex subunit 3 0.0250472
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0250084
ATP11A ATPase, class VI, type 11A 0.0248164
ASPH aspartate beta-hydroxylase 0.0247148
TTC3 tetratricopeptide repeat domain 3 0.0242176
AKAP9 A kinase (PRKA) anchor protein 9 0.0242164
PLEC plectin 0.0241734
HSPA8 heat shock 70kDa protein 8 0.0241282
GARS1 glycyl-tRNA synthetase 1 0.0241073
PRRC2B proline-rich coiled-coil 2B 0.0238414
FOSL2 FOS-like antigen 2 0.0234908
AGRN agrin 0.023054
ADAR adenosine deaminase, RNA-specific 0.0228998
ESYT2 extended synaptotagmin-like protein 2 0.0228463
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0226286
BLTP2 bridge-like lipid transfer protein family member 2 0.0224722
PTBP1 polypyrimidine tract binding protein 1 0.0223855
SND1 staphylococcal nuclease and tudor domain containing 1 0.0222998
RPS3 ribosomal protein S3 0.0220809
ATXN1 ataxin 1 0.0218728
RPS12 ribosomal protein S12 0.0218208
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0217687
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0214866
HM13 histocompatibility (minor) 13 0.0213926
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0213411
TRAPPC9 trafficking protein particle complex 9 0.0213283
TMSB10 thymosin beta 10 0.0212641
FKBP5 FK506 binding protein 5 0.0212307
DIDO1 death inducer-obliterator 1 0.0211405
FAM13A family with sequence similarity 13, member A 0.021098
RPS17 ribosomal protein S17 0.0210179
ARID1A AT rich interactive domain 1A (SWI-like) 0.0208395
PGK1 phosphoglycerate kinase 1 0.0206952
YBX1 Y box binding protein 1 0.0206877
AGFG1 ArfGAP with FG repeats 1 0.0204818
KIF1A kinesin family member 1A 0.0203402
ZBTB25 zinc finger and BTB domain containing 25 0.0203346
PMM2 phosphomannomutase 2 0.0201933
SEC16A SEC16 homolog A (S. cerevisiae) 0.0201894
AHNAK AHNAK nucleoprotein 0.0201529
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0200239
HYOU1 hypoxia up-regulated 1 0.0199813
RNF216 ring finger protein 216 0.0196292
EP400 E1A binding protein p400 0.0193503
CCDC91 coiled-coil domain containing 91 0.0192974
MKI67 marker of proliferation Ki-67 0.0192502
COL4A5 collagen, type IV, alpha 5 0.0189166
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 0.0188078
HES7 hes family bHLH transcription factor 7 0.0187576
CAMKMT calmodulin-lysine N-methyltransferase 0.0187523

decreased expression

Symbol Name Standardized Value
TFPI2 tissue factor pathway inhibitor 2 -0.109934
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.103487
KTN1 kinectin 1 (kinesin receptor) -0.0843069
VIM vimentin -0.0823635
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0777381
PTMA prothymosin, alpha -0.0748959
TM4SF1 transmembrane 4 L six family member 1 -0.0614799
OSMR oncostatin M receptor -0.0587653
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0578039
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0556006
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0538942
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.05044
HLA-B major histocompatibility complex, class I, B -0.049621
NIPBL Nipped-B homolog (Drosophila) -0.0476262
IFI6 interferon, alpha-inducible protein 6 -0.0457016
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0452052
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0446228
VDAC1 voltage-dependent anion channel 1 -0.044385
MYL12B myosin, light chain 12B, regulatory -0.0434323
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0431872
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0431654
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0431271
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0422634
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0420953
TXNRD1 thioredoxin reductase 1 -0.0419634
RPL35A ribosomal protein L35a -0.0418737
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0417746
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0417012
RTN4 reticulon 4 -0.0416126
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0414019
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0407522
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0403414
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0401512
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0395791
CCNL1 cyclin L1 -0.0374831
SPAG9 sperm associated antigen 9 -0.036609
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0365494
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0362296
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0360219
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0358005
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.035473
RPS21 ribosomal protein S21 -0.0346
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0345974
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0343472
NAP1L1 nucleosome assembly protein 1-like 1 -0.0341277
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L -0.0332129
ARL5B ADP-ribosylation factor-like 5B -0.032976
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.032857
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0324465
RPL38 ribosomal protein L38 -0.031308
CBX3 chromobox homolog 3 -0.0310704
RPLP0 ribosomal protein, large, P0 -0.0309126
AFTPH aftiphilin -0.0304447
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.030386
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0302253
KRT18 keratin 18, type I -0.0299787
CDK17 cyclin-dependent kinase 17 -0.029732
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0296413
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0296331
RPS6 ribosomal protein S6 -0.0296281
TPI1 triosephosphate isomerase 1 -0.0295454
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0290496
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.029026
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0289788
RAB7A RAB7A, member RAS oncogene family -0.02891
ATP5F1B ATP synthase F1 subunit beta -0.0287895
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0287371
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0287164
RSF1 remodeling and spacing factor 1 -0.0285965
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0284663
TPT1 tumor protein, translationally-controlled 1 -0.0282873
UBC ubiquitin C -0.028242
MCL1 myeloid cell leukemia 1 -0.0281205
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0280028
SRPK1 SRSF protein kinase 1 -0.0273397
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0271506
STC1 stanniocalcin 1 -0.0271443
MARCHF4 membrane associated ring-CH-type finger 4 -0.0270356
CAVIN1 caveolae associated protein 1 -0.0269678
AFF3 AF4/FMR2 family, member 3 -0.0269368
GTPBP4 GTP binding protein 4 -0.0266332
NOP58 NOP58 ribonucleoprotein -0.0261593
DIAPH3 diaphanous-related formin 3 -0.0258097
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0254936
TPM4 tropomyosin 4 -0.0254704
RPS23 ribosomal protein S23 -0.0253582
TAOK1 TAO kinase 1 -0.0252298
PRRC2C proline-rich coiled-coil 2C -0.0250829
EML4 echinoderm microtubule associated protein like 4 -0.0249812
RSL1D1 ribosomal L1 domain containing 1 -0.0249624
NF1 neurofibromin 1 -0.0248557
DKC1 dyskeratosis congenita 1, dyskerin -0.0248136
TPM3 tropomyosin 3 -0.0247277
EXT1 exostosin glycosyltransferase 1 -0.0246976
IFIH1 interferon induced with helicase C domain 1 -0.0246136
LMAN1 lectin, mannose-binding, 1 -0.0244979
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0244047
NABP1 nucleic acid binding protein 1 -0.0241407
SERINC3 serine incorporator 3 -0.0241218
TAGLN2 transgelin 2 -0.0237159