Budesonide_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Budesonide_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.102151
FKBP5 FK506 binding protein 5 0.0846917
HOMER2 homer scaffolding protein 2 0.084591
LPP LIM domain containing preferred translocation partner in lipoma 0.0814755
ERRFI1 ERBB receptor feedback inhibitor 1 0.0790506
POTEF POTE ankyrin domain family, member F 0.0782023
TMSB10 thymosin beta 10 0.0767807
FLNB filamin B, beta 0.0758838
TOP1 topoisomerase (DNA) I 0.06963
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0672405
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.066164
SSBP2 single-stranded DNA binding protein 2 0.0651295
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0650858
ESYT2 extended synaptotagmin-like protein 2 0.0647786
MT2A metallothionein 2A 0.0639358
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0611848
ELL2 elongation factor, RNA polymerase II, 2 0.0569668
PLEC plectin 0.0541666
ZBTB20 zinc finger and BTB domain containing 20 0.0539799
EFNA5 ephrin-A5 0.0515418
WSB1 WD repeat and SOCS box containing 1 0.0514965
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0484202
EPS8 epidermal growth factor receptor pathway substrate 8 0.0482188
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0442198
BASP1 brain abundant, membrane attached signal protein 1 0.0437747
ACTG1 actin gamma 1 0.0436166
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0407852
SGPP2 sphingosine-1-phosphate phosphatase 2 0.0393314
JARID2 jumonji, AT rich interactive domain 2 0.0391529
FCHO2 FCH domain only 2 0.0390867
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0383677
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0373142
NIBAN2 niban apoptosis regulator 2 0.0371383
NEBL nebulette 0.0365681
PYGB phosphorylase, glycogen; brain 0.0364865
LAMB3 laminin, beta 3 0.0358965
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0357641
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0345239
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0344411
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0341843
UGP2 UDP-glucose pyrophosphorylase 2 0.034094
KRT7 keratin 7, type II 0.0335788
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0333966
COL6A1 collagen, type VI, alpha 1 0.0326908
S100A10 S100 calcium binding protein A10 0.0321745
TSC22D3 TSC22 domain family, member 3 0.0319107
EGFR epidermal growth factor receptor 0.0317462
AKAP13 A kinase (PRKA) anchor protein 13 0.0317028
SACK1A scaffolding CK1 anchoring protein A 0.0316672
ACSL1 acyl-CoA synthetase long-chain family member 1 0.0315514
KRT8 keratin 8, type II 0.0307315
YAP1 Yes-associated protein 1 0.030495
IFI27 interferon, alpha-inducible protein 27 0.0304681
SDC4 syndecan 4 0.0298977
IL6ST interleukin 6 signal transducer 0.0292695
DPP4 dipeptidyl-peptidase 4 0.0290661
BIRC3 baculoviral IAP repeat containing 3 0.0289269
CTBP2 C-terminal binding protein 2 0.0284234
NUMB numb homolog (Drosophila) 0.0282438
MACF1 microtubule-actin crosslinking factor 1 0.0277455
BCL2L1 BCL2-like 1 0.0274939
MBNL1 muscleblind-like splicing regulator 1 0.0274809
DOCK5 dedicator of cytokinesis 5 0.0272352
TFCP2L1 transcription factor CP2-like 1 0.027194
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0271187
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.026862
PTPRF protein tyrosine phosphatase, receptor type, F 0.0268562
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0263673
FLNA filamin A, alpha 0.026114
MYO10 myosin X 0.025992
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0255292
HPCAL1 hippocalcin-like 1 0.0249908
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0249263
DSPP dentin sialophosphoprotein 0.0249207
EREG epiregulin 0.0244987
KRT18 keratin 18, type I 0.0241871
TXNIP thioredoxin interacting protein 0.0240582
AHNAK2 AHNAK nucleoprotein 2 0.0240328
SRRM2 serine/arginine repetitive matrix 2 0.0239956
JUP junction plakoglobin 0.0238791
MUC1 mucin 1, cell surface associated 0.0238576
JAK1 Janus kinase 1 0.0238183
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0235344
KMT2C lysine (K)-specific methyltransferase 2C 0.023328
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0232392
RAD51B RAD51 paralog B 0.0228393
ZFAND3 zinc finger, AN1-type domain 3 0.02249
RCOR1 REST corepressor 1 0.0224682
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0222408
SRPK2 SRSF protein kinase 2 0.0220813
TNRC6B trinucleotide repeat containing 6B 0.0219989
HDLBP high density lipoprotein binding protein 0.0219272
GOLGB1 golgin B1 0.0219023
TGFBI transforming growth factor, beta-induced, 68kDa 0.0218397
LARP1 La ribonucleoprotein domain family, member 1 0.021775
ENO1 enolase 1, (alpha) 0.0217742
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0217137
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0216277
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0215463
FHIT fragile histidine triad 0.0214831

decreased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase -0.138097
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.132709
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0890546
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0841273
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0753334
HMGA1 high mobility group AT-hook 1 -0.0727488
TM4SF1 transmembrane 4 L six family member 1 -0.0608053
ALCAM activated leukocyte cell adhesion molecule -0.0599461
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0530901
FAM3C family with sequence similarity 3, member C -0.0525835
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0513258
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0473583
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0473055
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0459748
LAMC2 laminin, gamma 2 -0.0451657
S100A6 S100 calcium binding protein A6 -0.0427383
PLAU plasminogen activator, urokinase -0.041485
CAPN2 calpain 2, (m/II) large subunit -0.040899
DTNA dystrobrevin, alpha -0.0400392
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0398997
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0397892
TMSB4X thymosin beta 4, X-linked -0.039063
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0381657
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0378587
SAMD4A sterile alpha motif domain containing 4A -0.0377268
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.03756
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0369986
MYO6 myosin VI -0.0369553
FN1 fibronectin 1 -0.0350619
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.032912
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.032638
CD47 CD47 molecule -0.032295
IGFBP3 insulin-like growth factor binding protein 3 -0.0314112
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0313099
PAPOLA poly(A) polymerase alpha -0.0304175
ADAM9 ADAM metallopeptidase domain 9 -0.0301499
GRB10 growth factor receptor-bound protein 10 -0.0295976
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0295747
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0289445
RPL35A ribosomal protein L35a -0.0286156
KMT2E lysine (K)-specific methyltransferase 2E -0.0285896
CD2AP CD2-associated protein -0.0280105
SH3KBP1 SH3-domain kinase binding protein 1 -0.0278609
NPEPPS aminopeptidase puromycin sensitive -0.0277377
BHLHE40 basic helix-loop-helix family, member e40 -0.0267803
MACC1 metastasis associated in colon cancer 1 -0.0266169
PPARD peroxisome proliferator-activated receptor delta -0.0265946
LMO7 LIM domain 7 -0.0259058
TACSTD2 tumor-associated calcium signal transducer 2 -0.0258054
TFG TRK-fused gene -0.0255289
DUSP10 dual specificity phosphatase 10 -0.025475
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0252952
SCEL sciellin -0.0248323
ARRDC3 arrestin domain containing 3 -0.0239709
CD46 CD46 molecule, complement regulatory protein -0.0239453
SLMAP sarcolemma associated protein -0.0237884
CCNL1 cyclin L1 -0.0233108
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0227771
CPNE8 copine VIII -0.0226979
MYO5B myosin VB -0.0225236
CD109 CD109 molecule -0.0225107
SMC4 structural maintenance of chromosomes 4 -0.0223139
SLC38A1 solute carrier family 38, member 1 -0.0221987
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0220614
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0219712
MRPS6 mitochondrial ribosomal protein S6 -0.0219555
NCEH1 neutral cholesterol ester hydrolase 1 -0.0217966
CD44 CD44 molecule (Indian blood group) -0.0215461
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0214009
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0211982
CLIP4 CAP-GLY domain containing linker protein family, member 4 -0.0211905
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0211035
DSCAM Down syndrome cell adhesion molecule -0.0208882
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0208282
PTMA prothymosin, alpha -0.0207486
ARHGAP29 Rho GTPase activating protein 29 -0.0206615
GLS2 glutaminase 2 (liver, mitochondrial) -0.020657
EPCAM epithelial cell adhesion molecule -0.0202196
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0202122
SPAG9 sperm associated antigen 9 -0.0200954
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0197586
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0197517
CLDN4 claudin 4 -0.0196594
FAM162A family with sequence similarity 162, member A -0.0191041
ANXA5 annexin A5 -0.0189494
MXD1 MAX dimerization protein 1 -0.0188701
RLF rearranged L-myc fusion -0.0187833
UBC ubiquitin C -0.0187421
SH3RF2 SH3 domain containing ring finger 2 -0.0186806
GPBP1 GC-rich promoter binding protein 1 -0.0185393
TXNRD1 thioredoxin reductase 1 -0.01843
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0183992
ANTXR2 anthrax toxin receptor 2 -0.0183204
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0182171
MIS18BP1 MIS18 binding protein 1 -0.0180285
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0180019
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0177894
FTL ferritin, light polypeptide -0.0175534
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0174636
ANXA2 annexin A2 -0.0172248