Budesonide_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

95 genes differentially expressed following the Budesonide_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP5 insulin-like growth factor binding protein 5 0.194204
SPAG9 sperm associated antigen 9 0.183071
LDHA lactate dehydrogenase A 0.143193
PALM2AKAP2 PALM2 and AKAP2 fusion 0.138927
GPC6 glypican 6 0.110733
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.108732
FN1 fibronectin 1 0.106706
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.100751
MYO1E myosin IE 0.0873045
PGK1 phosphoglycerate kinase 1 0.0853625
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0826432
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.07979
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0776797
LIMS1 LIM and senescent cell antigen-like domains 1 0.0755282
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0739807
JMJD1C jumonji domain containing 1C 0.0724065
LMO7 LIM domain 7 0.0704849
KMT2E lysine (K)-specific methyltransferase 2E 0.0672467
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.062918
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0617018
MON2 MON2 homolog (S. cerevisiae) 0.0564589
ZFAND3 zinc finger, AN1-type domain 3 0.0562069
PDE4D phosphodiesterase 4D, cAMP-specific 0.0550846
NDRG1 N-myc downstream regulated 1 0.0503368
NPAS2 neuronal PAS domain protein 2 0.0483847
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.046444
H1-0 H1.0 linker histone 0.0447823
THSD4 thrombospondin, type I, domain containing 4 0.0421253
EPS8 epidermal growth factor receptor pathway substrate 8 0.0416777
CCNY cyclin Y 0.0405015
AHNAK AHNAK nucleoprotein 0.0396593
SBF2 SET binding factor 2 0.038173
OGA O-GlcNAcase 0.0332018
AKAP12 A kinase (PRKA) anchor protein 12 0.0311674
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0281376
PARD3 par-3 family cell polarity regulator 0.0281015
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.026373
PDLIM5 PDZ and LIM domain 5 0.0239323
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0221031
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0213058
DST dystonin 0.0205833
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0186022
MAML3 mastermind-like 3 (Drosophila) 0.0180104
ANKRD11 ankyrin repeat domain 11 0.017268
INHBA inhibin, beta A 0.0158249
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0135407
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0131386
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.01113
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0105468
CD44 CD44 molecule (Indian blood group) 0.00549434
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.00118176
SAMD4A sterile alpha motif domain containing 4A 0.0010987

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.173261
EGFR epidermal growth factor receptor -0.157942
TRIO trio Rho guanine nucleotide exchange factor -0.145937
ASPH aspartate beta-hydroxylase -0.142471
KMT2C lysine (K)-specific methyltransferase 2C -0.133601
EFNA5 ephrin-A5 -0.121635
NAMPT nicotinamide phosphoribosyltransferase -0.0935465
TMSB10 thymosin beta 10 -0.0762752
RPS3 ribosomal protein S3 -0.0732182
FAM13A family with sequence similarity 13, member A -0.0696318
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0672101
IGFBP3 insulin-like growth factor binding protein 3 -0.0659833
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0653012
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0652179
ZBTB20 zinc finger and BTB domain containing 20 -0.0627253
FNDC3B fibronectin type III domain containing 3B -0.0626248
DLC1 DLC1 Rho GTPase activating protein -0.0597215
VIM vimentin -0.0552096
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0539799
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0499833
FMNL2 formin-like 2 -0.0476135
FAT1 FAT atypical cadherin 1 -0.0462449
FLNB filamin B, beta -0.0430831
ESYT2 extended synaptotagmin-like protein 2 -0.0389632
WSB1 WD repeat and SOCS box containing 1 -0.0381439
MED13L mediator complex subunit 13-like -0.0370843
MT2A metallothionein 2A -0.0362487
NALF1 NALCN channel auxiliary factor 1 -0.034998
PTK2 protein tyrosine kinase 2 -0.0315688
VMP1 vacuole membrane protein 1 -0.0306912
HLA-B major histocompatibility complex, class I, B -0.0256774
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0251373
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0247511
CDH13 cadherin 13 -0.0235122
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0227228
AKAP13 A kinase (PRKA) anchor protein 13 -0.021812
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0209397
MYOF myoferlin -0.0179765
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.013249
PTMA prothymosin, alpha -0.0132426
PSD3 pleckstrin and Sec7 domain containing 3 -0.00531009
COL6A3 collagen, type VI, alpha 3 -0.00168334
COL6A1 collagen, type VI, alpha 1 -2.94748E-4