Budesonide_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Budesonide_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.102865
TMSB10 thymosin beta 10 0.09265
ZNF292 zinc finger protein 292 0.0752512
H1-0 H1.0 linker histone 0.0633229
GPC3 glypican 3 0.05493
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0540356
PCLO piccolo presynaptic cytomatrix protein 0.0534979
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0522517
RPL11 ribosomal protein L11 0.0520337
PDGFC platelet derived growth factor C 0.051585
SRRM2 serine/arginine repetitive matrix 2 0.0415324
GARS1 glycyl-tRNA synthetase 1 0.0414816
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0413083
AHNAK AHNAK nucleoprotein 0.040636
DMD dystrophin 0.0402901
CENPF centromere protein F, 350/400kDa 0.0401328
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0397925
FKBP5 FK506 binding protein 5 0.03906
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0378915
ENAH enabled homolog (Drosophila) 0.0378351
UTRN utrophin 0.0365487
ARHGAP15 Rho GTPase activating protein 15 0.0342278
FXR1 fragile X mental retardation, autosomal homolog 1 0.0326275
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0322588
PDS5A PDS5 cohesin associated factor A 0.0322012
ANLN anillin, actin binding protein 0.0319448
CXADR coxsackie virus and adenovirus receptor 0.0318511
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0317152
AKAP13 A kinase (PRKA) anchor protein 13 0.0315517
KDM3A lysine (K)-specific demethylase 3A 0.0311857
TRAPPC9 trafficking protein particle complex 9 0.031142
NSD3 nuclear receptor binding SET domain protein 3 0.0304172
FOXO1 forkhead box O1 0.0302401
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0301967
CKAP5 cytoskeleton associated protein 5 0.0300019
FLNB filamin B, beta 0.0299042
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0298135
FLNA filamin A, alpha 0.0297782
PROS1 protein S (alpha) 0.029522
RAD21 RAD21 homolog (S. pombe) 0.0294472
EIF1 eukaryotic translation initiation factor 1 0.0287414
RPL37A ribosomal protein L37a 0.0284186
NPAS3 neuronal PAS domain protein 3 0.0279462
PHF3 PHD finger protein 3 0.0277734
H1-4 H1.4 linker histone, cluster member 0.0275003
VIM vimentin 0.0272763
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0271092
CSDE1 cold shock domain containing E1, RNA-binding 0.0270408
AHCTF1 AT hook containing transcription factor 1 0.0270212
CENPE centromere protein E, 312kDa 0.0267305
STMN1 stathmin 1 0.0265834
TRPS1 trichorhinophalangeal syndrome I 0.0265461
NEK7 NIMA-related kinase 7 0.0264124
IGF1R insulin-like growth factor 1 receptor 0.0264108
ADGRV1 adhesion G protein-coupled receptor V1 0.0262486
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0262073
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0259777
ZFAND6 zinc finger, AN1-type domain 6 0.0256016
RFPL4B ret finger protein-like 4B 0.0255638
TOX thymocyte selection-associated high mobility group box 0.0254184
GAB2 GRB2-associated binding protein 2 0.0253763
FIGN fidgetin 0.0251838
ZMYND8 zinc finger, MYND-type containing 8 0.0250996
PRPF8 pre-mRNA processing factor 8 0.0249067
RPS16 ribosomal protein S16 0.0248835
IGF2R insulin-like growth factor 2 receptor 0.0247997
KAT6A K(lysine) acetyltransferase 6A 0.0243349
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0242334
MAP7D1 MAP7 domain containing 1 0.0241724
NAMPT nicotinamide phosphoribosyltransferase 0.0241271
PBX3 pre-B-cell leukemia homeobox 3 0.0240359
VCL vinculin 0.0240265
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0238944
RTN4 reticulon 4 0.0238875
METAP2 methionyl aminopeptidase 2 0.0238179
PAWR PRKC, apoptosis, WT1, regulator 0.0238123
FOXG1 forkhead box G1 0.0236276
FBXL17 F-box and leucine-rich repeat protein 17 0.0235143
RYBP RING1 and YY1 binding protein 0.0232506
SERF2 small EDRK-rich factor 2 0.0230881
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0230623
PYGB phosphorylase, glycogen; brain 0.0229819
PAPOLA poly(A) polymerase alpha 0.0229689
HNRNPL heterogeneous nuclear ribonucleoprotein L 0.0223389
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.022269
STX16 syntaxin 16 0.022268
ZFAND3 zinc finger, AN1-type domain 3 0.0221714
PTBP1 polypyrimidine tract binding protein 1 0.0218951
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0217452
BPTF bromodomain PHD finger transcription factor 0.0216466
HES7 hes family bHLH transcription factor 7 0.0216417
UBAP2L ubiquitin associated protein 2-like 0.0214757
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0214158
CABLES1 Cdk5 and Abl enzyme substrate 1 0.0214147
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.021371
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.021332
RPL23 ribosomal protein L23 0.0213039
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 0.0212411
PNRC1 proline-rich nuclear receptor coactivator 1 0.0212062
MAP2K4 mitogen-activated protein kinase kinase 4 0.0212053

decreased expression

Symbol Name Standardized Value
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.130194
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.119534
COL11A1 collagen, type XI, alpha 1 -0.116917
ITGAV integrin, alpha V -0.0838018
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0695643
EMP1 epithelial membrane protein 1 -0.0645131
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.062147
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0601509
SLIT2 slit homolog 2 (Drosophila) -0.0562985
THBS1 thrombospondin 1 -0.0550103
COL3A1 collagen, type III, alpha 1 -0.0545518
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0531373
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0526638
TMSB4X thymosin beta 4, X-linked -0.0524708
BMPR1A bone morphogenetic protein receptor, type IA -0.0518509
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0507075
SPAG9 sperm associated antigen 9 -0.050567
BRWD1 bromodomain and WD repeat domain containing 1 -0.0498848
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0492342
ATP5F1B ATP synthase F1 subunit beta -0.048297
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0469281
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0463153
PGAP1 post-GPI attachment to proteins 1 -0.0457455
MRPS30 mitochondrial ribosomal protein S30 -0.0443852
COL1A2 collagen, type I, alpha 2 -0.0441888
SERBP1 SERPINE1 mRNA binding protein 1 -0.0438556
RPLP0 ribosomal protein, large, P0 -0.0427091
STAG2 stromal antigen 2 -0.0425688
PEG10 paternally expressed 10 -0.0425601
RERE arginine-glutamic acid dipeptide (RE) repeats -0.042463
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0422591
DSCAM Down syndrome cell adhesion molecule -0.0416664
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0403934
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0390816
SOX2 SRY (sex determining region Y)-box 2 -0.0390582
NOP58 NOP58 ribonucleoprotein -0.0388247
ZC3H15 zinc finger CCCH-type containing 15 -0.0381515
PCDH9 protocadherin 9 -0.0380396
ENO1 enolase 1, (alpha) -0.0377008
NF1 neurofibromin 1 -0.0376929
ATXN2 ataxin 2 -0.037311
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0371484
NFIA nuclear factor I/A -0.0370224
RPLP1 ribosomal protein, large, P1 -0.0367354
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0363191
NCAM2 neural cell adhesion molecule 2 -0.0360321
USP53 ubiquitin specific peptidase 53 -0.0359557
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.035602
OLA1 Obg-like ATPase 1 -0.0347908
COL5A2 collagen, type V, alpha 2 -0.034498
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0342595
ZNF217 zinc finger protein 217 -0.0333859
RPS19 ribosomal protein S19 -0.0332015
THRAP3 thyroid hormone receptor associated protein 3 -0.0323446
JMJD1C jumonji domain containing 1C -0.0317172
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.031467
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -0.0314044
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0312605
ANXA1 annexin A1 -0.0312161
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0311904
BIRC6 baculoviral IAP repeat containing 6 -0.0309884
WSB1 WD repeat and SOCS box containing 1 -0.0309427
CLIC4 chloride intracellular channel 4 -0.0308755
RAB10 RAB10, member RAS oncogene family -0.0308591
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0307491
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0305159
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0304723
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0304114
TNPO3 transportin 3 -0.0302947
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0299582
HMGB2 high mobility group box 2 -0.0297248
FOXP2 forkhead box P2 -0.0297172
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0295469
UBE2H ubiquitin-conjugating enzyme E2H -0.0294249
ANKRD33B ankyrin repeat domain 33B -0.0292529
WNK1 WNK lysine deficient protein kinase 1 -0.0292377
MTF2 metal response element binding transcription factor 2 -0.0290007
NAP1L1 nucleosome assembly protein 1-like 1 -0.028822
HDAC9 histone deacetylase 9 -0.0286577
MARCHF6 membrane associated ring-CH-type finger 6 -0.0283992
MAST2 microtubule associated serine/threonine kinase 2 -0.028023
RAB30 RAB30, member RAS oncogene family -0.0276612
HMGA2 high mobility group AT-hook 2 -0.0275253
CHD1 chromodomain helicase DNA binding protein 1 -0.0275024
LRRC4C leucine rich repeat containing 4C -0.0274838
RPS8 ribosomal protein S8 -0.0274644
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0271834
PTBP2 polypyrimidine tract binding protein 2 -0.0270502
XPO1 exportin 1 -0.0269305
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0268881
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0268651
TRIO trio Rho guanine nucleotide exchange factor -0.0267368
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0266961
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0265831
SENP6 SUMO1/sentrin specific peptidase 6 -0.0265778
CALU calumenin -0.0265773
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.0265242
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0261649
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0260723
PICALM phosphatidylinositol binding clathrin assembly protein -0.0259458