Budesonide_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Budesonide_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.289598
AKAP12 A kinase (PRKA) anchor protein 12 0.266722
FKBP5 FK506 binding protein 5 0.111537
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.107779
ERRFI1 ERBB receptor feedback inhibitor 1 0.103084
ZMYND8 zinc finger, MYND-type containing 8 0.0884403
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0865593
LDHA lactate dehydrogenase A 0.0676061
FTH1 ferritin, heavy polypeptide 1 0.062857
MT2A metallothionein 2A 0.0616016
PCBP3 poly(rC) binding protein 3 0.0598934
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0552014
BICC1 BicC family RNA binding protein 1 0.0501074
FLNB filamin B, beta 0.0470423
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.045923
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.045827
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0420386
ACSL1 acyl-CoA synthetase long-chain family member 1 0.0417561
SDC4 syndecan 4 0.0417487
LOX lysyl oxidase 0.041681
NAMPT nicotinamide phosphoribosyltransferase 0.0405941
CLMP CXADR-like membrane protein 0.0398297
TOP1 topoisomerase (DNA) I 0.0397397
SOD2 superoxide dismutase 2, mitochondrial 0.039572
FNDC3B fibronectin type III domain containing 3B 0.0382071
VCL vinculin 0.0381032
MT1X metallothionein 1X 0.0377549
HIPK2 homeodomain interacting protein kinase 2 0.0365698
PLIN2 perilipin 2 0.0349881
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0338423
IL6ST interleukin 6 signal transducer 0.0334247
TSC22D3 TSC22 domain family, member 3 0.032171
ABLIM3 actin binding LIM protein family, member 3 0.0318933
RBMS3 RNA binding motif, single stranded interacting protein 3 0.031876
SDK1 sidekick cell adhesion molecule 1 0.0317843
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0313103
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0310274
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0307748
HOMER2 homer scaffolding protein 2 0.0303343
SLC38A2 solute carrier family 38, member 2 0.029925
HMGA2 high mobility group AT-hook 2 0.0295081
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0286346
NDRG1 N-myc downstream regulated 1 0.0286022
AGTPBP1 ATP/GTP binding protein 1 0.0280996
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0280744
TNS3 tensin 3 0.0269397
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0268997
JAK2 Janus kinase 2 0.0268209
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0263715
SAA2 serum amyloid A2 0.0262038
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0255201
SORBS2 sorbin and SH3 domain containing 2 0.0252141
OSBPL8 oxysterol binding protein-like 8 0.0248213
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0247977
FOXO3 forkhead box O3 0.024741
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0242373
LAMB1 laminin, beta 1 0.0239805
BCL6 B-cell CLL/lymphoma 6 0.0239086
PRKN parkin RBR E3 ubiquitin protein ligase 0.0238273
ZSWIM6 zinc finger, SWIM-type containing 6 0.0235824
ELL2 elongation factor, RNA polymerase II, 2 0.0233988
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0233343
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0230891
RUNX2 runt-related transcription factor 2 0.0229878
JPH2 junctophilin 2 0.0229166
FLNA filamin A, alpha 0.0228409
TMSB10 thymosin beta 10 0.022781
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0227581
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0226433
DNER delta/notch-like EGF repeat containing 0.0222059
SSBP2 single-stranded DNA binding protein 2 0.0219186
ANGPTL4 angiopoietin-like 4 0.0218652
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0218263
EPAS1 endothelial PAS domain protein 1 0.0217519
EGR1 early growth response 1 0.0216636
TRAM2 translocation associated membrane protein 2 0.0216411
STOM stomatin 0.0216151
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0215904
ZBTB38 zinc finger and BTB domain containing 38 0.021238
FBXO32 F-box protein 32 0.0212301
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0211998
STXBP5 syntaxin binding protein 5 (tomosyn) 0.021137
AHNAK AHNAK nucleoprotein 0.0209093
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0208489
ZNF608 zinc finger protein 608 0.0207465
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0204371
GPC6 glypican 6 0.0202942
VMP1 vacuole membrane protein 1 0.0202101
MYO1E myosin IE 0.0201987
CUL4B cullin 4B 0.0197994
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0195938
NNMT nicotinamide N-methyltransferase 0.0195511
BCL2L1 BCL2-like 1 0.0195087
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0193942
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0191399
MBNL1 muscleblind-like splicing regulator 1 0.0190621
MCL1 myeloid cell leukemia 1 0.0190207
NIBAN2 niban apoptosis regulator 2 0.0190064
ZFP36L1 ZFP36 ring finger protein-like 1 0.0187913
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0187332

decreased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A -0.113413
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0848909
CADM1 cell adhesion molecule 1 -0.0705287
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0635761
EXT1 exostosin glycosyltransferase 1 -0.0597215
CD44 CD44 molecule (Indian blood group) -0.0547779
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0502885
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.049078
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0487206
SMAD3 SMAD family member 3 -0.0461255
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0459797
VCAN versican -0.0446988
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0440806
IGFBP3 insulin-like growth factor binding protein 3 -0.0432833
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0417197
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0413449
PDE10A phosphodiesterase 10A -0.0406852
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0406594
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0395165
IER3 immediate early response 3 -0.036995
UGCG UDP-glucose ceramide glucosyltransferase -0.0360114
THBS1 thrombospondin 1 -0.0352853
DST dystonin -0.0332356
ATP13A3 ATPase type 13A3 -0.0328133
CANX calnexin -0.0327082
PTMA prothymosin, alpha -0.031585
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0306713
RPS6 ribosomal protein S6 -0.0305599
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0301069
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0291263
DLG1 discs, large homolog 1 (Drosophila) -0.0289996
FRMD5 FERM domain containing 5 -0.0286066
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0270078
GOLGA4 golgin A4 -0.0270036
TRIO trio Rho guanine nucleotide exchange factor -0.0268263
ANXA2 annexin A2 -0.0266204
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0257307
COL6A3 collagen, type VI, alpha 3 -0.0255984
QKI QKI, KH domain containing, RNA binding -0.024152
ZNF292 zinc finger protein 292 -0.0239327
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0234497
ARRDC3 arrestin domain containing 3 -0.0230307
HELZ helicase with zinc finger -0.0228539
TKT transketolase -0.0226436
MXI1 MAX interactor 1, dimerization protein -0.0218056
SYNJ2 synaptojanin 2 -0.0217192
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0217188
SFRP1 secreted frizzled-related protein 1 -0.021695
TMEM123 transmembrane protein 123 -0.0213837
RAI14 retinoic acid induced 14 -0.0209943
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0203189
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0202788
LRRC7 leucine rich repeat containing 7 -0.0201562
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0199713
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0198925
TENT5A terminal nucleotidyltransferase 5A -0.019788
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0196422
TPM1 tropomyosin 1 (alpha) -0.0196298
KDM3A lysine (K)-specific demethylase 3A -0.0191737
TFG TRK-fused gene -0.0191723
MORF4L2 mortality factor 4 like 2 -0.0190927
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0189702
PGK1 phosphoglycerate kinase 1 -0.0189263
ICAM1 intercellular adhesion molecule 1 -0.0187395
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0187123
PDIA3 protein disulfide isomerase family A, member 3 -0.0186815
RLF rearranged L-myc fusion -0.0184295
CALR calreticulin -0.0182189
KMT2E lysine (K)-specific methyltransferase 2E -0.0180175
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0178723
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0178203
AFDN afadin, adherens junction formation factor -0.0175746
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0174546
TMSB4X thymosin beta 4, X-linked -0.0174338
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.017327
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.017246
SNX9 sorting nexin 9 -0.0172386
TUBB tubulin, beta class I -0.0170737
DEK DEK proto-oncogene -0.0170587
B2M beta-2-microglobulin -0.0170318
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0169508
ARL5B ADP-ribosylation factor-like 5B -0.016879
NCOA7 nuclear receptor coactivator 7 -0.0167549
NAP1L1 nucleosome assembly protein 1-like 1 -0.0166046
RNF145 ring finger protein 145 -0.016595
PPARD peroxisome proliferator-activated receptor delta -0.0165841
TXNRD1 thioredoxin reductase 1 -0.0165128
BHLHE40 basic helix-loop-helix family, member e40 -0.0164859
WDR45B WD repeat domain 45B -0.0164769
FRMPD4 FERM and PDZ domain containing 4 -0.0160781
RICTOR RPTOR independent companion of MTOR, complex 2 -0.016072
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0159642
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0159337
CDH13 cadherin 13 -0.0159335
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0158942
LAMP2 lysosomal-associated membrane protein 2 -0.0157829
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0157395
RPLP0 ribosomal protein, large, P0 -0.015718
YBX1 Y box binding protein 1 -0.0156576
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0155605