Budesonide_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Budesonide_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.154705
MT2A metallothionein 2A 0.136589
HIP1 huntingtin interacting protein 1 0.1207
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.110075
MT1X metallothionein 1X 0.100588
COL6A3 collagen, type VI, alpha 3 0.0858911
HIPK2 homeodomain interacting protein kinase 2 0.0854951
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0751015
GLUL glutamate-ammonia ligase 0.0657093
TGFBI transforming growth factor, beta-induced, 68kDa 0.0598991
TSC22D3 TSC22 domain family, member 3 0.0594463
NAV2 neuron navigator 2 0.0566338
FTH1 ferritin, heavy polypeptide 1 0.0557799
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.052405
FAM13A family with sequence similarity 13, member A 0.0503813
NCOA3 nuclear receptor coactivator 3 0.0492144
TOP1 topoisomerase (DNA) I 0.0487741
PDZD2 PDZ domain containing 2 0.0470638
ZMYND8 zinc finger, MYND-type containing 8 0.0467018
FKBP5 FK506 binding protein 5 0.046281
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0461459
AHNAK AHNAK nucleoprotein 0.0459352
LAMB1 laminin, beta 1 0.0440191
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.042672
TPST1 tyrosylprotein sulfotransferase 1 0.0426514
PID1 phosphotyrosine interaction domain containing 1 0.041417
SSBP2 single-stranded DNA binding protein 2 0.0389949
SND1 staphylococcal nuclease and tudor domain containing 1 0.0372882
SH3RF3 SH3 domain containing ring finger 3 0.0357568
TXNIP thioredoxin interacting protein 0.0357336
JPH2 junctophilin 2 0.0355929
TRA2A transformer 2 alpha homolog (Drosophila) 0.0351507
PRELID2 PRELI domain containing 2 0.0343809
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0339978
MT1E metallothionein 1E 0.0338869
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0315859
FLNA filamin A, alpha 0.031514
ABLIM3 actin binding LIM protein family, member 3 0.0310037
AVL9 AVL9 homolog (S. cerevisiase) 0.0307721
FOXO1 forkhead box O1 0.0297726
SH3BP4 SH3-domain binding protein 4 0.0289132
LDHA lactate dehydrogenase A 0.0284481
TRAM2 translocation associated membrane protein 2 0.027561
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.027468
FAM20C family with sequence similarity 20, member C 0.0272065
EGFR epidermal growth factor receptor 0.0269609
LOX lysyl oxidase 0.0269445
SOD2 superoxide dismutase 2, mitochondrial 0.0266502
ANLN anillin, actin binding protein 0.0262479
PCNX1 pecanex 1 0.0258836
ESYT2 extended synaptotagmin-like protein 2 0.0258313
AKAP13 A kinase (PRKA) anchor protein 13 0.0258132
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0258044
MYO1E myosin IE 0.025537
JARID2 jumonji, AT rich interactive domain 2 0.024715
GLRX glutaredoxin (thioltransferase) 0.0242711
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0238557
PALLD palladin, cytoskeletal associated protein 0.0235524
NRXN3 neurexin 3 0.0235385
USP47 ubiquitin specific peptidase 47 0.0229342
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0223495
DDIT4 DNA-damage-inducible transcript 4 0.0223193
IL1R1 interleukin 1 receptor, type I 0.0221895
AKAP12 A kinase (PRKA) anchor protein 12 0.0221418
NAMPT nicotinamide phosphoribosyltransferase 0.0220859
SDC4 syndecan 4 0.0217804
FOXO3 forkhead box O3 0.0217331
ACSL1 acyl-CoA synthetase long-chain family member 1 0.0216087
DUSP12 dual specificity phosphatase 12 0.0208984
TENT2 terminal nucleotidyltransferase 2 0.0207414
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0203818
PER1 period circadian clock 1 0.0196797
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.019518
TNS3 tensin 3 0.0193347
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0192874
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 0.0192248
IL6ST interleukin 6 signal transducer 0.0191474
KDM4B lysine (K)-specific demethylase 4B 0.0190718
SCLT1 sodium channel and clathrin linker 1 0.0189746
AFF4 AF4/FMR2 family, member 4 0.0189515
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0185573
YEATS2 YEATS domain containing 2 0.0185566
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.0182312
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0181593
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.0180258
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.01794
RLIM ring finger protein, LIM domain interacting 0.0178625
RUNX1 runt-related transcription factor 1 0.0178617
AKAP9 A kinase (PRKA) anchor protein 9 0.0178261
APOLD1 apolipoprotein L domain containing 1 0.0177021
DGKG diacylglycerol kinase, gamma 90kDa 0.0173105
EMP1 epithelial membrane protein 1 0.0172544
CSNK1A1 casein kinase 1, alpha 1 0.0172267
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0170689
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0170376
ZBTB16 zinc finger and BTB domain containing 16 0.0169492
BIRC3 baculoviral IAP repeat containing 3 0.0169364
SETD5 SET domain containing 5 0.0169347
FBXO32 F-box protein 32 0.0168486
RHOBTB3 Rho-related BTB domain containing 3 0.0168238

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.331735
CXCL8 chemokine (C-X-C motif) ligand 8 -0.105054
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.103087
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.100317
COL1A1 collagen, type I, alpha 1 -0.090894
B2M beta-2-microglobulin -0.0849657
VIM vimentin -0.0848041
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0839572
TIMP3 TIMP metallopeptidase inhibitor 3 -0.077149
HLA-B major histocompatibility complex, class I, B -0.0720062
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0690394
CDH13 cadherin 13 -0.0678709
COL1A2 collagen, type I, alpha 2 -0.0674921
EXT1 exostosin glycosyltransferase 1 -0.0663809
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.063454
PSD3 pleckstrin and Sec7 domain containing 3 -0.0578826
CANX calnexin -0.0542885
IL6 interleukin 6 -0.0537765
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0525656
CD44 CD44 molecule (Indian blood group) -0.0515659
COL6A1 collagen, type VI, alpha 1 -0.0504996
TRIO trio Rho guanine nucleotide exchange factor -0.0491164
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0481359
TMSB10 thymosin beta 10 -0.0473752
IGFBP7 insulin-like growth factor binding protein 7 -0.0454796
MAP1B microtubule-associated protein 1B -0.0430129
GLIS3 GLIS family zinc finger 3 -0.04225
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.042007
CDK6 cyclin-dependent kinase 6 -0.0411492
PRSS23 protease, serine, 23 -0.0389994
STC1 stanniocalcin 1 -0.0382383
CALU calumenin -0.0381563
F3 coagulation factor III (thromboplastin, tissue factor) -0.0376951
POTEF POTE ankyrin domain family, member F -0.0374066
MEF2A myocyte enhancer factor 2A -0.0367229
PTMA prothymosin, alpha -0.0361283
PDIA3 protein disulfide isomerase family A, member 3 -0.0352006
FTL ferritin, light polypeptide -0.0327561
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0315608
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0302531
PDIA6 protein disulfide isomerase family A, member 6 -0.0298822
HLA-C major histocompatibility complex, class I, C -0.0297761
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0296522
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0296157
VEGFC vascular endothelial growth factor C -0.0290118
TPM1 tropomyosin 1 (alpha) -0.028316
CALR calreticulin -0.0277601
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0277253
EGR1 early growth response 1 -0.0277248
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0273569
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0271045
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0266526
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0261257
DST dystonin -0.0261012
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0260537
CADM1 cell adhesion molecule 1 -0.0259288
ENO1 enolase 1, (alpha) -0.0257602
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0255357
HLA-A major histocompatibility complex, class I, A -0.0254423
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0252541
ATXN1 ataxin 1 -0.0250541
PTN pleiotrophin -0.0249503
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0249122
S100A10 S100 calcium binding protein A10 -0.024869
RAI14 retinoic acid induced 14 -0.024701
DLG1 discs, large homolog 1 (Drosophila) -0.0246553
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0237844
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0231949
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0230426
TUBA1B tubulin, alpha 1b -0.0227068
S100A6 S100 calcium binding protein A6 -0.0226714
GNAS GNAS complex locus -0.0224584
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0222689
JMJD1C jumonji domain containing 1C -0.0222232
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0221958
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0216734
FRMD4A FERM domain containing 4A -0.0215821
CTSB cathepsin B -0.0213139
VDAC1 voltage-dependent anion channel 1 -0.0211184
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0210795
NRP1 neuropilin 1 -0.0208519
AFF3 AF4/FMR2 family, member 3 -0.0208223
RPS6 ribosomal protein S6 -0.0207583
PRKCA protein kinase C, alpha -0.0206671
TPM4 tropomyosin 4 -0.0204903
NALF1 NALCN channel auxiliary factor 1 -0.020451
PKM pyruvate kinase, muscle -0.0204483
COL6A2 collagen, type VI, alpha 2 -0.0204
ZFAND3 zinc finger, AN1-type domain 3 -0.0203954
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0203458
SEPTIN7 septin 7 -0.0202979
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.020247
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0201026
DPYD dihydropyrimidine dehydrogenase -0.0199132
TENT5A terminal nucleotidyltransferase 5A -0.0197981
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.019666
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0196445
IGF1R insulin-like growth factor 1 receptor -0.0196399
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.019394
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0193175