Budesonide_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Budesonide_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZMYND8 zinc finger, MYND-type containing 8 0.124993
TMSB10 thymosin beta 10 0.114441
BIRC3 baculoviral IAP repeat containing 3 0.101363
ANKRD28 ankyrin repeat domain 28 0.090875
SMYD3 SET and MYND domain containing 3 0.0883627
FKBP5 FK506 binding protein 5 0.0784205
ESYT2 extended synaptotagmin-like protein 2 0.0756777
ZBTB38 zinc finger and BTB domain containing 38 0.072633
AKAP12 A kinase (PRKA) anchor protein 12 0.0609332
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0533085
POTEF POTE ankyrin domain family, member F 0.0497297
EFNA5 ephrin-A5 0.049147
ZFHX3 zinc finger homeobox 3 0.0446101
PER1 period circadian clock 1 0.0445559
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0442658
TXNIP thioredoxin interacting protein 0.0434311
CKAP5 cytoskeleton associated protein 5 0.0430012
YAP1 Yes-associated protein 1 0.0427181
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) 0.0425782
WAC WW domain containing adaptor with coiled-coil 0.0419409
TMEM245 transmembrane protein 245 0.0407546
MBNL1 muscleblind-like splicing regulator 1 0.0393921
ECT2 epithelial cell transforming 2 0.0381591
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0381582
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0375264
ITCH itchy E3 ubiquitin protein ligase 0.0368336
TOP1 topoisomerase (DNA) I 0.0365768
RPL23 ribosomal protein L23 0.0363321
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0358455
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0350884
RBM39 RNA binding motif protein 39 0.0346953
CLASP1 cytoplasmic linker associated protein 1 0.0346721
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0346542
ERRFI1 ERBB receptor feedback inhibitor 1 0.0343277
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0327667
DIAPH3 diaphanous-related formin 3 0.0326567
HOMER2 homer scaffolding protein 2 0.0325235
TNPO1 transportin 1 0.0315881
LAMB1 laminin, beta 1 0.0315568
GATAD2B GATA zinc finger domain containing 2B 0.0315049
ZBTB16 zinc finger and BTB domain containing 16 0.0310113
H1-0 H1.0 linker histone 0.0308655
NCOA6 nuclear receptor coactivator 6 0.0307321
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0305858
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0304844
USP22 ubiquitin specific peptidase 22 0.0303177
EP400 E1A binding protein p400 0.0301082
TBC1D5 TBC1 domain family, member 5 0.029706
PTPRG protein tyrosine phosphatase, receptor type, G 0.0291446
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0291383
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0290159
UBAC2 UBA domain containing 2 0.0287905
RBM33 RNA binding motif protein 33 0.0287666
NUP214 nucleoporin 214kDa 0.0287271
ZNF670 zinc finger protein 670 0.0286723
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 0.0286049
MKI67 marker of proliferation Ki-67 0.0285194
AKAP13 A kinase (PRKA) anchor protein 13 0.0284863
NCOR1 nuclear receptor corepressor 1 0.0281208
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0280627
TPI1 triosephosphate isomerase 1 0.0276762
IQGAP1 IQ motif containing GTPase activating protein 1 0.0275636
NCKAP1 NCK-associated protein 1 0.0273446
OGA O-GlcNAcase 0.0271663
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0270113
SKIC3 SKI3 subunit of superkiller complex 0.0269292
R3HDM1 R3H domain containing 1 0.0268686
KIAA1958 KIAA1958 0.0266736
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0264773
FANCI Fanconi anemia, complementation group I 0.0264722
PRPF8 pre-mRNA processing factor 8 0.0262394
CD59 CD59 molecule, complement regulatory protein 0.0261923
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0259968
SETD5 SET domain containing 5 0.0259211
PHF21A PHD finger protein 21A 0.025846
CEP250 centrosomal protein 250kDa 0.0258397
GSK3B glycogen synthase kinase 3 beta 0.0257302
XPO6 exportin 6 0.0257158
CRTAP cartilage associated protein 0.0255948
NAP1L1 nucleosome assembly protein 1-like 1 0.0253264
USP34 ubiquitin specific peptidase 34 0.0252319
FBXL17 F-box and leucine-rich repeat protein 17 0.0252114
ARID1A AT rich interactive domain 1A (SWI-like) 0.0250643
FNDC3B fibronectin type III domain containing 3B 0.0248855
MYOF myoferlin 0.0246551
TLK1 tousled-like kinase 1 0.0246115
DPYD dihydropyrimidine dehydrogenase 0.0245888
SEPTIN2 septin 2 0.0245795
ATXN2L ataxin 2-like 0.0245573
CNOT4 CCR4-NOT transcription complex, subunit 4 0.024471
AGTPBP1 ATP/GTP binding protein 1 0.024424
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0242674
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0242328
RPL32 ribosomal protein L32 0.0241106
FMNL2 formin-like 2 0.0240771
COG5 component of oligomeric golgi complex 5 0.0240578
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0240191
KLF9 Kruppel-like factor 9 0.0239094
WDR36 WD repeat domain 36 0.0236668
XRN2 5'-3' exoribonuclease 2 0.0234918

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.190118
IGFBP3 insulin-like growth factor binding protein 3 -0.174438
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.129791
RIGI RNA sensor RIG-I -0.0796974
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.078712
INTS6 integrator complex subunit 6 -0.0762072
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0704464
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0698392
HMGA2 high mobility group AT-hook 2 -0.0689789
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0689405
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0656806
ATXN1 ataxin 1 -0.0655139
TPT1 tumor protein, translationally-controlled 1 -0.0654503
MACF1 microtubule-actin crosslinking factor 1 -0.0609302
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0607179
CD44 CD44 molecule (Indian blood group) -0.0606507
PTMA prothymosin, alpha -0.0535993
ASPH aspartate beta-hydroxylase -0.0520938
NT5E 5'-nucleotidase, ecto (CD73) -0.051891
SDC4 syndecan 4 -0.0514522
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0500498
PBX3 pre-B-cell leukemia homeobox 3 -0.0499811
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0490799
SQSTM1 sequestosome 1 -0.0488536
IGF2 insulin-like growth factor 2 -0.0482249
NDRG1 N-myc downstream regulated 1 -0.0477908
NAV2 neuron navigator 2 -0.0466689
SVIL supervillin -0.045654
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0445271
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0437899
PCED1B PC-esterase domain containing 1B -0.0413298
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0412627
SLC38A2 solute carrier family 38, member 2 -0.0403684
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0397184
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0396055
ACTN1 actinin, alpha 1 -0.0390854
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0381023
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0379554
COL5A1 collagen, type V, alpha 1 -0.0375522
DST dystonin -0.0373546
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0373176
PYGL phosphorylase, glycogen, liver -0.0371631
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0370891
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.036662
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0364965
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0363959
HLA-C major histocompatibility complex, class I, C -0.0348904
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.034851
ANO6 anoctamin 6 -0.0348062
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0339992
FER fer (fps/fes related) tyrosine kinase -0.0335487
BHLHE40 basic helix-loop-helix family, member e40 -0.0332889
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0332613
DTNA dystrobrevin, alpha -0.0330405
ATG7 autophagy related 7 -0.0323462
RTN3 reticulon 3 -0.0319901
FLNB filamin B, beta -0.0316
CAVIN1 caveolae associated protein 1 -0.0314823
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0314819
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0313506
VIM vimentin -0.0308724
SPATS2L spermatogenesis associated, serine-rich 2-like -0.03084
BTG1 B-cell translocation gene 1, anti-proliferative -0.0303314
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0302806
GNAS GNAS complex locus -0.0302777
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0301908
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0300376
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0297518
BICD1 bicaudal D homolog 1 (Drosophila) -0.0296357
SH3KBP1 SH3-domain kinase binding protein 1 -0.0295671
EIF1 eukaryotic translation initiation factor 1 -0.0294728
EGR1 early growth response 1 -0.0294487
KTN1 kinectin 1 (kinesin receptor) -0.0294202
FN1 fibronectin 1 -0.0286099
TPM4 tropomyosin 4 -0.0284286
GLS2 glutaminase 2 (liver, mitochondrial) -0.027954
HDAC9 histone deacetylase 9 -0.0279495
PCNX4 pecanex 4 -0.0279246
IER3 immediate early response 3 -0.0274266
S100A10 S100 calcium binding protein A10 -0.0273465
ZEB1 zinc finger E-box binding homeobox 1 -0.0268654
AK1 adenylate kinase 1 -0.0267982
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0267957
RAD51B RAD51 paralog B -0.0267575
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0265904
COPB1 coatomer protein complex, subunit beta 1 -0.0265623
GPC5 glypican 5 -0.0264861
FNDC3A fibronectin type III domain containing 3A -0.0263686
AHR aryl hydrocarbon receptor -0.0260463
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0259888
PRR16 proline rich 16 -0.0259284
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0258927
ATM ATM serine/threonine kinase -0.0258312
FOXO3 forkhead box O3 -0.0255273
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0254187
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0252724
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.025266
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0252451
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0251634
ZBTB20 zinc finger and BTB domain containing 20 -0.0249281