Budesonide_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Budesonide perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Budesonide_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.310299
HMGA2 high mobility group AT-hook 2 0.164482
NRG1 neuregulin 1 0.123797
ITGA1 integrin, alpha 1 0.119499
HIPK2 homeodomain interacting protein kinase 2 0.110616
AKAP12 A kinase (PRKA) anchor protein 12 0.105736
FKBP5 FK506 binding protein 5 0.104639
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.101015
IRAK3 interleukin-1 receptor-associated kinase 3 0.10008
MT2A metallothionein 2A 0.0991225
SAMD4A sterile alpha motif domain containing 4A 0.0921998
OSMR oncostatin M receptor 0.0879491
ASPH aspartate beta-hydroxylase 0.0879054
NAMPT nicotinamide phosphoribosyltransferase 0.0857978
TMEM156 transmembrane protein 156 0.0802789
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0772866
PRELID2 PRELI domain containing 2 0.0761992
HOMER2 homer scaffolding protein 2 0.0715
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0661654
NRP1 neuropilin 1 0.0645585
EFNA5 ephrin-A5 0.0638869
GLUL glutamate-ammonia ligase 0.0635975
FNDC3B fibronectin type III domain containing 3B 0.0630908
IL6ST interleukin 6 signal transducer 0.0621843
RUNX2 runt-related transcription factor 2 0.060052
ACSL1 acyl-CoA synthetase long-chain family member 1 0.0597516
ZMYND8 zinc finger, MYND-type containing 8 0.0581474
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0580513
SMYD3 SET and MYND domain containing 3 0.057336
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0564674
TNS3 tensin 3 0.0527703
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0525093
NRIP1 nuclear receptor interacting protein 1 0.0517985
FTH1 ferritin, heavy polypeptide 1 0.0512212
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0508112
NPAS2 neuronal PAS domain protein 2 0.0504911
DOCK5 dedicator of cytokinesis 5 0.0500323
GLIS3 GLIS family zinc finger 3 0.0491193
TOP1 topoisomerase (DNA) I 0.048963
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0484889
TRIO trio Rho guanine nucleotide exchange factor 0.0482851
ETV1 ets variant 1 0.048256
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0482183
TXNIP thioredoxin interacting protein 0.0477617
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0467056
AHNAK AHNAK nucleoprotein 0.0461793
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0453387
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0451369
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0440247
MBD5 methyl-CpG binding domain protein 5 0.0436292
FRY furry homolog (Drosophila) 0.0435826
HPCAL1 hippocalcin-like 1 0.0432879
TMSB10 thymosin beta 10 0.0432447
KLHL5 kelch-like family member 5 0.0429118
MAML2 mastermind-like 2 (Drosophila) 0.0420786
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0405045
DPYD dihydropyrimidine dehydrogenase 0.0398234
PTK2 protein tyrosine kinase 2 0.0397608
TMEM165 transmembrane protein 165 0.0396264
TGM2 transglutaminase 2 0.0392362
FOXP1 forkhead box P1 0.038845
JAK2 Janus kinase 2 0.0386872
ERRFI1 ERBB receptor feedback inhibitor 1 0.0386349
TAS2R14 taste receptor, type 2, member 14 0.0384284
VCL vinculin 0.0375321
WSB1 WD repeat and SOCS box containing 1 0.0373431
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0368235
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0366308
LRMDA leucine rich melanocyte differentiation associated 0.0364842
CLASP1 cytoplasmic linker associated protein 1 0.0357999
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.035549
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0354108
STK39 serine threonine kinase 39 0.0351541
FBXO32 F-box protein 32 0.0350874
MBNL1 muscleblind-like splicing regulator 1 0.0347366
FAM13A family with sequence similarity 13, member A 0.0341714
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0339869
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0338774
SPIDR scaffolding protein involved in DNA repair 0.0337551
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0324156
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0319452
SRRM2 serine/arginine repetitive matrix 2 0.0317218
TGFB2 transforming growth factor, beta 2 0.0316877
TBC1D22A TBC1 domain family, member 22A 0.0315605
NAV2 neuron navigator 2 0.0310243
IRS2 insulin receptor substrate 2 0.0308143
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0306443
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0306116
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0305783
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0304441
SVIL supervillin 0.0303338
RAD51B RAD51 paralog B 0.0301988
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0298682
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0297696
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0296671
ZC3H12C zinc finger CCCH-type containing 12C 0.0295408
AOPEP aminopeptidase O (putative) 0.0292827
LPP LIM domain containing preferred translocation partner in lipoma 0.0292437
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0292257
FNDC3A fibronectin type III domain containing 3A 0.0291514

decreased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 -0.105513
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0864776
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0769707
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0674591
NDRG1 N-myc downstream regulated 1 -0.0351652
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0326728
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0283202
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0281573
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0269603
FAT1 FAT atypical cadherin 1 -0.0250372
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0250058
CADM1 cell adhesion molecule 1 -0.0243586
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0227243
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0218686
HILPDA hypoxia inducible lipid droplet-associated -0.0216578
INTS6 integrator complex subunit 6 -0.0203618
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0188066
MRPS6 mitochondrial ribosomal protein S6 -0.0186698
TMSB4X thymosin beta 4, X-linked -0.0183651
ERO1B endoplasmic reticulum oxidoreductase 1 beta -0.0179458
CALR calreticulin -0.0174903
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0174794
TFPI2 tissue factor pathway inhibitor 2 -0.0167718
VEGFA vascular endothelial growth factor A -0.0166623
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0163083
IFRD1 interferon-related developmental regulator 1 -0.0161322
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0160455
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0160288
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0159064
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0158054
IGFBP3 insulin-like growth factor binding protein 3 -0.0155739
LRRC23 leucine rich repeat containing 23 -0.0152161
NUP58 nucleoporin 58 -0.0151659
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0151417
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0149484
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0147286
SQSTM1 sequestosome 1 -0.0142213
B2M beta-2-microglobulin -0.0137349
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.013682
TUFT1 tuftelin 1 -0.0136266
BZW2 basic leucine zipper and W2 domains 2 -0.0133772
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0132585
INSIG1 insulin induced gene 1 -0.01325
PTMA prothymosin, alpha -0.0131617
NOP58 NOP58 ribonucleoprotein -0.0131057
DUSP5 dual specificity phosphatase 5 -0.0129108
KMT2E lysine (K)-specific methyltransferase 2E -0.0127457
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0125577
UBC ubiquitin C -0.0125179
EXT1 exostosin glycosyltransferase 1 -0.012462
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0124236
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0123674
CRY1 cryptochrome circadian clock 1 -0.0123601
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0123064
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0122396
CCNL1 cyclin L1 -0.012021
RND3 Rho family GTPase 3 -0.0117705
AHR aryl hydrocarbon receptor -0.0117335
JUN jun proto-oncogene -0.0116399
RYBP RING1 and YY1 binding protein -0.0116022
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 -0.0115732
SPAG9 sperm associated antigen 9 -0.0114562
SUCO SUN domain containing ossification factor -0.0114343
FOSL1 FOS-like antigen 1 -0.0113779
PDIA4 protein disulfide isomerase family A, member 4 -0.0111127
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -0.0110865
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.011073
PDIA6 protein disulfide isomerase family A, member 6 -0.0109122
BLZF1 basic leucine zipper nuclear factor 1 -0.0107374
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0106209
AHRR aryl-hydrocarbon receptor repressor -0.0105858
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0103626
WTAP Wilms tumor 1 associated protein -0.0101939
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0101592
CANX calnexin -0.0100854
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0100851
POU2F2 POU class 2 homeobox 2 -0.00997958
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.00992233
FGF18 fibroblast growth factor 18 -0.00985783
CD44 CD44 molecule (Indian blood group) -0.00979807
BTG1 B-cell translocation gene 1, anti-proliferative -0.00977671
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.00963541
GNAS GNAS complex locus -0.00963325
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.00959129
MORF4L1 mortality factor 4 like 1 -0.00954821
CALU calumenin -0.00953446
UGDH UDP-glucose 6-dehydrogenase -0.0094095
STC1 stanniocalcin 1 -0.00940751
SDCBP syndecan binding protein (syntenin) -0.0094071
USP15 ubiquitin specific peptidase 15 -0.00927832
MED27 mediator complex subunit 27 -0.00922806
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.00920865
RPL8 ribosomal protein L8 -0.00920055
BHLHE40 basic helix-loop-helix family, member e40 -0.00909848
FXR1 fragile X mental retardation, autosomal homolog 1 -0.00908894
PDIA3 protein disulfide isomerase family A, member 3 -0.0090225
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.00897215
RBBP5 retinoblastoma binding protein 5 -0.00897011
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.00892617
MARCKS myristoylated alanine-rich protein kinase C substrate -0.00892002